SG10201913980SA - Benzoxazepin oxazolidinone compounds and methods of use - Google Patents
Benzoxazepin oxazolidinone compounds and methods of useInfo
- Publication number
- SG10201913980SA SG10201913980SA SG10201913980SA SG10201913980SA SG10201913980SA SG 10201913980S A SG10201913980S A SG 10201913980SA SG 10201913980S A SG10201913980S A SG 10201913980SA SG 10201913980S A SG10201913980S A SG 10201913980SA SG 10201913980S A SG10201913980S A SG 10201913980SA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- oxazolidinone compounds
- benzoxazepin oxazolidinone
- benzoxazepin
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562188029P | 2015-07-02 | 2015-07-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201913980SA true SG10201913980SA (en) | 2020-03-30 |
Family
ID=56292756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201913980SA SG10201913980SA (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
Country Status (32)
Country | Link |
---|---|
US (5) | US9650393B2 (fr) |
EP (4) | EP3567045B1 (fr) |
JP (4) | JP6523490B2 (fr) |
KR (2) | KR102014326B1 (fr) |
CN (4) | CN112062778B (fr) |
AR (1) | AR105238A1 (fr) |
AU (2) | AU2016287463B2 (fr) |
CA (1) | CA2982708C (fr) |
CL (1) | CL2017003436A1 (fr) |
CO (1) | CO2017011038A2 (fr) |
CR (1) | CR20170563A (fr) |
DK (1) | DK3317284T3 (fr) |
ES (2) | ES2764497T3 (fr) |
HK (1) | HK1253003A1 (fr) |
HR (1) | HRP20192349T1 (fr) |
HU (1) | HUE046756T2 (fr) |
IL (3) | IL255200B (fr) |
LT (1) | LT3317284T (fr) |
MA (3) | MA49861A (fr) |
MX (2) | MX2017016344A (fr) |
MY (1) | MY195002A (fr) |
PE (2) | PE20181021A1 (fr) |
PH (2) | PH12017502425A1 (fr) |
PL (2) | PL3317284T3 (fr) |
PT (1) | PT3317284T (fr) |
RS (1) | RS59740B1 (fr) |
RU (1) | RU2730529C2 (fr) |
SG (1) | SG10201913980SA (fr) |
SI (1) | SI3317284T1 (fr) |
TW (4) | TWI698440B (fr) |
WO (1) | WO2017001645A1 (fr) |
ZA (1) | ZA201808370B (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3567045B1 (fr) * | 2015-07-02 | 2022-01-12 | F. Hoffmann-La Roche AG | Composés de benzoxazépine oxazolidinone et leurs procédés d'utilisation |
JP6522807B2 (ja) | 2015-07-02 | 2019-05-29 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ベンゾオキサゼピンオキサゾリジノン化合物及び使用方法 |
CA2988601C (fr) | 2015-07-02 | 2021-12-07 | F. Hoffmann-La Roche Ag | Lactames bicycliques et leurs methodes d'utilisation |
US10065970B2 (en) | 2015-09-08 | 2018-09-04 | Genentech, Inc. | Tricyclic PI3K inhibitor compounds and methods of use |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
EP3526219B1 (fr) | 2016-10-17 | 2021-12-15 | F. Hoffmann-La Roche AG | Lactames de pyridone bicycliques et leurs méthodes d'utilisation |
AU2017378188B2 (en) * | 2016-12-15 | 2020-11-26 | F. Hoffmann-La Roche Ag | Process for the preparation of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino) propanamide |
US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
TWI826373B (zh) * | 2017-04-28 | 2023-12-21 | 瑞士商赫孚孟拉羅股份公司 | (s)-2-((2-((s)-4-(二氟甲基)-2-氧代唑烷-3-基)-5,6-二氫苯并[f]咪唑并[1,2-d][1,4]氧氮呯-9-基)胺基)丙醯胺之多晶型及固體形式及製造方法 |
EP3781571B1 (fr) | 2018-04-20 | 2024-01-17 | F. Hoffmann-La Roche AG | Dérivés de n-[4-oxo-2,3-dihydro-pyrido[3,2-b][1,4]oxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxamide et composés similaires en tant qu'inhibiteurs de la kinase rip1 pour le traitement p.e. du syndrome de l'intestin irritable (sii) |
