BR112016006285A2 - método implementado usando um sistema de computador, produto de programa de computador, e, sistema - Google Patents
método implementado usando um sistema de computador, produto de programa de computador, e, sistemaInfo
- Publication number
- BR112016006285A2 BR112016006285A2 BR112016006285A BR112016006285A BR112016006285A2 BR 112016006285 A2 BR112016006285 A2 BR 112016006285A2 BR 112016006285 A BR112016006285 A BR 112016006285A BR 112016006285 A BR112016006285 A BR 112016006285A BR 112016006285 A2 BR112016006285 A2 BR 112016006285A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- computer program
- computer
- program product
- screening
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C99/00—Subject matter not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
- G16B35/20—Screening of libraries
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/60—In silico combinatorial chemistry
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/60—In silico combinatorial chemistry
- G16C20/64—Screening of libraries
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Theoretical Computer Science (AREA)
- Library & Information Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Evolutionary Biology (AREA)
- Computing Systems (AREA)
- Analytical Chemistry (AREA)
- Ecology (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
são descritos métodos para identificar biomoléculas com propriedades desejadas (ou que são a maioria adequadas para uma rodada de evolução direcionada) a partir de bibliotecas de biomolécula complexas ou conjuntos de tais bibliotecas. algumas modalidades da presente descrição provêm métodos para virtualmente triar proteínas para propriedades benéficas. algumas modalidades da presente descrição provêm métodos para virtualmente triar enzimas para atividade desejada e/ou seletividade para reações catalíticas que envolvem substratos particulares. algumas modalidades combinam triagem e evolução direcionada para projetar e desenvolver proteínas e enzimas tendo propriedades desejadas. sistemas e produtos de programa de computador que implementam os métodos também são providos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361883838P | 2013-09-27 | 2013-09-27 | |
US61/883,838 | 2013-09-27 | ||
PCT/US2014/057899 WO2015048572A1 (en) | 2013-09-27 | 2014-09-26 | Automated screening of enzyme variants |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112016006285A2 true BR112016006285A2 (pt) | 2017-08-01 |
BR112016006285B1 BR112016006285B1 (pt) | 2022-09-06 |
Family
ID=51662390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016006285-0A BR112016006285B1 (pt) | 2013-09-27 | 2014-09-26 | Método implementado usando um sistema de computador, meio de armazenamento legível por computador, e, sistema |
Country Status (15)
Country | Link |
---|---|
US (3) | US10696964B2 (pt) |
EP (2) | EP3418929B1 (pt) |
JP (3) | JP6857029B2 (pt) |
KR (1) | KR102342205B1 (pt) |
CN (1) | CN105765592B (pt) |
AU (1) | AU2014324669B2 (pt) |
BR (1) | BR112016006285B1 (pt) |
CA (1) | CA2923755C (pt) |
DK (2) | DK3049973T3 (pt) |
ES (2) | ES2857711T3 (pt) |
HU (2) | HUE053049T2 (pt) |
IL (1) | IL244457B (pt) |
RU (2) | RU2019140645A (pt) |
SG (1) | SG11201601695WA (pt) |
WO (1) | WO2015048572A1 (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE048104T2 (hu) | 2013-09-27 | 2020-05-28 | Codexis Inc | Szerkezet alapú prediktív modellezés |
