|
EP2734621B1
(en)
|
2011-07-22 |
2019-09-04 |
President and Fellows of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
CA2850509C
(en)
|
2011-10-14 |
2023-08-01 |
President And Fellows Of Harvard College |
Sequencing by structure assembly
|
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
KR20180009383A
(ko)
|
2012-02-24 |
2018-01-26 |
프레드 헛친슨 켄서 리서치 센터 |
이상혈색소증 치료를 위한 조성물 및 방법
|
|
WO2013176772A1
(en)
|
2012-05-25 |
2013-11-28 |
The Regents Of The University Of California |
Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
|
|
AU2013308770B2
(en)
|
2012-08-29 |
2019-01-17 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a genetic condition
|
|
CN110643600A
(zh)
*
|
2012-10-23 |
2020-01-03 |
基因工具股份有限公司 |
用于切割靶dna的系统及其用途
|
|
MX361412B
(es)
|
2012-11-27 |
2018-12-05 |
Childrens Medical Center |
Direccion de elementos reguladores distales de bcl11a para reinduccion de hemoglobina fetal.
|
|
LT3138910T
(lt)
|
2012-12-06 |
2017-11-10 |
Sigma-Aldrich Co. Llc |
Crispr pagrįstas genomo modifikavimas ir reguliavimas
|
|
SG10201707569YA
(en)
|
2012-12-12 |
2017-10-30 |
Broad Inst Inc |
Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications
|
|
SG10201704932UA
(en)
|
2012-12-17 |
2017-07-28 |
Harvard College |
Rna-guided human genome engineering
|
|
EP2971184B1
(en)
|
2013-03-12 |
2019-04-17 |
President and Fellows of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
|
NZ712727A
(en)
|
2013-03-14 |
2017-05-26 |
Caribou Biosciences Inc |
Compositions and methods of nucleic acid-targeting nucleic acids
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
KR102271292B1
(ko)
|
2013-03-15 |
2021-07-02 |
더 제너럴 하스피탈 코포레이션 |
Rna-안내 게놈 편집의 특이성을 증가시키기 위한 rna-안내 foki 뉴클레아제(rfn)의 용도
|
|
CN115261411A
(zh)
|
2013-04-04 |
2022-11-01 |
哈佛学院校长同事会 |
利用CRISPR/Cas系统的基因组编辑的治疗性用途
|
|
CA2910489A1
(en)
*
|
2013-05-15 |
2014-11-20 |
Sangamo Biosciences, Inc. |
Methods and compositions for treatment of a genetic condition
|
|
SG11201509962QA
(en)
|
2013-06-04 |
2016-01-28 |
Harvard College |
Rna-guideded transcriptional regulation
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
EP3825406A1
(en)
|
2013-06-17 |
2021-05-26 |
The Broad Institute Inc. |
Delivery and use of the crispr-cas systems, vectors and compositions for hepatic targeting and therapy
|
|
CA2915795C
(en)
|
2013-06-17 |
2021-07-13 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
SG11201510327TA
(en)
|
2013-06-17 |
2016-01-28 |
Broad Inst Inc |
Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
|
|
US10011850B2
(en)
|
2013-06-21 |
2018-07-03 |
The General Hospital Corporation |
Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
|
|
EP3019595A4
(en)
*
|
2013-07-09 |
2016-11-30 |
|
THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS
|
|
EP3666892A1
(en)
|
2013-07-10 |
2020-06-17 |
President and Fellows of Harvard College |
Orthogonal cas9 proteins for rna-guided gene regulation and editing
|
|
US10563225B2
(en)
|
2013-07-26 |
2020-02-18 |
President And Fellows Of Harvard College |
Genome engineering
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
CN106459995B
(zh)
|
2013-11-07 |
2020-02-21 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
HUE056436T2
(hu)
*
|
2013-11-13 |
2022-02-28 |
Childrens Medical Center |
Nukleáz közvetítette génexpresszió-szabályozás
|
|
AU2014350051A1
(en)
*
|
2013-11-18 |
2016-07-07 |
Crispr Therapeutics Ag |
CRISPR-Cas system materials and methods
