SG10201609322QA - Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof - Google Patents
Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereofInfo
- Publication number
- SG10201609322QA SG10201609322QA SG10201609322QA SG10201609322QA SG10201609322QA SG 10201609322Q A SG10201609322Q A SG 10201609322QA SG 10201609322Q A SG10201609322Q A SG 10201609322QA SG 10201609322Q A SG10201609322Q A SG 10201609322QA SG 10201609322Q A SG10201609322Q A SG 10201609322QA
- Authority
- SG
- Singapore
- Prior art keywords
- binding
- antibodies capable
- activated form
- form factor
- xia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12167438 | 2012-05-10 | ||
| EP12181697 | 2012-08-24 | ||
| EP13150361 | 2013-01-07 | ||
| US201361817675P | 2013-04-30 | 2013-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201609322QA true SG10201609322QA (en) | 2017-01-27 |
Family
ID=49550177
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201609322QA SG10201609322QA (en) | 2012-05-10 | 2013-05-08 | Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof |
| SG11201406719UA SG11201406719UA (en) | 2012-05-10 | 2013-05-08 | Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201406719UA SG11201406719UA (en) | 2012-05-10 | 2013-05-08 | Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US9783614B2 (pt) |
| EP (2) | EP2847228B1 (pt) |
| JP (2) | JP6348900B2 (pt) |
| KR (1) | KR102060376B1 (pt) |
| CN (1) | CN104684932B (pt) |
| AR (1) | AR091024A1 (pt) |
| AU (2) | AU2013258043B2 (pt) |
| BR (1) | BR112014027952B1 (pt) |
| CA (1) | CA2872926C (pt) |
| DK (1) | DK2847228T3 (pt) |
| ES (1) | ES2698950T3 (pt) |
| HK (1) | HK1207091A1 (pt) |
| HR (1) | HRP20181680T1 (pt) |
| HU (1) | HUE040580T2 (pt) |
| IL (1) | IL235238B (pt) |
| LT (1) | LT2847228T (pt) |
| MX (1) | MX362454B (pt) |
| NZ (1) | NZ701121A (pt) |
| PL (1) | PL2847228T3 (pt) |
| RS (1) | RS57889B1 (pt) |
| SG (2) | SG10201609322QA (pt) |
| SI (1) | SI2847228T1 (pt) |
| TW (2) | TWI631140B (pt) |
| WO (1) | WO2013167669A1 (pt) |
| ZA (1) | ZA201407784B (pt) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8236316B2 (en) | 2007-11-21 | 2012-08-07 | Oregon Health & Science University | Anti-factor XI monoclonal antibodies and methods of use thereof |
| EP2373691B1 (en) | 2008-12-18 | 2019-01-23 | Oregon Health&Science University | Anti-fxi antibodies and methods of use |
| ES2579832T3 (es) | 2011-10-14 | 2016-08-17 | Bristol-Myers Squibb Company | Compuestos de tetrahidroisoquinolina sustituida como inhibidores del factor XIa |
| CN103987697B (zh) | 2011-10-14 | 2017-04-26 | 百时美施贵宝公司 | 作为因子xia抑制剂的取代的四氢异喹啉化合物 |
| SG11201401384UA (en) | 2011-10-14 | 2014-09-26 | Bristol Myers Squibb Co | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| LT2847228T (lt) * | 2012-05-10 | 2018-11-12 | Bayer Pharma Aktiengesellschaft | Antikūnai, galintys jungtis prie koaguliacijos faktoriaus xi ir (arba) jo aktyvuotos formos faktoriaus xia, ir jų panaudojimas |
| EP2906552B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| CN104837833B (zh) | 2012-10-12 | 2017-07-14 | 百时美施贵宝公司 | Xia因子抑制剂的晶型 |
| WO2014059214A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| ES2712699T3 (es) | 2013-03-25 | 2019-05-14 | Bristol Myers Squibb Co | Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa |
| NO2760821T3 (pt) | 2014-01-31 | 2018-03-10 | ||
| CN116987080A (zh) | 2014-01-31 | 2023-11-03 | 百时美施贵宝公司 | 作为因子xia抑制剂的具有杂环p2′基团的大环化合物 |
| CN107148428B (zh) | 2014-08-07 | 2021-03-09 | 诺华股份有限公司 | 血管生成素样蛋白4抗体和使用方法 |
| EP3194437B1 (en) | 2014-08-07 | 2021-01-20 | Novartis AG | Angiopoietin-like 4 (angptl4) antibodies and methods of use |
| JP6526796B2 (ja) | 2014-09-04 | 2019-06-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｆｘｉａ阻害剤であるジアミドマクロ環 |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| NZ733580A (en) | 2015-01-02 | 2024-02-23 | Takeda Pharmaceuticals Co | Bispecific antibodies against plasma kallikrein and factor xii |
| JOP20200312A1 (ar) * | 2015-06-26 | 2017-06-16 | Novartis Ag | الأجسام المضادة للعامل xi وطرق الاستخدام |
| CA3025896A1 (en) | 2015-07-23 | 2017-01-26 | The Regents Of The University Of California | Antibodies to coagulation factor xia and uses thereof |
| CN108884169B (zh) | 2016-01-22 | 2022-03-22 | 默沙东公司 | 抗凝血因子xi抗体 |
| US11059905B2 (en) | 2016-03-23 | 2021-07-13 | Prothix B.V. | Monoclonal antibodies against the active site of factor XI and uses thereof |
