SE9903345D0 - Novel process - Google Patents

Novel process

Info

Publication number
SE9903345D0
SE9903345D0 SE9903345A SE9903345A SE9903345D0 SE 9903345 D0 SE9903345 D0 SE 9903345D0 SE 9903345 A SE9903345 A SE 9903345A SE 9903345 A SE9903345 A SE 9903345A SE 9903345 D0 SE9903345 D0 SE 9903345D0
Authority
SE
Sweden
Prior art keywords
novel process
acid
hydrolysing
amine
salts
Prior art date
Application number
SE9903345A
Other languages
English (en)
Swedish (sv)
Inventor
Mark Purdie
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Priority to SE9903345A priority Critical patent/SE9903345D0/xx
Publication of SE9903345D0 publication Critical patent/SE9903345D0/xx
Priority to NZ517552A priority patent/NZ517552A/en
Priority to EP00958856A priority patent/EP1216253B1/en
Priority to CNB008121826A priority patent/CN1150200C/zh
Priority to IL14844200A priority patent/IL148442A/xx
Priority to KR1020027003519A priority patent/KR100776105B1/ko
Priority to PCT/GB2000/003473 priority patent/WO2001021629A1/en
Priority to JP2001525004A priority patent/JP4881524B2/ja
Priority to ES00958856T priority patent/ES2200921T3/es
Priority to PT00958856T priority patent/PT1216253E/pt
Priority to AU70270/00A priority patent/AU771628B2/en
Priority to AT00958856T priority patent/ATE242778T1/de
Priority to CA002383829A priority patent/CA2383829C/en
Priority to BR0014057-0A priority patent/BR0014057A/pt
Priority to DK00958856T priority patent/DK1216253T3/da
Priority to DE60003323T priority patent/DE60003323T2/de
Priority to US10/088,177 priority patent/US6657076B1/en
Priority to TW089118778A priority patent/TWI274057B/zh
Priority to MYPI20004298A priority patent/MY119965A/en
Priority to ARP000104849A priority patent/AR029393A1/es
Priority to CO00070530A priority patent/CO5231228A1/es
Priority to ZA200201661A priority patent/ZA200201661B/en
Priority to NO20021269A priority patent/NO331532B1/no
Priority to HK02107336.6A priority patent/HK1045696B/zh
Priority to US10/725,820 priority patent/US7288673B2/en
Priority to IL168246A priority patent/IL168246A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3856—Polyphosphonic acids containing halogen or nitro(so) substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3843—Polyphosphonic acids containing no further substituents than -PO3H2 groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE9903345A 1999-09-17 1999-09-17 Novel process SE9903345D0 (sv)

Priority Applications (26)

