SG11201601695WA - Automated screening of enzyme variants - Google Patents
Automated screening of enzyme variantsInfo
- Publication number
- SG11201601695WA SG11201601695WA SG11201601695WA SG11201601695WA SG11201601695WA SG 11201601695W A SG11201601695W A SG 11201601695WA SG 11201601695W A SG11201601695W A SG 11201601695WA SG 11201601695W A SG11201601695W A SG 11201601695WA SG 11201601695W A SG11201601695W A SG 11201601695WA
- Authority
- SG
- Singapore
- Prior art keywords
- enzyme variants
- automated screening
- screening
- automated
- variants
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C99/00—Subject matter not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
- G16B35/20—Screening of libraries
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/60—In silico combinatorial chemistry
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/60—In silico combinatorial chemistry
- G16C20/64—Screening of libraries
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Theoretical Computer Science (AREA)
- Library & Information Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- Computing Systems (AREA)
- Analytical Chemistry (AREA)
- Ecology (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361883838P | 2013-09-27 | 2013-09-27 | |
PCT/US2014/057899 WO2015048572A1 (en) | 2013-09-27 | 2014-09-26 | Automated screening of enzyme variants |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201601695WA true SG11201601695WA (en) | 2016-04-28 |
Family
ID=51662390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201601695WA SG11201601695WA (en) | 2013-09-27 | 2014-09-26 | Automated screening of enzyme variants |
Country Status (15)
Country | Link |
---|---|
US (3) | US10696964B2 (ko) |
EP (2) | EP3418929B1 (ko) |
JP (3) | JP6857029B2 (ko) |
KR (1) | KR102342205B1 (ko) |
CN (1) | CN105765592B (ko) |
AU (1) | AU2014324669B2 (ko) |
BR (1) | BR112016006285B1 (ko) |
CA (1) | CA2923755C (ko) |
DK (2) | DK3049973T3 (ko) |
ES (2) | ES2693150T3 (ko) |
HU (2) | HUE039618T2 (ko) |
IL (1) | IL244457B (ko) |
RU (2) | RU2016116253A (ko) |
SG (1) | SG11201601695WA (ko) |
WO (1) | WO2015048572A1 (ko) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150134315A1 (en) | 2013-09-27 | 2015-05-14 | Codexis, Inc. | Structure based predictive modeling |
JP6857029B2 (ja) | 2013-09-27 | 2021-04-14 | コデクシス, インコーポレイテッド | 酵素バリアントの自動スクリーニング |
US20150142408A1 (en) * | 2013-11-15 | 2015-05-21 | Akiko Futamura | Computer-assisted modeling for treatment design |
US10370648B2 (en) | 2014-11-25 | 2019-08-06 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
BR112017013300A2 (pt) | 2014-12-22 | 2018-02-27 | Codexis Inc | alfa galactosidase a recombinante e/ou fragmento de alfa galactosidase a recombinante biologicamente ativo, composição, sequência de polinucleotídeos recombinantes, vetor de expressão, célula hospedeira, métodos para produzir uma variante de alfa galactosidase a e para tratar e/ou prevenir os sintomas da doença de fabry, composição farmacêutica, e, uso das composições. |
US10542961B2 (en) | 2015-06-15 | 2020-01-28 | The Research Foundation For The State University Of New York | System and method for infrasonic cardiac monitoring |
US20190112598A1 (en) * | 2016-03-09 | 2019-04-18 | President And Fellows Of Harvard College | Methods and Systems of Cell-Free Enzyme Discovery and Optimization |
MX2019009615A (es) | 2017-02-13 | 2019-10-14 | Codexis Inc | Polipeptidos dise?ados de fenilalanina amonio liasa. |
JP6917050B2 (ja) * | 2017-03-06 | 2021-08-11 | 学校法人早稲田大学 | 最適特性を有する非天然型タンパク質の製造方法 |
