SG10201508035TA - Inhibitors of bruton's tyrosine kinase - Google Patents

Inhibitors of bruton's tyrosine kinase

Info

Publication number
SG10201508035TA
SG10201508035TA SG10201508035TA SG10201508035TA SG10201508035TA SG 10201508035T A SG10201508035T A SG 10201508035TA SG 10201508035T A SG10201508035T A SG 10201508035TA SG 10201508035T A SG10201508035T A SG 10201508035TA SG 10201508035T A SG10201508035T A SG 10201508035TA
Authority
SG
Singapore
Prior art keywords
bruton
inhibitors
tyrosine kinase
tyrosine
kinase
Prior art date
Application number
SG10201508035TA
Other languages
English (en)
Inventor
Honigberg Lee
Verner Erik
J Buggy Joseph
Loury David
Chen Wei
Original Assignee
Pharmacyclics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/692,870 external-priority patent/US7732454B2/en
Application filed by Pharmacyclics Inc filed Critical Pharmacyclics Inc
Publication of SG10201508035TA publication Critical patent/SG10201508035TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/14—Post-translational modifications [PTMs] in chemical analysis of biological material phosphorylation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • General Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cell Biology (AREA)
SG10201508035TA 2007-03-28 2008-03-27 Inhibitors of bruton's tyrosine kinase SG10201508035TA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/692,870 US7732454B2 (en) 2006-09-22 2007-03-28 Inhibitors of Bruton's tyrosine kinase
US11/964,285 US7825118B2 (en) 2006-09-22 2007-12-26 Inhibitors of bruton's tyrosine kinase
US1712507P 2007-12-27 2007-12-27

Publications (1)

Publication Number Publication Date
SG10201508035TA true SG10201508035TA (en) 2015-10-29

Family

ID=39808864

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202107066WA SG10202107066WA (en) 2007-03-28 2008-03-27 Inhibitors of bruton's tyrosine kinase
SG10201508035TA SG10201508035TA (en) 2007-03-28 2008-03-27 Inhibitors of bruton's tyrosine kinase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10202107066WA SG10202107066WA (en) 2007-03-28 2008-03-27 Inhibitors of bruton's tyrosine kinase

Country Status (14)

Country Link
EP (6) EP2139487B1 (fr)
JP (2) JP5347202B2 (fr)
KR (1) KR101425248B1 (fr)
CN (2) CN101674834B (fr)
AU (1) AU2008232762B2 (fr)
BR (1) BRPI0810086B1 (fr)
CA (4) CA2681756C (fr)
EA (1) EA017865B1 (fr)
ES (1) ES2562215T3 (fr)
IL (8) IL295053A (fr)
MX (2) MX2009010284A (fr)
NZ (1) NZ579911A (fr)
SG (2) SG10202107066WA (fr)
WO (1) WO2008121742A2 (fr)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546404B2 (en) 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
EP1984331B1 (fr) 2006-02-16 2010-10-20 Schering Corporation Dérivés de pyrrolidine comme inhibiteurs de la erk
EP2532235A1 (fr) 2006-09-22 2012-12-12 Pharmacyclics, Inc. Inhibiteurs de la tyrosine kinase de bruton
MX2009010284A (es) * 2007-03-28 2010-01-29 Pharmacyclics Inc Inhibidores de la tirosina-cinasa de bruton.
US20120101114A1 (en) 2007-03-28 2012-04-26 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
US8716483B2 (en) 2008-02-21 2014-05-06 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
EP3311818A3 (fr) 2008-07-16 2018-07-18 Pharmacyclics, LLC Inhibiteurs de tyrosine-kinase de bruton pour le traitement de tumeurs solides
US8765754B2 (en) 2009-04-29 2014-07-01 Locus Pharmaceuticals, Inc. Pyrrolotriazine compounds
EP2464647B1 (fr) * 2009-08-11 2016-09-21 Bristol-Myers Squibb Company Azaindoles en tant qe modulateurs du recepteur btk et leur utilisation
US7741330B1 (en) * 2009-10-12 2010-06-22 Pharmacyclics, Inc. Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
MY189483A (en) * 2010-05-31 2022-02-16 Ono Pharmaceutical Co Purinone derivative
AU2015275321B2 (en) * 2010-06-03 2018-03-15 Pharmacyclics Llc The use of inhibitors of Bruton's tyrosine kinase (Btk)
MX2020004501A (es) 2010-06-03 2021-11-09 Pharmacyclics Llc El uso de inhibidores de la tirosina quinasa de bruton (btk).
