SG11201604923XA - Methods and systems for detecting genetic variants - Google Patents

Methods and systems for detecting genetic variants

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Publication number
SG11201604923XA
SG11201604923XA SG11201604923XA SG11201604923XA SG11201604923XA SG 11201604923X A SG11201604923X A SG 11201604923XA SG 11201604923X A SG11201604923X A SG 11201604923XA SG 11201604923X A SG11201604923X A SG 11201604923XA SG 11201604923X A SG11201604923X A SG 11201604923XA
Authority
SG
Singapore
Prior art keywords
systems
methods
genetic variants
detecting genetic
detecting
Prior art date
Application number
SG11201604923XA
Other languages
English (en)
Inventor
Helmy Eltoukhy
Amirali Talasaz
Original Assignee
Guardant Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53479708&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201604923X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Guardant Health Inc filed Critical Guardant Health Inc
Publication of SG11201604923XA publication Critical patent/SG11201604923XA/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122Massive parallel sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
SG11201604923XA 2013-12-28 2014-12-24 Methods and systems for detecting genetic variants SG11201604923XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361921456P 2013-12-28 2013-12-28
US201461948509P 2014-03-05 2014-03-05
PCT/US2014/072383 WO2015100427A1 (fr) 2013-12-28 2014-12-24 Procédés et systèmes de détection de variants génétiques

Publications (1)

Publication Number Publication Date
SG11201604923XA true SG11201604923XA (en) 2016-07-28

Family

ID=53479708

Family Applications (2)

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SG10201804519RA SG10201804519RA (en) 2013-12-28 2014-12-24 Methods and systems for detecting genetic variants
SG11201604923XA SG11201604923XA (en) 2013-12-28 2014-12-24 Methods and systems for detecting genetic variants

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201804519RA SG10201804519RA (en) 2013-12-28 2014-12-24 Methods and systems for detecting genetic variants

Country Status (9)

Country Link
US (17) US9920366B2 (fr)
EP (4) EP3771745A1 (fr)
JP (5) JP6571665B2 (fr)
CN (2) CN106062214B (fr)
AU (3) AU2014369841B2 (fr)
CA (1) CA2934822A1 (fr)
ES (3) ES2822125T3 (fr)
SG (2) SG10201804519RA (fr)
WO (1) WO2015100427A1 (fr)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
EP2473638B1 (fr) 2009-09-30 2017-08-09 Natera, Inc. Méthode non invasive de détermination d'une ploïdie prénatale
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
WO2011146632A1 (fr) 2010-05-18 2011-11-24 Gene Security Network Inc. Procédés de classification de ploïdie prénatale non invasive
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
JP6328934B2 (ja) 2010-12-22 2018-05-23 ナテラ, インコーポレイテッド 非侵襲性出生前親子鑑定法
AU2011352070A1 (en) 2010-12-30 2013-07-18 Foundation Medicine, Inc. Optimization of multigene analysis of tumor samples
AU2011358564B9 (en) 2011-02-09 2017-07-13 Natera, Inc Methods for non-invasive prenatal ploidy calling
WO2012129363A2 (fr) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Détection et analyse d'acide nucléique d'une cellule isolée
EP3246416A1 (fr) 2011-04-15 2017-11-22 The Johns Hopkins University Système de séquençage sûr
DK3363901T3 (da) 2012-02-17 2021-02-22 Hutchinson Fred Cancer Res Sammensætninger og fremgangsmåder til præcis identificering af mutationer
ES2828661T3 (es) 2012-03-20 2021-05-27 Univ Washington Through Its Center For Commercialization Métodos para reducir la tasa de error de la secuenciación de ADN masiva en paralelo mediante el uso de la secuenciación de secuencia consenso bicatenaria
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
KR102028375B1 (ko) 2012-09-04 2019-10-04 가던트 헬쓰, 인크. 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP2912468B1 (fr) 2012-10-29 2018-09-12 The Johns Hopkins University Test de papanicolaou pour les cancers de l'ovaire et de l'endomètre
US10847251B2 (en) 2013-01-17 2020-11-24 Illumina, Inc. Genomic infrastructure for on-site or cloud-based DNA and RNA processing and analysis
US9679104B2 (en) 2013-01-17 2017-06-13 Edico Genome, Corp. Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform
US9792405B2 (en) 2013-01-17 2017-10-17 Edico Genome, Corp. Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform
US10068054B2 (en) 2013-01-17 2018-09-04 Edico Genome, Corp. Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform
WO2014113736A1 (fr) 2013-01-17 2014-07-24 Edico Genome Corp. Systèmes, appareils et procédés bio-informatiques, exécutés sur une plate-forme de traitement en circuit intégré
US10691775B2 (en) 2013-01-17 2020-06-23 Edico Genome, Corp. Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
CN109706222A (zh) 2013-12-11 2019-05-03 安可济控股有限公司 用于检测罕见序列变体的组合物和方法
AU2014369841B2 (en) 2013-12-28 2019-01-24 Guardant Health, Inc. Methods and systems for detecting genetic variants
CN113774132A (zh) 2014-04-21 2021-12-10 纳特拉公司 检测染色体片段中的突变和倍性
ES2925014T3 (es) 2014-09-12 2022-10-13 Univ Leland Stanford Junior Identificación y uso de ácidos nucleicos circulantes
US10954559B2 (en) * 2014-11-21 2021-03-23 Mgi Tech Co., Ltd. Bubble-shaped adaptor element and method of constructing sequencing library with bubble-shaped adaptor element
CA2967447A1 (fr) 2014-12-05 2016-06-09 Foundation Medicine, Inc. Analyse multigenique de prelevements tumoraux
US9940266B2 (en) 2015-03-23 2018-04-10 Edico Genome Corporation Method and system for genomic visualization
US10844428B2 (en) * 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