| TW201802121A (zh) | 2016-05-25 | 2018-01-16 | 諾華公司 | 抗因子XI/XIa抗體之逆轉結合劑及其用途 |
| AU2017286432B2 (en) | 2016-06-14 | 2020-09-24 | Adimab, Llc | Anti-coagulation factor XI antibodies |
| BR112019005449A2 (pt) * | 2016-09-20 | 2019-10-01 | Aronora Inc | anticorpos inovadores contra fator xi e usos dos mesmos |
| US20200054719A1 (en) * | 2016-11-02 | 2020-02-20 | Erik Ian Tucker | E-we thrombin analog and fibrinolytic combination |
| EP3559047A1 (en) * | 2016-12-23 | 2019-10-30 | Novartis AG | Factor xi antibodies and methods of use |
| AU2017383537A1 (en) * | 2016-12-23 | 2019-06-27 | Novartis Ag | Methods of treatment with anti-factor XI/XIa antibodies |
| LT3570882T (lt) * | 2017-01-19 | 2021-12-10 | Bayer Pharma Aktiengesellschaft | Nauja stabili kompozicija, skirta antikūnams fxia |
| CN108409863B (zh) * | 2017-02-10 | 2023-09-26 | 上海仁会生物制药股份有限公司 | 抗凝血因子xi抗体 |
| US11958911B2 (en) | 2017-02-10 | 2024-04-16 | Shanghai Benemae Pharmaceutical | Anti-coagulation factor XI antibody |
| EP3713965A1 (en) | 2017-11-22 | 2020-09-30 | Novartis AG | Reversal binding agents for anti-factor xi/xia antibodies and uses thereof |
| JP7149721B2 (ja) | 2018-03-26 | 2022-10-07 | 株式会社Pfu | 情報処理装置、文字認識エンジン最適化方法及びプログラム |
| CN112543627A (zh) * | 2018-07-05 | 2021-03-23 | 拜耳公司 | 新型稳定的高浓度抗FXIa抗体制剂 |
| BR112021000823A2 (pt) * | 2018-08-01 | 2021-04-13 | Novo Nordisk A/S | Anticorpo multiespecífico ou seu fragmento de ligação a antígeno. |
| EP4246834A3 (en) | 2018-08-07 | 2023-11-01 | Nippon Telegraph And Telephone Corporation | Optical transport system and transport mode selection method |
| KR20210042352A (ko) * | 2018-08-09 | 2021-04-19 | 상하이 베네마에 파머수티컬 코포레이션 | 항-인자 xi 항체 |
| WO2020061067A2 (en) * | 2018-09-17 | 2020-03-26 | Board Of Regents, The University Of Texas System Texas System | Compositions and methods for treating bone injury |
| EP3873944A1 (en) | 2018-10-31 | 2021-09-08 | Bayer Aktiengesellschaft | Reversal agents for neutralizing the therapeutic activity of anti-fxia antibodies |
| WO2020154234A1 (en) * | 2019-01-21 | 2020-07-30 | Aronora Inc. | Novel humanized antibodies against factor xi having anti-thrombotic and anti-inflammatory effects and uses thereof |
| WO2020211674A1 (zh) | 2019-04-16 | 2020-10-22 | 四川科伦博泰生物医药股份有限公司 | 抗FXI/FXIa抗体及其用途 |
| CN110423278B (zh) | 2019-08-08 | 2020-07-17 | 上海博槿生物科技有限公司 | 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用 |
| JP2023106635A (ja) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法 |
| CN117487017A (zh) * | 2020-07-02 | 2024-02-02 | 北京拓界生物医药科技有限公司 | 抗FXI/FXIa抗体、其抗原结合片段及医药用途 |
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| LT2847228T (lt) * | 2012-05-10 | 2018-11-12 | Bayer Pharma Aktiengesellschaft | Antikūnai, galintys jungtis prie koaguliacijos faktoriaus xi ir (arba) jo aktyvuotos formos faktoriaus xia, ir jų panaudojimas |
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2013
- 2013-05-08 LT LTEP13721746.9T patent/LT2847228T/lt unknown
- 2013-05-08 ES ES13721746T patent/ES2698950T3/es active Active
- 2013-05-08 SG SG10201609322QA patent/SG10201609322QA/en unknown
- 2013-05-08 WO PCT/EP2013/059618 patent/WO2013167669A1/en active Application Filing
- 2013-05-08 AU AU2013258043A patent/AU2013258043B2/en active Active
- 2013-05-08 SG SG11201406719UA patent/SG11201406719UA/en unknown
- 2013-05-08 EP EP13721746.9A patent/EP2847228B1/en active Active
- 2013-05-08 CN CN201380037161.1A patent/CN104684932B/zh active Active
- 2013-05-08 BR BR112014027952-7A patent/BR112014027952B1/pt active IP Right Grant
- 2013-05-08 CA CA2872926A patent/CA2872926C/en active Active
- 2013-05-08 SI SI201331209T patent/SI2847228T1/sl unknown
- 2013-05-08 PL PL13721746T patent/PL2847228T3/pl unknown
- 2013-05-08 US US14/400,281 patent/US9783614B2/en active Active
- 2013-05-08 EP EP18176293.1A patent/EP3404045A1/en not_active Withdrawn
- 2013-05-08 NZ NZ701121A patent/NZ701121A/en unknown
- 2013-05-08 MX MX2014013568A patent/MX362454B/es active IP Right Grant
- 2013-05-08 HU HUE13721746A patent/HUE040580T2/hu unknown
- 2013-05-08 JP JP2015510818A patent/JP6348900B2/ja active Active
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2014
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2015
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2017
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