MX2017004782A - Derivados de 7-(morfolinil)-2-(n-piperazinil)metiltieno[2,3-c]piri dina como farmacos anticancerigenos. - Google Patents

Derivados de 7-(morfolinil)-2-(n-piperazinil)metiltieno[2,3-c]piri dina como farmacos anticancerigenos.

Info

Publication number
MX2017004782A
MX2017004782A MX2017004782A MX2017004782A MX2017004782A MX 2017004782 A MX2017004782 A MX 2017004782A MX 2017004782 A MX2017004782 A MX 2017004782A MX 2017004782 A MX2017004782 A MX 2017004782A MX 2017004782 A MX2017004782 A MX 2017004782A
Authority
MX
Mexico
Prior art keywords
piperazinyl
morpholinyl
anticancer drugs
pyridine derivatives
methyl thieno
Prior art date
Application number
MX2017004782A
Other languages
English (en)
Inventor
Satya Bhujanga Rao Adibhatla Kali
Chowdary Nannapaneni Venkaiah
Prasad Konakanchi Durga
Rao Pula Subba
Krishna PILLI Rama
Viswa Venkata Pavan Kumar MADDULA Lakshmana
Krishna Murthy KONDURI Srinivasa
Rama Rao RAVI Janaki
Vasanta Srinivasu Vuppalapati Naga
Kumar Thoota Sandeep
Reddy Muddasani Pulla
Original Assignee
Natco Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd
Publication of MX2017004782A publication Critical patent/MX2017004782A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a nuevas series de 7-(morfolinil)-2-(N-piperazinil)-metil tieno[2,3-c]piridinas sustituidas de la siguiente estructura de fórmula I, en donde R1, R2, R3 y R4 son definidos. (ver Fórmula).
MX2017004782A 2014-12-11 2014-12-11 Derivados de 7-(morfolinil)-2-(n-piperazinil)metiltieno[2,3-c]piri dina como farmacos anticancerigenos. MX2017004782A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2014/000770 WO2016092556A1 (en) 2014-12-11 2014-12-11 7-(morpholinyl)-2-(n-piperazinyl) methyl thieno [2, 3-c] pyridine derivatives as anticancer drugs

Publications (1)

Publication Number Publication Date
MX2017004782A true MX2017004782A (es) 2017-07-27

Family

ID=52595387

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017004782A MX2017004782A (es) 2014-12-11 2014-12-11 Derivados de 7-(morfolinil)-2-(n-piperazinil)metiltieno[2,3-c]piri dina como farmacos anticancerigenos.

Country Status (31)

