EP1861512A4 - Dispositif de réaction thermique et son procédé d'utilisation - Google Patents
Dispositif de réaction thermique et son procédé d'utilisationInfo
- Publication number
- EP1861512A4 EP1861512A4 EP06739049A EP06739049A EP1861512A4 EP 1861512 A4 EP1861512 A4 EP 1861512A4 EP 06739049 A EP06739049 A EP 06739049A EP 06739049 A EP06739049 A EP 06739049A EP 1861512 A4 EP1861512 A4 EP 1861512A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- same
- reaction device
- thermal reaction
- thermal
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/142—Preventing evaporation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
- B01L2200/147—Employing temperature sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20120160084 EP2518161A1 (fr) | 2005-03-18 | 2006-03-20 | Procédé de detection d'allèles mutants |
EP10197437A EP2371453A1 (fr) | 2005-03-18 | 2006-03-20 | Dispositif microfluidique |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/084,357 US7604965B2 (en) | 2003-04-03 | 2005-03-18 | Thermal reaction device and method for using the same |
US74996305P | 2005-12-12 | 2005-12-12 | |
PCT/US2006/010103 WO2006102264A1 (fr) | 2005-03-18 | 2006-03-20 | Dispositif de reaction thermique et son procede d'utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1861512A1 EP1861512A1 (fr) | 2007-12-05 |
EP1861512A4 true EP1861512A4 (fr) | 2009-12-09 |
Family
ID=37024154
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10197437A Withdrawn EP2371453A1 (fr) | 2005-03-18 | 2006-03-20 | Dispositif microfluidique |
EP06739049A Withdrawn EP1861512A4 (fr) | 2005-03-18 | 2006-03-20 | Dispositif de réaction thermique et son procédé d'utilisation |
EP20120160084 Ceased EP2518161A1 (fr) | 2005-03-18 | 2006-03-20 | Procédé de detection d'allèles mutants |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10197437A Withdrawn EP2371453A1 (fr) | 2005-03-18 | 2006-03-20 | Dispositif microfluidique |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20120160084 Ceased EP2518161A1 (fr) | 2005-03-18 | 2006-03-20 | Procédé de detection d'allèles mutants |
Country Status (2)
Country | Link |
---|---|
EP (3) | EP2371453A1 (fr) |
WO (1) | WO2006102264A1 (fr) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
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US20060030037A1 (en) | 2004-05-28 | 2006-02-09 | Victor Joseph | Thermo-controllable high-density chips for multiplex analyses |
WO2007087312A2 (fr) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Décompte moléculaire |
CN101711257A (zh) * | 2007-01-22 | 2010-05-19 | 瓦弗根公司 | 用于高通量化学反应的装置 |
WO2008121691A1 (fr) * | 2007-03-28 | 2008-10-09 | University Of Florida Research Foundation, Inc. | Dispositif de réseau microfluidique et système pour la détection de multiples analytes |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
CN110878345A (zh) | 2010-09-21 | 2020-03-13 | 安捷伦科技有限公司 | 通过分子计数提高等位基因调用的置信度 |
ES2776673T3 (es) | 2012-02-27 | 2020-07-31 | Univ North Carolina Chapel Hill | Métodos y usos para etiquetas moleculares |
GB2504240B (en) | 2012-02-27 | 2015-05-27 | Cellular Res Inc | Compositions and kits for molecular counting of nucleic acids |
US9670529B2 (en) | 2012-02-28 | 2017-06-06 | Population Genetics Technologies Ltd. | Method for attaching a counter sequence to a nucleic acid sample |
CN110872617A (zh) | 2012-09-04 | 2020-03-10 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
JP6545682B2 (ja) | 2013-08-28 | 2019-07-17 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 大規模並列単一細胞分析 |
