SG11201405963YA - Crystalline forms of (s) -4-amino-n- (1- (4 - chlorophenyl) - 3 - hydroxypropyl) -1- (7h - pyrrolo [2, 3-d] pyrimidi n-4-yl) piperidine-4-carboxamide - Google Patents

Crystalline forms of (s) -4-amino-n- (1- (4 - chlorophenyl) - 3 - hydroxypropyl) -1- (7h - pyrrolo [2, 3-d] pyrimidi n-4-yl) piperidine-4-carboxamide

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Publication number
SG11201405963YA
SG11201405963YA SG11201405963YA SG11201405963YA SG11201405963YA SG 11201405963Y A SG11201405963Y A SG 11201405963YA SG 11201405963Y A SG11201405963Y A SG 11201405963YA SG 11201405963Y A SG11201405963Y A SG 11201405963YA SG 11201405963Y A SG11201405963Y A SG 11201405963YA
Authority
SG
Singapore
Prior art keywords
pyrimidi
pyrrolo
carboxamide
chlorophenyl
piperidine
Prior art date
Application number
SG11201405963YA
Other languages
English (en)
Inventor
Gary Peter Tomkinson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SG11201405963YA publication Critical patent/SG11201405963YA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201405963YA 2012-04-17 2013-04-16 Crystalline forms of (s) -4-amino-n- (1- (4 - chlorophenyl) - 3 - hydroxypropyl) -1- (7h - pyrrolo [2, 3-d] pyrimidi n-4-yl) piperidine-4-carboxamide SG11201405963YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261625312P 2012-04-17 2012-04-17
PCT/GB2013/050973 WO2013156772A1 (en) 2012-04-17 2013-04-16 Crystalline forms of (s) -4-amino-n- (1- (4 - chlorophenyl) - 3 - hydroxypropyl) -1- (7h - pyrrolo [2, 3-d] pyrimidi n-4-yl) piperidine-4-carboxamide

Publications (1)

Publication Number Publication Date
SG11201405963YA true SG11201405963YA (en) 2014-11-27

Family

ID=48184235

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201405963YA SG11201405963YA (en) 2012-04-17 2013-04-16 Crystalline forms of (s) -4-amino-n- (1- (4 - chlorophenyl) - 3 - hydroxypropyl) -1- (7h - pyrrolo [2, 3-d] pyrimidi n-4-yl) piperidine-4-carboxamide

Country Status (17)

Country Link
US (2) US9487525B2 (xx)
EP (1) EP2847194B1 (xx)
JP (2) JP2015514741A (xx)
KR (1) KR20150002767A (xx)
CN (1) CN104203953B (xx)
AU (1) AU2013204533B2 (xx)
BR (1) BR112014025586B1 (xx)
CA (1) CA2869936C (xx)
ES (1) ES2650797T3 (xx)
HK (1) HK1206337A1 (xx)
IL (1) IL234966A0 (xx)
MX (1) MX2014012642A (xx)
MY (1) MY175052A (xx)
RU (1) RU2652377C2 (xx)
SG (1) SG11201405963YA (xx)
TW (1) TWI605046B (xx)
WO (1) WO2013156772A1 (xx)

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EP2815749A1 (en) 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
CN106661033B (zh) * 2014-05-28 2018-11-06 阿斯利康(瑞典)有限公司 用于制备azd5363的方法和在其中使用的新颖中间体
WO2017078752A1 (en) * 2015-11-06 2017-05-11 The Penn State Research Foundation Compositions and methods relating to cancer
US20240051964A1 (en) 2021-01-04 2024-02-15 Teva Pharmaceuticals International Gmbh Solid state forms of capivasertib and process for preparation thereof

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Also Published As

Publication number Publication date
CA2869936A1 (en) 2013-10-24
MY175052A (en) 2020-06-03
US9487525B2 (en) 2016-11-08
TWI605046B (zh) 2017-11-11
US10039766B2 (en) 2018-08-07
TW201345913A (zh) 2013-11-16
RU2652377C2 (ru) 2018-04-26
KR20150002767A (ko) 2015-01-07
MX2014012642A (es) 2014-11-25
BR112014025586A2 (xx) 2017-06-20
WO2013156772A1 (en) 2013-10-24
IL234966A0 (en) 2014-12-31
BR112014025586B1 (pt) 2022-02-22
ES2650797T3 (es) 2018-01-22
US20150087661A1 (en) 2015-03-26
EP2847194B1 (en) 2017-10-04
CA2869936C (en) 2020-07-28
AU2013204533B2 (en) 2017-02-02
JP2015514741A (ja) 2015-05-21
AU2013204533A1 (en) 2013-10-31
CN104203953B (zh) 2016-11-16
HK1206337A1 (en) 2016-01-08
JP2018039807A (ja) 2018-03-15
EP2847194A1 (en) 2015-03-18
CN104203953A (zh) 2014-12-10
RU2014143529A (ru) 2016-06-10
US20170027943A1 (en) 2017-02-02

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