SG11201604886WA - Non-human animals having humanized fc-gamma receptors - Google Patents
Non-human animals having humanized fc-gamma receptorsInfo
- Publication number
- SG11201604886WA SG11201604886WA SG11201604886WA SG11201604886WA SG11201604886WA SG 11201604886W A SG11201604886W A SG 11201604886WA SG 11201604886W A SG11201604886W A SG 11201604886WA SG 11201604886W A SG11201604886W A SG 11201604886WA SG 11201604886W A SG11201604886W A SG 11201604886WA
- Authority
- SG
- Singapore
- Prior art keywords
- humanized
- human animals
- gamma receptors
- receptors
- gamma
- Prior art date
Links
- 102000009490 IgG Receptors Human genes 0.000 title 1
- 108010073807 IgG Receptors Proteins 0.000 title 1
- 241001465754 Metazoa Species 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0387—Animal model for diseases of the immune system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461977037P | 2014-04-08 | 2014-04-08 | |
| PCT/US2015/024920 WO2015157415A1 (en) | 2014-04-08 | 2015-04-08 | Non-human animals having humanized fc-gamma receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201604886WA true SG11201604886WA (en) | 2016-07-28 |
Family
ID=52997579
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201604886WA SG11201604886WA (en) | 2014-04-08 | 2015-04-08 | Non-human animals having humanized fc-gamma receptors |
| SG10201908800Y SG10201908800YA (en) | 2014-04-08 | 2015-04-08 | Non-human animals having humanized fc-gamma receptors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201908800Y SG10201908800YA (en) | 2014-04-08 | 2015-04-08 | Non-human animals having humanized fc-gamma receptors |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US9474255B2 (sr) |
| EP (2) | EP3693383A1 (sr) |
| JP (2) | JP6652931B2 (sr) |
| KR (2) | KR102439412B1 (sr) |
| CN (2) | CN111690052B (sr) |
| AU (2) | AU2015243865C1 (sr) |
| CA (1) | CA2935472C (sr) |
| CY (1) | CY1123046T1 (sr) |
| DK (1) | DK3129400T3 (sr) |
| ES (1) | ES2794942T3 (sr) |
| HR (1) | HRP20200899T1 (sr) |
| HU (1) | HUE051088T2 (sr) |
| IL (2) | IL246497B (sr) |
| LT (1) | LT3129400T (sr) |
| MX (1) | MX2016013241A (sr) |
| PH (1) | PH12016501341A1 (sr) |
| PL (1) | PL3129400T3 (sr) |
| PT (1) | PT3129400T (sr) |
| RS (1) | RS60398B1 (sr) |
| RU (2) | RU2019128394A (sr) |
| SG (2) | SG11201604886WA (sr) |
| SI (1) | SI3129400T1 (sr) |
| WO (1) | WO2015157415A1 (sr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3129400T1 (sl) * | 2014-04-08 | 2020-07-31 | Regeneron Pharmaceuticals, Inc. | Živali, ki niso človek in imajo humanizirane receptorje FC-gama |
| NO2785538T3 (sr) | 2014-05-07 | 2018-08-04 | ||
| MX2016016903A (es) | 2014-06-19 | 2017-03-27 | Regeneron Pharma | Animales no humanos que tienen un gen de muerte celular programada 1 humanizado. |
| HUE059417T2 (hu) | 2014-11-24 | 2022-11-28 | Regeneron Pharma | Humanizált CD3-komplexet expresszáló nem humán állatok |
| MX2017007293A (es) | 2014-12-05 | 2018-03-12 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciacion 47 humanizado. |
| NZ742447A (en) | 2015-11-20 | 2022-12-23 | Regeneron Pharma | Non-human animals having a humanized lymphocyte-activation gene 3 |
| SG10202001578RA (en) | 2016-02-29 | 2020-04-29 | Regeneron Pharma | Rodents having a humanized tmprss gene |
| CA3076377A1 (en) | 2017-11-30 | 2019-06-06 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized trkb locus |
| JP7328243B2 (ja) * | 2018-03-26 | 2023-08-16 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 治療薬を試験するためのヒト化げっ歯類 |
| CA3098040A1 (en) | 2018-07-16 | 2020-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of ditra disease and uses thereof |
| US20240065239A1 (en) | 2020-12-16 | 2024-02-29 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2657221B2 (ja) | 1988-05-27 | 1997-09-24 | アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ | ヒトＦｃγレセプター▲ＩＩＩ▼ |
