SG11201907095UA - DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS - Google Patents
DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTSInfo
- Publication number
- SG11201907095UA SG11201907095UA SG11201907095UA SG11201907095UA SG11201907095UA SG 11201907095U A SG11201907095U A SG 11201907095UA SG 11201907095U A SG11201907095U A SG 11201907095UA SG 11201907095U A SG11201907095U A SG 11201907095UA SG 11201907095U A SG11201907095U A SG 11201907095UA
- Authority
- SG
- Singapore
- Prior art keywords
- imidazo
- heterocycloalkyl
- pyrimidin
- cycloalkyl
- pyridine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2017900290A AU2017900290A0 (en) | 2017-02-01 | Pyrimidin-2-amine derivatives as therapeutic compounds | |
| PCT/AU2018/000011 WO2018141002A2 (fr) | 2017-02-01 | 2018-02-01 | Dérivés de n-cycloalkyl/hétérocycloalkyle-4-(imidazo[1,2-a]pyridine)pyrimidin-2-amine en tant qu'agents thérapeutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201907095UA true SG11201907095UA (en) | 2019-08-27 |
Family
ID=63039275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201907095UA SG11201907095UA (en) | 2017-02-01 | 2018-02-01 | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11111245B2 (fr) |
| EP (1) | EP3577116A4 (fr) |
| JP (1) | JP7113528B2 (fr) |
| CN (1) | CN110418789B (fr) |
| AU (1) | AU2018214431B2 (fr) |
| CA (1) | CA3051604A1 (fr) |
| SG (1) | SG11201907095UA (fr) |
| WO (1) | WO2018141002A2 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3765459A1 (fr) | 2018-03-13 | 2021-01-20 | Shire Human Genetic Therapies, Inc. | Imidazopyridines substituées en tant qu'inhibiteurs de la kallicréine plasmatique et leurs utilisations |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| CN111362852B (zh) * | 2018-12-25 | 2023-06-16 | 浙江瑞博制药有限公司 | 一种药物中间体1-叔丁氧羰基-3-氮杂环丁酮的制备方法 |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020205560A1 (fr) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Composés sulfonylamides utilisés comme inhibiteurs de la cdk2 |
| WO2020223469A1 (fr) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Dérivés de n-(1-(méthylsulfonyl)pipéridin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine et composés apparentés utilisés en tant qu'inhibiteurs de kinase 2 dépendante des cyclines (cdk2) pour le traitement du cancer |
| WO2020223558A1 (fr) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Composés aminés tricycliques en tant qu'inhibiteurs de cdk2 |
| JP2022539849A (ja) * | 2019-07-10 | 2022-09-13 | オーセントラ セラピュティクス ピーティーワイ エルティーディー | 治療薬としての４－（イミダゾ［１，２－ａ］ピリジン－３－イル）－Ｎ－（ピリジニル）ピリミジン－２－アミンの誘導体 |
| CR20220066A (es) | 2019-08-14 | 2022-11-28 | Incyte Corp | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2 |
| WO2021055589A1 (fr) | 2019-09-18 | 2021-03-25 | Shire Human Genetic Therapies, Inc. | Inhibiteurs hétéroaryles de la kallicréine plasmatique |
| CN114728962A (zh) | 2019-09-18 | 2022-07-08 | 武田药品工业有限公司 | 血浆激肽释放酶抑制剂及其用途 |
| CN115298177A (zh) | 2019-10-11 | 2022-11-04 | 因赛特公司 | 作为cdk2抑制剂的双环胺 |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| HUP9901155A3 (en) | 1996-02-13 | 2003-04-28 | Astrazeneca Ab | Quinazoline derivatives as vegf inhibitors |
| KR100489174B1 (ko) | 1996-03-05 | 2005-09-30 | 제네카-파마 소시에떼아노님 | 4-아닐리노퀴나졸린유도체 |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| CZ306810B6 (cs) | 1999-02-10 | 2017-07-19 | Astrazeneca Ab | Použití chinazolinového derivátu jako inhibitoru angiogeneze |
