SG10201810830UA - Cell culture compositions and methods for polypeptide production - Google Patents

Cell culture compositions and methods for polypeptide production

Info

Publication number
SG10201810830UA
SG10201810830UA SG10201810830UA SG10201810830UA SG10201810830UA SG 10201810830U A SG10201810830U A SG 10201810830UA SG 10201810830U A SG10201810830U A SG 10201810830UA SG 10201810830U A SG10201810830U A SG 10201810830UA SG 10201810830U A SG10201810830U A SG 10201810830UA
Authority
SG
Singapore
Prior art keywords
methods
cell culture
polypeptide production
culture compositions
compositions
Prior art date
Application number
SG10201810830UA
Other languages
English (en)
Inventor
Steven Meier
Melissa Mun
Natarajan Vijayasankaran
Sharat Varma
Yi Yang
Boyan Zhang
Silvana Arevalo
Martin Gawlitzek
Veronica Carvalhal
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49380652&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201810830U(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of SG10201810830UA publication Critical patent/SG10201810830UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/005Protein-free medium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/20Transition metals
    • C12N2500/24Iron; Fe chelators; Transferrin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/32Amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/38Vitamins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/39Steroid hormones

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG10201810830UA 2012-04-24 2013-04-24 Cell culture compositions and methods for polypeptide production SG10201810830UA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261637778P 2012-04-24 2012-04-24
US201261637780P 2012-04-24 2012-04-24
US13/841,864 US20130281355A1 (en) 2012-04-24 2013-03-15 Cell culture compositions and methods for polypeptide production

Publications (1)

Publication Number Publication Date
SG10201810830UA true SG10201810830UA (en) 2018-12-28

Family

ID=49380652

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201810830UA SG10201810830UA (en) 2012-04-24 2013-04-24 Cell culture compositions and methods for polypeptide production
SG11201406903SA SG11201406903SA (en) 2012-04-24 2013-04-24 Cell culture compositions and methods for polypeptide production

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201406903SA SG11201406903SA (en) 2012-04-24 2013-04-24 Cell culture compositions and methods for polypeptide production

Country Status (22)

