SG11201701157UA - Combination therapy of tumor-targeted il-2 variant immunocytokines and antibodies against human pd-l1 - Google Patents

Combination therapy of tumor-targeted il-2 variant immunocytokines and antibodies against human pd-l1

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Publication number
SG11201701157UA
SG11201701157UA SG11201701157UA SG11201701157UA SG11201701157UA SG 11201701157U A SG11201701157U A SG 11201701157UA SG 11201701157U A SG11201701157U A SG 11201701157UA SG 11201701157U A SG11201701157U A SG 11201701157UA SG 11201701157U A SG11201701157U A SG 11201701157UA
Authority
SG
Singapore
Prior art keywords
tumor
targeted
combination therapy
antibodies against
against human
Prior art date
Application number
SG11201701157UA
Other languages
English (en)
Inventor
Pablo Umana
Christian Klein
Valeria G Nicolini
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201701157UA publication Critical patent/SG11201701157UA/en

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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
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    • C07K14/52Cytokines; Lymphokines; Interferons
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    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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SG11201701157UA 2014-08-29 2015-08-25 Combination therapy of tumor-targeted il-2 variant immunocytokines and antibodies against human pd-l1 SG11201701157UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14182778 2014-08-29
PCT/EP2015/069399 WO2016030350A1 (fr) 2014-08-29 2015-08-25 Thérapie combinatoire d'immunocytokines à variant de l'il -2 ciblées thérapie tumorale et d'anticorps anti-pd-l1 humaine

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SG11201701157UA true SG11201701157UA (en) 2017-03-30

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EP (1) EP3186283B1 (fr)
JP (3) JP6603707B2 (fr)
KR (1) KR102058846B1 (fr)
CN (1) CN106794245B (fr)
AR (1) AR101697A1 (fr)
AU (1) AU2015308527C1 (fr)
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MX (1) MX2017002426A (fr)
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PT (1) PT3186283T (fr)
RS (1) RS59939B1 (fr)
RU (1) RU2710354C2 (fr)
SG (1) SG11201701157UA (fr)
SI (1) SI3186283T1 (fr)
WO (1) WO2016030350A1 (fr)

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KR20210060670A (ko) 2008-12-09 2021-05-26 제넨테크, 인크. 항-pd-l1 항체 및 t 세포 기능을 향상시키기 위한 그의 용도
US9428567B2 (en) 2010-12-22 2016-08-30 The Board Of Trustees Of The Leland Stanford Junior University Antagonists of interleukin-2 receptor
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