SG11201504145PA - Tetracycline topical formulations, preparation and uses thereof - Google Patents

Tetracycline topical formulations, preparation and uses thereof

Info

Publication number
SG11201504145PA
SG11201504145PA SG11201504145PA SG11201504145PA SG11201504145PA SG 11201504145P A SG11201504145P A SG 11201504145PA SG 11201504145P A SG11201504145P A SG 11201504145PA SG 11201504145P A SG11201504145P A SG 11201504145PA SG 11201504145P A SG11201504145P A SG 11201504145PA
Authority
SG
Singapore
Prior art keywords
preparation
topical formulations
tetracycline
tetracycline topical
formulations
Prior art date
Application number
SG11201504145PA
Other languages
English (en)
Inventor
Mohammad Salman
Arturo Angel
Vijaya Swaminathan
Original Assignee
Hovione Scientia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Scientia Ltd filed Critical Hovione Scientia Ltd
Publication of SG11201504145PA publication Critical patent/SG11201504145PA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203Retinoic acids ; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201504145PA 2012-11-27 2013-11-08 Tetracycline topical formulations, preparation and uses thereof SG11201504145PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT106679A PT106679B (pt) 2012-11-27 2012-11-27 Formulações tópicas de tetraciclinas, sua preparação e usos
PCT/GB2013/052939 WO2014083311A1 (en) 2012-11-27 2013-11-08 Tetracycline topical formulations, preparation and uses thereof

Publications (1)

Publication Number Publication Date
SG11201504145PA true SG11201504145PA (en) 2015-07-30

Family

ID=49620233

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201504145PA SG11201504145PA (en) 2012-11-27 2013-11-08 Tetracycline topical formulations, preparation and uses thereof

Country Status (21)

Country Link
US (2) US9592246B2 (de)
EP (1) EP2925293B1 (de)
JP (1) JP6444308B2 (de)
KR (1) KR102235922B1 (de)
CN (1) CN104902875B (de)
AU (1) AU2013350941B2 (de)
BR (1) BR112015012162B1 (de)
CA (1) CA2895395C (de)
DK (1) DK2925293T3 (de)
ES (1) ES2645449T3 (de)
HU (1) HUE034932T2 (de)
IL (1) IL239022B (de)
MX (1) MX355174B (de)
NO (1) NO2925293T3 (de)
NZ (1) NZ708824A (de)
PL (1) PL2925293T3 (de)
PT (1) PT106679B (de)
RU (1) RU2639591C2 (de)
SG (1) SG11201504145PA (de)
WO (1) WO2014083311A1 (de)
ZA (1) ZA201504369B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
CA2502986C (en) 2002-10-25 2011-08-23 Foamix Ltd. Cosmetic and pharmaceutical foam
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
WO2010125470A2 (en) 2009-04-28 2010-11-04 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
CA2769677A1 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
CA2769625C (en) 2009-07-29 2017-04-11 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
WO2011039637A2 (en) 2009-10-02 2011-04-07 Foamix Ltd. Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
CA2970502A1 (en) * 2014-12-12 2016-06-16 The Schepens Eye Research Institute, Inc. Gdnf induction for the treatment of retinal disorders
JP2018506554A (ja) * 2015-02-25 2018-03-08 サン、ファーマ、アドバンスト、リサーチ、カンパニー、リミテッドSun Pharma Advanced Research Company Limited ナノ粒子組成物
TW201705962A (zh) 2015-03-23 2017-02-16 生物製藥X公司 皮膚用四環素醫藥組成物
CN105380900B (zh) * 2015-11-25 2018-05-29 徐州医学院 一种治疗痤疮的纳米磁疗外用凝胶及其制备方法和应用
MX2020012139A (es) 2016-09-08 2021-01-29 Vyne Pharmaceuticals Inc Composiciones y metodos para tratar rosacea y acne.
FR3064482B1 (fr) * 2017-04-03 2020-11-13 Horus Pharma Composition topique de doxycycline
MX2020004187A (es) * 2017-10-24 2020-09-21 Glenmark Pharmaceuticals Ltd Composicion farmaceutica topica de adapaleno y minociclina.
CN111655862A (zh) 2017-11-28 2020-09-11 希-莱科塔有限公司 使用海藻糖磷酸化酶变体生产海藻糖的方法
WO2019135166A1 (en) 2018-01-07 2019-07-11 Dr. Reddy's Laboratories Ltd. Minocycline for treating inflammatory skin conditions
US11202788B2 (en) * 2019-08-22 2021-12-21 Nanopharmaceutics, Inc. Topical doxycycline hydrogel with improved long-term stability
WO2021191273A1 (en) 2020-03-24 2021-09-30 Hovione Scientia Limited Compositions for use in treating meibomian gland dysfunction
US20220062308A1 (en) 2020-08-27 2022-03-03 Hovione Scientia Limited Methods and compositions for treating rosacea
US20220125829A1 (en) * 2020-10-28 2022-04-28 Hovione Scientia Limited Methods and compositions for treating meibomian gland dysfunction, dry eye disease, and related disorders
CN115463091B (zh) * 2022-10-27 2023-04-07 新基元(北京)医药科技有限公司 一种改善稳定性的米诺环素泡沫剂

