BR112017023121A2 - composto, composição farmacêutica, processo para a preparação de uma composição, método de tratamento do câncer, kit para o tratamento terapêutico do câncer e uso de um composto - Google Patents

composto, composição farmacêutica, processo para a preparação de uma composição, método de tratamento do câncer, kit para o tratamento terapêutico do câncer e uso de um composto

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Publication number
BR112017023121A2
BR112017023121A2 BR112017023121-2A BR112017023121A BR112017023121A2 BR 112017023121 A2 BR112017023121 A2 BR 112017023121A2 BR 112017023121 A BR112017023121 A BR 112017023121A BR 112017023121 A2 BR112017023121 A2 BR 112017023121A2
Authority
BR
Brazil
Prior art keywords
compound
cancer treatment
composition
preparing
pi3k
Prior art date
Application number
BR112017023121-2A
Other languages
English (en)
Other versions
BR112017023121B1 (pt
Inventor
Braun Marie-Gabrielle
Elliott Richard
Hanan Emily
Andrew Heald Robert
Macleod Calum
T. Staben Steven
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of BR112017023121A2 publication Critical patent/BR112017023121A2/pt
Publication of BR112017023121B1 publication Critical patent/BR112017023121B1/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00Formation or introduction of functional groups containing nitrogen
    • C07B43/06Formation or introduction of functional groups containing nitrogen of amide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D267/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02Seven-membered rings
    • C07D267/08Seven-membered rings having the hetero atoms in positions 1 and 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

são descritos compostos de benzoxazepina oxazolidinona com atividade ou função de modulação da fosfoinositídeo-3 quinase (pi3k) possuindo a estrutura de fórmula i, ou estereoisômeros, tautômeros ou seus sais farmaceuticamente aceitáveis, e com os substituintes e características estruturais descritos na presente invenção. também são descritos medicamentos e composições farmacêuticas que incluem os compostos de fórmula i, bem como métodos de uso de tais moduladores da pi3k, isolados e em combinação com outros agentes terapêuticos, para tratar doenças ou condições que são mediadas ou dependentes da desregulação de pi3k.
BR112017023121-2A 2015-07-02 2016-07-01 Composto, composição farmacêutica, processo para a preparação de uma composição farmacêutica, kit para o tratamento terapêutico do câncer, e uso de um composto BR112017023121B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562188029P 2015-07-02 2015-07-02
US62/188,029 2015-07-02
PCT/EP2016/065455 WO2017001645A1 (en) 2015-07-02 2016-07-01 Benzoxazepin oxazolidinone compounds and methods of use

Publications (2)

Publication Number Publication Date
BR112017023121A2 true BR112017023121A2 (pt) 2018-07-10
BR112017023121B1 BR112017023121B1 (pt) 2023-09-12

Family

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Also Published As

Publication number Publication date
US20180127404A1 (en) 2018-05-10
EP3778607A1 (en) 2021-02-17
US20170210733A1 (en) 2017-07-27
TWI698440B (zh) 2020-07-11
CN111909173A (zh) 2020-11-10
AR105238A1 (es) 2017-09-20
HUE046756T2 (hu) 2020-03-30
IL277774A (en) 2020-11-30
TWI649326B (zh) 2019-02-01
TW201712020A (zh) 2017-04-01
CL2017003436A1 (es) 2018-05-04
CN112062778A (zh) 2020-12-11
PL3317284T3 (pl) 2020-04-30
ES2764497T3 (es) 2020-06-03
ZA201808370B (en) 2023-03-29
KR102014326B1 (ko) 2019-08-26
CR20170563A (es) 2018-02-20
ES2908300T3 (es) 2022-04-28
TW201815798A (zh) 2018-05-01
CN112062778B (zh) 2024-04-19
AU2016287463B2 (en) 2020-07-02
UA121678C2 (uk) 2020-07-10
TW202108592A (zh) 2021-03-01
US10851091B2 (en) 2020-12-01
EP3317284A1 (en) 2018-05-09
EP3317284B1 (en) 2019-10-30
MA42295B1 (fr) 2020-02-28
JP2023103242A (ja) 2023-07-26
PE20181021A1 (es) 2018-06-27
WO2017001645A1 (en) 2017-01-05
RS59740B1 (sr) 2020-02-28
PH12020551315A1 (en) 2021-07-05
PH12017502425A1 (en) 2018-07-02
RU2018103454A (ru) 2019-08-05
HRP20192349T1 (hr) 2020-03-20
TW201936612A (zh) 2019-09-16
MA49861A (fr) 2021-05-05
RU2730529C2 (ru) 2020-08-24
KR102306071B1 (ko) 2021-10-01
JP6523490B2 (ja) 2019-06-05
CO2017011038A2 (es) 2018-02-09
US20190263793A1 (en) 2019-08-29
MY195002A (en) 2022-12-30
MX2017016344A (es) 2018-05-02
MX2020003415A (es) 2021-12-07
MA54252A (fr) 2022-04-27
IL272277B (en) 2021-01-31
US20210246129A1 (en) 2021-08-12
DK3317284T3 (da) 2020-01-13
IL255200B (en) 2020-05-31
US9650393B2 (en) 2017-05-16
US10112932B2 (en) 2018-10-30
CA2982708A1 (en) 2017-01-05
JP7266630B2 (ja) 2023-04-28
SI3317284T1 (sl) 2020-02-28
EP3778607B1 (en) 2023-08-30
AU2020204418A1 (en) 2020-07-23
NZ736222A (en) 2024-05-31
US20170015678A1 (en) 2017-01-19
PT3317284T (pt) 2020-01-10
CN107873032B (zh) 2020-07-17
EP4212536A1 (en) 2023-07-19
SG10201913980SA (en) 2020-03-30
JP2019178135A (ja) 2019-10-17
NZ775526A (en) 2024-05-31
CN112047960A (zh) 2020-12-08
CN112047960B (zh) 2024-08-02
IL255200A0 (en) 2017-12-31
AU2016287463A1 (en) 2017-10-26
EP3567045A1 (en) 2019-11-13
LT3317284T (lt) 2020-01-27
AU2020204418B2 (en) 2022-02-03
HK1253003A1 (zh) 2019-06-06
PE20211775A1 (es) 2021-09-08
CN107873032A (zh) 2018-04-03
EP3778607C0 (en) 2023-08-30
IL272277A (en) 2020-02-27
US11760753B2 (en) 2023-09-19
RU2018103454A3 (pt) 2019-11-21
EP3567045B1 (en) 2022-01-12
CA2982708C (en) 2023-10-03
JP2018519307A (ja) 2018-07-19
PL3567045T3 (pl) 2022-04-19
JP6880101B2 (ja) 2021-06-02
KR20190100432A (ko) 2019-08-28
US20240199594A1 (en) 2024-06-20
KR20180006460A (ko) 2018-01-17
JP2021119144A (ja) 2021-08-12
TWI601732B (zh) 2017-10-11

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/07/2016, OBSERVADAS AS CONDICOES LEGAIS