CN105765592B (zh) | 2013-09-27 | 2019-12-17 | 科德克希思公司 | 用于酶变体的自动筛选的方法、装置和系统 |
WO2015073971A1 (en) * | 2013-11-15 | 2015-05-21 | InfiniteBio | Computer-assisted modeling for treatment design |
HUE053363T2 (hu) | 2014-11-25 | 2021-06-28 | Codexis Inc | Módosított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására |
EP4234699A1 (en) | 2014-12-22 | 2023-08-30 | Codexis, Inc. | Human alpha-galactosidase variants |
US10542961B2 (en) | 2015-06-15 | 2020-01-28 | The Research Foundation For The State University Of New York | System and method for infrasonic cardiac monitoring |
WO2017155945A1 (en) * | 2016-03-09 | 2017-09-14 | President And Fellows Of Harvard College | Methods and systems of cell-free enzyme discovery and optimization |
NZ755628A (en) | 2017-02-13 | 2023-09-29 | Codexis Inc | Engineered phenylalanine ammonia lyase polypeptides |
JP6917050B2 (ja) * | 2017-03-06 | 2021-08-11 | 学校法人早稲田大学 | 最適特性を有する非天然型タンパク質の製造方法 |
WO2018200214A2 (en) | 2017-04-27 | 2018-11-01 | Codexis, Inc. | Ketoreductase polypeptides and polynucleotides |
BR112019023337A2 (pt) * | 2017-05-08 | 2020-06-16 | Codexis, Inc. | Ligase engenheirada, sequência de polinucleotídeo, vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo da ligase engenheirada, um produto de ligação, uma biblioteca de dna e uma pluralidade de fragmentos de dna adequados para sequenciamento, e, composição |
EP3404567A1 (en) * | 2017-05-19 | 2018-11-21 | Fujitsu Limited | A system and a method for discovery of predicted site-specific protein phosphorylation candidates |
US20180365372A1 (en) * | 2017-06-19 | 2018-12-20 | Jungla Inc. | Systems and Methods for the Interpretation of Genetic and Genomic Variants via an Integrated Computational and Experimental Deep Mutational Learning Framework |
WO2019005539A1 (en) | 2017-06-30 | 2019-01-03 | Codexis, Inc. | T7 POLYMERASE RNA VARIANTS |
US10793841B2 (en) | 2017-06-30 | 2020-10-06 | Codexis, Inc. | T7 RNA polymerase variants |
EP3652328A1 (en) * | 2017-07-14 | 2020-05-20 | c-LEcta GmbH | Ketoreductases |
CN107832577B (zh) * | 2017-10-30 | 2021-07-13 | 中国农业大学 | 一种筛选几丁质酶OfChtⅠ抑制剂的方法 |
CN107974484A (zh) * | 2017-11-10 | 2018-05-01 | 嘉兴欣贝莱生物科技有限公司 | 根皮素生物合成过程中查尔酮合成酶建模方法 |
CN112204402B (zh) * | 2018-03-05 | 2024-05-03 | 斯坦福大学托管董事会 | 基于机器学习和分子模拟的用于增强结合和活性预测的方法 |
EP3613855A1 (en) * | 2018-08-23 | 2020-02-26 | Clariant Produkte (Deutschland) GmbH | Method for the production of a nucleic acid library |
EP3640864A1 (en) | 2018-10-18 | 2020-04-22 | Fujitsu Limited | A computer-implemented method and apparatus for inferring a property of a biomedical entity |
AU2019373208A1 (en) | 2018-10-29 | 2021-05-13 | Codexis, Inc. | Engineered DNA polymerase variants |
AU2019397401A1 (en) | 2018-12-14 | 2021-06-17 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
EP3898960A4 (en) | 2018-12-20 | 2022-11-30 | Codexis, Inc. | VARIANTS OF HUMAN ALPHA GALACTOSIDASE |
CN109841263B (zh) * | 2019-02-22 | 2023-08-15 | 成都分迪科技有限公司 | 蛋白降解药物分子库及其构建方法 |
JP7344509B2 (ja) * | 2019-09-20 | 2023-09-14 | 公立大学法人 富山県立大学 | 光学活性フルオロアルコールおよび光学活性クロロフルオロアルコールの製造方法 |
EP4053269A4 (en) * | 2019-10-28 | 2022-11-02 | Asymchem Laboratories (Tianjin) Co., Ltd | TRANSAMINASE MUTANT AND USE THEREOF |
US11970722B2 (en) | 2019-12-20 | 2024-04-30 | Codexis, Inc. | Engineered acid alpha-glucosidase variants |
CN111681703A (zh) * | 2020-05-09 | 2020-09-18 | 北京纽伦智能科技有限公司 | 一种蛋白结构的对接方法及分布式蛋白结构对接系统 |