Application Number Priority Date Filing Date Title
SE9903345A SE9903345D0 (sv) 1999-09-17 1999-09-17 Novel process
US10/088,177 US6657076B1 (en) 1999-09-17 2000-09-11 Process for preparing methylene bisphosphonic and salts
CA002383829A CA2383829C (en) 1999-09-17 2000-09-11 Process for preparing methylene bisphosphonic and salts
DK00958856T DK1216253T3 (da) 1999-09-17 2000-09-11 Fremgangsmåde til fremstilling af methylendiphosphonsyrer og salte deraf
CNB008121826A CN1150200C (zh) 1999-09-17 2000-09-11 制备亚甲基二膦酸盐的方法
IL14844200A IL148442A (en) 1999-09-17 2000-09-11 Process for preparing salts of methylene bisphosphonic acid
KR1020027003519A KR100776105B1 (ko) 1999-09-17 2000-09-11 메틸렌 비스포스폰산 염의 제조 방법
PCT/GB2000/003473 WO2001021629A1 (en) 1999-09-17 2000-09-11 Process for preparing methylene bisphosphonic and salts
JP2001525004A JP4881524B2 (ja) 1999-09-17 2000-09-11 メチレンビスホスホン酸および塩の調製方法
ES00958856T ES2200921T3 (es) 1999-09-17 2000-09-11 Proceso para preparacion de acidos metileno-bisfosfonicos y sus sales.
PT00958856T PT1216253E (pt) 1999-09-17 2000-09-11 Processo para a preparacao de acidos metileno bisfosfonicos e seus sais
AU70270/00A AU771628B2 (en) 1999-09-17 2000-09-11 Process for preparing methylene bisphosphonic and salts
AT00958856T ATE242778T1 (de) 1999-09-17 2000-09-11 Verfahren für die herstellung von methylenbisphosphonsäure und deren salze
NZ517552A NZ517552A (en) 1999-09-17 2000-09-11 Process for preparing methylene bisphosphonic and salts
BR0014057-0A BR0014057A (pt) 1999-09-17 2000-09-11 Processo para preparar ácido metileno bisfosfÈnico substituìdo ou não substituìdo, e, sal do mesmo
EP00958856A EP1216253B1 (en) 1999-09-17 2000-09-11 Process for preparing methylene bisphosphonic acids and salts thereof
DE60003323T DE60003323T2 (de) 1999-09-17 2000-09-11 Verfahren für die herstellung von methylenbisphosphonsäure und deren salze
TW089118778A TWI274057B (en) 1999-09-17 2000-09-14 Salts of substituted or unsubstituted methylene bisphosphonic acid and process for preparing the same
MYPI20004298A MY119965A (en) 1999-09-17 2000-09-15 Process for preparing methylene bisphosphonic acids and salts thereof.
ARP000104849A AR029393A1 (es) 1999-09-17 2000-09-15 Sales de un acido metilenbifosfonico sustituido o sin sustituir, proceso para prepararlas
CO00070530A CO5231228A1 (es) 1999-09-17 2000-09-18 Proceso para la producciòn de nalquil-2-analogos de atp sustituidos
ZA200201661A ZA200201661B (en) 1999-09-17 2002-02-27 Process for preparing methylene bisphosphonic and salts.
NO20021269A NO331532B1 (no) 1999-09-17 2002-03-14 Fremgangsmate for fremstilling av salter av metylenbisfosfonsyre
HK02107336.6A HK1045696B (zh) 1999-09-17 2002-10-07 製備亞甲基二膦酸和鹽的方法
US10/725,820 US7288673B2 (en) 1999-09-17 2003-12-01 Salts of substituted methylene bisphosphonic acids
IL168246A IL168246A (en) 1999-09-17 2005-04-26 Mono salts of a substituted or unsubstituted methylene biphosphonic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9903345A SE9903345D0 (sv) 1999-09-17 1999-09-17 Novel process

Publications (1)

Publication Number Publication Date
SE9903345D0 true SE9903345D0 (sv) 1999-09-17

Family

ID=20417040

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9903345A SE9903345D0 (sv) 1999-09-17 1999-09-17 Novel process

Country Status (24)

