SG11201608667SA - Mdm2 inhibitors and therapeutic methods using the same - Google Patents

Mdm2 inhibitors and therapeutic methods using the same

Info

Publication number
SG11201608667SA
SG11201608667SA SG11201608667SA SG11201608667SA SG11201608667SA SG 11201608667S A SG11201608667S A SG 11201608667SA SG 11201608667S A SG11201608667S A SG 11201608667SA SG 11201608667S A SG11201608667S A SG 11201608667SA SG 11201608667S A SG11201608667S A SG 11201608667SA
Authority
SG
Singapore
Prior art keywords
same
therapeutic methods
mdm2 inhibitors
mdm2
inhibitors
Prior art date
Application number
SG11201608667SA
Other languages
English (en)
Inventor
Shaomeng Wang
Angelo Aguilar
Liu Liu
Jianfeng Lu
Donna Mceachern
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Publication of SG11201608667SA publication Critical patent/SG11201608667SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201608667SA 2014-04-17 2015-04-16 Mdm2 inhibitors and therapeutic methods using the same SG11201608667SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461980747P 2014-04-17 2014-04-17
PCT/US2015/026098 WO2015161032A1 (en) 2014-04-17 2015-04-16 Mdm2 inhibitors and therapeutic methods using the same

Publications (1)

Publication Number Publication Date
SG11201608667SA true SG11201608667SA (en) 2016-11-29

Family

ID=54321424

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201913742TA SG10201913742TA (en) 2014-04-17 2015-04-16 Mdm2 inhibitors and therapeutic methods using the same
SG11201608667SA SG11201608667SA (en) 2014-04-17 2015-04-16 Mdm2 inhibitors and therapeutic methods using the same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201913742TA SG10201913742TA (en) 2014-04-17 2015-04-16 Mdm2 inhibitors and therapeutic methods using the same

Country Status (12)

Country Link
US (1) US9745314B2 (es)
EP (1) EP3131544B1 (es)
JP (2) JP6694827B2 (es)
KR (2) KR102389552B1 (es)
CN (2) CN106794171B (es)
AU (1) AU2015247646B2 (es)
CA (1) CA2945527C (es)
ES (1) ES2712973T3 (es)
IL (2) IL248211B (es)
MX (2) MX2016013457A (es)
SG (2) SG10201913742TA (es)
WO (1) WO2015161032A1 (es)

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CN110812478B (zh) * 2018-08-08 2021-05-25 苏州亚盛药业有限公司 免疫疗法与mdm2抑制剂的组合
TWI750539B (zh) * 2018-11-23 2021-12-21 大陸商蘇州亞盛藥業有限公司 新穎藥物組成物及其用途
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TWI772753B (zh) * 2019-02-24 2022-08-01 大陸商蘇州亞盛藥業有限公司 Mdm2抑制劑的治療方法和生物標記物
TWI750728B (zh) * 2019-07-11 2021-12-21 大陸商蘇州亞盛藥業有限公司 2-吲哚啉螺環酮類化合物的製備方法及其中間體
US20220142975A1 (en) * 2019-07-19 2022-05-12 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical Combination and Use Thereof
TW202118488A (zh) * 2019-07-26 2021-05-16 大陸商蘇州亞盛藥業有限公司 Mdm2抑制劑的藥物組合物及其在預防和/或治療疾病中的用途
CN112852959A (zh) * 2019-11-27 2021-05-28 苏州亚盛药业有限公司 用于预测靶向细胞凋亡途径的化合物的抗癌功效的方法和组合物
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EP4041736A4 (en) * 2020-01-23 2023-06-07 Ascentage Pharma (Suzhou) Co., Ltd. AMORPHOUS FORM OR CRYSTALLINE FORM OF 2-INDOLINOLINOLOLYLSPIRONONE COMPOUNDS OR THEIR SALTS, SOLVENT COMPLEXES
CN113337602A (zh) * 2020-03-02 2021-09-03 苏州亚盛药业有限公司 Mdm2抑制剂的治疗方法和生物标志物
WO2021208911A1 (en) * 2020-04-14 2021-10-21 Ascentage Pharma (Suzhou) Co., Ltd. Novel medical use of mdm2 inhibitors
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Also Published As

Publication number Publication date
JP2020100662A (ja) 2020-07-02
US9745314B2 (en) 2017-08-29
CA2945527A1 (en) 2015-10-22
IL269462A (en) 2019-11-28
KR20220054697A (ko) 2022-05-03
EP3131544B1 (en) 2018-12-12
CA2945527C (en) 2022-05-17
MX2020003939A (es) 2020-08-13
KR20160136450A (ko) 2016-11-29
MX2016013457A (es) 2017-05-04
EP3131544A1 (en) 2017-02-22
KR102599945B1 (ko) 2023-11-09
IL248211A0 (en) 2016-11-30
JP6909323B2 (ja) 2021-07-28
CN106794171B (zh) 2020-03-24
ES2712973T3 (es) 2019-05-17
SG10201913742TA (en) 2020-03-30
AU2015247646B2 (en) 2019-06-06
NZ724963A (en) 2021-10-29
JP6694827B2 (ja) 2020-05-20
JP2017511360A (ja) 2017-04-20
EP3131544A4 (en) 2017-08-30
IL269462B (en) 2021-05-31
CN106794171A (zh) 2017-05-31
WO2015161032A1 (en) 2015-10-22
KR102389552B1 (ko) 2022-04-22
CN111718354A (zh) 2020-09-29
AU2015247646A1 (en) 2016-10-27
IL248211B (en) 2019-10-31
US20150299211A1 (en) 2015-10-22

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