| KR20030013433A (ko) | 2000-05-31 | 2003-02-14 | 아스트라제네카 아베 | 혈관 손상 활성을 가진 인돌 유도체 |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| EP1301497A1 (fr) | 2000-07-07 | 2003-04-16 | Angiogene Pharmaceuticals Limited | Derives de colchinol utilises comme agents de degradation vasculaire |
| HUP0301742A3 (en) | 2000-07-07 | 2005-08-29 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors, process for producing them, pharmaceutical compositions containing them and their use |
| CA2451008A1 (fr) | 2001-06-21 | 2003-01-03 | Smithkline Beecham Corporation | Derives d'imidazo'1,2-a!pyridine destines a la prevention et au traitement d'infections au virus de l'herpes |
| US7196095B2 (en) | 2001-06-25 | 2007-03-27 | Merck & Co., Inc. | (Pyrimidinyl) (phenyl) substituted fused heteroaryl p38 inhibiting and PKG kinase inhibiting compounds |
| ES2262893T3 (es) | 2001-10-05 | 2006-12-01 | Smithkline Beecham Corporation | Derivados de imidazo-piridina para su uso en el tratamiento de infeccion virica por herpes. |
| UA80296C2 (en) * | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
| WO2006038001A1 (fr) | 2004-10-06 | 2006-04-13 | Celltech R & D Limited | Derives d’aminopyrimidine en tant qu’inhibiteurs de la jnk |
| WO2006050086A2 (fr) * | 2004-10-29 | 2006-05-11 | Trek, Inc. | Dispositif de controle d'equilibre ionique |
| WO2006050076A1 (fr) | 2004-10-29 | 2006-05-11 | Janssen Pharmaceutica, N.V. | Composes de pyrrolyle fusionnes substitues par pyrimidinyle et utiles dans le traitement des troubles induits par la kinase |
| WO2010009155A2 (fr) * | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Composés inhibiteurs hétérocycliques condensés |
| WO2010049731A1 (fr) | 2008-10-29 | 2010-05-06 | Astrazeneca Ab | Pyrazolo et imidazo-pyridinyl-pyrimidinamines utilisés comme inhibiteurs de la tyrosine kinase igf-1r |
| JP5518905B2 (ja) | 2009-02-24 | 2014-06-11 | エフ．ホフマン−ラ ロシュ アーゲー | ＪＮＫモジュレーターとしてのイミダゾ［１，２−ａ］ピリジン |
| RU2012155144A (ru) * | 2010-06-04 | 2014-07-20 | Ф. Хоффманн-Ля Рош Аг | Ингибиторы jnk |
| WO2012066065A1 (fr) | 2010-11-17 | 2012-05-24 | Novartis Ag | Composés phényl-hétéroaryl amine et leurs utilisations |
| PT3126352T (pt) * | 2014-04-04 | 2018-12-27 | Syros Pharmaceuticals Inc | Inibidores da quinase dependente de ciclina 7 (cdk7) |
| CN113336746A (zh) | 2015-08-04 | 2021-09-03 | 常州千红生化制药股份有限公司 | N-(吡啶-2-基)-4-(噻唑-5-基)嘧啶-2-胺类化合物作为治疗性化合物 |
-
2018
- 2018-02-01 US US16/482,867 patent/US11111245B2/en active Active
- 2018-02-01 WO PCT/AU2018/000011 patent/WO2018141002A2/fr unknown
- 2018-02-01 SG SG11201907095UA patent/SG11201907095UA/en unknown
- 2018-02-01 CN CN201880015860.9A patent/CN110418789B/zh active Active
- 2018-02-01 CA CA3051604A patent/CA3051604A1/fr active Pending
- 2018-02-01 AU AU2018214431A patent/AU2018214431B2/en active Active
- 2018-02-01 JP JP2019541271A patent/JP7113528B2/ja active Active
- 2018-02-01 EP EP18748523.0A patent/EP3577116A4/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3577116A2 (fr) | 2019-12-11 |
| WO2018141002A2 (fr) | 2018-08-09 |
| US20200231586A1 (en) | 2020-07-23 |
| CA3051604A1 (fr) | 2018-08-09 |
| WO2018141002A3 (fr) | 2018-11-22 |
| JP2020505419A (ja) | 2020-02-20 |
| JP7113528B2 (ja) | 2022-08-05 |
| AU2018214431A1 (en) | 2019-08-29 |
| CN110418789A (zh) | 2019-11-05 |
| US11111245B2 (en) | 2021-09-07 |
| CN110418789B (zh) | 2022-03-25 |
| EP3577116A4 (fr) | 2020-12-02 |
| AU2018214431B2 (en) | 2021-07-29 |
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