CN114822717A (zh) * | 2021-01-28 | 2022-07-29 | 腾讯科技(深圳)有限公司 | 基于人工智能的药物分子处理方法、装置、设备及存储介质 |
WO2023022783A1 (en) * | 2021-08-17 | 2023-02-23 | University Of Southern California | System and method for computational enzyme design based on maximum entropy |
CN113921082B (zh) * | 2021-10-27 | 2023-04-07 | 云舟生物科技(广州)股份有限公司 | 基因搜索权重调整方法、计算机存储介质及电子设备 |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
JPH04179495A (ja) | 1990-11-14 | 1992-06-26 | M D Res Kk | 融合蛋白質、およびペプチド又は蛋白質の製造方法 |
US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US6309883B1 (en) | 1994-02-17 | 2001-10-30 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6995017B1 (en) | 1994-02-17 | 2006-02-07 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US6406855B1 (en) | 1994-02-17 | 2002-06-18 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
US20060257890A1 (en) | 1996-05-20 | 2006-11-16 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6395547B1 (en) | 1994-02-17 | 2002-05-28 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6096548A (en) | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
US6506602B1 (en) | 1996-03-25 | 2003-01-14 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US7148054B2 (en) | 1997-01-17 | 2006-12-12 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
DE69835360T2 (de) | 1997-01-17 | 2007-08-16 | Maxygen, Inc., Redwood City | EVOLUTION Prokaryotischer GANZER ZELLEN DURCH REKURSIVE SEQUENZREKOMBINATION |
US5914245A (en) | 1998-04-20 | 1999-06-22 | Kairos Scientific Inc. | Solid phase enzyme kinetics screening in microcolonies |
US6365408B1 (en) | 1998-06-19 | 2002-04-02 | Maxygen, Inc. | Methods of evolving a polynucleotides by mutagenesis and recombination |
JP4221100B2 (ja) | 1999-01-13 | 2009-02-12 | エルピーダメモリ株式会社 | 半導体装置 |
WO2000042559A1 (en) | 1999-01-18 | 2000-07-20 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
US6436675B1 (en) | 1999-09-28 | 2002-08-20 | Maxygen, Inc. | Use of codon-varied oligonucleotide synthesis for synthetic shuffling |
US6917882B2 (en) | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US6368861B1 (en) | 1999-01-19 | 2002-04-09 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US7702464B1 (en) | 2001-08-21 | 2010-04-20 | Maxygen, Inc. | Method and apparatus for codon determining |
US6961664B2 (en) | 1999-01-19 | 2005-11-01 | Maxygen | Methods of populating data structures for use in evolutionary simulations |
IL138002A0 (en) | 1999-01-19 | 2001-10-31 | Maxygen Inc | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US7024312B1 (en) | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US20070065838A1 (en) | 1999-01-19 | 2007-03-22 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
WO2000052155A2 (en) | 1999-03-05 | 2000-09-08 | Maxygen, Inc. | Recombination of insertion modified nucleic acids |
US6969763B1 (en) * | 1999-05-12 | 2005-11-29 | Isis Pharmaceuticals, Inc. | Molecular interaction sites of interleukin-2 RNA and methods of modulating the same |
US7430477B2 (en) | 1999-10-12 | 2008-09-30 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
US6519065B1 (en) | 1999-11-05 | 2003-02-11 | Jds Fitel Inc. | Chromatic dispersion compensation device |
AU2001250955A1 (en) * | 2000-03-23 | 2001-10-03 | California Institute Of Technology | Method and apparatus for predicting ligand binding interactions |
WO2001075767A2 (en) | 2000-03-30 | 2001-10-11 | Maxygen, Inc. | In silico cross-over site selection |