JP6995625B2 (ja) 2015-05-01 2022-01-14 ガーダント ヘルス, インコーポレイテッド 診断方法
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
EP3307908B1 (fr) 2015-06-09 2019-09-11 Life Technologies Corporation Procédés pour le marquage moléculaire
WO2016210224A1 (fr) 2015-06-24 2016-12-29 Dana-Farber Cancer Institute, Inc. Dégradation sélective de l'adn de type sauvage et enrichissement en allèles mutants à l'aide d'une nucléase
CA2993019A1 (fr) * 2015-07-21 2017-01-26 Guardant Health, Inc. Acides nucleiques verrouilles pour capturer des genes de fusion
WO2017027653A1 (fr) 2015-08-11 2017-02-16 The Johns Hopkins University Analyse du fluide d'un kyste ovarien
KR20180033587A (ko) * 2015-08-12 2018-04-03 써큘로진 테라노스틱스, 엘엘씨 제자리 증폭에 의한 세포-유리 핵산 분자의 제조 방법
EP3356382A4 (fr) * 2015-09-25 2019-04-03 Contextual Genomics Inc. Procédés d'assurance de qualité moléculaire destinés à être utilisés dans le séquençage
EP3359693A4 (fr) 2015-10-09 2019-03-06 Accuragen Holdings Limited Procédés et compositions pour enrichissement de produits d'amplification
JP6913089B2 (ja) 2015-11-11 2021-08-04 レゾリューション バイオサイエンス, インコーポレイテッド Dnaライブラリーの高効率構築
CN109072294A (zh) * 2015-12-08 2018-12-21 特温斯特兰德生物科学有限公司 用于双重测序的改良衔接子、方法和组合物
SG11201805119QA (en) * 2015-12-17 2018-07-30 Guardant Health Inc Methods to determine tumor gene copy number by analysis of cell-free dna
US10068183B1 (en) 2017-02-23 2018-09-04 Edico Genome, Corp. Bioinformatics systems, apparatuses, and methods executed on a quantum processing platform
US20170270245A1 (en) 2016-01-11 2017-09-21 Edico Genome, Corp. Bioinformatics systems, apparatuses, and methods for performing secondary and/or tertiary processing
ES2924487T3 (es) * 2016-01-29 2022-10-07 Hoffmann La Roche Un adaptador de conformación en Y novedoso para secuenciación de ácidos nucleicos y procedimiento de uso
US11479878B2 (en) 2016-03-16 2022-10-25 Dana-Farber Cancer Institute, Inc. Methods for genome characterization
WO2017181146A1 (fr) 2016-04-14 2017-10-19 Guardant Health, Inc. Méthodes de détection précoce du cancer
US11384382B2 (en) 2016-04-14 2022-07-12 Guardant Health, Inc. Methods of attaching adapters to sample nucleic acids
EP3458586B1 (fr) * 2016-05-16 2022-12-28 Accuragen Holdings Limited Procédé de séquençage amélioré par identification de brin
CN109074430B (zh) 2016-05-26 2022-03-29 贝克顿迪金森公司 分子标记计数调整方法
WO2018009723A1 (fr) 2016-07-06 2018-01-11 Guardant Health, Inc. Procédés de profilage d'un fragmentome d'acides nucléiques sans cellule
US11821028B2 (en) 2016-07-12 2023-11-21 QIAGEN Sciences, LLP Single end duplex DNA sequencing
WO2018031486A1 (fr) * 2016-08-08 2018-02-15 Karius, Inc. Réduction du signal provenant d'acides nucléiques contaminants
WO2018031808A1 (fr) 2016-08-10 2018-02-15 Cirina, Inc. Méthodes d'analyse de fragments d'acides nucléiques
WO2018035170A1 (fr) 2016-08-15 2018-02-22 Accuragen Holdings Limited Compositions et procédés permettant de détecter des variants de séquences rares
RU2019108294A (ru) 2016-08-25 2020-09-25 Резолюшн Байосайенс, Инк. Способы обнаружения изменений количества геномных копий в образцах днк
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
CA3027919C (fr) * 2016-09-30 2023-02-28 Guardant Health, Inc. Procedes d'analyse multiresolution d'acides nucleiques acellulaires
WO2018067517A1 (fr) 2016-10-04 2018-04-12 Natera, Inc. Procédés pour caractériser une variation de nombre de copies à l'aide d'un séquençage de ligature de proximité
US11667951B2 (en) 2016-10-24 2023-06-06 Geneinfosec, Inc. Concealing information present within nucleic acids
CN117056774A (zh) 2016-11-08 2023-11-14 贝克顿迪金森公司 用于细胞标记分类的方法
CN109952612B (zh) 2016-11-08 2023-12-01 贝克顿迪金森公司 用于表达谱分类的方法
US20200248244A1 (en) * 2016-11-15 2020-08-06 Personal Genome Diagnostics Inc. Non-unique barcodes in a genotyping assay
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
US11101019B2 (en) * 2016-12-08 2021-08-24 Life Technologies Corporation Methods for detecting mutation load from a tumor sample
EP3551756A4 (fr) * 2016-12-12 2020-07-15 Dana Farber Cancer Institute, Inc. Compositions et procédés pour le codage par code-barres moléculaire de molécules d'adn avant l'enrichissement des mutations et/ou la détection des mutations
CN106544341A (zh) * 2017-01-17 2017-03-29 上海亿康医学检验所有限公司 高效检测样本中的ctDNA的方法
CA3050247A1 (fr) 2017-01-18 2018-07-26 Illumina, Inc. Procedes et systemes de generation et de correction d'erreur d'ensembles d'indices moleculaires uniques ayant des longueurs moleculaires heterogenes
CA3049139A1 (fr) 2017-02-21 2018-08-30 Natera, Inc. Compositions, procedes, et kits d'isolement d'acides nucleiques
ES2929281T3 (es) * 2017-03-23 2022-11-28 Univ Washington Métodos para el enriquecimiento de secuencias de ácidos nucleicos dirigidos con aplicaciones para la secuenciación de ácidos nucleicos con corrección de errores
US11584958B2 (en) 2017-03-31 2023-02-21 Grail, Llc Library preparation and use thereof for sequencing based error correction and/or variant identification
EP3625713A1 (fr) * 2017-05-19 2020-03-25 Guardant Health, Inc. Procédés et systèmes de détection d'insertions et de délétions
US11542540B2 (en) 2017-06-16 2023-01-03 Life Technologies Corporation Control nucleic acids, and compositions, kits, and uses thereof
US11505826B2 (en) 2017-07-12 2022-11-22 Agilent Technologies, Inc. Sequencing method for genomic rearrangement detection
EP3432176A1 (fr) * 2017-07-20 2019-01-23 Siemens Healthcare GmbH Scansoft : procédé de détection de suppressions génomiques et de duplications en données de séquençage parallèle massif
WO2019023243A1 (fr) 2017-07-24 2019-01-31 Dana-Farber Cancer Institute, Inc. Procédés et compositions pour sélectionner et amplifier des cibles d'adn dans un mélange de réaction unique