|
|
US10787684B2
(en)
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
US9074199B1
(en)
|
2013-11-19 |
2015-07-07 |
President And Fellows Of Harvard College |
Mutant Cas9 proteins
|
|
US9840699B2
(en)
|
2013-12-12 |
2017-12-12 |
President And Fellows Of Harvard College |
Methods for nucleic acid editing
|
|
CN106536729A
(zh)
|
2013-12-12 |
2017-03-22 |
布罗德研究所有限公司 |
使用粒子递送组分靶向障碍和疾病的crispr‑cas系统和组合物的递送、用途和治疗应用
|
|
AU2014361781B2
(en)
|
2013-12-12 |
2021-04-01 |
Massachusetts Institute Of Technology |
Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing
|
|
EP3089989B1
(en)
*
|
2013-12-31 |
2020-06-24 |
The Regents of The University of California |
Cas9 crystals and methods of use thereof
|
|
CN106133141B
(zh)
|
2014-01-08 |
2021-08-20 |
哈佛学院董事及会员团体 |
Rna引导的基因驱动
|
|
EP3105325B2
(en)
|
2014-02-13 |
2024-10-23 |
Takara Bio USA, Inc. |
Methods of depleting a target molecule from an initial collection of nucleic acids, and compositions and kits for practicing the same
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
EP3116997B1
(en)
|
2014-03-10 |
2019-05-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
WO2015148860A1
(en)
*
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating beta-thalassemia
|
|
WO2015148863A2
(en)
*
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
EP3122181A4
(en)
*
|
2014-03-26 |
2018-04-25 |
The Brigham and Women's Hospital, Inc. |
Compositions and methods for ex vivo expansion of human hematopoietic stem/progenitor cells
|
|
BR112016024565A2
(pt)
|
2014-04-25 |
2018-01-23 |
Children's Medical Center Corporation |
composições e métodos de tratar hemoglobinopatias
|
|
WO2016007839A1
(en)
|
2014-07-11 |
2016-01-14 |
President And Fellows Of Harvard College |
Methods for high-throughput labelling and detection of biological features in situ using microscopy
|
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
|
US11071289B2
(en)
*
|
2014-08-14 |
2021-07-27 |
Biocytogen Boston Corp |
DNA knock-in system
|
|
WO2016037165A1
(en)
|
2014-09-07 |
2016-03-10 |
Selecta Biosciences, Inc. |
Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses
|
|
JP6722176B2
(ja)
*
|
2014-09-16 |
2020-07-15 |
サンガモ セラピューティクス, インコーポレイテッド |
造血幹細胞におけるヌクレアーゼ媒介性ゲノム工学および補正のための方法および組成物
|
|
WO2016049531A1
(en)
|
2014-09-26 |
2016-03-31 |
Purecircle Usa Inc. |
Single nucleotide polymorphism (snp) markers for stevia
|
|
US12180263B2
(en)
|
2014-11-06 |
2024-12-31 |
President And Fellows Of Harvard College |
Cells lacking B2M surface expression and methods for allogeneic administration of such cells
|
|
CA2969619A1
(en)
|
2014-12-03 |
2016-06-09 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
|
EP3230451B1
(en)
|
2014-12-12 |
2021-04-07 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016094880A1
(en)
*
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
EP3230452B1
(en)
|
2014-12-12 |
2025-06-11 |
The Broad Institute, Inc. |
Dead guides for crispr transcription factors
|
|
WO2016106244A1
(en)
|
2014-12-24 |
2016-06-30 |
The Broad Institute Inc. |
Crispr having or associated with destabilization domains
|
|
WO2016118726A2
(en)
|
2015-01-21 |
2016-07-28 |
Sangamo Biosciences, Inc. |
Methods and compositions for identification of highly specific nucleases
|
|
JP6800859B2
(ja)
|
2015-01-26 |
2020-12-16 |
フェイト セラピューティクス,インコーポレイテッド |
造血細胞分化を誘導するための方法および組成物
|
|
CN107532168A
(zh)
*
|
2015-02-23 |
2018-01-02 |
克里斯珀医疗股份公司 |