PT2710005T (pt) * 2011-05-17 2016-11-16 Principia Biopharma Inc Inibidores de tirosina-quinase
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
SG10201604682VA (en) * 2011-06-10 2016-07-28 Merck Patent Gmbh Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity
WO2013003629A2 (fr) * 2011-06-28 2013-01-03 Pharmacyclics, Inc. Procédés et compositions visant à inhiber la résorption osseuse
CA2841111A1 (fr) 2011-07-08 2013-01-17 Novartis Ag Nouveaux derives de pyrrolopyrimidine
CA2841080A1 (fr) 2011-07-13 2013-01-17 Pharmacyclics, Inc. Inhibiteurs de tyrosine kinase de bruton
AU2012285988B2 (en) * 2011-07-19 2017-05-25 Merck Sharp & Dohme B.V. 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides Btk-inhibitors
EP2548877A1 (fr) 2011-07-19 2013-01-23 MSD Oss B.V. Dérivés de 4-(pyridine condensée à 5 chaînons)benzamide comme inhibiteurs de BTK
ES2708224T3 (es) * 2011-07-19 2019-04-09 Merck Sharp & Dohme 4-Imidazopiridazín-1-il-benzamidas y 4-imidazotriazín-1-il-benzamidas como inhibidores de Btk
EP3409278B8 (fr) 2011-07-21 2020-11-04 Sumitomo Dainippon Pharma Oncology, Inc. Inhibiteurs de protéine kinase hétérocycliques
AR088643A1 (es) * 2011-11-03 2014-06-25 Genentech Inc Compuestos de 8-fluoroftalazin-1(2h)-ona
PL2786996T3 (pl) 2011-11-29 2017-01-31 Ono Pharmaceutical Co., Ltd. Chlorowodorowa pochodna purynonu
KR20130076046A (ko) * 2011-12-28 2013-07-08 한미약품 주식회사 타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
MX351513B (es) 2012-01-19 2017-10-17 Taiho Pharmaceutical Co Ltd Compuesto de alquinilbenceno 3,5-disustituido y sales del mismo.
US8501724B1 (en) * 2012-01-31 2013-08-06 Pharmacyclics, Inc. Purinone compounds as kinase inhibitors
TW201336847A (zh) * 2012-02-07 2013-09-16 Taiho Pharmaceutical Co Ltd 喹啉基吡咯并嘧啶化合物或其鹽
HUE029343T2 (en) * 2012-02-23 2017-02-28 Taiho Pharmaceutical Co Ltd Quinolylpyrrolo-pyrimidyl fused ring compounds and salts thereof
JPWO2013133367A1 (ja) * 2012-03-09 2015-07-30 カルナバイオサイエンス株式会社 新規トリアジン誘導体
US9365566B2 (en) 2012-03-27 2016-06-14 Takeda Pharmaceutical Company Limited Cinnoline derivatives
EP2855484A4 (fr) * 2012-05-31 2015-12-16 Pharmascience Inc Inhibiteurs de protéine kinases
TWI662963B (zh) 2012-06-04 2019-06-21 美商製藥有限責任公司 布魯頓氏酪胺酸激酶抑制劑之結晶形式
CA2782774A1 (fr) 2012-07-06 2014-01-06 Pharmascience Inc. Inhibiteurs de proteine kinase
KR20180088926A (ko) 2012-07-24 2018-08-07 파마싸이클릭스 엘엘씨 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
CA2881519A1 (fr) * 2012-08-10 2014-02-13 Boehringer Ingelheim International Gmbh Composes heteroromatiques en tant qu'inhibiteurs de la tyrosine kinase de bruton (btk)
WO2014036016A1 (fr) * 2012-08-31 2014-03-06 Principia Biopharma Inc. Dérivés de benzimidazole en tant qu'inhibiteurs d'itk
ES2731833T3 (es) 2012-09-10 2019-11-19 Principia Biopharma Inc Compuestos pirazolopirimidínicos comos inhibidores de cinasas
JP2015537033A (ja) 2012-11-15 2015-12-24 ファーマサイクリックス，インク． キナーゼ阻害剤としてのピロロピリミジン化合物