CN107858426B (zh) * 2017-08-22 2021-04-09 上海派森诺生物科技股份有限公司 一种用于肿瘤个体化用药16个基因热点检测的杂交捕获试剂盒及其方法
US11447818B2 (en) 2017-09-15 2022-09-20 Illumina, Inc. Universal short adapters with variable length non-random unique molecular identifiers
SG11202002381TA (en) * 2017-09-20 2020-04-29 Guardant Health Inc Methods and systems for differentiating somatic and germline variants
WO2019060804A1 (fr) * 2017-09-25 2019-03-28 Cellular Research, Inc. Correction d'erreur de récepteur code-barres immunitaire
AU2018366213A1 (en) 2017-11-08 2020-05-14 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
JP7054133B2 (ja) 2017-11-09 2022-04-13 国立研究開発法人国立がん研究センター 配列解析方法、配列解析装置、参照配列の生成方法、参照配列生成装置、プログラム、および記録媒体
CN108154007B (zh) * 2017-11-28 2021-06-29 西安电子科技大学 一种基于单肿瘤样本拷贝数变异及缺失类型检测方法
CN108319813B (zh) * 2017-11-30 2020-12-25 无锡臻和生物科技有限公司 循环肿瘤dna拷贝数变异的检测方法和装置
US20190206510A1 (en) * 2017-11-30 2019-07-04 Illumina, Inc. Validation methods and systems for sequence variant calls
US11961591B2 (en) 2017-12-01 2024-04-16 Life Technologies Corporation Methods, systems, and computer-readable media for tandem duplication detection
WO2019132010A1 (fr) * 2017-12-28 2019-07-04 タカラバイオ株式会社 Procédé, appareil et programme d'estimation de type de base dans une séquence de bases
WO2019183640A1 (fr) 2018-03-23 2019-09-26 Board Of Regents, The University Of Texas System Séquençage efficace d'adn double brin avec un taux d'erreurs extrêmement faible
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
CA3096261A1 (fr) * 2018-04-13 2019-10-17 Guardant Health, Inc. Procedes de detection et de suppression d'erreurs d'alignement provoquees par des evenements de fusion
US10329627B1 (en) * 2018-04-23 2019-06-25 Inivata Ltd. Method for predicting and monitoring response to an immune checkpoint inhibitor
US20210040564A1 (en) * 2018-04-23 2021-02-11 Inivata Ltd. Method for predicting and monitoring response to an immune checkpoint inhibitor
WO2019236478A1 (fr) 2018-06-04 2019-12-12 Guardant Health, Inc. Méthodes et systèmes pour déterminer l'origine cellulaire d'acides nucléiques acellulaires
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
US20210269873A1 (en) * 2018-07-12 2021-09-02 Twinstrand Biosciences, Inc. Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications
CA3107376A1 (fr) 2018-08-08 2020-02-13 Inivata Ltd. Procede de sequencage a l'aide d'une pcr multiplex a replication variable
US20220033806A1 (en) * 2018-09-21 2022-02-03 Roche Sequencing Solutions, Inc. System and Method for Modular and Combinatorial Nucleic Acid Sample Preparation for Sequencing
AU2019351130A1 (en) 2018-09-27 2021-04-08 Grail, Llc Methylation markers and targeted methylation probe panel
US11608524B1 (en) * 2018-10-25 2023-03-21 Wisconsin Alumni Research Foundation Methods of analyzing cells
CA3116176A1 (fr) * 2018-10-31 2020-05-07 Guardant Health, Inc. Procedes, compositions et systemes pour etalonner des essais de partitionnement epigenetique
KR20200054430A (ko) * 2018-11-09 2020-05-20 주식회사 셀레믹스 폐암 조직 내 세포 유래 돌연변이를 검출하기 위한 프로브 제조 및 검출 방법
JP2022514010A (ja) 2018-12-20 2022-02-09 ガーダント ヘルス, インコーポレイテッド 核酸分子の回収率を改善するための方法、組成物、およびシステム
CN109767812A (zh) * 2018-12-25 2019-05-17 江苏医联生物科技有限公司 用于检测肿瘤外周血样本变异序列的方法
AU2020216438A1 (en) 2019-01-31 2021-07-29 Guardant Health, Inc. Compositions and methods for isolating cell-free DNA
US11939636B2 (en) 2019-05-31 2024-03-26 Guardant Health, Inc. Methods and systems for improving patient monitoring after surgery
US20220243267A1 (en) * 2019-05-31 2022-08-04 North Carolina State University Compositions and methods related to quantitative reduced representation sequencing
CN114502742A (zh) * 2019-08-01 2022-05-13 特温斯特兰德生物科学有限公司 用于核酸测序及相关应用的方法和试剂
GB2595193B (en) 2019-11-06 2022-10-12 Univ Leland Stanford Junior Methods and systems for analyzing nucleic acid molecules
KR102273152B1 (ko) * 2019-11-11 2021-07-05 사회복지법인 삼성생명공익재단 유전자 변이 검출수단의 검출능력 평가용 조성물의 제조방법
CN115087745A (zh) * 2020-01-08 2022-09-20 香港中文大学 无细胞样品中的双末端dna片段类型及其用途
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
JP2023544721A (ja) 2020-09-30 2023-10-25 ガーダント ヘルス, インコーポレイテッド 分配およびメチル化依存性ヌクレアーゼを使用してdnaを解析するための組成物および方法
CN112592976B (zh) * 2020-12-30 2021-09-21 深圳市海普洛斯生物科技有限公司 一种检测met基因扩增的方法及装置
US11783912B2 (en) 2021-05-05 2023-10-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for analyzing nucleic acid molecules
WO2023018944A1 (fr) * 2021-08-12 2023-02-16 The Johns Hopkins University Procédés de détection de mutation simultanée et d'analyse de méthylation
WO2023023402A2 (fr) 2021-08-20 2023-02-23 Guardant Health, Inc. Procédés pour le codage à barres moléculaire et d'échantillon simultané
WO2023150633A2 (fr) 2022-02-02 2023-08-10 Guardant Health, Inc. Amorces multifonctionnelles pour lectures de séquençage appariées
CN114724628B (zh) * 2022-04-24 2022-11-08 华中农业大学 一种对多物种进行多核苷酸变异鉴定和注释的方法
WO2024006908A1 (fr) 2022-06-30 2024-01-04 Guardant Health, Inc. Enrichissement d'adn méthylé de manière aberrante

Family Cites Families (274)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725536A (en) 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US6150517A (en) 1986-11-24 2000-11-21 Gen-Probe Methods for making oligonucleotide probes for the detection and/or quantitation of non-viral organisms
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
US4942124A (en) 1987-08-11 1990-07-17 President And Fellows Of Harvard College Multiplex sequencing
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5656731A (en) 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5200314A (en) 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