Country Link
US (2) US20130281355A1 (ru)
EP (2) EP2841561B1 (ru)
JP (4) JP6367792B2 (ru)
KR (2) KR102115052B1 (ru)
CN (2) CN104428409A (ru)
AR (1) AR090822A1 (ru)
AU (2) AU2013251647B2 (ru)
BR (1) BR112014026308A8 (ru)
CA (1) CA2871006C (ru)
ES (1) ES2716301T3 (ru)
HK (1) HK1208496A1 (ru)
HR (1) HRP20190484T1 (ru)
IL (1) IL235235A0 (ru)
MX (2) MX363493B (ru)
MY (1) MY181513A (ru)
NZ (1) NZ701791A (ru)
PL (1) PL2841561T3 (ru)
RU (2) RU2018146497A (ru)
SG (2) SG10201810830UA (ru)
SI (1) SI2841561T1 (ru)
WO (1) WO2013163294A1 (ru)
ZA (2) ZA201408092B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9334319B2 (en) 2012-04-20 2016-05-10 Abbvie Inc. Low acidic species compositions
ES2798307T3 (es) 2013-03-15 2020-12-10 Hoffmann La Roche Composiciones de cultivo de células con antioxidantes y procedimientos para la producción de polipéptidos
EP2968544A4 (en) * 2013-03-15 2016-10-12 Hoffmann La Roche CELL CULTURE MEDIA AND METHOD FOR PRODUCING ANTIBODY
US9598667B2 (en) * 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
GB201708655D0 (en) 2017-05-31 2017-07-12 Ucb Biopharma Sprl Cell culture methods
JP2020523030A (ja) * 2017-06-16 2020-08-06 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ バイオリアクタにおいてのプロセスのアウトカムを予測するための、および、そのプロセスのモデリングのための方法
EP3492582A1 (en) 2017-12-01 2019-06-05 UCB Biopharma SPRL Cell culture methods
CN111500662A (zh) * 2018-06-25 2020-08-07 深圳市菲鹏生物制药股份有限公司 调节cho-k1表达系统所分泌抗体的酸性峰含量的方法
EP4051790A4 (en) * 2019-10-31 2023-11-01 William Marsh Rice University GENETICALLY ENGINEERED CELLS FOR CONTROLLED PRODUCTION
PE20221770A1 (es) * 2019-12-06 2022-11-11 Regeneron Pharma Composiciones de proteina anti-vegf y metodos para producir la misma
WO2021153723A1 (ja) 2020-01-31 2021-08-05 中外製薬株式会社 着色を抑制したポリペプチドを含む組成物の製造方法
JP7404929B2 (ja) 2020-02-26 2023-12-26 富士フイルムビジネスイノベーション株式会社 発光装置、光学装置及び計測装置
JP7404930B2 (ja) 2020-02-26 2023-12-26 富士フイルムビジネスイノベーション株式会社 発光装置、光学装置及び計測装置
GB202012991D0 (en) 2020-08-20 2020-10-07 Ucb Biopharma Sprl Cell culture processes
CN116635416A (zh) * 2020-12-22 2023-08-22 诺华股份有限公司 用于在细胞培养期间降低分泌的重组表达蛋白质中半胱氨酸残基的氧化水平的方法
GB202105424D0 (en) 2021-04-16 2021-06-02 UCB Biopharma SRL Cell culture processes
CN118076878A (zh) 2021-09-02 2024-05-24 勃林格殷格翰国际公司 确定未来颜色值或相应属性及其装置的方法
WO2023063611A1 (ko) * 2021-10-12 2023-04-20 프레스티지바이오로직스 주식회사 항체 집단의 제조 방법