Country Link
US (1) US10106554B2 (es)
EP (1) EP3230289B1 (es)
JP (1) JP6454419B2 (es)
KR (1) KR102328921B1 (es)
CN (1) CN107074873B (es)
AP (1) AP2017009749A0 (es)
AU (1) AU2014413483B2 (es)
BR (1) BR112017005518B1 (es)
CA (1) CA2959980C (es)
CO (1) CO2017002266A2 (es)
CY (1) CY1122080T1 (es)
DK (1) DK3230289T3 (es)
EA (1) EA036819B1 (es)
ES (1) ES2750268T3 (es)
HR (1) HRP20192041T1 (es)
HU (1) HUE047144T2 (es)
IL (1) IL252254B (es)
LT (1) LT3230289T (es)
MA (1) MA40110B2 (es)
MX (1) MX2017004782A (es)
MY (1) MY188946A (es)
NZ (1) NZ729078A (es)
PH (1) PH12017500342A1 (es)
PL (1) PL3230289T3 (es)
PT (1) PT3230289T (es)
RS (1) RS59409B1 (es)
SG (1) SG11201702162PA (es)
SI (1) SI3230289T1 (es)
UA (1) UA117318C2 (es)
WO (1) WO2016092556A1 (es)
ZA (1) ZA201701036B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115298177A (zh) * 2019-10-11 2022-11-04 因赛特公司 作为cdk2抑制剂的双环胺
AU2020406139A1 (en) 2019-12-20 2022-06-30 Bayer Aktiengesellschaft Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof
EP4326276A1 (en) * 2021-04-21 2024-02-28 Natco Pharma Ltd Improved process for the preparation of 7-(morpholinyl)-2-(n-piperazinyl)methylthieno[2, 3-c]pyridine derivatives
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579526A (en) 1968-11-13 1971-05-18 Research Corp Preparation of thienopyridines
FR2411838A1 (fr) 1977-12-19 1979-07-13 Parcor Nouveaux derives des thieno (2-3-c) et (3,2-c) pyridines, leurs procede de preparation et leur application therapeutique
US4839365A (en) 1987-05-19 1989-06-13 Shinogi & Co., Ltd. Thienopyridine derivatives useful in treating gastric ulcers
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
WO2000075145A1 (en) 1999-06-03 2000-12-14 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
EP1753428A4 (en) * 2004-05-14 2010-09-15 Abbott Lab INHIBITORS OF KINASES AS THERAPEUTIC AGENTS
GB0608264D0 (en) * 2006-04-26 2006-06-07 Piramed Ltd Pharmaceutical compounds
AU2007242594A1 (en) * 2006-04-26 2007-11-01 F. Hoffmann-La Roche Ag Pyrimidine derivatives as PI3K inhibitors
RU2523890C2 (ru) * 2007-09-12 2014-07-27 Дженентек, Инк. Комбинации ингибиторов фосфоинозитид 3-киназы и химиотерапевтических агентов и способы применения
GB0723748D0 (en) 2007-12-04 2008-01-16 Ucb Pharma Sa Therapeutic agents
CL2009000780A1 (es) 2008-03-31 2010-01-15 Genentech Inc Compuestos derivados de heterociclil-pirano-heterociclilo, heterociclil-oxepina-heterociclilo, benzopirano-heterociclilo y benzoxepina-heterociclilo sustituidos; composicion farmaceutica; procedimiento de preparacion de la composicion; kit farmaceutico; y su uso en el tratamiento del cancer, mediado por la inhibicion de pi3k.
KR101430424B1 (ko) * 2009-01-08 2014-08-14 쿠리스 인코퍼레이션 아연 결합 모이어티를 갖는 포스포이노시티드 ３-키나제 억제제
KR20120081164A (ko) 2009-09-29 2012-07-18 엑스커버리 홀딩 컴퍼니 엘엘씨 Ｐｉ3ｋ(델타) 선택적 억제제
CA2787714C (en) 2010-01-22 2019-04-09 Joaquin Pastor Fernandez Inhibitors of pi3 kinase
RU2013138835A (ru) * 2011-02-09 2015-03-20 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения в качестве ингибиторов pi3 киназы

Also Published As

Publication number Publication date
AU2014413483B2 (en) 2019-07-25
WO2016092556A1 (en) 2016-06-16
PH12017500342A1 (en) 2017-07-17
BR112017005518B1 (pt) 2022-11-29
AU2014413483A1 (en) 2017-03-09
EA201791294A1 (ru) 2017-11-30
PT3230289T (pt) 2019-10-30
US10106554B2 (en) 2018-10-23
CN107074873A (zh) 2017-08-18
MY188946A (en) 2022-01-14
RS59409B1 (sr) 2019-11-29
BR112017005518A2 (pt) 2017-12-05
JP2017537139A (ja) 2017-12-14
EP3230289B1 (en) 2019-08-14
IL252254B (en) 2019-08-29
KR20170090434A (ko) 2017-08-07
CN107074873B (zh) 2022-01-07
CY1122080T1 (el) 2020-11-25
CA2959980A1 (en) 2016-06-16
CO2017002266A2 (es) 2017-05-31
NZ729078A (en) 2021-07-30
PL3230289T3 (pl) 2020-03-31
HRP20192041T1 (hr) 2020-02-07
SG11201702162PA (en) 2017-04-27
UA117318C2 (uk) 2018-07-10
ES2750268T3 (es) 2020-03-25
MA40110A1 (fr) 2017-12-29
HUE047144T2 (hu) 2020-04-28
JP6454419B2 (ja) 2019-01-16
LT3230289T (lt) 2019-10-10
IL252254A0 (en) 2017-07-31
EA036819B1 (ru) 2020-12-23
DK3230289T3 (da) 2019-10-28
CA2959980C (en) 2023-04-25
ZA201701036B (en) 2019-06-26
US20170320891A1 (en) 2017-11-09
AP2017009749A0 (en) 2017-02-28
MA40110B2 (fr) 2020-12-31
KR102328921B1 (ko) 2021-11-19
EP3230289A1 (en) 2017-10-18
SI3230289T1 (sl) 2019-10-30

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