CN103848810A (zh) * 2012-11-30 2014-06-11 北京赛林泰医药技术有限公司 鲁顿酪氨酸激酶抑制剂
WO2014114185A1 (fr) * 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Inhibiteurs de btk
WO2014129596A1 (fr) 2013-02-22 2014-08-28 大鵬薬品工業株式会社 Procédé de production de composé tricyclique, et composé tricyclique apte à être produit par ledit procédé de production
JO3377B1 (ar) 2013-03-11 2019-03-13 Takeda Pharmaceuticals Co مشتقات بيريدينيل وبيريدينيل مندمج
WO2014151620A1 (fr) * 2013-03-14 2014-09-25 Boehringer Ingelheim International Gmbh Dérivés de 5-thiazolecarboxamide et leur utilisation en tant qu'inhibiteurs de btk
US8940893B2 (en) 2013-03-15 2015-01-27 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as BTK inhibitors
JP6777398B2 (ja) * 2013-03-15 2020-10-28 ヤンセン ファーマシューティカ エヌ．ベー． 薬剤を調製するための方法と中間体
BR112015025250A2 (pt) * 2013-04-02 2017-07-18 Hoffmann La Roche inibidores de tirosina quinase de bruton
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
GB201309085D0 (en) 2013-05-20 2013-07-03 Redx Pharma Ltd Compounds
JP6139782B2 (ja) * 2013-05-21 2017-05-31 チャンスー メドリューション リミテッド 置換ピラゾロピリミジン化合物、及びその薬学的に許容される塩、並びにこれらの溶媒和物、立体異性体、及び互変異性体、並びにこれらを含む医薬組成物
CA2917167A1 (fr) 2013-07-02 2015-01-08 Pharmacyclics Llc Composes purinones comme inhibiteurs de kinase
ES2819398T3 (es) 2013-07-18 2021-04-15 Taiho Pharmaceutical Co Ltd Agente terapéutico para el cáncer resistente al inhibidor de FGFR
DK3023100T3 (da) * 2013-07-18 2019-05-27 Taiho Pharmaceutical Co Ltd Antitumorlægemiddel til intermitterende administration af fgfr-hæmmer
JP6800750B2 (ja) 2013-08-02 2020-12-16 ファーマサイクリックス エルエルシー 固形腫瘍の処置方法
JP6429292B2 (ja) 2013-08-12 2018-11-28 ファーマサイクリックス エルエルシー Ｈｅｒ２増幅性癌の処置のための方法
WO2015022926A1 (fr) * 2013-08-12 2015-02-19 大鵬薬品工業株式会社 Nouveau composé pyrimidine fusionnée ou son sel
CA2925624C (fr) 2013-09-30 2021-06-15 Beijing Synercare Pharma Tech Co., Ltd. Inhibiteurs de nicotinimide substitues de btk et leur preparation et utilisation dans le traitement du cancer, d'inflammations et des maladies auto-immunes
CR20160203A (es) 2013-09-30 2016-08-31 Pharmacyclics Llc Inhibidores de tirosina cinasa de bruton
US9795604B2 (en) 2013-10-25 2017-10-24 Pharmacyclics Llc Methods of treating and preventing graft versus host disease
CA2833867A1 (fr) * 2013-11-21 2015-05-21 Pharmascience Inc. Inhibiteurs de proteine kinase
BR112016012794A2 (pt) 2013-12-05 2017-08-08 Acerta Pharma Bv Combinação terapêutica de um inibidor de pi3k e um inibidor de btk
US9637486B2 (en) 2013-12-20 2017-05-02 Merck Sharp & Dohme Corp. Btk inhibitors
US9834554B2 (en) 2013-12-20 2017-12-05 Merck Sharp & Dohme Corp. BTK inhibitors
US10272083B2 (en) 2014-01-21 2019-04-30 Acerta Pharma B.V. Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor
EP3099674B1 (fr) 2014-01-29 2018-10-24 Boehringer Ingelheim International Gmbh Composés de pyrazole utilisés en tant qu'inhibiteurs de btk