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
JPS5863385A (ja) 1981-10-02 1983-04-15 ハナ・バイオロジツクス・インコ−ポレ−テツド 免疫系由来の細胞用培地
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4816401A (en) 1985-09-09 1989-03-28 University Of Rochester Serum free cell culture medium
US5091178A (en) 1986-02-21 1992-02-25 Oncogen Tumor therapy with biologically active anti-tumor antibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
AU632065B2 (en) 1988-09-23 1992-12-17 Novartis Vaccines And Diagnostics, Inc. Cell culture medium for enhanced cell growth, culture longevity and product expression
US6048728A (en) 1988-09-23 2000-04-11 Chiron Corporation Cell culture medium for enhanced cell growth, culture longevity, and product expression
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
JPH03180176A (ja) * 1989-11-16 1991-08-06 W R Grace & Co 細胞培養のための基礎栄養培地
EP0502036B1 (en) 1989-11-22 1995-12-20 Genentech, Inc. Latency associated peptide and uses therefor
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
DK1136556T3 (da) 1991-11-25 2005-10-03 Enzon Inc Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner
JPH07102147B2 (ja) * 1992-03-16 1995-11-08 株式会社ミドリ十字 ヒト血清アルブミンの着色抑制方法
US5856179A (en) 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US5512477A (en) 1994-04-21 1996-04-30 Genzyme Corporation Serum-free medium supplement
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
EP0802257B1 (fr) * 1996-04-19 2002-08-21 Societe Des Produits Nestle S.A. Lignée immortalisée de cellules épithéliales du colon humain
ATE399855T1 (de) * 1996-10-10 2008-07-15 Invitrogen Corp Tierzellkulturmedium mit pflanzlichen nährstoffen
US20020012991A1 (en) 1997-04-07 2002-01-31 Florence Chua Nee Ho Kit Fong Cell culture media for enhanced protein production
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US6160099A (en) * 1998-11-24 2000-12-12 Jonak; Zdenka Ludmila Anti-human αv β3 and αv β5 antibodies
US20060286668A1 (en) 1999-04-30 2006-12-21 Invitrogen Corporation Animal-cell culture media comprising non-animal or plant-derived nutrients
US6900056B2 (en) * 2001-02-15 2005-05-31 Centocor, Inc. Chemically defined medium for cultured mammalian cells
EP1404813A4 (en) 2001-06-13 2004-11-24 Genentech Inc METHOD FOR CULTIVATING ANIMAL CELLS AND POLYPEPTIDE PRODUCTION IN ANIMAL CELLS
GB0208041D0 (en) * 2002-04-08 2002-05-22 Lonza Biologics Plc Method of culturing animal cells
AR047392A1 (es) 2002-10-22 2006-01-18 Wyeth Corp Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines
GB0304799D0 (en) * 2003-03-03 2003-04-09 Glaxosmithkline Biolog Sa Novel method
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
EP1705251A4 (en) * 2003-10-09 2009-10-28 Kyowa Hakko Kirin Co Ltd PROCESS FOR PRODUCING ANTIBODY COMPOSITION BY RNA INHIBITION OF FUNCTION OF $ G (A) 1,6-FUCOSYLTRANSFERASE
US7294484B2 (en) * 2004-08-27 2007-11-13 Wyeth Research Ireland Limited Production of polypeptides
US20060051347A1 (en) 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
AU2005302516A1 (en) * 2004-10-29 2006-05-11 Centocor, Inc. Chemically defined media compositions
CN100569940C (zh) * 2006-08-16 2009-12-16 华东理工大学 人胚胎肾(hek)293细胞无血清培养基
BRPI0716762A2 (pt) * 2006-09-13 2013-09-24 Abbott Lab melhorias da cultura celular
BRPI0721097A2 (pt) 2006-12-11 2014-07-01 Hoffmann La Roche Formulação parenteral de anticorpo abeta
US20100041146A1 (en) * 2007-01-12 2010-02-18 Nippon Sheet Glass Company, Limited Three-dimensional cell culture carrier and method for cell culture using the same
EP2183358B1 (en) * 2007-07-20 2013-03-27 Dongguk University Industry Academic Cooperation Foundation Method for the preparation of dermal papilla tissue employing mesenchymal stem cells
CA2698103A1 (en) * 2007-08-31 2009-03-05 Amgen Inc. Solid-state protein formulation
KR101286895B1 (ko) * 2008-04-17 2013-07-16 와이어쓰 엘엘씨 골 형태발생 단백질의 개선된 생산 방법
JP2012503487A (ja) * 2008-09-26 2012-02-09 シェーリング コーポレイション 高力価抗体の製造
JO3672B1 (ar) * 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
US9540426B2 (en) * 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
PL2563904T3 (pl) 2010-04-26 2015-06-30 Novartis Ag Udoskonalona pożywka do hodowli komórkowej