DE69132843T2 (de) 1990-12-06 2002-09-12 Affymetrix Inc N D Ges D Staat Identifizierung von Nukleinsäuren in Proben
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5981179A (en) 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US6020124A (en) 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
US5981176A (en) 1992-06-17 1999-11-09 City Of Hope Method of detecting and discriminating between nucleic acid sequences
DE69431719T2 (de) 1993-06-25 2003-09-18 Affymetrix Inc N D Ges D Staat Hybridisierung und sequenzierung von nukleinsäuren
US5500356A (en) 1993-08-10 1996-03-19 Life Technologies, Inc. Method of nucleic acid sequence selection
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US20030017081A1 (en) 1994-02-10 2003-01-23 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5714330A (en) 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US6600996B2 (en) 1994-10-21 2003-07-29 Affymetrix, Inc. Computer-aided techniques for analyzing biological sequences
EP0709466B1 (fr) 1994-10-28 2006-09-27 Gen-Probe Incorporated Compositions et procédés pour la détection et quantification simultanée de plusieurs séquences d'acide nucléique
US5648245A (en) 1995-05-09 1997-07-15 Carnegie Institution Of Washington Method for constructing an oligonucleotide concatamer library by rolling circle replication
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
GB9516636D0 (en) 1995-08-14 1995-10-18 Univ London In-situ nucleic acid amplification and detection
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
CA2248981C (fr) 1996-03-15 2009-11-24 The Penn State Research Foundation Detection d'acide nucleique extracellulaire lie a des tumeurs dans le plasma ou le serum sanguin a l'aide d'essais d'amplification d'acide nucleique
PT938320E (pt) 1996-03-26 2010-09-22 Michael S Kopreski Método que permite a utilização de arn extracelular extraído de plasma ou de soro para detectar, monitorizar ou avaliar o cancro
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
US5935793A (en) 1996-09-27 1999-08-10 The Chinese University Of Hong Kong Parallel polynucleotide sequencing method using tagged primers
US6124092A (en) 1996-10-04 2000-09-26 The Perkin-Elmer Corporation Multiplex polynucleotide capture methods and compositions
US6117631A (en) 1996-10-29 2000-09-12 Polyprobe, Inc. Detection of antigens via oligonucleotide antibody conjugates
US6046005A (en) 1997-01-15 2000-04-04 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
CA2291180A1 (fr) 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. Systeme et appareil destines au traitement sequentiel des analytes
AU1603199A (en) 1997-12-03 1999-06-16 Curagen Corporation Methods and devices for measuring differential gene expression
AU5584999A (en) 1998-08-28 2000-03-21 Invitrogen Corporation System for the rapid manipulation of nucleic acid sequences
WO2000014282A1 (fr) 1998-09-04 2000-03-16 Lynx Therapeutics, Inc. Procede de depistage de polymorphisme genique
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
WO2000046402A1 (fr) 1999-02-05 2000-08-10 Amersham Pharmacia Biotech Uk Limited Technique d'analyse genomique
US6629040B1 (en) 1999-03-19 2003-09-30 University Of Washington Isotope distribution encoded tags for protein identification
EP1165839A2 (fr) 1999-03-26 2002-01-02 Whitehead Institute For Biomedical Research Reseaux universels
EP1169479B1 (fr) 1999-04-09 2006-06-28 EXACT Sciences Corporation Procedes de detection d'acides nucleiques revelateurs de cancer
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
DE60045059D1 (de) 1999-04-20 2010-11-18 Nat Inst Of Advanced Ind Scien Verfahren und Sonden zur Bestimmung der Konzentration von Nukleinsäure-Molekülen und Verfahren zur Analyse der gewonnenen Daten
US6242186B1 (en) 1999-06-01 2001-06-05 Oy Jurilab Ltd. Method for detecting a risk of cancer and coronary heart disease and kit therefor
US6326148B1 (en) 1999-07-12 2001-12-04 The Regents Of The University Of California Detection of copy number changes in colon cancer
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
ATE458831T1 (de) 1999-12-07 2010-03-15 Exact Sciences Corp Verfahren zum nachweis von lungenneoplasmen in fäkalen proben
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
JP2003521252A (ja) 2000-02-07 2003-07-15 イルミナ インコーポレイテッド ユニバーサルプライミングを用いる核酸検出方法
US20020072058A1 (en) 2000-03-24 2002-06-13 Voelker Leroy L. Method for amplifying quinolone-resistance-determining-regions and identifying polymorphic variants thereof
US20030207300A1 (en) 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
EP1158055A1 (fr) 2000-05-26 2001-11-28 Xu Qi University of Teaxs Laboratoire de Leucémie Chen Méthode pour le diagnostic de cancers
ATE380883T1 (de) 2000-10-24 2007-12-15 Univ Leland Stanford Junior Direkte multiplex charakterisierung von genomischer dna
US20020142345A1 (en) 2000-12-22 2002-10-03 Nelsen Anita J. Methods for encoding and decoding complex mixtures in arrayed assays
US20030049616A1 (en) 2001-01-08 2003-03-13 Sydney Brenner Enzymatic synthesis of oligonucleotide tags
CA2344599C (fr) 2001-05-07 2011-07-12 Bioneer Corporation Amplification selective d'adn dont la sequence nucleotidique est totalement inconnue par reaction en chaine de la polymerase
US7406385B2 (en) 2001-10-25 2008-07-29 Applera Corporation System and method for consensus-calling with per-base quality values for sample assemblies
ES2253461T3 (es) 2002-03-05 2006-06-01 Epigenomics Ag Procedimiento y dispositivo para la determinacion de la especificidad del tejido y del adn que flota libre en tejidos corporales.