Country Link
US (2) US6657076B1 (no)
EP (1) EP1216253B1 (no)
JP (1) JP4881524B2 (no)
KR (1) KR100776105B1 (no)
CN (1) CN1150200C (no)
AR (1) AR029393A1 (no)
AT (1) ATE242778T1 (no)
AU (1) AU771628B2 (no)
BR (1) BR0014057A (no)
CA (1) CA2383829C (no)
CO (1) CO5231228A1 (no)
DE (1) DE60003323T2 (no)
DK (1) DK1216253T3 (no)
ES (1) ES2200921T3 (no)
HK (1) HK1045696B (no)
IL (2) IL148442A (no)
MY (1) MY119965A (no)
NO (1) NO331532B1 (no)
NZ (1) NZ517552A (no)
PT (1) PT1216253E (no)
SE (1) SE9903345D0 (no)
TW (1) TWI274057B (no)
WO (1) WO2001021629A1 (no)
ZA (1) ZA200201661B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903345D0 (sv) * 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
CN101282730A (zh) * 2005-10-06 2008-10-08 依奈特制药公司 有机碱的磷酸抗原盐及其结晶方法
JP5363045B2 (ja) * 2008-07-24 2013-12-11 大八化学工業株式会社 ホスホン酸の製造方法
BR112017014996A2 (pt) 2015-01-14 2018-03-20 Chiesi Farm Spa formulações farmacêuticas e recipientes selados
CN111647016A (zh) * 2020-07-10 2020-09-11 成都纽瑞特医疗科技股份有限公司 羟基亚甲基二膦酸盐的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3251907A (en) * 1962-08-23 1966-05-17 Procter & Gamble Method for preparing tetra-secondary alkyl methylenediphosphonates
CA777769A (en) 1963-03-18 1968-02-06 H. Roy Clarence Substituted methylene diphosphonic acid compounds and detergent compositions
JPS54125777A (en) 1978-03-20 1979-09-29 Kao Corp Bleaching composition
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4478763A (en) * 1982-10-20 1984-10-23 Univ. Of Southern California Process for preparing alpha-fluorinated alkanediphosphonates
JPS61123709A (ja) * 1984-11-19 1986-06-11 Nippon Soken Inc 排気ガス微粒子浄化機能を有する内燃機関の制御装置
US4689123A (en) * 1986-12-23 1987-08-25 The Dow Chemical Company Novel tetraphosphonic acid compounds, intermediates and a process for their production
FI83421C (fi) * 1989-06-21 1991-07-10 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
FI83657C (fi) * 1989-09-08 1991-08-12 Huhtamaeki Oy Foerfarande foer framstaellning av metylenbisfosfonsyror.
FI89366C (fi) 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
HU221501B (en) 1993-02-10 2002-10-28 Astrazeneca Ab N-alkyl-2-substituted atp analogues
EP0742279A1 (en) 1995-05-10 1996-11-13 The Procter & Gamble Company Acidic aqueous liquid compositions
SE9701219D0 (sv) 1997-04-04 1997-04-04 Astra Pharma Prod New compounds
FI109088B (fi) 1997-09-19 2002-05-31 Leiras Oy Tabletti ja menetelmä sen valmistamiseksi
SE9903345D0 (sv) * 1999-09-17 1999-09-17 Astra Pharma Prod Novel process

Also Published As

Publication number Publication date
IL148442A0 (en) 2002-09-12
DK1216253T3 (da) 2003-09-15
ATE242778T1 (de) 2003-06-15
US7288673B2 (en) 2007-10-30
ZA200201661B (en) 2003-08-27
WO2001021629A1 (en) 2001-03-29
EP1216253A1 (en) 2002-06-26
KR20020029135A (ko) 2002-04-17
IL168246A (en) 2010-05-17
CA2383829A1 (en) 2001-03-29
EP1216253B1 (en) 2003-06-11
BR0014057A (pt) 2002-05-21
DE60003323D1 (de) 2003-07-17
AU7027000A (en) 2001-04-24
CN1371383A (zh) 2002-09-25
NO20021269D0 (no) 2002-03-14
JP2003509517A (ja) 2003-03-11
KR100776105B1 (ko) 2007-11-15
AR029393A1 (es) 2003-06-25
PT1216253E (pt) 2003-10-31
ES2200921T3 (es) 2004-03-16
CA2383829C (en) 2009-01-20
DE60003323T2 (de) 2004-04-29
TWI274057B (en) 2007-02-21
US6657076B1 (en) 2003-12-02
MY119965A (en) 2005-08-30
HK1045696A1 (en) 2002-12-06
IL148442A (en) 2005-08-31
AU771628B2 (en) 2004-04-01
NZ517552A (en) 2003-09-26
JP4881524B2 (ja) 2012-02-22
CO5231228A1 (es) 2002-12-27
NO20021269L (no) 2002-03-14
HK1045696B (zh) 2003-11-21
CN1150200C (zh) 2004-05-19
NO331532B1 (no) 2012-01-23
US20040171870A1 (en) 2004-09-02

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