Also Published As

Publication number Publication date
EP2841561A1 (en) 2015-03-04
US20130281355A1 (en) 2013-10-24
MX363493B (es) 2019-03-26
KR20150003351A (ko) 2015-01-08
ZA201707452B (en) 2021-03-31
HK1208496A1 (en) 2016-03-04
CA2871006C (en) 2021-05-25
CN104428409A (zh) 2015-03-18
JP7323272B2 (ja) 2023-08-08
JP2018183154A (ja) 2018-11-22
MX2014012838A (es) 2015-10-22
KR20200057795A (ko) 2020-05-26
IL235235A0 (en) 2014-12-31
PL2841561T3 (pl) 2019-05-31
RU2018146497A (ru) 2019-02-04
HRP20190484T1 (hr) 2019-05-17
NZ701791A (en) 2017-03-31
AU2019202259B2 (en) 2021-11-11
BR112014026308A2 (pt) 2017-06-27
JP2021104023A (ja) 2021-07-26
JP2015515281A (ja) 2015-05-28
EP2841561B1 (en) 2019-01-16
BR112014026308A8 (pt) 2021-06-01
SI2841561T1 (sl) 2019-04-30
JP2023156371A (ja) 2023-10-24
AR090822A1 (es) 2014-12-10
MY181513A (en) 2020-12-24
RU2678142C2 (ru) 2019-01-23
EP3533864A1 (en) 2019-09-04
WO2013163294A1 (en) 2013-10-31
AU2013251647B2 (en) 2019-04-04
KR102339106B1 (ko) 2021-12-15
KR102115052B1 (ko) 2020-05-25
JP6367792B2 (ja) 2018-08-01
SG11201406903SA (en) 2014-12-30
MX2019003427A (es) 2020-11-12
ES2716301T3 (es) 2019-06-11
CN111440758A (zh) 2020-07-24
AU2019202259A1 (en) 2019-04-18
AU2013251647A1 (en) 2014-12-18
US20240093143A1 (en) 2024-03-21
CA2871006A1 (en) 2013-10-31
ZA201408092B (en) 2019-03-27
RU2014147018A (ru) 2016-06-10

Similar Documents

Publication Publication Date Title
SG10201810830UA (en) Cell culture compositions and methods for polypeptide production
SG10201809452RA (en) Cell culture compositions with antioxidants and methods for polypeptide production
MY156588A (en) Systems using cell culture for production of isoprene
MX2015011781A (es) Medio de cultivo celular y metodos de produccion de anticuerpos.
WO2010096588A3 (en) Cell culture media containing combinations of proteins
MY186219A (en) Production of proteins in glutamine-free cell culture media
WO2014143744A3 (en) Benzylisoquinoline alkaloids (bia) producing microbes, and methods of making and using the same
EP3546570A4 (en) KIT WITH MEDIUM FOR THE CULTURE OF SERUM-FREE IMMUNELL CELLS, METHOD FOR THE CULTURE OF IMMUNAL CELLS BY USE OF THE KIT, SERUM-FREE IMMUNE CELL CULTURE RECEIVED BY THE KIT OR CULTURE METHOD AND COSMETIC COMPOSITION
WO2012019122A3 (en) Simplified basic media for human pluripotent cell culture
SG10201805291TA (en) Production of heterodimeric proteins
MY170720A (en) Antibody formulations
GB201203085D0 (en) Hydrogels
MY178338A (en) Compositions and methods for biological production of lactate from c1 compounds using lactate dehydrogenase transformants
WO2012003402A3 (en) Compositions and methods for culturing microorganisms
EA201590550A1 (ru) Композиции и способы получения гликопротеинов
EA201492185A1 (ru) Способ получения рекомбинантной идуронат-2-сульфатазы
WO2011129462A3 (en) A YEAST EXTRACT CONTAINING γ-Glu-X OR γ-Glu-X-Gly AND A METHOD FOR PRODUCING THE SAME
MX2021001981A (es) Metodos para preparar un poloxamero para usar en medio de cultivo celular.
EP4039796A4 (en) METHOD FOR PRODUCING COMPOSITION FOR CELL CULTURE, COMPOSITION FOR CELL CULTURE OBTAINED THEREBY, AND CELL CULTURE METHOD USING SAME
WO2014049382A3 (en) Ethylenediamine fermentative production by a recombinant microorganism
EP3511410A4 (en) MEDIUM FOR THE CULTURE OF STEM CELLS, METHOD FOR THE CULTURE OF STEM CELLS, STEM CELL GROWTH PROMOTER AND COMPOSITION AND METHOD FOR THE PRODUCTION THEREOF
MY169178A (en) Direct and indirect organogenesis of jatropha
EA200900984A1 (ru) Улучшение клеточного роста
WO2012054935A3 (en) Formation of hematopoietic progenitor cells from mesenchymal stem cells
WO2012107445A3 (en) Soft substrate for cell culture and process for preparing the same