JP6162904B2 (ja) 2014-02-03 2017-07-12 カディラ ヘルスケア リミティド 新規複素環式化合物
JP6504548B2 (ja) 2014-02-21 2019-04-24 プリンシピア バイオファーマ インコーポレイテッド Ｂｔｋ阻害剤の塩および固体形態
US9885086B2 (en) 2014-03-20 2018-02-06 Pharmacyclics Llc Phospholipase C gamma 2 and resistance associated mutations
JP6528779B2 (ja) 2014-03-25 2019-06-12 小野薬品工業株式会社 びまん性大細胞型ｂ細胞リンパ腫の予防および／または治療剤
US9937171B2 (en) 2014-04-11 2018-04-10 Acerta Pharma B.V. Methods of blocking the CXCR-4/SDF-1 signaling pathway with inhibitors of bruton's tyrosine kinase
CN105017256A (zh) 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
CN106458919B (zh) * 2014-05-13 2019-03-15 广东东阳光药业有限公司 一种中间体的制备方法
CN104086551B (zh) * 2014-06-06 2016-09-21 人福医药集团股份公司 化合物及其制备方法和用途
GB201410430D0 (en) 2014-06-11 2014-07-23 Redx Pharma Ltd Compounds
US9949971B2 (en) 2014-06-17 2018-04-24 Acerta Pharma B.V. Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor
MX2017000331A (es) * 2014-07-07 2017-08-25 Eternity Bioscience Inc Compuestos de aminopiridazinona como inhibidores de quinasas de proteina.
EP3174539A4 (fr) * 2014-08-01 2017-12-13 Pharmacyclics, LLC Inhibiteurs de la tyrosine kinase de bruton
MX2017001671A (es) 2014-08-07 2017-07-04 Pharmacyclics Llc Formulaciones novedosas de un inhibidor de la tirosina cinasa de bruton.
CN105461720B (zh) * 2014-08-08 2019-08-06 南京圣和药业股份有限公司 吗啉类酪氨酸激酶抑制剂
DK3179991T3 (da) 2014-08-11 2021-12-06 Acerta Pharma Bv Terapeutiske kombinationer af en btk-inhibitor og en bcl-2-inhibitor
EP3212653A2 (fr) * 2014-10-30 2017-09-06 Sandoz AG Acrylamides actifs
CN104407067B (zh) * 2014-11-17 2016-01-20 广东东阳光药业有限公司 依鲁替尼及其异构体的检测方法
CN104447761A (zh) * 2014-11-27 2015-03-25 广东东阳光药业有限公司 一种吡唑衍生物的制备方法
US10485797B2 (en) 2014-12-18 2019-11-26 Principia Biopharma Inc. Treatment of pemphigus
CN105837576B (zh) * 2015-01-14 2019-03-26 湖北生物医药产业技术研究院有限公司 Btk抑制剂
MA41350A (fr) * 2015-01-14 2017-11-21 Janssen Pharmaceutica Nv Synthèse d'un inhibiteur de la tyrosine kinase de bruton
CN104557945B (zh) * 2015-01-27 2017-08-04 安润医药科技（苏州）有限公司 依鲁替尼合成方法
EP3257855B1 (fr) * 2015-02-12 2020-04-22 Shanghai Dude Medical Science and Technology Co., Ltd. Procédé de préparation d'ibrutinib
ES2971597T3 (es) 2015-03-03 2024-06-06 Pharmacyclics Llc Formulaciones farmacéuticas del inhibidor de la tirosina quinasa de Bruton
US9717745B2 (en) 2015-03-19 2017-08-01 Zhejiang DTRM Biopharma Co. Ltd. Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
CN106146508A (zh) * 2015-03-19 2016-11-23 浙江导明医药科技有限公司 优化的联合用药及其治疗癌症和自身免疫疾病的用途
WO2016151438A1 (fr) * 2015-03-20 2016-09-29 Sun Pharmaceutical Industries Limited Procédé de préparation d'ibrutinib
MA41828A (fr) * 2015-03-27 2018-01-30 Pharmacyclics Llc Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton
MA41827A (fr) * 2015-03-27 2018-01-30 Pharmacyclics Llc Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton
MX2017012568A (es) 2015-03-31 2018-01-25 Taiho Pharmaceutical Co Ltd Cristal del compuesto alquinil benceno 3,5-disustituido.