| EP0663952A4 (en) | 1992-09-11 | 1997-06-11 | Univ California | TRANSGENIC NON-HUMAN ANIMALS WITH TARGETED INTERRUPTED TRANSDUCTION GENES IN LYMPHOCYTES. |
| US5877396A (en) | 1993-04-23 | 1999-03-02 | Sloan Kettering Institute For Cancer Research | Mice mutant for functional Fc receptors and method of treating autoimmune diseases |
| US6111166A (en) * | 1994-09-19 | 2000-08-29 | Medarex, Incorporated | Transgenic mice expressing human Fcα and β receptors |
| US6676927B1 (en) | 1999-01-20 | 2004-01-13 | The Rockefeller University | Animal model and methods for its use in the selection of cytotoxic antibodies |
| FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| EP2365062B1 (en) * | 2001-02-20 | 2016-11-23 | University Of Georgia Research Foundation, Inc. | Rapid production of monoclonal antibodies |
| FR2822161B1 (fr) | 2001-03-15 | 2003-09-19 | Genoway | Cellule et animal transgenique modelisant les reponses humaines allergiques mediees par les ige, et leurs utilisations |
| GB0110029D0 (en) * | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| JP4653915B2 (ja) | 2001-10-29 | 2011-03-16 | 独立行政法人科学技術振興機構 | 全身性エリテマトーデスモデル非ヒト動物 |
| US6911321B2 (en) * | 2001-12-19 | 2005-06-28 | Genentech, Inc. | Non-human primate Fc receptors and methods of use |
| DE60318065T2 (de) | 2002-06-07 | 2008-11-20 | Trillium Therapeutics Inc., Toronto | Fcyriia-transgenes tiermodell für autoimmunkrankheit |
| JP2004147535A (ja) | 2002-10-29 | 2004-05-27 | Japan Science & Technology Agency | ギラン・バレー症候群及び／又はフィッシャー症候群発症モデル非ヒト動物 |
| ATE401787T1 (de) | 2002-12-16 | 2008-08-15 | Genentech Inc | Menschliches cd20 exprimierende transgene mäuse |
| FR2858235B1 (fr) | 2003-07-31 | 2006-02-17 | Lab Francais Du Fractionnement | Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs |
| AU2005250408B2 (en) * | 2004-05-27 | 2010-09-23 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
| WO2006039418A2 (en) * | 2004-09-30 | 2006-04-13 | Medarex, Inc. | Human monoclonal antibodies to fc gamma receptor ii (cd32) |
| CA2644903A1 (en) | 2006-03-10 | 2007-09-20 | Macrogenics, Inc. | Identification and engineering of antibodies with variant heavy chains and methods of using same |
| US20080003225A1 (en) | 2006-06-29 | 2008-01-03 | Henri Vie | Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors |
| JP5299902B2 (ja) | 2007-01-30 | 2013-09-25 | 中外製薬株式会社 | キメラＦｃγレセプター及び該レセプターを用いたＡＤＣＣ活性測定方法 |
| US7816082B2 (en) * | 2007-03-06 | 2010-10-19 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods of identifying pancreatic cancer cells |
| DK2288623T3 (da) * | 2008-05-23 | 2014-01-27 | Ablexis Llc | Fremgangsmåde til frembringelse af enkelt-vl-domæne-antistoffer hos transgene dyr |
| WO2009158696A1 (en) * | 2008-06-27 | 2009-12-30 | Zymogenetics, Inc. | SOLUBLE HYBRID Fcγ RECEPTORS AND RELATED METHODS |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| ES2595376T3 (es) * | 2009-12-10 | 2016-12-29 | Regeneron Pharmaceuticals, Inc. | Ratones que producen anticuerpos de cadena pesada |
| SG10201408415PA (en) | 2009-12-21 | 2015-01-29 | Regeneron Pharma | HUMANIZED FCγ R MICE |
| RS53683B1 (sr) | 2011-10-28 | 2015-04-30 | Regeneron Pharmaceuticals Inc. | Humanizovani il-6 i il-6 receptor |
| LT3262932T (lt) | 2011-10-28 | 2019-08-26 | Regeneron Pharmaceuticals, Inc. | Pelės su genetiškai modifikuotu pagrindiniu histosuderinamumo kompleksu |
| RU2660564C2 (ru) | 2011-10-28 | 2018-07-06 | Регенерон Фармасьютикалз, Инк. | Генетически модифицированные мыши, экспрессирующие химерные молекулы главного комплекса гистосовместимости |
| CN114766432A (zh) | 2012-11-05 | 2022-07-22 | 再生元制药公司 | 经遗传修饰的非人动物及其使用方法 |