US20020133297A1 (en) * | 2001-01-17 | 2002-09-19 | Jinn-Moon Yang | Ligand docking method using evolutionary algorithm |
EP1470219A4 (en) | 2001-04-16 | 2005-10-05 | California Inst Of Techn | PEROXIDE MOLDED CYTOCHROME OXYGENASE P450 OXYGENASE VARIANTS |
WO2003008563A2 (en) | 2001-07-20 | 2003-01-30 | California Institute Of Technology | Improved cytochrome p450 oxygenases |
US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
DK2278509T3 (en) | 2002-03-01 | 2014-12-15 | Codexis Mayflower Holdings Llc | Methods, systems and software for identification of functional biomolecules |
US7747391B2 (en) | 2002-03-01 | 2010-06-29 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
US7620500B2 (en) | 2002-03-09 | 2009-11-17 | Maxygen, Inc. | Optimization of crossover points for directed evolution |
US20060099667A1 (en) * | 2002-10-28 | 2006-05-11 | Francois Andre | Method for performing restrained dynamics docking of one or multiple substrates on multi-specific enzymes |
US20060121455A1 (en) * | 2003-04-14 | 2006-06-08 | California Institute Of Technology | COP protein design tool |
CN1468959A (zh) * | 2003-06-02 | 2004-01-21 | 复旦大学 | 非典型性肺炎冠状病毒蛋白质空间构象模型及其应用 |
EP1639091B1 (en) | 2003-06-17 | 2012-12-05 | California University Of Technology | Regio- and enantioselective alkane hydroxylation with modified cytochrome p450 |
US8005620B2 (en) | 2003-08-01 | 2011-08-23 | Dna Twopointo Inc. | Systems and methods for biopolymer engineering |
US7435570B2 (en) | 2003-08-11 | 2008-10-14 | California Institute Of Technology | Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use |
JP2005309877A (ja) | 2004-04-22 | 2005-11-04 | National Institute Of Advanced Industrial & Technology | 機能性生体分子の配列解析方法 |
WO2006044378A2 (en) | 2004-10-12 | 2006-04-27 | University Of Iowa Research Foundation | Rapid computational identification of targets |
WO2006121455A1 (en) | 2005-05-10 | 2006-11-16 | The Salk Institute For Biological Studies | Dynamic signal processing |
KR101535678B1 (ko) * | 2006-01-23 | 2015-07-09 | 조셉 피. 에리코 | 표적 약물 개발의 방법 및 조성물 |
RU2008140858A (ru) | 2006-03-15 | 2010-04-20 | Ксир (Za) | Способ скрининга соединений, обладающих активностью ингибитора глутамин синтетазы |
KR20090031938A (ko) | 2006-07-05 | 2009-03-30 | 더 스크립스 리서치 인스티튜트 | 방향성 진화로 촉매 작용을 최적화시킨 키메라 징크 핑거 리컴비나제 |
US7814234B2 (en) | 2006-10-30 | 2010-10-12 | Microsoft Corporation | Offline execution of web based applications |
WO2008103248A1 (en) | 2007-02-08 | 2008-08-28 | Codexis, Inc. | Ketoreductases and uses thereof |
US20090118130A1 (en) | 2007-02-12 | 2009-05-07 | Codexis, Inc. | Structure-activity relationships |
WO2009029554A2 (en) | 2007-08-24 | 2009-03-05 | Codexis, Inc. | Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane |
WO2009036404A2 (en) | 2007-09-13 | 2009-03-19 | Codexis, Inc. | Ketoreductase polypeptides for the reduction of acetophenones |
KR20100061571A (ko) | 2007-09-28 | 2010-06-07 | 코덱시스, 인코포레이티드 | 케토리덕타제 폴리펩티드 및 이의 용도 |
CN101883846A (zh) | 2007-10-01 | 2010-11-10 | 科德克希思公司 | 用于生成氮杂环丁酮的还原酶多肽 |
JP2010539991A (ja) | 2007-10-04 | 2010-12-24 | ハルシオン モレキュラー | 電子顕微鏡を用いた核酸ポリマーの配列決定 |
WO2009064015A1 (ja) | 2007-11-12 | 2009-05-22 | In-Silico Sciences, Inc. | インシリコスクリーニング装置、および、インシリコスクリーニング方法 |
CA2726850C (en) | 2008-06-13 | 2015-06-02 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
US8383346B2 (en) | 2008-06-13 | 2013-02-26 | Codexis, Inc. | Combined automated parallel synthesis of polynucleotide variants |