US20030186251A1 (en) 2002-04-01 2003-10-02 Brookhaven Science Associates, Llc Genome sequence tags
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US7822555B2 (en) 2002-11-11 2010-10-26 Affymetrix, Inc. Methods for identifying DNA copy number changes
JP2006519977A (ja) 2002-11-11 2006-08-31 アフィメトリックス インコーポレイテッド Dnaコピー数変化を同定するための方法
US10229244B2 (en) 2002-11-11 2019-03-12 Affymetrix, Inc. Methods for identifying DNA copy number changes using hidden markov model based estimations
US7704687B2 (en) 2002-11-15 2010-04-27 The Johns Hopkins University Digital karyotyping
ES2338654T5 (es) 2003-01-29 2017-12-11 454 Life Sciences Corporation Amplificación de ácidos nucleicos en emulsión de perlas
EP1606417A2 (fr) 2003-03-07 2005-12-21 Rubicon Genomics Inc. Immortalisation d'adn in vitro et amplification genomique complete a l'aide de bibliotheques generees a partir d'adn fragmente de maniere aleatoire
US20040259118A1 (en) 2003-06-23 2004-12-23 Macevicz Stephen C. Methods and compositions for nucleic acid sequence analysis
WO2005010145A2 (fr) 2003-07-05 2005-02-03 The Johns Hopkins University Procede et compositions de detection et d'enumeration de variations genetiques
ATE435301T1 (de) 2003-10-16 2009-07-15 Sequenom Inc Nicht invasiver nachweis fötaler genetischer merkmale
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
US20070111233A1 (en) 2003-10-30 2007-05-17 Bianchi Diana W Prenatal diagnosis using cell-free fetal DNA in amniotic fluid
EP1709203A2 (fr) 2004-01-23 2006-10-11 Lingvitae AS Amelioration des reactions de ligature de polynucleotides
DE602005018166D1 (de) 2004-02-12 2010-01-21 Population Genetics Technologi Genetische analyse mittels sequenzspezifischem sortieren
US20100216153A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20060046258A1 (en) 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
WO2005111242A2 (fr) 2004-05-10 2005-11-24 Parallele Bioscience, Inc. Etablissement numerique de profils pour des populations de polynucleotides
US7378423B2 (en) 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
US7276720B2 (en) 2004-07-19 2007-10-02 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US20060035258A1 (en) 2004-08-06 2006-02-16 Affymetrix, Inc. Methods for identifying DNA copy number changes
US7937225B2 (en) 2004-09-03 2011-05-03 New York University Systems, methods and software arrangements for detection of genome copy number variation
US20060073506A1 (en) 2004-09-17 2006-04-06 Affymetrix, Inc. Methods for identifying biological samples
WO2006047787A2 (fr) 2004-10-27 2006-05-04 Exact Sciences Corporation Methode de surveillance de la progression ou la recurrence d'une maladie
US7424371B2 (en) 2004-12-21 2008-09-09 Helicos Biosciences Corporation Nucleic acid analysis
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
ITRM20050068A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
EP1856293A2 (fr) 2005-03-16 2007-11-21 Compass Genetics, Llc Procédés et compositions pour relèves de mesures sur de multiples plate-formes analytiques
EP1861512A4 (fr) 2005-03-18 2009-12-09 Fluidigm Corp Dispositif de réaction thermique et son procédé d'utilisation
ES2313143T3 (es) 2005-04-06 2009-03-01 Maurice Stroun Metodo para el diagnostico de cancer mediante la deteccion de adn y arn circulantes.
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
CA2910861C (fr) 2005-09-29 2018-08-07 Michael Josephus Theresia Van Eijk Criblage a haut debit de populations mutagenisees
US7537897B2 (en) * 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
US20070172839A1 (en) 2006-01-24 2007-07-26 Smith Douglas R Asymmetrical adapters and methods of use thereof
US8383338B2 (en) 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
IL282783B2 (en) 2006-05-18 2023-09-01 Caris Mpi Inc A system and method for determining a personalized medical intervention for a disease stage
WO2008111990A1 (fr) 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Analyse de cellules rares par division d'échantillon et utilisation de marqueurs d'adn
FR2904833A1 (fr) * 2006-08-11 2008-02-15 Bioquanta Sarl Procede de dosage d'acide nuclieque par fluorescence
CA2958994C (fr) 2006-11-15 2019-05-07 Biospherex Llc Trousse de sequencage multiplex et analyse ecogenomique
US20110014607A1 (en) 2006-12-06 2011-01-20 Jirtle Randy L Imprinted genes and disease
US9090693B2 (en) 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
DK2121989T4 (da) 2007-03-13 2022-06-20 Amgen Inc K-ras-mutationer og anti-EGFR-antistofbehandling
WO2008148072A2 (fr) 2007-05-24 2008-12-04 The Brigham And Women's Hospital, Inc. Variations genetiques liees a une maladies et methodes de detection et d'utilisation de ces variations
WO2008150432A1 (fr) 2007-06-01 2008-12-11 454 Life Sciences Corporation Système et procédé d'identification d'échantillons individuels à partir d'un mélange multiplex
US8182993B2 (en) 2007-06-06 2012-05-22 Pacific Biosciences Of California, Inc. Methods and processes for calling bases in sequence by incorporation methods
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
PT2557517T (pt) 2007-07-23 2023-01-04 Univ Hong Kong Chinese Determinação de um desequilíbrio de sequências de ácido nucleico
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
WO2009033178A1 (fr) * 2007-09-07 2009-03-12 Fluidigm Corporation Détermination de la variation du nombre de copies, procédés et systèmes
ES2694573T3 (es) 2007-11-21 2018-12-21 Cosmosid Inc. Sistema de identificación de genomas
