UA104866C2 - Імплантат октреотиду, який містить вивільняючу речовину - Google Patents

Імплантат октреотиду, який містить вивільняючу речовину

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Publication number
UA104866C2
UA104866C2 UAA201100800A UAA201100800A UA104866C2 UA 104866 C2 UA104866 C2 UA 104866C2 UA A201100800 A UAA201100800 A UA A201100800A UA A201100800 A UAA201100800 A UA A201100800A UA 104866 C2 UA104866 C2 UA 104866C2
Authority
UA
Ukraine
Prior art keywords
ocreotide
implant
release agent
octreotide
kits
Prior art date
Application number
UAA201100800A
Other languages
English (en)
Russian (ru)
Inventor
Петр Кузма
Стефані Декер
Гарі Куандт
Original Assignee
Ендо Фармас'Ютікалз Солюшнз Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ендо Фармас'Ютікалз Солюшнз Інк. filed Critical Ендо Фармас'Ютікалз Солюшнз Інк.
Publication of UA104866C2 publication Critical patent/UA104866C2/uk

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

Винахід належить до фармацевтики та медицини і стосується композиції для контрольованого вивільнення октреотиду після імплантації суб'єктові, яка включає препарат, що містить октреотид, включений у гідрофільний полімер, де гідрофільний полімер, але не препарат, додатково містить вивільняючу речовину з молекулярною вагою щонайменше близько 1000 дальтон. Винахід також стосується способу зменшення рівнів ГР або рівнів IGF-1 у суб'єкта та/або лікування хвороби, яка є чутливою до октреотиду, розладу або симптому, який передбачає підшкірну імплантацію принаймні одного сухого імплантованого пристрою, та набору для нього.
UAA201100800A 2008-06-25 2009-06-24 Імплантат октреотиду, який містить вивільняючу речовину UA104866C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7562508P 2008-06-25 2008-06-25
US8014408P 2008-07-11 2008-07-11
PCT/US2009/048484 WO2009158415A1 (en) 2008-06-25 2009-06-24 Octreotide implant having a release agent

Publications (1)

Publication Number Publication Date
UA104866C2 true UA104866C2 (uk) 2014-03-25

Family

ID=41259098

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201100800A UA104866C2 (uk) 2008-06-25 2009-06-24 Імплантат октреотиду, який містить вивільняючу речовину

Country Status (15)

Country Link
US (2) US7960335B2 (uk)
EP (1) EP2317975B1 (uk)
JP (1) JP5536053B2 (uk)
KR (1) KR20110025974A (uk)
CN (1) CN102231976B (uk)
AU (1) AU2009262263B2 (uk)
BR (1) BRPI0914336A2 (uk)
CA (1) CA2729139C (uk)
HK (2) HK1158491A1 (uk)
IL (1) IL210218A (uk)
MX (1) MX2011000036A (uk)
RU (1) RU2521291C2 (uk)
UA (1) UA104866C2 (uk)
WO (1) WO2009158415A1 (uk)
ZA (1) ZA201100221B (uk)

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US20100022450A1 (en) 2010-01-28
IL210218A (en) 2015-05-31
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US20110206745A1 (en) 2011-08-25
US8383577B2 (en) 2013-02-26
CN102231976B (zh) 2014-05-07
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CA2729139C (en) 2016-07-26
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JP2011526289A (ja) 2011-10-06
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BRPI0914336A2 (pt) 2017-05-30
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