治疗血红蛋白病的材料和方法
|
|
US12129471B2
(en)
|
2015-02-23 |
2024-10-29 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
|
CA2981715A1
(en)
|
2015-04-06 |
2016-10-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chemically modified guide rnas for crispr/cas-mediated gene regulation
|
|
US10155938B2
(en)
*
|
2015-04-14 |
2018-12-18 |
City Of Hope |
Coexpression of CAS9 and TREX2 for targeted mutagenesis
|
|
CN104805118A
(zh)
*
|
2015-04-22 |
2015-07-29 |
扬州大学 |
一种苏禽黄鸡胚胎干细胞特定基因进行靶向敲除方法
|
|
WO2016178207A1
(en)
*
|
2015-05-04 |
2016-11-10 |
Ramot At Tel-Aviv University Ltd. |
Methods and kits for fragmenting dna
|
|
EP3763814A1
(en)
*
|
2015-05-08 |
2021-01-13 |
The Children's Medical Center Corporation |
Targeting bcl11a enhancer functional regions for fetal hemoglobin reinduction
|
|
US10968426B2
(en)
|
2015-05-08 |
2021-04-06 |
President And Fellows Of Harvard College |
Universal donor stem cells and related methods
|
|
JP7030522B2
(ja)
*
|
2015-05-11 |
2022-03-07 |
エディタス・メディシン、インコーポレイテッド |
幹細胞における遺伝子編集のための最適化crispr/cas9システムおよび方法
|
|
AU2016261927B2
(en)
*
|
2015-05-12 |
2022-04-07 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
|
US11911415B2
(en)
|
2015-06-09 |
2024-02-27 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for improving transplantation
|
|
CA2989831A1
(en)
*
|
2015-06-17 |
2016-12-22 |
The Uab Research Foundation |
Crispr/cas9 complex for genomic editing
|
|
AU2016278959A1
(en)
|
2015-06-17 |
2018-01-18 |
The Uab Research Foundation |
CRISPR/Cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
|
|
AU2016279062A1
(en)
|
2015-06-18 |
2019-03-28 |
Omar O. Abudayyeh |
Novel CRISPR enzymes and systems
|
|
WO2017040348A1
(en)
|
2015-08-28 |
2017-03-09 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9897378B2
(en)
|
2015-10-08 |
2018-02-20 |
Nyc Designed Inspirations Llc |
Cosmetic makeup sponge/blender container
|
|
SG10202104041PA
(en)
|
2015-10-23 |
2021-06-29 |
Harvard College |
Nucleobase editors and uses thereof
|
|
US20180325947A1
(en)
*
|
2015-10-27 |
2018-11-15 |
Children's Hospital Medical Center |
Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and/or genetic manipulation
|
|
MX2018005611A
(es)
|
2015-11-03 |
2018-11-09 |
Harvard College |
Metodo y aparato para la formacion de imagenes volumetricas de una matriz tridimensional que contiene acido nucleico.
|
|
EP3371314B1
(en)
|
2015-11-04 |
2023-07-05 |
Fate Therapeutics, Inc. |
Genomic engineering of pluripotent cells
|
|
US12043843B2
(en)
|
2015-11-04 |
2024-07-23 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of hemoglobinopathies
|
|
KR20250033315A
(ko)
*
|
2015-11-04 |
2025-03-07 |
페이트 세러퓨틱스, 인코포레이티드 |
조혈 세포 분화를 유도하기 위한 방법 및 조성물
|
|
MY192848A
(en)
*
|
2015-12-28 |
2022-09-12 |
Intellia Therapeutics Inc |
Compositions and methods for the treatment of hemoglobinopathies
|
|
AU2017212713B2
(en)
|
2016-01-27 |
2023-01-19 |
Oncorus, Inc. |
Oncolytic viral vectors and uses thereof
|
|
WO2017147278A1
(en)
|
2016-02-25 |
2017-08-31 |
The Children's Medical Center Corporation |
Customized class switch of immunoglobulin genes in lymphoma and hybridoma by crispr/cas9 technology
|
|
KR102723347B1
(ko)
*
|
2016-03-14 |
2024-10-28 |
에디타스 메디신, 인코포레이티드 |
베타 이상헤모글로빈증의 치료를 위한 crispr/cas-관련 방법 및 조성물
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
IL262416B2
(en)
*
|
2016-04-18 |
2024-02-01 |
Crispr Therapeutics Ag |
Materials and methods for the treatment of hemoglobin diseases
