SG10201804151QA - Anti-egfr antibodies and uses thereof - Google Patents

Anti-egfr antibodies and uses thereof

Info

Publication number
SG10201804151QA
SG10201804151QA SG10201804151QA SG10201804151QA SG10201804151QA SG 10201804151Q A SG10201804151Q A SG 10201804151QA SG 10201804151Q A SG10201804151Q A SG 10201804151QA SG 10201804151Q A SG10201804151Q A SG 10201804151QA SG 10201804151Q A SG10201804151Q A SG 10201804151QA
Authority
SG
Singapore
Prior art keywords
antibodies
egfr
bind
certain embodiments
present
Prior art date
Application number
SG10201804151QA
Other languages
English (en)
Inventor
Christopher Daly
Gavin Thurston
Nicholas Papadopoulos
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10201804151QA publication Critical patent/SG10201804151QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG10201804151QA 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof SG10201804151QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261663984P 2012-06-25 2012-06-25
US201361821000P 2013-05-08 2013-05-08

Publications (1)

Publication Number Publication Date
SG10201804151QA true SG10201804151QA (en) 2018-07-30

Family

ID=48782632

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201804151QA SG10201804151QA (en) 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof
SG11201407163XA SG11201407163XA (en) 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof
SG10201610590UA SG10201610590UA (en) 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG11201407163XA SG11201407163XA (en) 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof
SG10201610590UA SG10201610590UA (en) 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof

Country Status (24)

Country Link
US (3) US9132192B2 (ru)
EP (1) EP2864357B1 (ru)
JP (1) JP6486268B2 (ru)
KR (1) KR20150023387A (ru)
CN (1) CN104411722B (ru)
AR (1) AR091545A1 (ru)
AU (2) AU2013280610B2 (ru)
BR (1) BR112014029099A2 (ru)
CA (1) CA2876697C (ru)
CL (1) CL2014003465A1 (ru)
CO (1) CO7160093A2 (ru)
EA (1) EA030421B1 (ru)
ES (1) ES2816645T3 (ru)
HK (1) HK1206040A1 (ru)
IL (1) IL235392B (ru)
MX (1) MX356329B (ru)
MY (2) MY164604A (ru)
NZ (1) NZ701633A (ru)
PH (1) PH12014502437B1 (ru)
SG (3) SG10201804151QA (ru)
TW (2) TWI641619B (ru)
UY (1) UY34876A (ru)
WO (1) WO2014004427A2 (ru)
ZA (1) ZA201407927B (ru)

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Publication number Publication date
UY34876A (es) 2013-12-31
EA030421B1 (ru) 2018-08-31
MX356329B (es) 2018-05-24
CN104411722B (zh) 2017-11-17
MY164604A (en) 2018-01-30
ES2816645T3 (es) 2021-04-05
HK1206040A1 (en) 2015-12-31
IL235392B (en) 2019-02-28
MX2014014361A (es) 2015-02-05
KR20150023387A (ko) 2015-03-05
WO2014004427A3 (en) 2014-03-27
WO2014004427A8 (en) 2014-12-18
US9132192B2 (en) 2015-09-15
TWI641619B (zh) 2018-11-21
NZ701633A (en) 2017-08-25
MY181086A (en) 2020-12-17
US20150337043A1 (en) 2015-11-26
JP2015521629A (ja) 2015-07-30
CA2876697C (en) 2021-07-13
TW201402610A (zh) 2014-01-16
WO2014004427A2 (en) 2014-01-03
CA2876697A1 (en) 2014-01-03
CL2014003465A1 (es) 2015-02-27
AU2013280610B2 (en) 2018-04-26
ZA201407927B (en) 2015-11-25
US20130344093A1 (en) 2013-12-26
PH12014502437A1 (en) 2015-01-12
SG11201407163XA (en) 2014-11-27
AU2013280610A1 (en) 2014-11-20
PH12014502437B1 (en) 2015-01-12
AR091545A1 (es) 2015-02-11
EP2864357B1 (en) 2020-07-01
US20180036405A1 (en) 2018-02-08
BR112014029099A2 (pt) 2017-07-18
CO7160093A2 (es) 2015-01-15
EP2864357A2 (en) 2015-04-29
EA201590085A1 (ru) 2015-04-30
CN104411722A (zh) 2015-03-11
US9789184B2 (en) 2017-10-17
TW201843172A (zh) 2018-12-16
AU2018204895A1 (en) 2018-07-26
SG10201610590UA (en) 2017-02-27
JP6486268B2 (ja) 2019-03-20

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