MX2016012997A - (5,6-dihidro)pirimido[4,5-e]indolizinas. - Google Patents

(5,6-dihidro)pirimido[4,5-e]indolizinas.

Info

Publication number
MX2016012997A
MX2016012997A MX2016012997A MX2016012997A MX2016012997A MX 2016012997 A MX2016012997 A MX 2016012997A MX 2016012997 A MX2016012997 A MX 2016012997A MX 2016012997 A MX2016012997 A MX 2016012997A MX 2016012997 A MX2016012997 A MX 2016012997A
Authority
MX
Mexico
Prior art keywords
indolizines
pyrimido
dihydro
cancer
aryl
Prior art date
Application number
MX2016012997A
Other languages
English (en)
Other versions
MX368767B (es
Inventor
Petrus Antonius De Man Adrianus
Christian Buijsman Rogier
Gerard STERRENBURG Jan
Cornelis Marinus UITDEHAAG Joost
Johannes Petrus DE WIT Joeri
Jenny Rudolf Zaman Guido
Original Assignee
Netherlands Translational Res Center B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Netherlands Translational Res Center B V filed Critical Netherlands Translational Res Center B V
Publication of MX2016012997A publication Critical patent/MX2016012997A/es
Publication of MX368767B publication Critical patent/MX368767B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

Abstract

La invención se refiere a un compuesto de fórmula I: (ver Fórmula) Fórmula I, en donde, R1 y R2 se seleccionan independientemente entre el grupo que consiste de arilo de (C6-10) opcionalmente sustituido y grupos heteroarilo de (C1-5); los compuestos se pueden utilizar en composiciones farmacéuticas, en particular en el tratamiento del cáncer.
MX2016012997A 2014-04-07 2015-03-30 (5,6-dihidro)pirimido[4,5-e]indolizinas. MX368767B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14163734 2014-04-07
EP15153207 2015-01-30
PCT/EP2015/056839 WO2015155042A1 (en) 2014-04-07 2015-03-30 (5,6-dihydro)pyrimido[4,5-e]indolizines

Publications (2)

Publication Number Publication Date
MX2016012997A true MX2016012997A (es) 2016-12-07
MX368767B MX368767B (es) 2019-10-15

Family

ID=52774240

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016012997A MX368767B (es) 2014-04-07 2015-03-30 (5,6-dihidro)pirimido[4,5-e]indolizinas.

Country Status (16)

Country Link
US (2) US9856258B2 (es)
EP (1) EP3129374B1 (es)
JP (1) JP6518690B2 (es)
KR (1) KR102432420B1 (es)
CN (1) CN106132963B (es)
AU (1) AU2015243694B2 (es)
BR (1) BR112016022342B1 (es)
CA (1) CA2944610C (es)
DK (1) DK3129374T3 (es)
ES (1) ES2716165T3 (es)
HU (1) HUE043108T2 (es)
MX (1) MX368767B (es)
PL (1) PL3129374T3 (es)
PT (1) PT3129374T (es)
RU (1) RU2692479C2 (es)
WO (1) WO2015155042A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3283642T (pt) * 2015-04-17 2024-01-02 Crossfire Oncology Holding B V Biomarcadores de prognóstico para quimioterapia inibidora de ttk
CN109071542B (zh) * 2016-02-19 2021-07-20 凤凰分子设计公司 可用作rsk抑制剂的羧酰胺衍生物
EP4108659A1 (en) 2016-06-07 2022-12-28 Jacobio Pharmaceuticals Co., Ltd. Novel heterocyclic derivatives useful as shp2 inhibitors
CN106551938B (zh) * 2016-11-26 2017-11-24 广东安诺药业股份有限公司 一种治疗非酒精性脂肪肝的药物及其应用
AU2018239542C1 (en) 2017-03-23 2021-02-11 Jacobio Pharmaceuticals Co., Ltd. Novel heterocyclic derivatives useful as SHP2 inhibitors
WO2023113477A1 (en) * 2021-12-15 2023-06-22 Sillajen, Inc. Pharmaceutical combinations for use in the treatment of neoplastic diseases
WO2023113479A1 (en) * 2021-12-15 2023-06-22 Sillajen, Inc. Pharmaceutical compositions comprising modified beta-cyclodextrins
WO2023113478A1 (en) * 2021-12-15 2023-06-22 Sillajen, Inc. Methods of treating neoplastic diseases
WO2023167549A1 (en) * 2022-03-04 2023-09-07 Sillajen, Inc. Pharmaceutical combinations for use in the treatment of neoplastic diseases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ531378A (en) * 2001-09-19 2006-11-30 Aventis Pharma S Indolizines as kinase protein inhibitors suitable for treating solid tumours
GEP20094664B (en) 2003-05-22 2009-04-10 Nerviano Medical Sciences Srl Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
WO2008065054A1 (en) 2006-11-28 2008-06-05 Nerviano Medical Sciences S.R.L. Tricyclic indoles and (4,5-dihydro) indoles
AU2009264431B2 (en) * 2008-06-26 2013-11-07 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazolines
WO2010111406A2 (en) 2009-03-24 2010-09-30 Myriad Pharmaceuticals, Inc. Compounds and therapeutic uses thereof
US8586598B2 (en) 2009-04-29 2013-11-19 Nerviano Medical Sciences S.R.L. CDK inhibitor salts
ES2553114T3 (es) 2009-07-29 2015-12-04 Nerviano Medical Sciences S.R.L. Sales de inhibidor de plk
TW201107329A (en) 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
EP2343297A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
US20130303532A1 (en) * 2010-12-17 2013-11-14 Bayer Intellectual Property Gmbh Imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment hyperproliferative disorders
WO2012101032A1 (en) * 2011-01-26 2012-08-02 Nerviano Medical Sciences S.R.L. Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors
AU2014302710B2 (en) 2013-06-24 2018-10-04 Merck Patent Gmbh Imidazole compounds as modulators of FSHR and uses thereof

Also Published As

Publication number Publication date
KR102432420B1 (ko) 2022-08-17
USRE48974E1 (en) 2022-03-15
PL3129374T3 (pl) 2019-07-31
EP3129374A1 (en) 2017-02-15
PT3129374T (pt) 2019-03-25
CA2944610C (en) 2024-01-09
BR112016022342A8 (pt) 2021-07-20
RU2016141405A3 (es) 2018-10-02
CA2944610A1 (en) 2015-10-15
CN106132963A (zh) 2016-11-16
RU2692479C2 (ru) 2019-06-25
BR112016022342A2 (pt) 2017-08-15
ES2716165T3 (es) 2019-06-10
CN106132963B (zh) 2019-08-06
KR20170013866A (ko) 2017-02-07
MX368767B (es) 2019-10-15
BR112016022342B1 (pt) 2022-10-04
US9856258B2 (en) 2018-01-02
HUE043108T2 (hu) 2019-07-29
JP6518690B2 (ja) 2019-05-22
JP2017510595A (ja) 2017-04-13
EP3129374B1 (en) 2018-12-19
AU2015243694A1 (en) 2016-11-03
DK3129374T3 (en) 2019-04-08
AU2015243694B2 (en) 2019-01-17
US20170096432A1 (en) 2017-04-06
WO2015155042A1 (en) 2015-10-15
RU2016141405A (ru) 2018-05-07

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