CN101999003A (zh) 2008-02-12 2011-03-30 诺瓦蒂斯公司 分离无细胞凋亡或胎儿核酸的方法
US8216789B2 (en) 2008-02-27 2012-07-10 University Of Washington Diagnostic panel of cancer antibodies and methods for use
US8206926B2 (en) 2008-03-26 2012-06-26 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
CA2991818C (fr) 2008-03-28 2022-10-11 Pacific Biosciences Of California, Inc. Compositions et procedes pour le sequencage d'acide nucleique
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
US20110160290A1 (en) 2008-05-21 2011-06-30 Muneesh Tewari Use of extracellular rna to measure disease
DE102008025656B4 (de) 2008-05-28 2016-07-28 Genxpro Gmbh Verfahren zur quantitativen Analyse von Nukleinsäuren, Marker dafür und deren Verwendung
US20090298709A1 (en) 2008-05-28 2009-12-03 Affymetrix, Inc. Assays for determining telomere length and repeated sequence copy number
US20100041048A1 (en) 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
US20100062494A1 (en) 2008-08-08 2010-03-11 President And Fellows Of Harvard College Enzymatic oligonucleotide pre-adenylation
US20100069250A1 (en) 2008-08-16 2010-03-18 The Board Of Trustees Of The Leland Stanford Junior University Digital PCR Calibration for High Throughput Sequencing
WO2010028288A2 (fr) 2008-09-05 2010-03-11 Aueon, Inc. Procédés pour la stratification et l’annotation des options de traitement médicamenteux contre le cancer
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
SI2334812T1 (sl) 2008-09-20 2017-05-31 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 Neinvazivna diagnoza fetalne anevploidije s sekvenciranjem
EP2379748A4 (fr) 2008-12-23 2012-08-29 Illumina Inc Libération multibase pour lectures longues dans le séquençage par des protocoles de synthèse
US20100323348A1 (en) 2009-01-31 2010-12-23 The Regents Of The University Of Colorado, A Body Corporate Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process
WO2010127186A1 (fr) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Produits de construction d'acide nucléique et leurs procédés d'utilisation
US20120165202A1 (en) 2009-04-30 2012-06-28 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
US20130143747A1 (en) 2011-12-05 2013-06-06 Myriad Genetics, Incorporated Methods of detecting cancer
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
US20100330571A1 (en) 2009-06-25 2010-12-30 Robins Harlan S Method of measuring adaptive immunity
WO2011011426A2 (fr) 2009-07-20 2011-01-27 Bar Harbor Biotechnology, Inc. Procédés d'évaluation d'un risque de maladie
PL2488033T3 (pl) 2009-10-16 2019-12-31 Novartis Ag Kombinacja zawierająca inhibitor MEK i inhibitor B-raf
ES2564656T3 (es) 2009-10-26 2016-03-28 Lifecodexx Ag Medios y métodos para el diagnóstico no invasivo de la aneuploidía cromosómica
CN102597272A (zh) 2009-11-12 2012-07-18 艾索特里克斯遗传实验室有限责任公司 基因座的拷贝数分析
US9023769B2 (en) 2009-11-30 2015-05-05 Complete Genomics, Inc. cDNA library for nucleic acid sequencing
US9752187B2 (en) 2009-12-11 2017-09-05 Nucleix Categorization of DNA samples
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
WO2011087760A2 (fr) 2009-12-22 2011-07-21 Sequenom, Inc. Procédés et kits pour identifier une aneuploïdie
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
WO2011090556A1 (fr) 2010-01-19 2011-07-28 Verinata Health, Inc. Procédés pour déterminer une fraction d'acide nucléique fœtal dans des échantillons maternels
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
US9323888B2 (en) * 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
US20110177512A1 (en) 2010-01-19 2011-07-21 Predictive Biosciences, Inc. Method for assuring amplification of an abnormal nucleic acid in a sample
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
WO2011091046A1 (fr) 2010-01-19 2011-07-28 Verinata Health, Inc. Identification de cellules polymorphes dans des mélanges d'adn génomique par séquençage du génome entier
EP2366031B1 (fr) 2010-01-19 2015-01-21 Verinata Health, Inc Méthodes de séquençage pour le diagnostic prénatal
EP2536854B1 (fr) 2010-02-18 2017-07-19 The Johns Hopkins University Biomarqueurs tumoraux personnalisés
AU2011221227B2 (en) 2010-02-25 2015-07-09 Dana-Farber Cancer Institute, Inc. BRAF mutations conferring resistance to BRAF inhibitors
EP2547698B1 (fr) 2010-03-14 2015-07-29 The Translational Genomics Research Institute Procédés de détermination de la sensibilité de tumeurs à des inhibiteurs de la tyrosine kinase
CN101967517B (zh) 2010-03-19 2012-11-07 黄乐群 一种无需借助pcr的基因检测方法
WO2011130751A1 (fr) 2010-04-16 2011-10-20 Chronix Biomedical Biomarqueurs d'acides nucléiques circulants associés à un cancer du sein
WO2011140510A2 (fr) 2010-05-06 2011-11-10 Bioo Scientific Corporation Ligature d'oligonucléotides, attribution de code-barres, procédés et compositions pour amélioration de qualité des données et du débit à l'aide du séquençage massif parallèle
ES2647612T3 (es) 2010-06-04 2017-12-22 Chronix Biomedical Biomarcadores de ácidos nucleicos en circulación asociados al cáncer de próstata
ES2960184T3 (es) 2010-06-09 2024-03-01 Keygene Nv Códigos de barras de secuencias combinatorias para el cribado de alto rendimiento
EP2400035A1 (fr) 2010-06-28 2011-12-28 Technische Universität München Procédés et compositions pour le diagnostic de tumeurs stromales gastro-intestinales
US20120046877A1 (en) * 2010-07-06 2012-02-23 Life Technologies Corporation Systems and methods to detect copy number variation