|
|
CA3022290A1
(en)
|
2016-04-25 |
2017-11-02 |
President And Fellows Of Harvard College |
Hybridization chain reaction methods for in situ molecular detection
|
|
WO2017191503A1
(en)
*
|
2016-05-05 |
2017-11-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
CA3031785A1
(en)
*
|
2016-07-25 |
2018-02-01 |
Bluebird Bio, Inc. |
Bcl11a homing endonuclease variants, compositions, and methods of use
|
|
KR102827276B1
(ko)
|
2016-08-03 |
2025-07-01 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
WO2018031683A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
CN106244555A
(zh)
*
|
2016-08-23 |
2016-12-21 |
广州医科大学附属第三医院 |
一种提高基因打靶的效率的方法及β‑球蛋白基因位点的碱基原位修复方法
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
ES2952525T3
(es)
*
|
2016-09-08 |
2023-11-02 |
2Seventy Bio Inc |
Variantes de endonucleasa homing PD-1, composiciones y métodos de uso
|
|
CN110214180A
(zh)
|
2016-10-14 |
2019-09-06 |
哈佛大学的校长及成员们 |
核碱基编辑器的aav递送
|
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
|
CA3050514A1
(en)
|
2017-01-27 |
2018-08-02 |
Children's Hospital Medical Center |
Methods of enhancing engraftment activity of hematopoietic stem cells
|
|
TW201839136A
(zh)
*
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
JP2020510038A
(ja)
|
2017-03-09 |
2020-04-02 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
がんワクチン
|
|
KR20190127797A
(ko)
|
2017-03-10 |
2019-11-13 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
시토신에서 구아닌으로의 염기 편집제
|
|
WO2018170184A1
(en)
|
2017-03-14 |
2018-09-20 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
GB2575930A
(en)
|
2017-03-23 |
2020-01-29 |
Harvard College |
Nucleobase editors comprising nucleic acid programmable DNA binding proteins
|
|
WO2018195402A1
(en)
|
2017-04-20 |
2018-10-25 |
Egenesis, Inc. |
Methods for generating genetically modified animals
|
|
EP3612551B1
(en)
|
2017-04-21 |
2024-09-04 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
WO2018200597A1
(en)
*
|
2017-04-24 |
2018-11-01 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Homology directed repair compositions for the treatment of hemoglobinopathies
|
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
|
US11788087B2
(en)
|
2017-05-25 |
2023-10-17 |
The Children's Medical Center Corporation |
BCL11A guide delivery
|
|
WO2018218188A2
(en)
|
2017-05-25 |
2018-11-29 |
The General Hospital Corporation |
Base editors with improved precision and specificity
|
|
WO2018220210A1
(en)
*
|
2017-06-02 |
2018-12-06 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Recombinant lentiviral vector for stem cell-based gene therapy of sickle cell disorder
|
|
US11866726B2
(en)
|
2017-07-14 |
2024-01-09 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
RU2771110C2
(ru)
|
2017-07-26 |
2022-04-26 |
Онкорус, Инк. |
Онколитические вирусные векторы и их применение
|
|
US11732274B2
(en)
|
2017-07-28 |
2023-08-22 |
President And Fellows Of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
US11779654B2
(en)
|
2017-10-04 |
2023-10-10 |
2Seventy Bio, Inc. |
PCSK9 endonuclease variants, compositions, and methods of use
|
|
AU2018347583A1
(en)
|
2017-10-13 |
2020-05-21 |
Selecta Biosciences, Inc. |
Methods and compositions for attenuating anti-viral transfer vector IgM responses
|
|
CA3082251A1
(en)
|
2017-10-16 |
2019-04-25 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
MA50849A
(fr)
*
|
2017-10-26 |
2020-09-02 |
Vertex Pharma |
