MX368767B - (5,6-dihidro)pirimido[4,5-e]indolizinas. - Google Patents

(5,6-dihidro)pirimido[4,5-e]indolizinas.

Info

Publication number
MX368767B
MX368767B MX2016012997A MX2016012997A MX368767B MX 368767 B MX368767 B MX 368767B MX 2016012997 A MX2016012997 A MX 2016012997A MX 2016012997 A MX2016012997 A MX 2016012997A MX 368767 B MX368767 B MX 368767B
Authority
MX
Mexico
Prior art keywords
indolizines
pyrimido
dihydro
cancer
aryl
Prior art date
Application number
MX2016012997A
Other languages
English (en)
Other versions
MX2016012997A (es
Inventor
Petrus Antonius De Man Adrianus
Christian Buijsman Rogier
Gerard STERRENBURG Jan
Cornelis Marinus UITDEHAAG Joost
Johannes Petrus DE WIT Joeri
Jenny Rudolf Zaman Guido
Original Assignee
Netherlands Translational Res Center B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Netherlands Translational Res Center B V filed Critical Netherlands Translational Res Center B V
Publication of MX2016012997A publication Critical patent/MX2016012997A/es
Publication of MX368767B publication Critical patent/MX368767B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a un compuesto de fórmula I: (ver Fórmula) Fórmula I, en donde, R1 y R2 se seleccionan independientemente entre el grupo que consiste de arilo de (C6-10) opcionalmente sustituido y grupos heteroarilo de (C1-5); los compuestos se pueden utilizar en composiciones farmacéuticas, en particular en el tratamiento del cáncer.
MX2016012997A 2014-04-07 2015-03-30 (5,6-dihidro)pirimido[4,5-e]indolizinas. MX368767B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14163734 2014-04-07
EP15153207 2015-01-30
PCT/EP2015/056839 WO2015155042A1 (en) 2014-04-07 2015-03-30 (5,6-dihydro)pyrimido[4,5-e]indolizines

Publications (2)

Publication Number Publication Date
MX2016012997A MX2016012997A (es) 2016-12-07
MX368767B true MX368767B (es) 2019-10-15

Family

ID=52774240

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016012997A MX368767B (es) 2014-04-07 2015-03-30 (5,6-dihidro)pirimido[4,5-e]indolizinas.

Country Status (16)

