SG11201407402TA - Carbazole-containing sulfonamides as cryptochrome modulators - Google Patents
Carbazole-containing sulfonamides as cryptochrome modulatorsInfo
- Publication number
- SG11201407402TA SG11201407402TA SG11201407402TA SG11201407402TA SG11201407402TA SG 11201407402T A SG11201407402T A SG 11201407402TA SG 11201407402T A SG11201407402T A SG 11201407402TA SG 11201407402T A SG11201407402T A SG 11201407402TA SG 11201407402T A SG11201407402T A SG 11201407402TA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- carbazole
- suite
- pct
- unless
- Prior art date
Links
- UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 title abstract 4
- 229940124530 sulfonamide Drugs 0.000 title abstract 3
- 150000003456 sulfonamides Chemical class 0.000 title abstract 3
- KCYOZNARADAZIZ-CWBQGUJCSA-N 2-[(2e,4e,6e,8e,10e,12e,14e)-15-(4,4,7a-trimethyl-2,5,6,7-tetrahydro-1-benzofuran-2-yl)-6,11-dimethylhexadeca-2,4,6,8,10,12,14-heptaen-2-yl]-4,4,7a-trimethyl-2,5,6,7-tetrahydro-1-benzofuran-6-ol Chemical compound O1C2(C)CC(O)CC(C)(C)C2=CC1C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)C1C=C2C(C)(C)CCCC2(C)O1 KCYOZNARADAZIZ-CWBQGUJCSA-N 0.000 title abstract 2
- KCYOZNARADAZIZ-PPBBKLJYSA-N Cryptochrome Natural products O[C@@H]1CC(C)(C)C=2[C@@](C)(O[C@H](/C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(\C)/[C@H]3O[C@@]4(C)C(C(C)(C)CCC4)=C3)/C)\C)/C)C=2)C1 KCYOZNARADAZIZ-PPBBKLJYSA-N 0.000 title abstract 2
- 108010037139 Cryptochromes Proteins 0.000 title abstract 2
- KCYOZNARADAZIZ-XZOHMNSDSA-N beta-cryptochrome Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C1OC2(C)CC(O)CC(C)(C)C2=C1)C=CC=C(/C)C3OC4(C)CCCC(C)(C)C4=C3 KCYOZNARADAZIZ-XZOHMNSDSA-N 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102220240796 rs553605556 Human genes 0.000 abstract 2
- 208000014311 Cushing syndrome Diseases 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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PCT/US2013/040604 WO2013170186A1 (fr) | 2012-05-11 | 2013-05-10 | Sulfonamides contenant du carbazole en tant que modulateurs de cryptochrome |
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JP (5) | JP6377054B2 (fr) |
KR (1) | KR102136431B1 (fr) |
CN (2) | CN104640856B (fr) |
AR (1) | AR092319A1 (fr) |
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CA (1) | CA2873214C (fr) |
HK (1) | HK1250232A1 (fr) |
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RU (1) | RU2654484C1 (fr) |
SG (1) | SG11201407402TA (fr) |
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CA2873214C (fr) | 2012-05-11 | 2021-02-16 | Reset Therapeutics, Inc. | Sulfonamides contenant du carbazole en tant que modulateurs de cryptochrome |
GB201309333D0 (en) | 2013-05-23 | 2013-07-10 | Agency Science Tech & Res | Purine diones as WNT pathway modulators |
AR098747A1 (es) * | 2013-12-13 | 2016-06-08 | Allergan Inc | Formas polimórficas de un compuesto similar a esteroides y métodos para su preparación y uso |
TWI690521B (zh) * | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
KR101542324B1 (ko) * | 2014-04-09 | 2015-08-05 | 동아대학교 산학협력단 | 손상된 dna의 회복 속도 비교를 위한 정보 제공 방법 |
WO2015185487A1 (fr) * | 2014-06-04 | 2015-12-10 | Roche Diagnostics Gmbh | Procédé et dispositif de séparation de métabolites ou de stéréo-isomères par spectrométrie à mobilité d'ions |
WO2018007323A1 (fr) * | 2016-07-04 | 2018-01-11 | Bayer Cropscience Aktiengesellschaft | Benzosultames et analogues et leur utilisation comme des fongicides |
CN107941976B (zh) * | 2017-09-28 | 2019-11-19 | 浙江新化化工股份有限公司 | 一种2-甲氧基环己胺的含量测定方法 |
JP7187152B2 (ja) * | 2018-01-12 | 2022-12-12 | 三星電子株式会社 | 化合物、有機エレクトロルミネッセンス素子用材料、有機エレクトロルミネッセンス素子用組成物、有機エレクトロルミネッセンス素子、及び化合物の製造方法 |
KR20210075071A (ko) * | 2018-08-14 | 2021-06-22 | 오스테오큐씨 인코포레이티드 | 피롤로-디피리딘 화합물 |
CN113166086A (zh) * | 2018-09-05 | 2021-07-23 | 组装生物科学股份有限公司 | 用于治疗hbv的环状磺酰胺化合物 |
CN109232596B (zh) * | 2018-09-05 | 2020-03-17 | 大连九信精细化工有限公司 | 一种二苯并呋喃咔唑的合成方法 |
CN114854803A (zh) * | 2022-04-21 | 2022-08-05 | 山东农业大学 | 镰刀菌对3,6-二氯咔唑生物降解的方法 |
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2014
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