Substances et procédés pour le traitement d'hémoglobinopathies
|
|
CN109722414A
(zh)
*
|
2017-10-27 |
2019-05-07 |
博雅辑因(北京)生物科技有限公司 |
一种高效制备成熟红细胞的方法以及用于制备成熟红细胞的培养基
|
|
MA51107A
(fr)
|
2017-12-05 |
2020-10-14 |
Vertex Pharma |
Cellules souches et progénitrices hématopoïétiques humaines cd34+ modifiées par crispr-cas9 et utilisations associées
|
|
EP3724214A4
(en)
|
2017-12-15 |
2021-09-01 |
The Broad Institute Inc. |
SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING
|
|
EP3749767A1
(en)
|
2018-02-05 |
2020-12-16 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of hemoglobinopathies
|
|
WO2019150203A1
(en)
|
2018-02-05 |
2019-08-08 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
JP2021515037A
(ja)
|
2018-02-26 |
2021-06-17 |
アントルクス,インコーポレーテッド |
寛容原性リポソーム及びその使用方法
|
|
SG11202008956XA
(en)
|
2018-03-14 |
2020-10-29 |
Editas Medicine Inc |
Systems and methods for the treatment of hemoglobinopathies
|
|
US10968257B2
(en)
|
2018-04-03 |
2021-04-06 |
The Broad Institute, Inc. |
Target recognition motifs and uses thereof
|
|
WO2019204226A1
(en)
|
2018-04-16 |
2019-10-24 |
University Of Massachusetts |
Compositions and methods for improved gene editing
|
|
CN112469823A
(zh)
*
|
2018-04-27 |
2021-03-09 |
西雅图儿童医院d/b/a西雅图儿童研究所 |
布鲁顿氏酪氨酸激酶的基于talen和基于crispr/cas的基因编辑
|
|
US12350284B2
(en)
|
2018-05-02 |
2025-07-08 |
The Children's Medical Center Corporation |
BCL11A microRNAs for treating hemoglobinopathies
|
|
KR20250134703A
(ko)
|
2018-05-11 |
2025-09-11 |
빔 테라퓨틱스, 인크. |
프로그래밍가능한 염기 편집기 시스템을 이용하여 병원성 아미노산을 치환하는 방법
|
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
IL312102B1
(en)
|
2018-06-14 |
2025-09-01 |
2Seventy Bio Inc |
Chimeric antigen receptors cd79a
|
|
CN113301924A
(zh)
|
2018-08-18 |
2021-08-24 |
哈佛学院校长同事会 |
原位基因编辑
|
|
US12421507B2
(en)
|
2018-08-20 |
2025-09-23 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of CRISPR-CAS9
|
|
US20200102563A1
(en)
*
|
2018-10-02 |
2020-04-02 |
Exosome Therapeutics, Inc. |
Exosome loaded therapeutics for treating sickle cell disease
|
|
US12312584B2
(en)
|
2018-10-02 |
2025-05-27 |
Exosome Therapeutics, Inc. |
cGMP exosome loaded therapeutics for treating sickle cell disease
|
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
|
US12281338B2
(en)
|
2018-10-29 |
2025-04-22 |
The Broad Institute, Inc. |
Nucleobase editors comprising GeoCas9 and uses thereof
|
|
EP3887521A1
(en)
*
|
2018-11-29 |
2021-10-06 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
EP3893922A4
(en)
|
2018-12-10 |
2022-09-14 |
2seventy bio, Inc. |
VARIANTS OF ENDONUCLEASE HOMING
|
|
WO2020131862A1
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Crispr-associated transposase systems and methods of use thereof
|
|
US12264323B2
(en)
|
2018-12-17 |
2025-04-01 |
The Broad Institute, Inc. |
CRISPR CPF1 direct repeat variants
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
EP3921417A4
(en)
|
2019-02-04 |
2022-11-09 |
The General Hospital Corporation |
VARIANTS OF ADENINE DNA BASES WITH REDUCED OFF-TARGET RNA EDIT
|
|
CN120005859A
(zh)
|
2019-02-13 |
2025-05-16 |
比姆医疗股份有限公司 |
治疗血红素病变的组合物和方法
|
|
DE112020001306T5
(de)
|
2019-03-19 |
2022-01-27 |
Massachusetts Institute Of Technology |
Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CN110042124A
(zh)
*
|
2019-04-25 |
2019-07-23 |
国家卫生健康委科学技术研究所 |
基因组碱基编辑增加人红细胞中胎儿血红蛋白水平的试剂盒及应用
|
|
PE20220003A1
(es)
*
|
2019-04-30 |
2022-01-05 |
Edigene Inc |