| AU2014218897C1 (en) | 2013-02-20 | 2019-03-07 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized T-cell co-receptors |
| LT2958937T (lt) | 2013-02-22 | 2018-11-26 | Regeneron Pharmaceuticals, Inc. | Pelė, ekspresuojanti humanizuotą audinių dermės kompleksą |
| DK3175706T3 (en) | 2013-09-23 | 2019-03-04 | Regeneron Pharma | Non-human animals with a humanized signal regulatory protein gene |
| SG10201900003WA (en) | 2013-11-19 | 2019-02-27 | Regeneron Pharma | Non-human animals having a humanized b-cell activating factor gene |
| US20150143559A1 (en) | 2013-11-19 | 2015-05-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
| SI3129400T1 (sl) * | 2014-04-08 | 2020-07-31 | Regeneron Pharmaceuticals, Inc. | Živali, ki niso človek in imajo humanizirane receptorje FC-gama |
-
2015
- 2015-04-08 SI SI201531233T patent/SI3129400T1/sl unknown
- 2015-04-08 PT PT157180605T patent/PT3129400T/pt unknown
- 2015-04-08 EP EP20156988.6A patent/EP3693383A1/en active Pending
- 2015-04-08 LT LTEP15718060.5T patent/LT3129400T/lt unknown
- 2015-04-08 CN CN202010590143.8A patent/CN111690052B/zh active Active
- 2015-04-08 KR KR1020217005817A patent/KR102439412B1/ko active IP Right Grant
- 2015-04-08 CN CN201580019102.0A patent/CN106163273B/zh active Active
- 2015-04-08 JP JP2016561676A patent/JP6652931B2/ja active Active
- 2015-04-08 SG SG11201604886WA patent/SG11201604886WA/en unknown
- 2015-04-08 RU RU2019128394A patent/RU2019128394A/ru unknown
- 2015-04-08 DK DK15718060.5T patent/DK3129400T3/da active
- 2015-04-08 MX MX2016013241A patent/MX2016013241A/es unknown
- 2015-04-08 US US14/681,617 patent/US9474255B2/en active Active
- 2015-04-08 HU HUE15718060A patent/HUE051088T2/hu unknown
- 2015-04-08 ES ES15718060T patent/ES2794942T3/es active Active
- 2015-04-08 RS RS20200649A patent/RS60398B1/sr unknown
- 2015-04-08 CA CA2935472A patent/CA2935472C/en active Active
- 2015-04-08 RU RU2016143036A patent/RU2700484C2/ru active
- 2015-04-08 SG SG10201908800Y patent/SG10201908800YA/en unknown
- 2015-04-08 WO PCT/US2015/024920 patent/WO2015157415A1/en active Application Filing
- 2015-04-08 PL PL15718060T patent/PL3129400T3/pl unknown
- 2015-04-08 AU AU2015243865A patent/AU2015243865C1/en active Active
- 2015-04-08 KR KR1020167027893A patent/KR102223264B1/ko active Application Filing
- 2015-04-08 EP EP15718060.5A patent/EP3129400B1/en active Active
-
2016
- 2016-06-28 IL IL246497A patent/IL246497B/en active IP Right Grant
- 2016-07-05 PH PH12016501341A patent/PH12016501341A1/en unknown
- 2016-09-27 US US15/277,092 patent/US10555507B2/en active Active
-
2019
- 2019-01-21 IL IL264364A patent/IL264364B/en active IP Right Grant
- 2019-12-20 US US16/723,733 patent/US11503812B2/en active Active
-
2020
- 2020-01-24 JP JP2020009985A patent/JP6858283B2/ja active Active
- 2020-06-04 HR HRP20200899TT patent/HRP20200899T1/hr unknown
- 2020-06-16 CY CY20201100549T patent/CY1123046T1/el unknown
- 2020-08-10 AU AU2020217312A patent/AU2020217312C1/en active Active
-
2022
- 2022-10-17 US US17/967,510 patent/US20230232795A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL286414A (en) | Non-human animals expressing a cd3 complex of human origin | |
| IL250536A0 (en) | Chimeric antigen receptors | |
| IL251030B (en) | Chimeric antigen receptors | |
| IL246497A0 (en) | Non-human animals with human fc–gamma receptors | |
| GB201617290D0 (en) | Novel chimeric antigen receptors | |
| SI3230310T1 (sl) | Anti-CD70 himerni antigenski receptorji | |
| GB201403972D0 (en) | Chimeric antigen receptor | |
| GB201511730D0 (en) | Leash accessory | |
| PT3101131T (pt) | Anticorpo antitranstirretina humanizado | |
| ZA201406728B (en) | Rearing device for laying hens | |
| GB201406055D0 (en) | Wire trough | |
| GB201409761D0 (en) | Chimeric antigen receptor | |
| GB201403481D0 (en) | Chimeric antigen receptor |