EP3615058A4 (en) * | 2017-04-27 | 2021-06-02 | Codexis, Inc. | KETOREDUCTASE-POLYPEPTIDES AND POLYNUCLEOTIDES |
JP7401902B2 (ja) * | 2017-05-08 | 2023-12-20 | コデクシス, インコーポレイテッド | 遺伝子操作されたリガーゼバリアント |
EP3404567A1 (en) * | 2017-05-19 | 2018-11-21 | Fujitsu Limited | A system and a method for discovery of predicted site-specific protein phosphorylation candidates |
CA3067642A1 (en) * | 2017-06-19 | 2018-12-27 | Jungla Llc | Interpretation of genetic and genomic variants via an integrated computational and experimental deep mutational learning framework |
EP3645711A4 (en) | 2017-06-30 | 2021-04-21 | Codexis, Inc. | T7 RNA POLYMERASE VARIANTS |
JP2020530267A (ja) | 2017-06-30 | 2020-10-22 | コデクシス, インコーポレイテッド | T7 rnaポリメラーゼバリアント |
CN110914446B (zh) * | 2017-07-14 | 2024-02-06 | C-乐克塔股份有限公司 | 酮还原酶 |
CN107832577B (zh) * | 2017-10-30 | 2021-07-13 | 中国农业大学 | 一种筛选几丁质酶OfChtⅠ抑制剂的方法 |
CN107974484A (zh) * | 2017-11-10 | 2018-05-01 | 嘉兴欣贝莱生物科技有限公司 | 根皮素生物合成过程中查尔酮合成酶建模方法 |
JP7343911B2 (ja) * | 2018-03-05 | 2023-09-13 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 結合および活性予測を強化するための機械学習および分子シミュレーションに基づく方法 |
EP3613855A1 (en) * | 2018-08-23 | 2020-02-26 | Clariant Produkte (Deutschland) GmbH | Method for the production of a nucleic acid library |
EP3640864A1 (en) * | 2018-10-18 | 2020-04-22 | Fujitsu Limited | A computer-implemented method and apparatus for inferring a property of a biomedical entity |
EP3874033A4 (en) | 2018-10-29 | 2022-08-03 | Codexis, Inc. | MANIPULATED VARIANTS OF DNA POLYMERASE |
AU2019397401A1 (en) | 2018-12-14 | 2021-06-17 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
BR112021011750A2 (pt) | 2018-12-20 | 2021-08-31 | Codexis, Inc. | Alfa-galactosidase a recombinante e/ou fragmento de alfa-galactosidase a recombinante, composição, sequência de polinucleotídeo recombinante, vetor de expressão, célula hospedeira, métodos para produzir uma variante de alfa-galactosidase a e para tratar e/ou prevenir os sintomas da doença de fabry, composição farmacêutica, e, uso das composições |
CN109841263B (zh) * | 2019-02-22 | 2023-08-15 | 成都分迪科技有限公司 | 蛋白降解药物分子库及其构建方法 |
JP7344509B2 (ja) * | 2019-09-20 | 2023-09-14 | 公立大学法人 富山県立大学 | 光学活性フルオロアルコールおよび光学活性クロロフルオロアルコールの製造方法 |
WO2021081713A1 (zh) * | 2019-10-28 | 2021-05-06 | 凯莱英医药集团(天津)股份有限公司 | 转氨酶突变体及其应用 |
JP2023507575A (ja) | 2019-12-20 | 2023-02-24 | コデクシス, インコーポレイテッド | 操作された酸性アルファ-グルコシダーゼバリアント |
CN111681703A (zh) * | 2020-05-09 | 2020-09-18 | 北京纽伦智能科技有限公司 | 一种蛋白结构的对接方法及分布式蛋白结构对接系统 |
CN114822717A (zh) * | 2021-01-28 | 2022-07-29 | 腾讯科技(深圳)有限公司 | 基于人工智能的药物分子处理方法、装置、设备及存储介质 |
WO2023022783A1 (en) * | 2021-08-17 | 2023-02-23 | University Of Southern California | System and method for computational enzyme design based on maximum entropy |
CN113921082B (zh) * | 2021-10-27 | 2023-04-07 | 云舟生物科技(广州)股份有限公司 | 基因搜索权重调整方法、计算机存储介质及电子设备 |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
JPH04179495A (ja) | 1990-11-14 | 1992-06-26 | M D Res Kk | 融合蛋白質、およびペプチド又は蛋白質の製造方法 |
US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6309883B1 (en) | 1994-02-17 | 2001-10-30 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
US6395547B1 (en) | 1994-02-17 | 2002-05-28 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6995017B1 (en) | 1994-02-17 | 2006-02-07 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US20060257890A1 (en) | 1996-05-20 | 2006-11-16 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US6406855B1 (en) | 1994-02-17 | 2002-06-18 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6506602B1 (en) | 1996-03-25 | 2003-01-14 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6096548A (en) | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