Country Link
US (3) USRE48974E1 (es)
EP (1) EP3129374B1 (es)
JP (1) JP6518690B2 (es)
KR (1) KR102432420B1 (es)
CN (1) CN106132963B (es)
AU (1) AU2015243694B2 (es)
BR (1) BR112016022342B1 (es)
CA (1) CA2944610C (es)
DK (1) DK3129374T3 (es)
ES (1) ES2716165T3 (es)
HU (1) HUE043108T2 (es)
MX (1) MX368767B (es)
PL (1) PL3129374T3 (es)
PT (1) PT3129374T (es)
RU (1) RU2692479C2 (es)
WO (1) WO2015155042A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106132963B (zh) * 2014-04-07 2019-08-06 荷兰转化研究中心有限责任公司 (5,6-二氢)嘧啶并[4,5-e]吲嗪
CN107567503B (zh) * 2015-04-17 2022-03-22 荷兰转化研究中心有限责任公司 用于ttk抑制剂化疗的预后生物标记
PL3416964T3 (pl) * 2016-02-19 2021-10-18 Phoenix Molecular Designs Pochodne 6-okso-n-(1-(benzylo)-1h-pirazol-4-ilo)-6,7,8,9-tetrahydropirydo[3’,2’:4,5]pirolo[1,2-a]pirazyno-2-karboksyamidu jako inhibitory kinazy rybosomalnej s6 p90 (rsk) do leczenia nowotworu złośliwego
EA202092442A3 (ru) 2016-06-07 2021-08-31 Джакобио Фармасьютикалс Ко., Лтд. Новые гетероциклические производные, применимые в качестве ингибиторов shp2
CN106551938B (zh) * 2016-11-26 2017-11-24 广东安诺药业股份有限公司 一种治疗非酒精性脂肪肝的药物及其应用
AU2018239542C1 (en) 2017-03-23 2021-02-11 Jacobio Pharmaceuticals Co., Ltd. Novel heterocyclic derivatives useful as SHP2 inhibitors
US20210393623A1 (en) 2018-09-26 2021-12-23 Jacobio Pharmaceuticals Co., Ltd. Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors
CN113677681A (zh) 2019-02-11 2021-11-19 凤凰分子设计公司 Rsk抑制剂的结晶形式
WO2023113478A1 (en) * 2021-12-15 2023-06-22 Sillajen, Inc. Methods of treating neoplastic diseases
MX2024007450A (es) * 2021-12-15 2024-07-04 Sillajen Inc Combinaciones farmaceuticas para utilizarse en el tratamiento de enfermedades neoplasicas.
MX2024007452A (es) * 2021-12-15 2024-07-09 Sillajen Inc Composiciones farmaceuticas que comprenden beta-ciclodextrinas modificadas.
AU2023228543A1 (en) * 2022-03-04 2024-08-22 Sillajen, Inc. Pharmaceutical combinations for use in the treatment of neoplastic diseases.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04002243A (es) * 2001-09-19 2004-06-29 Aventis Pharma Sa Compuestos quimicos.
US7482354B2 (en) 2003-05-22 2009-01-27 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
EP2118102B1 (en) 2006-11-28 2013-06-12 Nerviano Medical Sciences S.r.l. Tricyclic indoles and (4,5-dihydro) indoles
EP2303891B1 (en) * 2008-06-26 2016-02-17 Les Laboratoires Servier Pyrazolo-quinazolines as protein kinase activity modulators
WO2010111406A2 (en) 2009-03-24 2010-09-30 Myriad Pharmaceuticals, Inc. Compounds and therapeutic uses thereof
US8586598B2 (en) 2009-04-29 2013-11-19 Nerviano Medical Sciences S.R.L. CDK inhibitor salts
WO2011012534A1 (en) 2009-07-29 2011-02-03 Nerviano Medical Sciences S.R.L. Plk inhibitor salts
TW201107329A (en) 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
EP2343297A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
EP2651948A1 (en) 2010-12-17 2013-10-23 Bayer Intellectual Property GmbH Imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment hyperproliferative disorders
CN103339134B (zh) * 2011-01-26 2015-12-23 内尔维阿诺医学科学有限公司 三环吡咯并衍生物、它们的制备方法和它们作为激酶抑制剂的应用
WO2014209978A1 (en) 2013-06-24 2014-12-31 Merck Patent Gmbh Imidazole compounds as modulators of fshr and uses thereof
CN106132963B (zh) * 2014-04-07 2019-08-06 荷兰转化研究中心有限责任公司 (5,6-二氢)嘧啶并[4,5-e]吲嗪

Also Published As

Publication number Publication date
US20170096432A1 (en) 2017-04-06
WO2015155042A1 (en) 2015-10-15
MX2016012997A (es) 2016-12-07
HUE043108T2 (hu) 2019-07-29
EP3129374A1 (en) 2017-02-15
PL3129374T3 (pl) 2019-07-31
KR102432420B1 (ko) 2022-08-17
EP3129374B1 (en) 2018-12-19
DK3129374T3 (en) 2019-04-08
CA2944610A1 (en) 2015-10-15
US9856258B2 (en) 2018-01-02
JP2017510595A (ja) 2017-04-13
USRE48974E1 (en) 2022-03-15
AU2015243694B2 (en) 2019-01-17
RU2016141405A3 (es) 2018-10-02
USRE50082E1 (en) 2024-08-20
AU2015243694A1 (en) 2016-11-03
JP6518690B2 (ja) 2019-05-22
CN106132963A (zh) 2016-11-16
BR112016022342B1 (pt) 2022-10-04
ES2716165T3 (es) 2019-06-10
CN106132963B (zh) 2019-08-06
RU2692479C2 (ru) 2019-06-25
RU2016141405A (ru) 2018-05-07
BR112016022342A8 (pt) 2021-07-20
CA2944610C (en) 2024-01-09
PT3129374T (pt) 2019-03-25
KR20170013866A (ko) 2017-02-07
BR112016022342A2 (pt) 2017-08-15

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