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WO2015100427A1 (fr) | 2013-12-28 | 2015-07-02 | Guardant Health, Inc. | Procédés et systèmes de détection de variants génétiques |
CN107250379B (zh) | 2015-02-19 | 2021-12-28 | 贝克顿迪金森公司 | 结合蛋白质组信息和基因组信息的高通量单细胞分析 |
JP6620160B2 (ja) | 2015-02-20 | 2019-12-11 | タカラ バイオ ユーエスエー, インコーポレイテッド | 単一細胞の迅速かつ正確な分注、視覚化及び解析のための方法 |
EP3262192B1 (fr) | 2015-02-27 | 2020-09-16 | Becton, Dickinson and Company | Codage à barres moléculaire à adressage spatial |
ES2934982T3 (es) | 2015-03-30 | 2023-02-28 | Becton Dickinson Co | Métodos para la codificación con códigos de barras combinatorios |
US11390914B2 (en) | 2015-04-23 | 2022-07-19 | Becton, Dickinson And Company | Methods and compositions for whole transcriptome amplification |
WO2016196229A1 (fr) | 2015-06-01 | 2016-12-08 | Cellular Research, Inc. | Méthodes de quantification d'arn |
CN108026524A (zh) | 2015-09-11 | 2018-05-11 | 赛卢拉研究公司 | 用于核酸文库标准化的方法和组合物 |
CN117174167A (zh) | 2015-12-17 | 2023-12-05 | 夸登特健康公司 | 通过分析无细胞dna确定肿瘤基因拷贝数的方法 |
CN105653102B (zh) * | 2016-03-23 | 2018-12-21 | 南京铁道职业技术学院 | 红外线感应电子白板 |
AU2017261189B2 (en) | 2016-05-02 | 2023-02-09 | Becton, Dickinson And Company | Accurate molecular barcoding |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
EP3465502B1 (fr) | 2016-05-26 | 2024-04-10 | Becton, Dickinson and Company | Méthodes d'ajustement de compte des étiquettes moléculaires |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
WO2018017892A1 (fr) | 2016-07-21 | 2018-01-25 | Takara Bio Usa, Inc. | Imagerie multi-z et distribution à l'aide de dispositifs multipuits |
KR102522023B1 (ko) | 2016-09-26 | 2023-04-17 | 셀룰러 리서치, 인크. | 바코딩된 올리고뉴클레오티드 서열을 갖는 시약을 이용한 단백질 발현의 측정 |
EP3539035B1 (fr) | 2016-11-08 | 2024-04-17 | Becton, Dickinson and Company | Procédés destinés à la classification de profil d'expression |
JP7228510B2 (ja) | 2016-11-08 | 2023-02-24 | ベクトン・ディキンソン・アンド・カンパニー | 細胞標識分類の方法 |
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DE112018000433T5 (de) * | 2017-01-19 | 2019-10-02 | Agilent Technologies Inc. | Optisches multi-temperatur-spektrometer-modul, systeme und verfahren zu deren verwendung |
US11319583B2 (en) | 2017-02-01 | 2022-05-03 | Becton, Dickinson And Company | Selective amplification using blocking oligonucleotides |
CA3059559A1 (fr) | 2017-06-05 | 2018-12-13 | Becton, Dickinson And Company | Indexation d'echantillon pour des cellules uniques |
EP3728636A1 (fr) | 2017-12-19 | 2020-10-28 | Becton, Dickinson and Company | Particules associées à des oligonucléotides |
CN112243461B (zh) | 2018-05-03 | 2024-07-12 | 贝克顿迪金森公司 | 在相对的转录物末端进行分子条形码化 |
CN112272710A (zh) | 2018-05-03 | 2021-01-26 | 贝克顿迪金森公司 | 高通量多组学样品分析 |
WO2020072380A1 (fr) | 2018-10-01 | 2020-04-09 | Cellular Research, Inc. | Détermination de séquences de transcripts 5' |
US11932849B2 (en) | 2018-11-08 | 2024-03-19 | Becton, Dickinson And Company | Whole transcriptome analysis of single cells using random priming |
CN113195717A (zh) | 2018-12-13 | 2021-07-30 | 贝克顿迪金森公司 | 单细胞全转录组分析中的选择性延伸 |
WO2020150356A1 (fr) | 2019-01-16 | 2020-07-23 | Becton, Dickinson And Company | Normalisation de réaction en chaîne de la polymérase par titrage d'amorce |
US11661631B2 (en) | 2019-01-23 | 2023-05-30 | Becton, Dickinson And Company | Oligonucleotides associated with antibodies |
WO2020214642A1 (fr) | 2019-04-19 | 2020-10-22 | Becton, Dickinson And Company | Procédés d'association de données phénotypiques et de données de séquençage monocellule |