CN102131813B (zh) | 2008-06-24 | 2014-07-30 | 科德克希思公司 | 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法 |
ES2602430T3 (es) | 2008-07-25 | 2017-02-21 | Glaxosmithkline Biologicals S.A. | Polipéptidos, polinucleótidos y composiciones para uso en el tratamiento de tuberculosis latente |
ES2560459T3 (es) | 2008-08-27 | 2016-02-19 | Codexis, Inc. | Polipéptidos cetorreductasa para la producción de una 3-aril-3-hidroxipropanamina a partir de una 3-aril-3-cetopropanamina |
WO2010054319A2 (en) | 2008-11-10 | 2010-05-14 | Codexis, Inc. | Penicillin-g acylases |
WO2010077470A2 (en) * | 2008-11-19 | 2010-07-08 | University Of Washington | Enzyme catalysts for diels-alder reactions |
SG172231A1 (en) | 2008-12-18 | 2011-07-28 | Codexis Inc | Recombinant halohydrin dehalogenase polypeptides |
WO2010075574A2 (en) | 2008-12-25 | 2010-07-01 | Codexis, Inc. | Enone reductases |
EP3354727B1 (en) | 2009-01-08 | 2020-10-07 | Codexis, Inc. | Transaminase polypeptides |
ES2448816T3 (es) | 2009-02-26 | 2014-03-17 | Codexis, Inc. | Biocatalizadores de transaminasa |
WO2011011630A2 (en) | 2009-07-23 | 2011-01-27 | Codexis, Inc. | Nitrilase biocatalysts |
SG181535A1 (en) | 2009-12-08 | 2012-07-30 | Codexis Inc | Synthesis of prazole compounds |
CN102939383B (zh) | 2009-12-30 | 2015-04-29 | 先锋国际良种公司 | 用于靶向多核苷酸修饰的方法和组合物 |
US9267159B2 (en) | 2010-12-08 | 2016-02-23 | Codexis, Inc. | Biocatalysts and methods for the synthesis of armodafinil |
CN102156823B (zh) * | 2011-02-18 | 2015-04-22 | 复旦大学 | 一种靶向作用于蛋白激酶非活性构象的化合物筛选方法 |
NZ703347A (en) | 2012-06-29 | 2016-05-27 | Wisconsin Alumni Res Found | Use of 2-methylene-19-nor-(20s)-1α,25-dihydroxyvitamin d3 to treat secondary hyperparathyroidism |
US20140303952A1 (en) | 2013-04-08 | 2014-10-09 | City University Of Hong Kong | Protein-ligand docking |
CN103265635A (zh) * | 2013-04-28 | 2013-08-28 | 中山大学附属第一医院 | 一种通用的靶向蛋白嵌合型分子化合物的构建方法 |
CN103324861B (zh) | 2013-07-10 | 2016-07-20 | 南京大学 | 基于分子动力学模拟的核受体介导内分泌干扰物质的虚拟筛选方法 |
CN105765592B (zh) | 2013-09-27 | 2019-12-17 | 科德克希思公司 | 用于酶变体的自动筛选的方法、装置和系统 |
HUE048104T2 (hu) | 2013-09-27 | 2020-05-28 | Codexis Inc | Szerkezet alapú prediktív modellezés |
-
2014
- 2014-09-26 CN CN201480065215.XA patent/CN105765592B/zh active Active
- 2014-09-26 BR BR112016006285-0A patent/BR112016006285B1/pt active IP Right Grant
- 2014-09-26 US US14/498,864 patent/US10696964B2/en active Active
- 2014-09-26 HU HUE18187438A patent/HUE053049T2/hu unknown
- 2014-09-26 KR KR1020167010661A patent/KR102342205B1/ko active IP Right Grant
- 2014-09-26 ES ES18187438T patent/ES2857711T3/es active Active
- 2014-09-26 RU RU2019140645A patent/RU2019140645A/ru unknown
- 2014-09-26 JP JP2016516874A patent/JP6857029B2/ja active Active
- 2014-09-26 ES ES14781426.3T patent/ES2693150T3/es active Active
- 2014-09-26 SG SG11201601695WA patent/SG11201601695WA/en unknown
- 2014-09-26 EP EP18187438.9A patent/EP3418929B1/en active Active
- 2014-09-26 WO PCT/US2014/057899 patent/WO2015048572A1/en active Application Filing
- 2014-09-26 DK DK14781426.3T patent/DK3049973T3/en active
- 2014-09-26 AU AU2014324669A patent/AU2014324669B2/en active Active
- 2014-09-26 HU HUE14781426A patent/HUE039618T2/hu unknown
- 2014-09-26 RU RU2016116253A patent/RU2016116253A/ru unknown
- 2014-09-26 EP EP14781426.3A patent/EP3049973B1/en active Active
- 2014-09-26 DK DK18187438.9T patent/DK3418929T3/da active