KR20210018304A (ko) * | 2018-05-30 | 2021-02-17 | 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 | 트리사이클릭 유도체를 함유하는 억제제, 이를 위한 제조 방법, 및 이의 적용 |
AU2019310335A1 (en) * | 2018-07-23 | 2021-02-11 | F. Hoffmann-La Roche Ag | Methods of treating cancer with PI3K inhibitor, GDC-0077 |
EP3863618A1 (fr) | 2018-10-08 | 2021-08-18 | F. Hoffmann-La Roche AG | Méthodes de traitement du cancer avec des inhibiteurs de pi3k alpha et de la metformine |
CN109265408B (zh) * | 2018-12-11 | 2020-09-01 | 上海皓元生物医药科技有限公司 | 二氟甲基取代噁烷-2-酮的合成方法 |
CN113195000A (zh) | 2018-12-21 | 2021-07-30 | 第一三共株式会社 | 抗体-药物缀合物和激酶抑制剂的组合 |
CN111995541A (zh) * | 2019-05-27 | 2020-11-27 | 润佳(苏州)医药科技有限公司 | 含有稳定重同位素的酰胺官能团的化合物及其应用 |
WO2021088845A1 (fr) * | 2019-11-04 | 2021-05-14 | 贝达药业股份有限公司 | Composé imidazolidinone et son procédé de préparation et son utilisation |
AU2020389670A1 (en) * | 2019-11-25 | 2022-05-19 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Three fused ring derivative-containing salt or crystal form and pharmaceutical composition thereof |
CN112830935B (zh) * | 2019-11-25 | 2023-12-22 | 上海翰森生物医药科技有限公司 | 含三并环类衍生物自由碱的晶型及其药物组合物 |
CA3156205A1 (fr) | 2019-12-03 | 2021-06-10 | Jennifer O'hara Lauchle | Polytherapies pour le traitement du cancer du sein |
EP4259662A1 (fr) | 2020-12-11 | 2023-10-18 | Genentech, Inc. | Polythérapies pour le traitement du cancer her2 |
CA3206323A1 (fr) * | 2021-01-29 | 2022-08-04 | Jingjie HUANG | Composes tricycliques et leur utilisation |
IL308459A (en) | 2021-05-13 | 2024-01-01 | Betta Pharmaceuticals Co Ltd | A polymorph of an imidazolidinone compound, its preparation method and use |
CN117377660A (zh) | 2021-05-28 | 2024-01-09 | 基因泰克公司 | 用于苯并氧氮杂䓬恶唑烷酮化合物的制备的方法 |
WO2023002988A1 (fr) | 2021-07-19 | 2023-01-26 | 京セラ株式会社 | Procédé de communication |
US20230321102A1 (en) | 2022-04-06 | 2023-10-12 | Genentech, Inc. | TREATMENT OF CANCER USING COMBINATION THERAPIES COMPRISING GDC-6036 and GDC-0077 |
CN117466913A (zh) * | 2022-07-27 | 2024-01-30 | 南京明德新药研发有限公司 | 一种5,6-二氢苯并[f]咪唑并[1,2-d][1,4]噁吖庚英化合物的晶型及其制备方法 |
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JP6522807B2 (ja) | 2015-07-02 | 2019-05-29 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ベンゾオキサゼピンオキサゾリジノン化合物及び使用方法 |
EP3567045B1 (fr) | 2015-07-02 | 2022-01-12 | F. Hoffmann-La Roche AG | Composés de benzoxazépine oxazolidinone et leurs procédés d'utilisation |
AU2017378188B2 (en) | 2016-12-15 | 2020-11-26 | F. Hoffmann-La Roche Ag | Process for the preparation of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino) propanamide |
TWI826373B (zh) * | 2017-04-28 | 2023-12-21 | 瑞士商赫孚孟拉羅股份公司 | (s)-2-((2-((s)-4-(二氟甲基)-2-氧代唑烷-3-基)-5,6-二氫苯并[f]咪唑并[1,2-d][1,4]氧氮呯-9-基)胺基)丙醯胺之多晶型及固體形式及製造方法 |
AU2019310335A1 (en) | 2018-07-23 | 2021-02-11 | F. Hoffmann-La Roche Ag | Methods of treating cancer with PI3K inhibitor, GDC-0077 |
EP3863618A1 (fr) | 2018-10-08 | 2021-08-18 | F. Hoffmann-La Roche AG | Méthodes de traitement du cancer avec des inhibiteurs de pi3k alpha et de la metformine |