US7148054B2 (en) | 1997-01-17 | 2006-12-12 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
DE69835360T2 (de) | 1997-01-17 | 2007-08-16 | Maxygen, Inc., Redwood City | EVOLUTION Prokaryotischer GANZER ZELLEN DURCH REKURSIVE SEQUENZREKOMBINATION |
US5914245A (en) | 1998-04-20 | 1999-06-22 | Kairos Scientific Inc. | Solid phase enzyme kinetics screening in microcolonies |
US6365408B1 (en) | 1998-06-19 | 2002-04-02 | Maxygen, Inc. | Methods of evolving a polynucleotides by mutagenesis and recombination |
JP4221100B2 (ja) | 1999-01-13 | 2009-02-12 | エルピーダメモリ株式会社 | 半導体装置 |
AU2415200A (en) | 1999-01-18 | 2000-08-01 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
US6368861B1 (en) | 1999-01-19 | 2002-04-09 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6436675B1 (en) | 1999-09-28 | 2002-08-20 | Maxygen, Inc. | Use of codon-varied oligonucleotide synthesis for synthetic shuffling |
US6917882B2 (en) | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
EP1072010B1 (en) | 1999-01-19 | 2010-04-21 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US20070065838A1 (en) | 1999-01-19 | 2007-03-22 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6961664B2 (en) | 1999-01-19 | 2005-11-01 | Maxygen | Methods of populating data structures for use in evolutionary simulations |
US7024312B1 (en) | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US7702464B1 (en) | 2001-08-21 | 2010-04-20 | Maxygen, Inc. | Method and apparatus for codon determining |
AU3719500A (en) | 1999-03-05 | 2000-09-21 | Maxygen, Inc. | Recombination of insertion modified nucleic acids |
US6969763B1 (en) | 1999-05-12 | 2005-11-29 | Isis Pharmaceuticals, Inc. | Molecular interaction sites of interleukin-2 RNA and methods of modulating the same |
US7430477B2 (en) | 1999-10-12 | 2008-09-30 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
US6519065B1 (en) | 1999-11-05 | 2003-02-11 | Jds Fitel Inc. | Chromatic dispersion compensation device |
EP1272839A4 (en) | 2000-03-23 | 2006-03-01 | California Inst Of Techn | METHOD AND APPARATUS FOR PREDICTING LINK INTERACTIONS FOR LIGANDS |
AU4964101A (en) | 2000-03-30 | 2001-10-15 | Maxygen Inc | In silico cross-over site selection |
US20020133297A1 (en) | 2001-01-17 | 2002-09-19 | Jinn-Moon Yang | Ligand docking method using evolutionary algorithm |
EP1470219A4 (en) | 2001-04-16 | 2005-10-05 | California Inst Of Techn | PEROXIDE MOLDED CYTOCHROME OXYGENASE P450 OXYGENASE VARIANTS |
WO2003008563A2 (en) | 2001-07-20 | 2003-01-30 | California Institute Of Technology | Improved cytochrome p450 oxygenases |
US7747391B2 (en) | 2002-03-01 | 2010-06-29 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
US7783428B2 (en) | 2002-03-01 | 2010-08-24 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
US7620500B2 (en) | 2002-03-09 | 2009-11-17 | Maxygen, Inc. | Optimization of crossover points for directed evolution |
AU2003276548A1 (en) * | 2002-10-28 | 2004-05-13 | Centre National De La Recherche Scientifique (C.N.R.S.) | A method for performing restrained dynamics docking of one or multiple substrates on multi-specific enzymes |
US20060121455A1 (en) * | 2003-04-14 | 2006-06-08 | California Institute Of Technology | COP protein design tool |
CN1468959A (zh) * | 2003-06-02 | 2004-01-21 | 复旦大学 | 非典型性肺炎冠状病毒蛋白质空间构象模型及其应用 |
EP1639091B1 (en) | 2003-06-17 | 2012-12-05 | California University Of Technology | Regio- and enantioselective alkane hydroxylation with modified cytochrome p450 |
US8005620B2 (en) | 2003-08-01 | 2011-08-23 | Dna Twopointo Inc. | Systems and methods for biopolymer engineering |