- 2014-09-26 CA CA2923755A patent/CA2923755C/en active Active
-
2016
- 2016-03-06 IL IL244457A patent/IL244457B/en active IP Right Grant
-
2018
- 2018-12-19 JP JP2018237169A patent/JP2019083025A/ja not_active Withdrawn
-
2020
- 2020-05-15 US US16/875,848 patent/US11535845B2/en active Active
-
2021
- 2021-05-28 JP JP2021089944A patent/JP2021131901A/ja active Pending
-
2022
- 2022-11-02 US US17/979,711 patent/US20230048421A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112016006285A2 (pt) | método implementado usando um sistema de computador, produto de programa de computador, e, sistema | |
BR112015018449A2 (pt) | método para identificar moléculas biológicas para afetar uma atividade desejada e sistema de computação | |
MX2016016713A (es) | Procesos y sistemas para el montaje de secuencias de acido nucleico. | |
EP4219745A3 (en) | Spatially encoded biological assays using a microfluidic device | |
BR112017019591A2 (pt) | imunomodulares | |
BR112016006284A2 (pt) | método para conduzir evolução direcionada, produto de programa de computador, e, sistema de computador | |
BR112018011567A2 (pt) | método de purificação de uma proteína de interesse, e, uso de um método. | |
MX2016007541A (es) | Moléculas modificadas de ácido nucleico y usos de las mismas. | |
BR122022007092B8 (pt) | Método para construir um perfil de dna, método para construir uma biblioteca de ácido nucléico, biblioteca de ácido nucléico, pluralidade de iniciadores e kit | |
BR112015006255A2 (pt) | Métodos para a produção de produtos químicos e derivados dos mesmos | |
BR112013001421A2 (pt) | método para a iluminação controlada de uma área com um sistema de iluminação, produto de programa de computador, sistema de iluminação e sistema de iluminação | |
MX364957B (es) | Composiciones y metodos para microcapsulas. | |
BR112012017267A2 (pt) | ácidos graxos de cadeia ramificada dispersos e produção biológica dos mesmos | |
IN2014DN08135A (pt) | ||
MX2021003772A (es) | Modulacion de globulos de polimero para procesamiento de adn. | |
BR112019001194A2 (pt) | sistemas e métodos para preparar e coprocessar óleo biocru | |
EP3721377A4 (en) | SYSTEMS AND PROCEDURES FOR EFFICIENT PERFORMANCE OF BIOLOGICAL TESTS | |
BR112017004029A2 (pt) | produção de poliolefinas com catalisadores à base de cromo | |
EP4220399A3 (en) | Dynamic reconfiguration of applications on a multi-processor embedded system | |
EA201790504A1 (ru) | Монослой мононуклеарных клеток периферической крови или клеток костного мозга и его применение | |
EA201890391A1 (ru) | Модульные композиции для утилизации растворимых биомолекул и связанные с этим способы | |
WO2013140250A8 (en) | Method to overcome dna chemical modifications sensitivity of engineered tale dna binding domains | |
BR112016008477A2 (pt) | Corpos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica e usos do anticorpo | |
NZ734644A (en) | Chemically encoded spatially addressed library screening platforms | |
BR112012000273A2 (pt) | método de processamento de sinais respiratórios, sistema de processamento de sinais respiratórios, programa de computador ou produto de programa de computador para realizar o método e transportador |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: G06F 19/00 , G06F 19/16 Ipc: C12N 15/10 (2006.01), G16B 35/00 (2006.01), G16B 3 |
|
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/09/2014, OBSERVADAS AS CONDICOES LEGAIS |