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB769274A (en) * 1954-04-22 1957-03-06 Pfizer Therapeutic preparations of tetracycline antibiotics in oil
GB1581335A (en) 1976-07-05 1980-12-10 Leo Pharm Prod Ltd 16-s-acyl derivatives of fusidic acid
US4505896A (en) 1979-04-19 1985-03-19 Elorac, Ltd. Method of treating acne vulgaris and composition
JPS5788115A (en) * 1980-10-06 1982-06-01 Miles Lab Stable non-aqueous solution of tetracycline antibiotic salt
US5122519A (en) 1989-06-27 1992-06-16 American Cyanamid Company Stable, cosmetically acceptable topical gel formulation and method of treatment for acne
US5874479A (en) 1991-03-01 1999-02-23 Warner-Lambert Company Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same
US6113921A (en) 1993-03-23 2000-09-05 Pharmos Corp. Topical and transdermal delivery system utilizing submicron oil spheres
US5905092A (en) 1994-09-27 1999-05-18 Virotex Corporation Reel/Frame Topical antibiotic composition providing optimal moisture environment for rapid wound healing that reduces skin contraction
US5747058A (en) 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
BR9707551B1 (pt) * 1996-02-16 2009-01-13 composiÇÕes para a limpeza do corpo ou dos cabelos contendo um antiféngico e um composto de enxofre, e xampu.
JPH09255578A (ja) * 1996-03-22 1997-09-30 Sekisui Chem Co Ltd 感染性皮膚疾患治療用外用剤
US5834008A (en) 1996-09-19 1998-11-10 U.S. Biomaterials Corp. Composition and method for acceleration of wound and burn healing
US6433068B1 (en) * 1997-03-07 2002-08-13 David S. Morrison Hydrocarbon gels as suspending and dispersing agents and products
US6455583B1 (en) * 1998-05-08 2002-09-24 The University Of Miami Method for treating meibomian gland disease
US20030007939A1 (en) 1998-07-31 2003-01-09 Howard Murad Pharmaceutical compositions and methods for managing dermatological conditions
US6432934B1 (en) * 1998-08-06 2002-08-13 Advanced Vision Research Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease
WO2001003742A1 (fr) * 1999-07-12 2001-01-18 Suntory Limited Composition de medicament pour administration topique
US6946118B1 (en) 1999-09-14 2005-09-20 Orapharma, Inc. Formulations for treating or preventing mucositis
US6667045B2 (en) 1999-10-01 2003-12-23 Joseph Scott Dahle Topical applications for skin treatment
US20030077301A1 (en) 1999-12-16 2003-04-24 Maibach Howard I. Topical pharmaceutical composition for the treatment of inflammatory dermatoses
US6967023B1 (en) 2000-01-10 2005-11-22 Foamix, Ltd. Pharmaceutical and cosmetic carrier or composition for topical application
US20020010162A1 (en) 2000-03-02 2002-01-24 Raul Fleischmajer Treatment of psoriasis with matrix metalloproteinase inhibitors
US7758888B2 (en) 2000-04-21 2010-07-20 Sol-Gel Technologies Ltd. Composition exhibiting enhanced formulation stability and delivery of topical active ingredients
JP4653282B2 (ja) * 2000-05-23 2011-03-16 昭和薬品化工株式会社 ミノサイクリン含有組成物
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
EP2311440A1 (de) * 2001-04-05 2011-04-20 Collagenex Pharmaceuticals, Inc. Gesteuerte Freigabe von Tetracyclinverbindungen und Tetracyclinderivaten
JP4745608B2 (ja) 2001-07-27 2011-08-10 バイタル ヘルス サイエンシズ プロプライアタリー リミティド 電子伝達剤のリン酸誘導体を用いた皮膚治療
JP4723857B2 (ja) 2002-06-17 2011-07-13 ヴィキュロン ファーマシューティカルズ インコーポレイテッド アクネの治療のためのge2270因子a3のアミド誘導体の使用
US20040076699A1 (en) * 2002-07-15 2004-04-22 Chaudhuri Ratan K. Topical anhydrous delivery system
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
KR100738264B1 (ko) 2003-06-11 2007-07-12 더 프록터 앤드 갬블 캄파니 예비형성된 하이드로겔 제품을 포함하는 사용시-제조 장치
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US7241746B2 (en) 2003-08-06 2007-07-10 Regena Therapeutics, Lc Method and composition for treating periodontal disease
CA2548532C (en) 2004-09-27 2014-12-02 Jan De Rijk Methods and compositions for treatment of water
US7531164B2 (en) 2005-10-21 2009-05-12 Duke University Preventing bacterial or viral infectivity and composition containing infection preventing additive
GB2432529B (en) 2005-11-25 2008-04-23 Univ Feng Chia Antimicrobial compositions and wound dressings
JP4959991B2 (ja) * 2006-03-03 2012-06-27 株式会社日本点眼薬研究所 トラニラストまたはその薬理学的に許容される塩を含有する懸濁性医薬組成物
US20080188446A1 (en) 2007-02-02 2008-08-07 Warner Chilcott Company Inc. Tetracycline compositions for topical administration
WO2008097850A1 (en) 2007-02-02 2008-08-14 Warner Chilcott Company, Inc. Tretracycline compositions for topical administration
BRPI0808410A2 (pt) 2007-02-28 2015-06-23 Aciex Therapeutics Inc Métodos e composições para normalizar secreções da glândula meibomiana
CN102688492A (zh) * 2007-03-23 2012-09-26 分子研究中心公司 包含四环素类的抗炎组合物及其用途
AU2008280131B9 (en) 2007-07-25 2014-11-13 Ixodes Ag Topical antibiotic composition for the prevention of Lyme disease
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
WO2010041141A2 (en) 2008-10-07 2010-04-15 Foamix Ltd. Oil-based foamable carriers and formulations
GB0800145D0 (en) * 2008-01-04 2008-02-13 Reckitt Benckiser Uk Ltd Skincare treatment
EP2266626B1 (de) * 2008-03-28 2014-06-18 AnGesMG, Inc. Zusammensetzung zur topischen anwendung mit einem transkriptionsfaktor-decoy als wirkstoff
WO2009134875A2 (en) * 2008-04-29 2009-11-05 Hair Systems, Inc. Composition and method for cream bleach product
US20100029765A1 (en) 2008-07-30 2010-02-04 Ranbaxy Labortories Limited Topical aqueous composition comprising tretinoin
US20100129448A1 (en) * 2008-08-18 2010-05-27 Nanotherapeutics, Inc. Topical hydrogel composition
WO2010125470A2 (en) 2009-04-28 2010-11-04 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
PT104644B (pt) 2009-06-26 2012-11-06 Hovione Farmaciencia S A Formulação tópica contendo uma tetraciclina e método de tratamento de infecções cutâneas usando a mesma
US9155915B2 (en) 2009-07-27 2015-10-13 Dermadoctor, Inc. Moisturizing retinol composition
WO2011039637A2 (en) 2009-10-02 2011-04-07 Foamix Ltd. Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
WO2011138678A2 (en) * 2010-05-04 2011-11-10 Foamix Ltd. Compositions, gels and foams with rheology modulators and uses thereof
GB2474930B (en) * 2009-10-02 2012-07-04 Foamix Ltd Topical tetracycline compositions
WO2011106697A1 (en) 2010-02-25 2011-09-01 Schepens Eye Research Institute Therapeutic compositions for the treatment of dry eye disease
US20120076742A1 (en) 2010-04-21 2012-03-29 Phillips D Howard Topical drug delivery system with dual carriers
PT105116B (pt) 2010-05-14 2012-10-16 Hovione Farmaciencia S A Novas partículas de tetraciclina e agente protector.
BRPI1002601E2 (pt) 2010-06-01 2020-06-30 Embrapa Pesquisa Agropecuaria composição nanoestruturada de uso veterinário para administração de fármacos
US20120093876A1 (en) * 2010-10-13 2012-04-19 Aciex, Inc. Ophthalmic Formulations, Methods Of Manufacture And Methods of Normalizing Meibomian Gland Secretions
US8481591B2 (en) 2010-11-01 2013-07-09 Stiefel Research Australia Pty. Ltd. Polymeric topical compositions
JP2014503586A (ja) 2011-01-24 2014-02-13 アンテリオス, インコーポレイテッド 油組成物