DK1660646T3 (en) | 2003-08-11 | 2015-03-09 | California Inst Of Techn | Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use |
JP2005309877A (ja) | 2004-04-22 | 2005-11-04 | National Institute Of Advanced Industrial & Technology | 機能性生体分子の配列解析方法 |
WO2006044378A2 (en) | 2004-10-12 | 2006-04-27 | University Of Iowa Research Foundation | Rapid computational identification of targets |
WO2006121455A1 (en) | 2005-05-10 | 2006-11-16 | The Salk Institute For Biological Studies | Dynamic signal processing |
MX2008009494A (es) * | 2006-01-23 | 2009-01-07 | Joseph P Errico | Metodos y composiciones de desarrollo dirigido de farmacos. |
RU2008140858A (ru) | 2006-03-15 | 2010-04-20 | Ксир (Za) | Способ скрининга соединений, обладающих активностью ингибитора глутамин синтетазы |
KR20090031938A (ko) | 2006-07-05 | 2009-03-30 | 더 스크립스 리서치 인스티튜트 | 방향성 진화로 촉매 작용을 최적화시킨 키메라 징크 핑거 리컴비나제 |
US7814234B2 (en) | 2006-10-30 | 2010-10-12 | Microsoft Corporation | Offline execution of web based applications |
KR101502634B1 (ko) | 2007-02-08 | 2015-03-16 | 코덱시스, 인코포레이티드 | 케토 환원 효소 및 이의 용도 |
EP2118281A2 (en) | 2007-02-12 | 2009-11-18 | Codexis, Inc. | Structure-activity relationships |
WO2009029554A2 (en) | 2007-08-24 | 2009-03-05 | Codexis, Inc. | Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane |
JP5973131B2 (ja) | 2007-09-13 | 2016-08-23 | コデクシス, インコーポレイテッド | アセトフェノンの還元のためのケトレダクターゼポリペプチド |
KR20100061571A (ko) | 2007-09-28 | 2010-06-07 | 코덱시스, 인코포레이티드 | 케토리덕타제 폴리펩티드 및 이의 용도 |
EP2205727B1 (en) | 2007-10-01 | 2015-06-24 | Codexis, Inc. | Ketoreductase polypeptides for the production of azetidinone |
CA2701726A1 (en) | 2007-10-04 | 2009-04-09 | Halcyon Molecular | Sequencing nucleic acid polymers with electron microscopy |
WO2009064015A1 (ja) | 2007-11-12 | 2009-05-22 | In-Silico Sciences, Inc. | インシリコスクリーニング装置、および、インシリコスクリーニング方法 |
ES2705694T3 (es) | 2008-06-13 | 2019-03-26 | Codexis Inc | Método de síntesis de variantes de polinucleótidos |
US8383346B2 (en) | 2008-06-13 | 2013-02-26 | Codexis, Inc. | Combined automated parallel synthesis of polynucleotide variants |
MX2010014500A (es) | 2008-06-24 | 2011-05-30 | Codexis Inc | Procedimientos biocataliticos para la preparacion de compuestos de prolina biciclica fusionada sustancialmente estereomericamente puros. |
SI2315773T1 (sl) | 2008-07-25 | 2016-12-30 | Glaxosmithkline Biologicals S.A. | Polipeptidi, polinukleotidi in sestavki za uporabo pri zdravljenju latentne tuberkuloze |
HUE026181T2 (en) | 2008-08-27 | 2016-05-30 | Codexis Inc | Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine |
US8247192B2 (en) | 2008-11-10 | 2012-08-21 | Codexis, Inc. | Penicillin-G acylases |
US8688427B2 (en) * | 2008-11-19 | 2014-04-01 | University Of Washington | Enzyme catalysts for diels-alder reactions |
EP2379713A4 (en) | 2008-12-18 | 2013-07-10 | Codexis Inc | RECOMBINANT HALOHYDRIN DEHALOGENASE POLYPEPTIDES |
EP2382308B1 (en) | 2008-12-25 | 2015-03-04 | Codexis, Inc. | Enone reductases |
DK2385983T3 (en) | 2009-01-08 | 2018-02-12 | Codexis Inc | Transaminase POLYPEPTIDES |
ES2448816T3 (es) | 2009-02-26 | 2014-03-17 | Codexis, Inc. | Biocatalizadores de transaminasa |
US8614081B2 (en) | 2009-07-23 | 2013-12-24 | Codexis, Inc. | Nitrilase biocatalysts |
CN102884178B (zh) | 2009-12-08 | 2014-12-03 | 科德克希思公司 | 拉唑化合物的合成 |
US8704041B2 (en) | 2009-12-30 | 2014-04-22 | Pioneer Hi Bred International Inc | Methods and compositions for targeted polynucleotide modification |
WO2012078800A2 (en) | 2010-12-08 | 2012-06-14 | Codexis, Inc. | Biocatalysts and methods for the synthesis of armodafinil |