CA3156205A1 (fr) | 2019-12-03 | 2021-06-10 | Jennifer O'hara Lauchle | Polytherapies pour le traitement du cancer du sein |
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2016
- 2016-07-01 EP EP19171677.8A patent/EP3567045B1/fr active Active
- 2016-07-01 EP EP22204250.9A patent/EP4212536A1/fr active Pending
- 2016-07-01 ES ES16733600T patent/ES2764497T3/es active Active
- 2016-07-01 ES ES19171677T patent/ES2908300T3/es active Active
- 2016-07-01 PL PL16733600T patent/PL3317284T3/pl unknown
- 2016-07-01 TW TW108100214A patent/TWI698440B/zh active
- 2016-07-01 PL PL19171677T patent/PL3567045T3/pl unknown
- 2016-07-01 EP EP20174298.8A patent/EP3778607B1/fr active Active
- 2016-07-01 MX MX2017016344A patent/MX2017016344A/es active IP Right Grant
- 2016-07-01 WO PCT/EP2016/065455 patent/WO2017001645A1/fr active Application Filing
- 2016-07-01 EP EP16733600.7A patent/EP3317284B1/fr active Active
- 2016-07-01 JP JP2017567428A patent/JP6523490B2/ja active Active
- 2016-07-01 RU RU2018103454A patent/RU2730529C2/ru active
- 2016-07-01 TW TW106122915A patent/TWI649326B/zh active
- 2016-07-01 CN CN202010779436.0A patent/CN112062778B/zh active Active
- 2016-07-01 CR CR20170563A patent/CR20170563A/es unknown
- 2016-07-01 US US15/200,301 patent/US9650393B2/en active Active
- 2016-07-01 HU HUE16733600A patent/HUE046756T2/hu unknown
- 2016-07-01 MY MYPI2017705097A patent/MY195002A/en unknown
- 2016-07-01 PT PT167336007T patent/PT3317284T/pt unknown
- 2016-07-01 MA MA049861A patent/MA49861A/fr unknown
- 2016-07-01 AR ARP160102006A patent/AR105238A1/es unknown
- 2016-07-01 RS RS20191662A patent/RS59740B1/sr unknown
- 2016-07-01 PE PE2017002721A patent/PE20181021A1/es unknown
- 2016-07-01 KR KR1020177037599A patent/KR102014326B1/ko active IP Right Grant
- 2016-07-01 KR KR1020197024122A patent/KR102306071B1/ko active IP Right Grant
- 2016-07-01 CN CN202010786032.4A patent/CN112047960A/zh active Pending
- 2016-07-01 CN CN202010778340.2A patent/CN111909173A/zh active Pending
- 2016-07-01 MX MX2020003415A patent/MX2020003415A/es unknown
- 2016-07-01 PE PE2021000504A patent/PE20211775A1/es unknown
- 2016-07-01 TW TW109117051A patent/TW202108592A/zh unknown
- 2016-07-01 LT LTEP16733600.7T patent/LT3317284T/lt unknown
- 2016-07-01 CN CN201680039251.8A patent/CN107873032B/zh active Active
- 2016-07-01 SG SG10201913980SA patent/SG10201913980SA/en unknown
- 2016-07-01 MA MA42295A patent/MA42295B1/fr unknown
- 2016-07-01 DK DK16733600.7T patent/DK3317284T3/da active
- 2016-07-01 MA MA054252A patent/MA54252A/fr unknown
- 2016-07-01 AU AU2016287463A patent/AU2016287463B2/en active Active
- 2016-07-01 CA CA2982708A patent/CA2982708C/fr active Active
- 2016-07-01 SI SI201630571T patent/SI3317284T1/sl unknown
- 2016-07-01 TW TW105120987A patent/TWI601732B/zh active
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2017
- 2017-04-07 US US15/481,764 patent/US20170210733A1/en not_active Abandoned
- 2017-10-10 US US15/729,507 patent/US10112932B2/en active Active
- 2017-10-22 IL IL255200A patent/IL255200B/en active IP Right Grant
- 2017-10-27 CO CONC2017/0011038A patent/CO2017011038A2/es unknown
- 2017-12-22 PH PH12017502425A patent/PH12017502425A1/en unknown
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