CN106146511A (zh) * 2015-04-03 2016-11-23 安润医药科技（苏州）有限公司 吡唑并嘧啶衍生物、制备方法、药物组合物及用途
ES2955554T3 (es) 2015-04-09 2023-12-04 Ono Pharmaceutical Co Proceso para producir un derivado de purinona
CN106146512B (zh) * 2015-04-09 2018-07-17 北京睿创康泰医药研究院有限公司 依鲁替尼的制备方法
CN104844573A (zh) * 2015-04-17 2015-08-19 中国药科大学 嘧啶类btk抑制剂、其制备方法及医药用途
MA42242A (fr) * 2015-06-24 2018-05-02 Principia Biopharma Inc Inhibiteurs de la tyrosine kinase
RS64195B1 (sr) 2015-07-02 2023-06-30 Acerta Pharma Bv Čvrsti oblici i formulacije (s)-4-(8-amino-3-(1-(but-2-inoil)pirolidin-2-il)imidazo[1,5-a]pirazin-1-il)-n-(piridin-2-il)benzamida
LV15201B (lv) 2015-08-31 2017-07-20 Latvijas Organiskās Sintēzes Institūts Ibrutiniba izejvielas iegūšanas paņēmiens
CN108349981B (zh) * 2015-09-01 2021-03-30 大鹏药品工业株式会社 新型的吡唑并[3，4－d]嘧啶化合物或其盐
MA41559A (fr) * 2015-09-08 2017-12-26 Taiho Pharmaceutical Co Ltd Composé de pyrimidine condensé ou un sel de celui-ci
TW201722957A (zh) * 2015-09-15 2017-07-01 葛蘭素史克智慧財產（第二）有限公司 化學化合物
EP4116303A1 (fr) 2015-09-16 2023-01-11 Loxo Oncology, Inc. Dérivés de pyrazolopyrimidine en tant qu'inhibiteurs de btk pour le traitement du cancer
CO2018006164A2 (es) 2015-12-16 2018-09-20 Loxo Oncology Inc Compuestos útiles como inhibidores de cinasa
KR102691112B1 (ko) 2015-12-16 2024-08-05 베링거 인겔하임 인터내셔날 게엠베하 자가 면역 질환의 치료에 유용한 비피라졸릴 유도체
WO2017118277A1 (fr) 2016-01-05 2017-07-13 江苏恒瑞医药股份有限公司 Forme cristalline d'un inhibiteur de la tyrosine kinase de bruton (btk) et son procédé de préparation
EP3402789B1 (fr) 2016-01-13 2020-03-18 Boehringer Ingelheim International Gmbh Isoquinolones comme inhibiteurs de btk
CN106995446B (zh) * 2016-01-22 2021-07-02 山东新时代药业有限公司 布鲁顿酪氨酸激酶抑制剂制备方法
WO2017134588A1 (fr) 2016-02-04 2017-08-10 Shilpa Medicare Limited Procédé de préparation d'ibrutinib
WO2017133630A1 (fr) * 2016-02-05 2017-08-10 北京盛诺基医药科技有限公司 Inhibiteur de la tyrosine kinase de bruton
JP7085985B2 (ja) 2016-03-04 2022-06-17 大鵬薬品工業株式会社 悪性腫瘍治療用製剤及び組成物
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
CN109071496B (zh) 2016-03-31 2021-07-30 武田药品有限公司 异喹啉基三唑酮复合物
MX2018012456A (es) 2016-04-12 2019-03-07 Lilly Co Eli Terapia combinatoria con inhibidores notch y pi3k/mtor.
