SG11201706947TA - Reducing immune tolerance induced by pd-l1 - Google Patents
Reducing immune tolerance induced by pd-l1Info
- Publication number
- SG11201706947TA SG11201706947TA SG11201706947TA SG11201706947TA SG11201706947TA SG 11201706947T A SG11201706947T A SG 11201706947TA SG 11201706947T A SG11201706947T A SG 11201706947TA SG 11201706947T A SG11201706947T A SG 11201706947TA SG 11201706947T A SG11201706947T A SG 11201706947TA
- Authority
- SG
- Singapore
- Prior art keywords
- immune tolerance
- tolerance induced
- reducing immune
- reducing
- induced
- Prior art date
Links
- 230000006058 immune tolerance Effects 0.000 title 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562126804P | 2015-03-02 | 2015-03-02 | |
PCT/CN2016/075061 WO2016138846A1 (en) | 2015-03-02 | 2016-03-01 | Reducing immune tolerance induced by pd‐l1 |
Publications (1)
Publication Number | Publication Date |
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SG11201706947TA true SG11201706947TA (en) | 2017-09-28 |
Family
ID=56848306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201706947TA SG11201706947TA (en) | 2015-03-02 | 2016-03-01 | Reducing immune tolerance induced by pd-l1 |
Country Status (11)
Country | Link |
---|---|
US (4) | US9572837B2 (ja) |
EP (2) | EP3549612A1 (ja) |
JP (2) | JP6336684B2 (ja) |
KR (1) | KR102133857B1 (ja) |
CN (2) | CN107073138B (ja) |
AU (1) | AU2016228080B2 (ja) |
BR (1) | BR112017018770A2 (ja) |
CA (1) | CA2976684C (ja) |
RU (1) | RU2688692C2 (ja) |
SG (1) | SG11201706947TA (ja) |
WO (1) | WO2016138846A1 (ja) |
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HRP20220890T1 (hr) * | 2015-02-06 | 2022-10-14 | National University Of Singapore | Postupci za povećanje učinkovitosti terapijskih imunosnih stanica |
KR102133857B1 (ko) * | 2015-03-02 | 2020-07-20 | 이노베이티브 셀룰러 테라퓨틱스 코퍼레이션 리미티드 | Pd-l1에 의해 유도된 면역관용의 감소 |
CN114634943A (zh) | 2015-05-18 | 2022-06-17 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
CA2997551A1 (en) * | 2015-09-04 | 2017-03-09 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use |
WO2017100428A1 (en) | 2015-12-09 | 2017-06-15 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of using same |
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CN110612119A (zh) | 2017-02-07 | 2019-12-24 | 西雅图儿童医院(Dba西雅图儿童研究所) | 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂 |
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EP3612210A4 (en) | 2017-04-19 | 2021-01-27 | Board Of Regents, The University Of Texas System | IMMUNE CELLS EXPRESSING MODIFIED ANTIGEN RECEPTORS |
KR20200035304A (ko) | 2017-08-10 | 2020-04-02 | 싱가포르국립대학교 | T 세포 수용체-결핍 키메라 항원 수용체 t-세포 및 이의 사용 방법 |
CA3077187A1 (en) * | 2017-09-26 | 2019-04-04 | Longwood University | Pd1-specific chimeric antigen receptor as an immunotherapy |
CN109836493A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种靶向cd19的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
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US20220088074A1 (en) * | 2019-02-21 | 2022-03-24 | Regents Of The University Of Minnesota | Genetically modified gamma delta t cells and methods of making and using |
US11739136B2 (en) * | 2019-03-18 | 2023-08-29 | Innovative Cellular Therapeutics Holdings, Ltd. | Inducible dominant negative PD-1 and uses in adoptive cell therapy |
CN109868263A (zh) * | 2019-03-29 | 2019-06-11 | 深圳精准医疗科技有限公司 | 重组单纯疱疹病毒及其制备方法和应用、重组载体的构建方法及其应用 |
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CN110423767A (zh) * | 2019-07-12 | 2019-11-08 | 华东师范大学 | 表达可溶性pd-1的嵌合抗原受体car基因及应用 |
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KR102133857B1 (ko) | 2015-03-02 | 2020-07-20 | 이노베이티브 셀룰러 테라퓨틱스 코퍼레이션 리미티드 | Pd-l1에 의해 유도된 면역관용의 감소 |
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CA2997551A1 (en) | 2015-09-04 | 2017-03-09 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use |
EP3362074B1 (en) | 2015-10-16 | 2023-08-09 | President and Fellows of Harvard College | Regulatory t cell pd-1 modulation for regulating t cell effector immune responses |
WO2017100428A1 (en) | 2015-12-09 | 2017-06-15 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of using same |
WO2019140100A1 (en) | 2018-01-11 | 2019-07-18 | Innovative Cellular Therapeutics Inc. | Modified cell expansion and uses thereof |
WO2020086989A1 (en) | 2018-10-25 | 2020-04-30 | Innovative Cellular Therapeutics CO., LTD. | Increase or maintaining t-cell subpopulations in adoptive t-cell therapy |
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CN107073138A (zh) | 2017-08-18 |
US10619136B2 (en) | 2020-04-14 |
RU2017130985A (ru) | 2019-03-04 |
CN108410892B (zh) | 2021-05-28 |
KR20170124576A (ko) | 2017-11-10 |
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CA2976684A1 (en) | 2016-09-09 |
BR112017018770A2 (pt) | 2018-04-17 |
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US20190316086A1 (en) | 2019-10-17 |
RU2017130985A3 (ja) | 2019-03-04 |
US20160256488A1 (en) | 2016-09-08 |
JP6767347B2 (ja) | 2020-10-14 |
CN108410892A (zh) | 2018-08-17 |
US20210079349A1 (en) | 2021-03-18 |
EP3089761B1 (en) | 2019-06-12 |
US20170096638A1 (en) | 2017-04-06 |
JP6336684B2 (ja) | 2018-06-06 |
CN107073138B (zh) | 2018-06-29 |
AU2016228080A1 (en) | 2017-09-07 |
US10865382B2 (en) | 2020-12-15 |
JP2018064568A (ja) | 2018-04-26 |
CA2976684C (en) | 2024-03-05 |
US11932873B2 (en) | 2024-03-19 |
EP3089761A1 (en) | 2016-11-09 |
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