SG11201507669YA - Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type - Google Patents

Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type

Info

Publication number
SG11201507669YA
SG11201507669YA SG11201507669YA SG11201507669YA SG11201507669YA SG 11201507669Y A SG11201507669Y A SG 11201507669YA SG 11201507669Y A SG11201507669Y A SG 11201507669YA SG 11201507669Y A SG11201507669Y A SG 11201507669YA SG 11201507669Y A SG11201507669Y A SG 11201507669YA
Authority
SG
Singapore
Prior art keywords
immunotherapy
dementia
alzheimer
prevention
type
Prior art date
Application number
SG11201507669YA
Other languages
English (en)
Inventor
Chang Yi Wang
Original Assignee
United Biomedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United Biomedical Inc filed Critical United Biomedical Inc
Publication of SG11201507669YA publication Critical patent/SG11201507669YA/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0007Nervous system antigens; Prions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/58Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00Reverse transcribing DNA viruses
    • C12N2730/00011Details
    • C12N2730/10011Hepadnaviridae
    • C12N2730/10111Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18411Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18434Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
SG11201507669YA 2013-03-15 2013-04-23 Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type SG11201507669YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/843,883 US9102752B2 (en) 2013-03-15 2013-03-15 Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type
PCT/US2013/037865 WO2014143087A1 (en) 2013-03-15 2013-04-23 Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type

Publications (1)

Publication Number Publication Date
SG11201507669YA true SG11201507669YA (en) 2015-10-29

Family

ID=51527985

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201507669YA SG11201507669YA (en) 2013-03-15 2013-04-23 Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type

Country Status (19)

Country Link
US (4) US9102752B2 (pt)
EP (1) EP2968485B1 (pt)
JP (3) JP6208319B2 (pt)
KR (2) KR20180132962A (pt)
CN (2) CN105228644B (pt)
AU (3) AU2013381835A1 (pt)
BR (1) BR112015023105A8 (pt)
CA (1) CA2906313A1 (pt)
DK (1) DK2968485T3 (pt)
ES (1) ES2800028T3 (pt)
HK (1) HK1212600A1 (pt)
IL (2) IL241597B (pt)
MX (2) MX364689B (pt)
PT (1) PT2968485T (pt)
RU (1) RU2696566C2 (pt)
SG (1) SG11201507669YA (pt)
TW (1) TWI561529B (pt)
WO (1) WO2014143087A1 (pt)
ZA (2) ZA201507526B (pt)

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CN106565847B (zh) * 2016-10-26 2020-12-01 清华大学 化合物、多肽及其用途
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SG11202003624SA (en) * 2017-10-27 2020-05-28 United Neuroscience Tau peptide immunogen constructs
EP3724218A2 (en) * 2017-12-11 2020-10-21 UBI IP Holdings Peptide immunogens of il-31 and formulations thereof for the treatment and/or prevention of atopic dermatitis
SG11202006215TA (en) * 2017-12-31 2020-07-29 United Biomedical Inc Peptide immunogens and formulations thereof targeting membrane-bound ige for treatment of ige mediated allergic diseases
JP2021514361A (ja) * 2018-02-13 2021-06-10 シーダーズ—シナイ メディカル センター 病的神経変性及び加齢性認知機能低下の特定及び処置のための方法及び系
CN112218655A (zh) * 2018-05-04 2021-01-12 Ubi Ip 控股公司 以人工混合t辅助细胞表位以有限度的t细胞炎性反应促进目标抗体的生产
TWI676635B (zh) * 2018-06-15 2019-11-11 英屬開曼群島商聯腦科學公司 α-突觸核蛋白C端胜肽免疫原及其用於治療突觸核蛋白疾病的配方
JP2022514668A (ja) * 2018-12-19 2022-02-14 ユナイテッド・バイオメディカル・インコーポレーテッド 合成ペプチド免疫原のための免疫刺激薬としての人工無差別tヘルパー細胞エピトープ
EP3902554A4 (en) * 2018-12-28 2022-12-14 United Biomedical Inc. INTERLEUKIN 6 (IL-6) TARGETING PEPTIDE IMMUNOGENS AND RELATED FORMULATIONS FOR THE IMMUNOTHERAPY OF DISEASES IMPACTED BY IL-6 DYSREGULATION
SG11202107046YA (en) * 2018-12-31 2021-07-29 United Neuroscience Ltd Peptide immunogens targeting calcitonin gene-related peptide (cgrp) and formulations thereof for prevention and treatment of migraine
CN110759987B (zh) * 2019-10-29 2021-06-08 中国人民解放军军事科学院军事医学研究院 构象特异性的重组Aβ1-42样寡聚体抗原、其制备方法和应用
CA3168991A1 (en) * 2020-01-23 2021-07-29 United Biomedical, Inc. Peptide immunogens targeting pituitary adenylate cyclase-activating peptide (pacap) and formulations thereof for prevention and treatment of migraine
KR20230016164A (ko) 2020-03-10 2023-02-01 라이프아크 시클릭 펩티드
CN116635517A (zh) * 2020-11-17 2023-08-22 伊利亚德生物技术有限公司 与神经退行性疾病相关的神经病理的治疗和预防
US20240159777A1 (en) * 2021-03-16 2024-05-16 Neurovision Imaging, Inc. Biofluid-Based Methods for Diagnosing Alzheimer’s Disease-Associated Conditions
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Also Published As

Publication number Publication date
US20180244739A1 (en) 2018-08-30
PT2968485T (pt) 2020-06-26
EP2968485A4 (en) 2016-09-07
EP2968485B1 (en) 2020-03-04
CN105228644B (zh) 2018-07-13
IL241597B (en) 2020-07-30
HK1212600A1 (zh) 2016-06-17
US20190194280A1 (en) 2019-06-27
AU2013381835A1 (en) 2015-10-08
JP2017226646A (ja) 2017-12-28
AU2017203425A1 (en) 2017-06-08
KR20150132396A (ko) 2015-11-25
JP6784646B2 (ja) 2020-11-11
ES2800028T3 (es) 2020-12-23
EP2968485A1 (en) 2016-01-20
TW201434478A (zh) 2014-09-16
BR112015023105A2 (pt) 2017-11-21
RU2696566C2 (ru) 2019-08-05
JP2019196397A (ja) 2019-11-14
JP6208319B2 (ja) 2017-10-04
MX364689B (es) 2019-05-06
AU2017203425B2 (en) 2019-07-11
BR112015023105A8 (pt) 2018-01-23
RU2015142996A (ru) 2017-04-24
MX2019005268A (es) 2019-07-01
DK2968485T3 (da) 2020-06-08
AU2019246916A1 (en) 2019-10-31
MX2015013235A (es) 2016-04-04
TWI561529B (en) 2016-12-11
KR101926030B1 (ko) 2018-12-10
IL265910A (en) 2019-06-30
JP2016513638A (ja) 2016-05-16
RU2019123453A (ru) 2019-09-10
WO2014143087A1 (en) 2014-09-18
CN105228644A (zh) 2016-01-06
CN108794615A (zh) 2018-11-13
ZA201906683B (en) 2023-04-26
ZA201507526B (en) 2019-12-18
US20160068581A1 (en) 2016-03-10
US9102752B2 (en) 2015-08-11
US20140271690A1 (en) 2014-09-18
CA2906313A1 (en) 2014-09-18
KR20180132962A (ko) 2018-12-12

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