EP4004231A1 (fr) | 2019-07-22 | 2022-06-01 | Becton, Dickinson and Company | Dosage de séquençage par immunoprécipitation de la chromatine monocellulaire |
CN114729350A (zh) | 2019-11-08 | 2022-07-08 | 贝克顿迪金森公司 | 使用随机引发获得用于免疫组库测序的全长v(d)j信息 |
CN115244184A (zh) | 2020-01-13 | 2022-10-25 | 贝克顿迪金森公司 | 用于定量蛋白和rna的方法和组合物 |
US11661625B2 (en) | 2020-05-14 | 2023-05-30 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
WO2022109343A1 (fr) | 2020-11-20 | 2022-05-27 | Becton, Dickinson And Company | Profilage de protéines hautement exprimées et faiblement exprimées |
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WO2004089810A2 (fr) * | 2003-04-03 | 2004-10-21 | Fluidigm Corp. | Dispositifs microfluidiques et leurs procedes d'utilisation |
US20050252773A1 (en) * | 2003-04-03 | 2005-11-17 | Fluidigm Corporation | Thermal reaction device and method for using the same |
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EP1417336A4 (fr) | 2001-07-15 | 2005-06-22 | Keck Graduate Inst | Amplification exponentielle d'acides nucleiques au moyen d'endonucleases de coupure |
-
2006
- 2006-03-20 EP EP10197437A patent/EP2371453A1/fr not_active Withdrawn
- 2006-03-20 EP EP06739049A patent/EP1861512A4/fr not_active Withdrawn
- 2006-03-20 WO PCT/US2006/010103 patent/WO2006102264A1/fr active Application Filing
- 2006-03-20 EP EP20120160084 patent/EP2518161A1/fr not_active Ceased
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2004089810A2 (fr) * | 2003-04-03 | 2004-10-21 | Fluidigm Corp. | Dispositifs microfluidiques et leurs procedes d'utilisation |
US20050252773A1 (en) * | 2003-04-03 | 2005-11-17 | Fluidigm Corporation | Thermal reaction device and method for using the same |
Non-Patent Citations (5)
Title |
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OEHLER VIVIAN G ET AL: "Absolute quantitative detection of Abl tyrosine kinase domain mutations using a novel microfluidic platform and allele-specific PCR", BLOOD 16 NOV 2005, vol. 106, no. 11, 16 November 2005 (2005-11-16), pages ABSTRACT 2859, XP002550112, ISSN: 0006-4971, Retrieved from the Internet <URL:http://abstracts.hematologylibrary.org/cgi/content/abstract/106/11/2859?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=absolute+quantitative+tyrosine+kinase&searchid=1&FIRSTINDEX=0&volume=106&issue=11&resourcetype=HWCIT> [retrieved on 20091012] * |
POHL GUDRUN ET AL: "Principle and applications of digital PCR", EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, FUTURE DRUGS, LONDON, GB, vol. 4, no. 1, 1 January 2004 (2004-01-01), pages 41 - 47, XP009109051, ISSN: 1473-7159 * |
See also references of WO2006102264A1 * |
WABUYELE MUSUNDI B ET AL: "Approaching real-time molecular diagnostics: single-pair fluorescence resonance energy transfer (spFRET) detection for the analysis of low abundant point mutations in K-ras oncogenes.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 11 JUN 2003, vol. 125, no. 23, 11 June 2003 (2003-06-11), pages 6937 - 6945, XP002550111, ISSN: 0002-7863 * |
WANG YUN ET AL: "Microarrays assembled in microfluidic chips fabricated from poly(methyl methacrylate) for the detection of low-abundant DNA mutations.", ANALYTICAL CHEMISTRY 1 MAR 2003, vol. 75, no. 5, 1 March 2003 (2003-03-01), pages 1130 - 1140, XP002550110, ISSN: 0003-2700 * |
Also Published As
Publication number | Publication date |
---|---|
EP2371453A1 (fr) | 2011-10-05 |
WO2006102264A1 (fr) | 2006-09-28 |
EP1861512A1 (fr) | 2007-12-05 |
EP2518161A1 (fr) | 2012-10-31 |
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