Also Published As

Publication number Publication date
CA2895395C (en) 2021-04-06
CA2895395A1 (en) 2014-06-05
JP2016500095A (ja) 2016-01-07
US9592246B2 (en) 2017-03-14
PT106679A (pt) 2014-05-27
NZ708824A (en) 2019-01-25
JP6444308B2 (ja) 2018-12-26
EP2925293A1 (de) 2015-10-07
IL239022B (en) 2020-11-30
ES2645449T3 (es) 2017-12-05
CN104902875B (zh) 2018-04-03
US20140147504A1 (en) 2014-05-29
KR20150104102A (ko) 2015-09-14
IL239022A0 (en) 2015-07-30
RU2015122786A (ru) 2017-01-10
ZA201504369B (en) 2017-01-25
US10213443B2 (en) 2019-02-26
HUE034932T2 (en) 2018-03-28
BR112015012162B1 (pt) 2021-02-23
CN104902875A (zh) 2015-09-09
US20170182071A1 (en) 2017-06-29
DK2925293T3 (da) 2017-11-06
PL2925293T3 (pl) 2017-12-29
RU2639591C2 (ru) 2017-12-21
EP2925293B1 (de) 2017-08-02
WO2014083311A1 (en) 2014-06-05
AU2013350941A1 (en) 2015-07-16
MX355174B (es) 2018-04-09
PT106679B (pt) 2015-03-25
MX2015006632A (es) 2016-02-17
AU2013350941B2 (en) 2018-04-26
NO2925293T3 (de) 2017-12-30
KR102235922B1 (ko) 2021-04-05

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