SG11201603115YA - Conjugates of somatostatin and its analogs - Google Patents

Conjugates of somatostatin and its analogs

Info

Publication number
SG11201603115YA
SG11201603115YA SG11201603115YA SG11201603115YA SG11201603115YA SG 11201603115Y A SG11201603115Y A SG 11201603115YA SG 11201603115Y A SG11201603115Y A SG 11201603115YA SG 11201603115Y A SG11201603115Y A SG 11201603115YA SG 11201603115Y A SG11201603115Y A SG 11201603115YA
Authority
SG
Singapore
Prior art keywords
somatostatin
conjugates
analogs
Prior art date
Application number
SG11201603115YA
Other languages
English (en)
Inventor
Eric L Schneider
Brian Hearn
Gary Ashley
Daniel V Santi
Original Assignee
Prolynx Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolynx Llc filed Critical Prolynx Llc
Publication of SG11201603115YA publication Critical patent/SG11201603115YA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/31Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SG11201603115YA 2013-10-22 2014-10-22 Conjugates of somatostatin and its analogs SG11201603115YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361894226P 2013-10-22 2013-10-22
PCT/US2014/061844 WO2015061503A1 (en) 2013-10-22 2014-10-22 Conjugates of somatostatin and its analogs

Publications (1)

Publication Number Publication Date
SG11201603115YA true SG11201603115YA (en) 2016-05-30

Family

ID=52993525

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201803370XA SG10201803370XA (en) 2013-10-22 2014-10-22 Conjugates of somatostatin and its analogs
SG11201603115YA SG11201603115YA (en) 2013-10-22 2014-10-22 Conjugates of somatostatin and its analogs

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201803370XA SG10201803370XA (en) 2013-10-22 2014-10-22 Conjugates of somatostatin and its analogs

Country Status (10)

Country Link
US (2) US10086049B2 (es)
EP (1) EP3060230A4 (es)
JP (1) JP2016534064A (es)
KR (1) KR20160075665A (es)
CN (1) CN106232131A (es)
AU (1) AU2014340095A1 (es)
CA (1) CA2928407A1 (es)
MX (1) MX2016005285A (es)
SG (2) SG10201803370XA (es)
WO (1) WO2015061503A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018118902A1 (en) * 2016-12-19 2018-06-28 The Regents Of The University Of California Dual-enzyme responsive peptides
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
WO2018218004A1 (en) 2017-05-24 2018-11-29 The Board Of Regents Of The University Of Texas System Linkers for antibody drug conjugates
EP3684414A4 (en) * 2017-09-19 2021-06-09 Immunwork Inc. PHARMACEUTICAL CONSTRUCTIONS WITH IMPROVED BINDING AFFINITY WITH ALBUMIN
TW202027794A (zh) 2018-10-03 2020-08-01 瑞士商諾華公司 血管生成素樣3多肽之持續遞送
CN114630818A (zh) * 2019-09-30 2022-06-14 北京轩义医药科技有限公司 蛋白-大分子偶联物及其使用方法
EP4073064A4 (en) * 2019-12-11 2024-01-24 Massachusetts Gen Hospital METHOD FOR IMAGING CELLS
CN114409736B (zh) * 2022-01-28 2023-09-15 中国科学院精密测量科学与技术创新研究院 一种基于两亲性寡肽的定相排列介质及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214792B1 (en) * 1996-04-12 2001-04-10 David Lew Simon Method for treating acute and severe diarrhea
JP2004534721A (ja) 2000-10-31 2004-11-18 ピーアール ファーマシューティカルズ,インク. 生理活性分子の向上した送達のための方法及び組成物
CN103550137B (zh) 2005-03-11 2015-07-29 益德威士医药股份有限公司 奥曲肽的受控释放制剂
GB0711656D0 (en) * 2007-06-15 2007-07-25 Camurus Ab Formulations
UA104866C2 (uk) 2008-06-25 2014-03-25 Ендо Фармас'Ютікалз Солюшнз Інк. Імплантат октреотиду, який містить вивільняючу речовину
DK2306986T3 (en) 2008-06-26 2018-06-18 Prolynx Llc PRODRUGS AND PHARMACEUTICAL Macromolecule Conjugates with Controlled Drug Release Rates
US8640315B1 (en) 2009-10-28 2014-02-04 Robert E. Nikkel Rotating adapter assembly
CN105456206B (zh) * 2010-01-13 2018-12-14 益普生制药股份有限公司 用于延缓释放生长抑素类似物的药物组合物的制备方法
WO2011140393A1 (en) 2010-05-05 2011-11-10 Prolynx Llc Controlled release from macromolecular conjugates
WO2011140376A1 (en) 2010-05-05 2011-11-10 Prolynx Llc Controlled drug release from dendrimers
WO2011140392A1 (en) 2010-05-05 2011-11-10 Prolynx Llc Controlled drug release from solid supports
CA2848142C (en) * 2011-09-07 2021-05-18 Prolynx Llc Hydrogels with biodegradable crosslinking
JP6081480B2 (ja) 2011-12-05 2017-02-15 カムルス エービー 頑強な徐放性製剤

Also Published As

Publication number Publication date
US20160271227A1 (en) 2016-09-22
CA2928407A1 (en) 2015-04-30
JP2016534064A (ja) 2016-11-04
EP3060230A1 (en) 2016-08-31
EP3060230A4 (en) 2017-06-14
SG10201803370XA (en) 2018-06-28
WO2015061503A1 (en) 2015-04-30
MX2016005285A (es) 2016-10-28
US10413594B2 (en) 2019-09-17
KR20160075665A (ko) 2016-06-29
CN106232131A (zh) 2016-12-14
US10086049B2 (en) 2018-10-02
AU2014340095A1 (en) 2016-05-26
US20180296648A1 (en) 2018-10-18

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