EP3458091B1 (fr) 2016-05-20 2021-11-17 Eli Lilly and Company Traitement d'association utilisant des inhibiteurs de notch et de pd-1 ou pd-l1
CN106083860A (zh) * 2016-06-23 2016-11-09 艾美科健（中国）生物医药有限公司 一种依鲁替尼中间体的合成与纯化工艺
BR112018077503A2 (pt) 2016-06-29 2019-04-09 Principia Biopharma Inc. formulações de liberação modificada de 2-[3-[4-amino-3-(2-fluoro-4- fenoxi-fenil)pirazolo [3,4-d]pirimidin-1-il]piperidino-1- carbonil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il] pent-2-enenitrila
ES2878973T3 (es) * 2016-06-30 2021-11-19 Hangzhou Bangshun Pharmaceutical Co Ltd Derivado de fenilo de imidazopiridinamina y uso del mismo
CN107759602B (zh) * 2016-08-17 2020-04-21 中国科学院上海药物研究所 含有共轭联烯结构的化合物、其药物组合物和用途
EP3492471B1 (fr) * 2016-08-17 2020-12-02 Shenzhen TargetRx, Inc. Composé bicyclique fusionné pour inhiber l'activité de la tyrosine kinase
MA46205A (fr) * 2016-09-08 2019-07-17 Sabila Biosciences Llc Composés 1,2-dithiolane utiles dans la neuroprotection, les maladies et les états auto-immuns et cancéreux
SG10202102845XA (en) 2016-09-19 2021-05-28 Mei Pharma Inc Combination therapy
EP3525796A1 (fr) 2016-10-12 2019-08-21 Eli Lilly and Company Traitement ciblé de lymphome à cellules t matures
CN108069974B (zh) * 2016-11-15 2019-12-10 杭州和正医药有限公司 一种选择性布鲁顿酪氨酸激酶抑制剂及其应用
JOP20190113A1 (ar) * 2016-11-18 2019-05-15 Biocad Joint Stock Co مثبطات بروتون تيروزين كيناز
CN108101905A (zh) * 2016-11-24 2018-06-01 中国科学院上海药物研究所 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
MX2019006288A (es) 2016-12-03 2020-10-01 Juno Therapeutics Inc Metodos y composiciones para el uso de celulas t terapeuticas en combinacion con inhibidores de quinasa.
CN106588937B (zh) * 2017-01-16 2018-09-21 东莞市真兴贝特医药技术有限公司 咪唑并吡嗪类化合物及其制备方法和应用
US10370381B2 (en) 2017-02-24 2019-08-06 Gilead Sciences, Inc. Inhibitors of bruton'S tyrosine kinase
WO2018156901A1 (fr) 2017-02-24 2018-08-30 Gilead Sciences, Inc. Inhibiteurs de tyrosine kinase de bruton
MX2019011116A (es) * 2017-03-22 2020-02-05 Liao Xibin Inhibidores de la tirosina quinasa de bruton.
CN108727230B (zh) * 2017-04-21 2021-03-23 江苏希迪制药有限公司 依鲁替尼中间体及其制备方法
CN107043366B (zh) * 2017-04-25 2020-05-26 中国药科大学 4-氨基嘧啶类化合物、其制备方法及医药用途
CN109111446B (zh) * 2017-06-22 2021-11-30 上海度德医药科技有限公司 一种具有药物活性的杂芳基化合物
CN107602564B (zh) * 2017-09-20 2019-08-30 南京亘泰医药技术有限公司 布鲁顿酪氨酸激酶抑制剂
TW201922256A (zh) 2017-10-27 2019-06-16 中國大陸商浙江導明醫藥科技有限公司 治療淋巴樣惡性疾病之方法
US11100492B2 (en) 2018-02-19 2021-08-24 Peter Garrett General purpose re-loadable card aggregation implementation
US11028088B2 (en) * 2018-03-10 2021-06-08 Yale University Modulators of BTK proteolysis and methods of use
AU2019239404B2 (en) 2018-03-19 2021-12-23 Taiho Pharmaceutical Co., Ltd. Pharmaceutical composition including sodium alkyl sulfate
CA3096984A1 (fr) 2018-04-05 2019-10-10 Sumitomo Dainippon Pharma Oncology, Inc. Inhibiteurs de kinases axl et leur utilisation
EP3773560A4 (fr) 2018-04-13 2022-01-19 Sumitomo Dainippon Pharma Oncology, Inc. Inhibiteurs de kinase pim pour le traitement de néoplasmes myéloprolifératifs et de fibrose associée au cancer
US20210113568A1 (en) 2018-04-27 2021-04-22 Ono Pharmaceutical Co., Ltd. PREVENTIVE AND/OR THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASE COMPRISING COMPOUND HAVING Btk INHIBITORY ACTIVITY AS ACTIVE INGREDIENT
