SG10201608167UA - 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal - Google Patents

7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal

Info

Publication number
SG10201608167UA
SG10201608167UA SG10201608167UA SG10201608167UA SG10201608167UA SG 10201608167U A SG10201608167U A SG 10201608167UA SG 10201608167U A SG10201608167U A SG 10201608167UA SG 10201608167U A SG10201608167U A SG 10201608167UA SG 10201608167U A SG10201608167U A SG 10201608167UA
Authority
SG
Singapore
Prior art keywords
fluoropyrrolidine
cyclopropylamino
dihydroquinoline
fluoroethyl
oxo
Prior art date
Application number
SG10201608167UA
Other languages
English (en)
Inventor
Ichiro Araya
Akinori Goto
Wataru Minagawa
Keiko Funada
Muneki Nagao
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of SG10201608167UA publication Critical patent/SG10201608167UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SG10201608167UA 2011-11-10 2012-11-09 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal SG10201608167UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011246209 2011-11-10
JP2012071739 2012-03-27

Publications (1)

Publication Number Publication Date
SG10201608167UA true SG10201608167UA (en) 2016-11-29

Family

ID=48289529

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201608167UA SG10201608167UA (en) 2011-11-10 2012-11-09 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal
SG11201401817TA SG11201401817TA (en) 2011-11-10 2012-11-09 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201401817TA SG11201401817TA (en) 2011-11-10 2012-11-09 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal

Country Status (16)

Country Link
US (3) US9090587B2 (hr)
EP (2) EP2778159B1 (hr)
JP (4) JP5871948B2 (hr)
KR (2) KR102162208B1 (hr)
CN (2) CN103930414B (hr)
AU (1) AU2016273899B2 (hr)
BR (1) BR112014010765B1 (hr)
CA (1) CA2855022C (hr)
ES (2) ES2747303T3 (hr)
IN (1) IN2014DN03277A (hr)
NZ (1) NZ623808A (hr)
RU (2) RU2615509C2 (hr)
SA (1) SA112330992B1 (hr)
SG (2) SG10201608167UA (hr)
TW (1) TWI547492B (hr)
WO (1) WO2013069297A1 (hr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SA112330992B1 (ar) * 2011-11-10 2015-09-13 كيورين فارماسوتيكال كو.، ليمتد صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي
CN105338982B (zh) 2013-04-25 2017-10-10 杏林制药株式会社 固体药用组合物
CA2910121A1 (en) * 2013-04-25 2014-10-30 Kyorin Pharmaceutical Co., Ltd. A pharmaceutical composition comprising a 1,4-dihydroquinoline carboxylic acid a cellulosic excipient and a salting-out agent
WO2014174848A1 (ja) * 2013-04-25 2014-10-30 杏林製薬株式会社 錠剤
GB201402071D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2016063544A1 (ja) * 2014-10-23 2016-04-28 杏林製薬株式会社 固形医薬組成物
EP3210607A4 (en) * 2014-10-23 2018-06-06 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
CA2978261A1 (en) * 2015-03-13 2016-09-22 Kyorin Pharmaceutical Co., Ltd. Respiratory infection treating agent
EP3305294A4 (en) * 2015-06-02 2019-02-20 Kyorin Pharmaceutical Co., Ltd. AQUEOUS MEDICINE
WO2016195020A1 (ja) * 2015-06-02 2016-12-08 杏林製薬株式会社 水性液剤
CA2988092A1 (en) * 2015-06-02 2016-12-08 Kyorin Pharmaceutical Co., Ltd. Aqueous liquid formulation
TWI818910B (zh) 2017-06-16 2023-10-21 日商杏林製藥股份有限公司 吸入性肺炎、肺化膿症或肺膿瘍之治療劑
EA202090066A1 (ru) 2018-03-30 2020-04-15 Керин Фармасьютикал Ко., Лтд. Терапевтическое средство для лечения аспирационной пневмонии, легочного нагноения или абсцесса легких

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA944369B (en) * 1993-08-27 1995-02-13 Hokuriku Seuyaku Co Ltd 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative
CN1158846A (zh) * 1995-05-09 1997-09-10 昆山市康壮达兽药厂 盐酸氟哌酸的合成工艺
US20030119060A1 (en) 2001-08-10 2003-06-26 Desrosiers Peter J. Apparatuses and methods for creating and testing pre-formulations and systems for same
WO2003076428A1 (fr) * 2002-03-08 2003-09-18 Daiichi Pharmaceutical Co., Ltd. Derive d'acide quinolone-carboxylique
AU2004272414B2 (en) * 2003-09-10 2009-05-28 Kyorin Pharmaceutical Co., Ltd. 7-(4-substituted 3- cyclopropylaminomethyl-1- pyrrolidinyl) quinolonecarboxylic acid derivative
CN101003540A (zh) * 2006-01-18 2007-07-25 广州白云山制药股份有限公司广州白云山制药总厂 一种抗感染化合物和用途
SA112330992B1 (ar) * 2011-11-10 2015-09-13 كيورين فارماسوتيكال كو.، ليمتد صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي

Also Published As

Publication number Publication date
US20140288310A1 (en) 2014-09-25
EP2778159B1 (en) 2017-03-01
TWI547492B (zh) 2016-09-01
RU2014123567A (ru) 2015-12-20
JP6514069B2 (ja) 2019-05-15
CN103930414A (zh) 2014-07-16
RU2017109814A3 (hr) 2020-04-08
AU2016273899B2 (en) 2017-07-27
JPWO2013069297A1 (ja) 2015-04-02
BR112014010765A2 (pt) 2017-06-13
SA112330992B1 (ar) 2015-09-13
TW201332991A (zh) 2013-08-16
CN103930414B (zh) 2016-01-20
CA2855022A1 (en) 2013-05-16
AU2012337206A1 (en) 2014-05-22
EP2778159A4 (en) 2015-06-03
AU2016273899A1 (en) 2017-01-12
EP2778159A1 (en) 2014-09-17
SG11201401817TA (en) 2014-08-28
EP3112359A1 (en) 2017-01-04
WO2013069297A1 (ja) 2013-05-16
KR20190065456A (ko) 2019-06-11
US9328089B2 (en) 2016-05-03
USRE47785E1 (en) 2019-12-31
US20150284361A1 (en) 2015-10-08
JP6349435B2 (ja) 2018-06-27
CN104945375A (zh) 2015-09-30
KR102162208B1 (ko) 2020-10-06
AU2012337206B2 (en) 2016-09-15
NZ623808A (en) 2015-07-31
JP6818719B2 (ja) 2021-01-20
JP2018158949A (ja) 2018-10-11
BR112014010765B1 (pt) 2020-07-14
JP5871948B2 (ja) 2016-03-01
ES2621664T3 (es) 2017-07-04
RU2615509C2 (ru) 2017-04-05
CN104945375B (zh) 2017-07-04
US9090587B2 (en) 2015-07-28
JP2017160243A (ja) 2017-09-14
IN2014DN03277A (hr) 2015-05-22
ES2747303T3 (es) 2020-03-10
RU2017109814A (ru) 2019-01-23
JP2016027045A (ja) 2016-02-18
EP3112359B1 (en) 2019-08-21
CA2855022C (en) 2019-05-07
KR20140098074A (ko) 2014-08-07
AU2012337206A8 (en) 2016-09-22

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