CN102156823B (zh) | 2011-02-18 | 2015-04-22 | 复旦大学 | 一种靶向作用于蛋白激酶非活性构象的化合物筛选方法 |
SG11201408731WA (en) | 2012-06-29 | 2015-01-29 | Wisconsin Alumni Res Found | USE OF 2-METHYLENE-19-NOR-(20S)-1α,25-DIHYDROXYVITAMIN D<sb>3</sb> TO TREAT SECONDARY HYPERPARATHYROIDISM |
US20140303952A1 (en) | 2013-04-08 | 2014-10-09 | City University Of Hong Kong | Protein-ligand docking |
CN103265635A (zh) * | 2013-04-28 | 2013-08-28 | 中山大学附属第一医院 | 一种通用的靶向蛋白嵌合型分子化合物的构建方法 |
CN103324861B (zh) | 2013-07-10 | 2016-07-20 | 南京大学 | 基于分子动力学模拟的核受体介导内分泌干扰物质的虚拟筛选方法 |
JP6857029B2 (ja) | 2013-09-27 | 2021-04-14 | コデクシス, インコーポレイテッド | 酵素バリアントの自動スクリーニング |
US20150134315A1 (en) | 2013-09-27 | 2015-05-14 | Codexis, Inc. | Structure based predictive modeling |
-
2014
- 2014-09-26 JP JP2016516874A patent/JP6857029B2/ja active Active
- 2014-09-26 RU RU2016116253A patent/RU2016116253A/ru unknown
- 2014-09-26 WO PCT/US2014/057899 patent/WO2015048572A1/en active Application Filing
- 2014-09-26 KR KR1020167010661A patent/KR102342205B1/ko active IP Right Grant
- 2014-09-26 ES ES14781426.3T patent/ES2693150T3/es active Active
- 2014-09-26 AU AU2014324669A patent/AU2014324669B2/en active Active
- 2014-09-26 HU HUE14781426A patent/HUE039618T2/hu unknown
- 2014-09-26 EP EP18187438.9A patent/EP3418929B1/en active Active
- 2014-09-26 US US14/498,864 patent/US10696964B2/en active Active
- 2014-09-26 ES ES18187438T patent/ES2857711T3/es active Active
- 2014-09-26 CA CA2923755A patent/CA2923755C/en active Active
- 2014-09-26 EP EP14781426.3A patent/EP3049973B1/en active Active
- 2014-09-26 SG SG11201601695WA patent/SG11201601695WA/en unknown
- 2014-09-26 DK DK14781426.3T patent/DK3049973T3/en active
- 2014-09-26 DK DK18187438.9T patent/DK3418929T3/da active
- 2014-09-26 RU RU2019140645A patent/RU2019140645A/ru unknown
- 2014-09-26 CN CN201480065215.XA patent/CN105765592B/zh active Active
- 2014-09-26 BR BR112016006285-0A patent/BR112016006285B1/pt active IP Right Grant
- 2014-09-26 HU HUE18187438A patent/HUE053049T2/hu unknown
-
2016
- 2016-03-06 IL IL244457A patent/IL244457B/en active IP Right Grant
-
2018
- 2018-12-19 JP JP2018237169A patent/JP2019083025A/ja not_active Withdrawn
-
2020
- 2020-05-15 US US16/875,848 patent/US11535845B2/en active Active
-
2021
- 2021-05-28 JP JP2021089944A patent/JP2021131901A/ja active Pending
-
2022
- 2022-11-02 US US17/979,711 patent/US20230048421A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL244457A0 (en) | Automatic filtering of enzyme variants | |
HK1222466A1 (zh) | 遺傳變異分析 | |
HK1215432A1 (zh) | 篩選方法 | |
ZA201600633B (en) | Variant enzymes | |
IL243702A0 (en) | Cartomizer structure for automatic assembly | |
SG11201507018XA (en) | Automated desktop placement | |
GB201406784D0 (en) | A method of screening samples | |
IL240742A0 (en) | Methods for generating libraries for directed evolution | |
HUE063222T2 (hu) | Fotobioreaktor | |
GB2525555B (en) | Methods of processing cocoa | |
PL3071969T3 (pl) | Sposób analizy | |
PT3057995T (pt) | Processo de acilação | |
EP2943575A4 (en) | COMPOSITIONS AND METHODS FOR PRODUCING ENZYMES | |
GB201322673D0 (en) | Screening method | |
GB201315195D0 (en) | Identifying presence of substances | |
GB201303906D0 (en) | Assay method | |
GB201611891D0 (en) | Automated connection assembly | |
GB201213770D0 (en) | Screening methods | |
GB201310948D0 (en) | Screening methods | |
GB201401001D0 (en) | Enzyme function probes | |
AU5220P (en) | Jewel of DesertTopaz Delosperma cooperi | |
GB201318464D0 (en) | Modified enzymes | |
GB201321410D0 (en) | Novel screening method | |
GB201309876D0 (en) | Screening method | |
GB201308893D0 (en) | Screening method |