CN112512597A (zh) 2018-07-26 2021-03-16 大日本住友制药肿瘤公司 用于治疗与acvr1表达异常相关的疾病的方法以及用于此的acvr1抑制剂
CN112638878A (zh) 2018-08-29 2021-04-09 安塞塔制药公司 制备4-{8-氨基-3-[(2S)-1-(丁-2-炔酰基)-吡咯烷-2-基]咪唑并[1,5-a]-吡嗪-1-基}N-(吡啶-2-基)-苯甲酰胺的方法
CN111440172B (zh) * 2019-01-17 2022-02-11 暨南大学 丙烯酰胺类化合物及其应用
CN111454268B (zh) * 2019-01-18 2023-09-08 明慧医药（上海）有限公司 作为布鲁顿酪氨酸激酶抑制剂的环状分子
CA3127502A1 (fr) 2019-02-12 2020-08-20 Sumitomo Dainippon Pharma Oncology, Inc. Formulations comprenant des inhibiteurs de proteine kinase heterocycliques
CA3129665A1 (fr) 2019-03-21 2020-09-24 Onxeo Molecule dbait associee a un inhibiteur de kinase pour le traitement du cancer
WO2020252397A1 (fr) * 2019-06-12 2020-12-17 Baylor College Of Medicine Chimères ciblant la protéolyse à petites molécules et leurs méthodes d'utilisation
HRP20240283T1 (hr) * 2019-09-26 2024-05-10 Jumbo Drug Bank Co., Ltd. Derivati 4-fluoro-1h-pirazolo[3,4-c]piridina kao selektivni inhibitori brutonove tirozin kinaze (btk) za liječenje b-staničnih limfoma i autoimunih bolesti
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
US20230322761A1 (en) * 2020-03-11 2023-10-12 Beigene, Ltd. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use
WO2021184154A1 (fr) 2020-03-16 2021-09-23 Flash Therapeutics, Llc Composés pour le traitement ou l'inhibition de la récurrence d'une leucémie myéloïde aiguë
WO2022094172A2 (fr) * 2020-10-30 2022-05-05 Newave Pharmaceutical Inc. Inhibiteurs de btk
CN112574216B (zh) * 2020-12-16 2022-03-08 天津济坤医药科技有限公司 一种化合物及其制备方法以及其在制备治疗抗癌药物中的应用
CN113004246B (zh) * 2021-02-22 2022-02-01 广西医科大学 1，3，5-三嗪-2-胺-4，6取代衍生物或其药学上可接受的盐和用途
CN113402523B (zh) * 2021-07-13 2022-07-12 西安交通大学 一种靶向肥大细胞MrgX2小分子荧光探针及制备方法和应用
CN114195790B (zh) * 2021-11-18 2023-01-06 江苏阿尔法药业股份有限公司 一种依鲁替尼的合成方法
CN114276355B (zh) * 2022-01-26 2023-04-07 江苏阿尔法药业股份有限公司 一种依鲁替尼的制备方法
CN114605418B (zh) * 2022-03-15 2023-09-05 广东医科大学附属医院 一类具有抗肿瘤活性的依鲁替尼丙烯酰胺类衍生物及其合成方法与应用
WO2024097653A1 (fr) 2022-10-31 2024-05-10 Sumitomo Pharma America, Inc. Inhibiteur de pim-1 pour le traitement de néoplasmes myéloprolifératifs

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
GB9226855D0 (en) * 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
US6326469B1 (en) 1994-04-22 2001-12-04 Sugen, Inc. Megakaryocytic protein tyrosine kinases
WO1997049706A1 (fr) * 1996-06-25 1997-12-31 Novartis Ag 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES SUBSTITUES ET UTILISATION DE CES COMPOSES
HUP0001507A3 (en) * 1997-03-19 2002-01-28 Abbott Gmbh & Co Kg Pyrrolo [2,3-d] pyrimidine derivatives, process for their preparation, their use and pharmaceutical compositions containing them
US6303652B1 (en) * 1998-08-21 2001-10-16 Hughes Institute BTK inhibitors and methods for their identification and use
US20050287596A9 (en) * 1998-06-26 2005-12-29 Braisted Andrew C Novel ligands and libraries of ligands
US6998233B2 (en) * 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
US6335155B1 (en) * 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
SK3812002A3 (en) 1999-09-17 2003-09-11 Abbott Gmbh & Co Kg Pyrazolopyrimidines as therapeutic agents
US6414013B1 (en) 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
MXPA03008560A (es) * 2001-03-22 2004-06-30 Abbot Gmbh & Co Kg Pirazolopirimidinas como agentes terapeuticos.