Metodo para la prediccion de eficacia del tratamiento de hemoglobinopatia
|
|
CN111939271A
(zh)
*
|
2019-04-30 |
2020-11-17 |
博雅辑因(北京)生物科技有限公司 |
一种血红蛋白病治疗有效性预测方法
|
|
EP3976802A1
(en)
|
2019-05-28 |
2022-04-06 |
Selecta Biosciences, Inc. |
Methods and compositions for attenuated anti-viral transfer vector immune response
|
|
US20220380756A1
(en)
*
|
2019-06-28 |
2022-12-01 |
Asc Therapeutics Inc. |
Methods and compositions for treating thalassemia or sickle cell disease
|
|
AU2020358863A1
(en)
|
2019-10-03 |
2022-05-12 |
Celyntra Therapeutics Sa |
CRISPR systems with engineered dual guide nucleic acids
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
CN115175991A
(zh)
|
2019-10-16 |
2022-10-11 |
博德研究所 |
工程化肌肉靶向组合物
|
|
EP4058586A4
(en)
*
|
2019-11-15 |
2024-04-10 |
The Board of Trustees of the Leland Stanford Junior University |
Targeted integration at alpha-globin locus in human hematopoietic stem and progenitor cells
|
|
CN112979823B
(zh)
*
|
2019-12-18 |
2022-04-08 |
华东师范大学 |
一种用于治疗和/或预防β血红蛋白病的产品及融合蛋白
|
|
JP2023519346A
(ja)
|
2020-03-27 |
2023-05-10 |
メンドゥス・ベスローテン・フェンノートシャップ |
養子細胞療法の有効性を増強するための白血病由来の改変細胞のエクスビボ(ex vivo)使用
|
|
AU2021267940A1
(en)
|
2020-05-08 |
2022-12-08 |
President And Fellows Of Harvard College |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
US20230279438A1
(en)
*
|
2020-05-13 |
2023-09-07 |
Inserm (Institut National De La Santé Et La Recherche Médicale) |
Base editing approaches for the treatment of betahemoglobinopathies
|
|
CA3179130A1
(en)
*
|
2020-06-04 |
2021-12-09 |
Lior IZHAR |
Novel omni-59, 61, 67, 76, 79, 80, 81, and 82 crispr nucleases
|
|
CA3182607A1
(en)
|
2020-06-30 |
2022-01-06 |
Erik Hans MANTING |
Use of leukemia-derived cells in ovarian cancer vaccines
|
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
|
JPWO2022050377A1
(cg-RX-API-DMAC7.html)
*
|
2020-09-04 |
2022-03-10 |
|
|
|
WO2022140150A1
(en)
*
|
2020-12-21 |
2022-06-30 |
2Seventy Bio, Inc. |
Compositions and methods for site-directed mutagenesis
|
|
AU2022227650A1
(en)
|
2021-02-25 |
2023-10-12 |
Celyntra Therapeutics Sa |
Compositions and methods for targeting, editing, or modifying genes
|
|
US20220305100A1
(en)
|
2021-03-12 |
2022-09-29 |
Dcprime B.V. |
Methods of vaccination and use of cd47 blockade
|
|
US20250179481A1
(en)
|
2021-06-01 |
2025-06-05 |
Celyntra Therapeutics Sa |
Compositions and methods for targeting, editing, or modifying genes
|
|
CN113481184A
(zh)
*
|
2021-08-06 |
2021-10-08 |
北京大学 |
融合蛋白以及其使用方法
|
|
US11884915B2
(en)
|
2021-09-10 |
2024-01-30 |
Agilent Technologies, Inc. |
Guide RNAs with chemical modification for prime editing
|
|
WO2023064367A1
(en)
|
2021-10-12 |
2023-04-20 |
Selecta Biosciences, Inc. |
Methods and compositions for attenuating anti-viral transfer vector igm responses
|
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
|
WO2023167882A1
(en)
|
2022-03-01 |
2023-09-07 |
Artisan Development Labs, Inc. |
Composition and methods for transgene insertion
|
|
WO2023172624A1
(en)
|
2022-03-09 |
2023-09-14 |
Selecta Biosciences, Inc. |
Immunosuppressants in combination with anti-igm agents and related dosing
|
|
CN114457119B
(zh)
*
|
2022-04-11 |
2022-08-12 |
中吉智药(南京)生物技术有限公司 |
慢病毒载体在制备治疗β-地中海贫血药物中的应用
|
|
EP4273242A1
(en)
*
|
2022-05-03 |
2023-11-08 |
ETH Zurich |
Crispr-based modification of human hbd gene
|
|
CN117427169A
(zh)
*
|
2023-10-24 |
2024-01-23 |
中国医学科学院基础医学研究所 |
同时破坏HBB竞争和HBG表观沉默在治疗β-血红蛋白病中的应用
|