FR2962369B1 (fr) 2010-07-07 2014-03-21 Michelin Soc Tech Armature de sommet pour pneumatique d'avion
US20120053073A1 (en) 2010-07-23 2012-03-01 President And Fellows Of Harvard College Methods for Detecting Signatures of Disease or Conditions in Bodily Fluids
SG187646A1 (en) 2010-07-29 2013-03-28 Toto Ltd Photocatalyst coated body and photocatalyst coating liquid
WO2012018387A2 (fr) 2010-08-02 2012-02-09 Population Diagnotics, Inc. Compositions et méthodes de recherche de mutations causales dans des troubles génétiques
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
EP2426217A1 (fr) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Procédés analytiques pour acides nucléiques libres dans les cellules et applications
EP3211421A1 (fr) 2010-09-09 2017-08-30 Traxxsson, LLC Combinaison de procédés de diagnostic du cancer chez un patient
DK2623613T3 (en) 2010-09-21 2016-10-03 Population Genetics Tech Ltd Increasing the reliability of the allele-indications by molecular counting
WO2012042374A2 (fr) 2010-10-01 2012-04-05 Anssi Jussi Nikolai Taipale Procédé de détermination du nombre ou de la concentration de molécules
DK2625320T3 (da) 2010-10-08 2019-07-01 Harvard College High-throughput enkeltcellestregkodning
US8725422B2 (en) 2010-10-13 2014-05-13 Complete Genomics, Inc. Methods for estimating genome-wide copy number variations
EP3461914A1 (fr) * 2010-10-22 2019-04-03 Cold Spring Harbor Laboratory Comptage de variétés d'acides nucléiques permettant d'obtenir des informations de nombre de copies génomiques
WO2012066451A1 (fr) 2010-11-15 2012-05-24 Pfizer Inc. Signature génique de pronostic et prédictive pour le cancer du côlon
KR102040307B1 (ko) 2010-11-30 2019-11-27 더 차이니즈 유니버시티 오브 홍콩 암과 연관된 유전적 또는 분자적 이상들의 검출
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
EP2655666A2 (fr) 2010-12-23 2013-10-30 Sequenom, Inc. Détection de variations génétiques foetales
AU2011352070A1 (en) 2010-12-30 2013-07-18 Foundation Medicine, Inc. Optimization of multigene analysis of tumor samples
US20140011694A1 (en) 2011-01-11 2014-01-09 Via Genomes, Inc. Methods, systems, databases, kits and arrays for screening for and predicting the risk of an identifying the presence of tumors and cancers
ES2645953T3 (es) 2011-01-17 2017-12-11 Life Technologies Corporation Ligamiento enzimático de ácidos nucleicos
WO2012103031A2 (fr) 2011-01-25 2012-08-02 Ariosa Diagnostics, Inc. Détection d'anomalies génétiques
AU2011358564B9 (en) * 2011-02-09 2017-07-13 Natera, Inc Methods for non-invasive prenatal ploidy calling
US20120238464A1 (en) 2011-03-18 2012-09-20 Baylor Research Institute Biomarkers for Predicting the Recurrence of Colorectal Cancer Metastasis
WO2012129363A2 (fr) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Détection et analyse d'acide nucléique d'une cellule isolée
AU2012236200B2 (en) 2011-03-30 2015-05-14 Verinata Health, Inc. Method for verifying bioassay samples
EP2670866A4 (fr) 2011-04-05 2015-09-02 Translational Genomics Res Inst Biomarqueurs et leurs procédés d'utilisation
EP3246416A1 (fr) 2011-04-15 2017-11-22 The Johns Hopkins University Système de séquençage sûr
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
EP3789498A1 (fr) 2011-04-25 2021-03-10 Bio-rad Laboratories, Inc. Procédés d'analyse d'acide nucléique
WO2013022504A1 (fr) 2011-05-06 2013-02-14 New England Biolabs, Inc. Amélioration de la ligature
SG10201605049QA (en) 2011-05-20 2016-07-28 Fluidigm Corp Nucleic acid encoding reactions
WO2012162584A1 (fr) * 2011-05-26 2012-11-29 Synta Pharmaceuticals Corp. Polythérapie de composés inhibiteurs de hsp90 avec inhibiteurs de chk
US9752176B2 (en) 2011-06-15 2017-09-05 Ginkgo Bioworks, Inc. Methods for preparative in vitro cloning
US9340826B2 (en) 2011-08-01 2016-05-17 Celemics, Inc. Method of preparing nucleic acid molecules
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
WO2013033721A1 (fr) 2011-09-02 2013-03-07 Atreca, Inc. Code-barres adn pour le séquençage multiplex
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
US20130079241A1 (en) 2011-09-15 2013-03-28 Jianhua Luo Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) * 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013052907A2 (fr) 2011-10-06 2013-04-11 Sequenom, Inc. Méthodes et procédés pour évaluation non invasive de variations génétiques
US20130102485A1 (en) 2011-10-19 2013-04-25 Inhan Lee Method of Determining a Diseased State in a Subject
PL2768985T3 (pl) 2011-10-21 2019-10-31 Chronix Biomedical Biomarkery będące krążącymi kwasami nukleinowymi związane z rakiem jelita grubego
NO3051026T3 (fr) 2011-10-21 2018-07-28
US20130122499A1 (en) 2011-11-14 2013-05-16 Viomics, Inc. System and method of detecting local copy number variation in dna samples
JP5418579B2 (ja) * 2011-12-06 2014-02-19 株式会社デンソー 開閉眼検出装置
US10214775B2 (en) 2011-12-07 2019-02-26 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
KR101768652B1 (ko) 2011-12-08 2017-08-16 파이브3 제노믹스, 엘엘씨 Mdm2-포함 이중 소염색체들 및 그의 방법들
EP3434789A1 (fr) 2012-01-13 2019-01-30 Data2Bio Génotypage par séquençage de nouvelle génération
DK3363901T3 (da) 2012-02-17 2021-02-22 Hutchinson Fred Cancer Res Sammensætninger og fremgangsmåder til præcis identificering af mutationer
ES2776673T3 (es) 2012-02-27 2020-07-31 Univ North Carolina Chapel Hill Métodos y usos para etiquetas moleculares
JP6375230B2 (ja) 2012-02-27 2018-08-15 セルラー リサーチ, インコーポレイテッド 分子計数のための組成物およびキット