US20040248906A1 (en) * 2001-08-10 2004-12-09 Donato Nicholas J Use of c-src inhibitors alone or in combination with st1571 for the treatment of leukaemia
IL161409A0 (en) * 2001-11-21 2004-09-27 Sunesis Pharmaceuticals Inc Methods for ligand discovery
US20050084905A1 (en) * 2002-03-21 2005-04-21 Prescott John C. Identification of kinase inhibitors
GB2388594A (en) * 2002-05-16 2003-11-19 Bayer Ag Imidazo-triazine PDE 4 inhibitors
GB0303910D0 (en) * 2003-02-20 2003-03-26 Merck Sharp & Dohme Therapeutic agents
US7687506B2 (en) * 2003-04-11 2010-03-30 The Regents Of The University Of California Selective serine/threonine kinase inhibitors
EP1473039A1 (fr) * 2003-05-02 2004-11-03 Centre National De La Recherche Scientifique (Cnrs) Utilisation d'inhibiteurs et d'oligonucleotitides antisense de BTK pour le traitement de la mastocytose proliferative
US7405295B2 (en) * 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
JP2005089352A (ja) * 2003-09-16 2005-04-07 Kissei Pharmaceut Co Ltd 新規なイミダゾ［１，５−ａ］ピラジン誘導体、それを含有する医薬組成物およびそれらの用途
ATE525377T1 (de) * 2003-10-15 2011-10-15 Osi Pharm Inc Imidazoä1,5-aüpyrazine als inhibitoren von tyrosinkinase
ITMI20041314A1 (it) * 2004-06-30 2004-09-30 Nuvera Fuel Cells Europ Srl Dispositivo di raffreddamento per celle a combustibili a membrana
AR053090A1 (es) * 2004-07-20 2007-04-25 Osi Pharm Inc Imidazotriazinas como inhibidores de proteina quinasas y su uso para la preparacion de medicamentos
CA2582225A1 (fr) * 2004-09-28 2006-04-06 Mingde Xia Antagonistes anti-ccr2 a base de dipiperidine substituee
BRPI0517619A (pt) * 2004-11-10 2008-10-14 Cgi Pharmaceuticals Inc entidades quìmicas de imidazo[1,2-a] pirazin-8-ilaminas, suas composições farmacêuticas, uso dos referidos compostos na preparação de medicamento, processo de preparação de medicamento e métodos de utilização dos referidos compostos
EP1891066B1 (fr) * 2005-05-13 2010-12-22 Irm, Llc Composes et compositions convenant comme inhibiteurs de proteine kinase
WO2007002433A1 (fr) * 2005-06-22 2007-01-04 Plexxikon, Inc. Derives de pyrrolo [2, 3-b] pyridine utilises comme inhibiteurs de proteines kinases
BRPI0621027A2 (pt) * 2006-01-13 2011-11-29 Pharmacyclics Inc composto, composição farmacêutica
US8604031B2 (en) * 2006-05-18 2013-12-10 Mannkind Corporation Intracellular kinase inhibitors
EP2532235A1 (fr) * 2006-09-22 2012-12-12 Pharmacyclics, Inc. Inhibiteurs de la tyrosine kinase de bruton
ES2403546T3 (es) * 2006-11-03 2013-05-20 Pharmacyclics, Inc. Sonda de actividad de la tirosina-cinasa de Bruton y procedimiento de utilización
MX2009010284A (es) * 2007-03-28 2010-01-29 Pharmacyclics Inc Inhibidores de la tirosina-cinasa de bruton.

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