WO2013128281A1 (fr) 2012-02-28 2013-09-06 Population Genetics Technologies Ltd Procédé de fixation d'une contre-séquence à un échantillon d'acides nucléiques
US9890429B2 (en) 2012-02-29 2018-02-13 Dana-Farber Cancer Institute, Inc. Compositions, kits, and methods for the identification, assessment, prevention, and therapy of cancer
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
EP2825675B1 (fr) 2012-03-13 2017-12-27 Patel, Abhijit Ajit Mesure des variants d'acide nucléique au moyen du séquençage hautement multiplexé, à très haut débit et à suppression d'erreur
WO2013142213A1 (fr) 2012-03-20 2013-09-26 Wake Forest University Health Sciences Procédés, systèmes et supports lisibles par ordinateur pour suivre et vérifier la réception de contenus d'une livraison au sein d'une organisation
ES2828661T3 (es) 2012-03-20 2021-05-27 Univ Washington Through Its Center For Commercialization Métodos para reducir la tasa de error de la secuenciación de ADN masiva en paralelo mediante el uso de la secuenciación de secuencia consenso bicatenaria
EP4239081A3 (fr) 2012-03-26 2023-11-08 The Johns Hopkins University Détection rapide d'aneuploïdie
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
WO2013159035A2 (fr) 2012-04-19 2013-10-24 Medical College Of Wisconsin, Inc. Surveillance hautement sensible utilisant une détection d'adn acellulaire
EP2850211B1 (fr) 2012-05-14 2021-09-08 iRepertoire, Inc. Procédé pour augmenter la précision de détection quantitative de polynucléotides
WO2013181170A1 (fr) * 2012-05-31 2013-12-05 Board Of Regents, The University Of Texas System Procédé de séquençage précis d'adn
SG11201407888RA (en) 2012-06-11 2014-12-30 Sequenta Inc Method of sequence determination using sequence tags
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
WO2014004726A1 (fr) 2012-06-26 2014-01-03 Caifu Chen Procédés, compositions et kits pour le diagnostic, le pronostic et la surveillance d'un cancer
AU2013204615A1 (en) 2012-07-20 2014-02-06 Verinata Health, Inc. Detecting and classifying copy number variation in a fetal genome
US11180812B2 (en) * 2012-08-17 2021-11-23 Cornell University Use of DNA in circulating exosomes as a diagnostic marker for metastatic disease
KR102028375B1 (ko) 2012-09-04 2019-10-04 가던트 헬쓰, 인크. 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
WO2014149134A2 (fr) 2013-03-15 2014-09-25 Guardant Health Inc. Systèmes et méthodes pour détecter des mutations rares et des variations du nombre de copies
EP3981408A1 (fr) 2012-09-04 2022-04-13 Novartis AG Dabrafenib et trametinib dans une méthode de traitement adjuvant du cancer
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US9932576B2 (en) 2012-12-10 2018-04-03 Resolution Bioscience, Inc. Methods for targeted genomic analysis
EP2941753A4 (fr) 2013-01-05 2016-08-17 Foundation Medicine Inc Système et procédé pour le suivi et l'analyse de résultats
CA3150658A1 (en) 2013-01-18 2014-07-24 Foundation Medicine, Inc. Methods of treating cholangiocarcinoma
US20160034638A1 (en) 2013-03-14 2016-02-04 University Of Rochester System and Method for Detecting Population Variation from Nucleic Acid Sequencing Data
US10017807B2 (en) 2013-03-15 2018-07-10 Verinata Health, Inc. Generating cell-free DNA libraries directly from blood
GB2584364A (en) 2013-03-15 2020-12-02 Abvitro Llc Single cell bar-coding for antibody discovery
ES2946689T3 (es) 2013-03-15 2023-07-24 Univ Leland Stanford Junior Identificación y uso de marcadores tumorales de ácido nucleico circulante
CA2905410A1 (fr) 2013-03-15 2014-09-25 Abbott Molecular Inc. Systemes et procedes pour la detection de changements de nombre de copie de genome
SG11201507739TA (en) 2013-03-19 2015-10-29 Toppan Printing Co Ltd Method for predicting sensitivity to egfr inhibitor
JP6618894B2 (ja) 2013-05-23 2019-12-11 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 個別的エピゲノミクスのための天然クロマチンへの転移
JP2015096049A (ja) 2013-11-15 2015-05-21 凸版印刷株式会社 Vegf阻害剤長期奏功性予測方法
AU2014369841B2 (en) 2013-12-28 2019-01-24 Guardant Health, Inc. Methods and systems for detecting genetic variants
EP3643795B1 (fr) 2014-04-14 2022-03-30 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Procédé de détermination de mort de cellules ou de tissues par analyse de methylation de l'adn
ES2844229T3 (es) 2014-05-13 2021-07-21 Univ Texas Mutaciones génicas y alteraciones en el número de copias de EGFR, KRAS y MET
WO2016015058A2 (fr) 2014-07-25 2016-01-28 University Of Washington Procédés de détermination de types de tissus et/ou de cellules permettant d'obtenir de l'adn sans cellules, et procédés d'identification d'une maladie ou d'un trouble les employant
US20180082012A1 (en) 2014-07-25 2018-03-22 Bgi Genomics Co., Ltd. Method and device for determining fraction of cell-free nucleic acids in biological sample and use thereof
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
CN106716425A (zh) 2014-09-10 2017-05-24 百思威基因公司 健康和保健管理方法及用于其实践的系统
ES2925014T3 (es) 2014-09-12 2022-10-13 Univ Leland Stanford Junior Identificación y uso de ácidos nucleicos circulantes
PT3256605T (pt) 2015-02-10 2022-03-17 Univ Hong Kong Chinese Deteção de mutações para rastreio de cancro e análise fetal
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
CN109072294A (zh) 2015-12-08 2018-12-21 特温斯特兰德生物科学有限公司 用于双重测序的改良衔接子、方法和组合物
WO2017181146A1 (fr) 2016-04-14 2017-10-19 Guardant Health, Inc. Méthodes de détection précoce du cancer

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