SE9502196D0 - Ultrasensitive immunoassays - Google Patents

Ultrasensitive immunoassays

Info

Publication number
SE9502196D0
SE9502196D0 SE9502196A SE9502196A SE9502196D0 SE 9502196 D0 SE9502196 D0 SE 9502196D0 SE 9502196 A SE9502196 A SE 9502196A SE 9502196 A SE9502196 A SE 9502196A SE 9502196 D0 SE9502196 D0 SE 9502196D0
Authority
SE
Sweden
Prior art keywords
oligonucleotides
amplified
detection
cross
antigen
Prior art date
Application number
SE9502196A
Other languages
English (en)
Other versions
SE504798C2 (sv
SE9502196L (sv
Inventor
Ulf Landegren
Original Assignee
Ulf Landegren
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ulf Landegren filed Critical Ulf Landegren
Priority to SE9502196A priority Critical patent/SE504798C2/sv
Publication of SE9502196D0 publication Critical patent/SE9502196D0/sv
Priority to PCT/SE1996/000779 priority patent/WO1997000446A1/en
Priority to JP50299197A priority patent/JP4091113B2/ja
Priority to EP96918976A priority patent/EP0832431B1/en
Priority to CA002224674A priority patent/CA2224674C/en
Priority to US08/981,310 priority patent/US6878515B1/en
Priority to DE69614539T priority patent/DE69614539T2/de
Priority to AU61439/96A priority patent/AU702125B2/en
Publication of SE9502196L publication Critical patent/SE9502196L/sv
Publication of SE504798C2 publication Critical patent/SE504798C2/sv
Priority to US11/011,438 priority patent/US20050233351A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SE9502196A 1995-06-16 1995-06-16 Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten SE504798C2 (sv)

Priority Applications (9)

Application Number Priority Date Filing Date Title
SE9502196A SE504798C2 (sv) 1995-06-16 1995-06-16 Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
AU61439/96A AU702125B2 (en) 1995-06-16 1996-06-14 Immunoassay and kit with two reagents that are cross-linked if they adhere to an analyte
CA002224674A CA2224674C (en) 1995-06-16 1996-06-14 Immunoassay and kit with two reagents that are cross-linked if they adhere to an analyte
JP50299197A JP4091113B2 (ja) 1995-06-16 1996-06-14 分析物に付着したときに架橋する２種類の試薬によるイムノアッセイとキット
EP96918976A EP0832431B1 (en) 1995-06-16 1996-06-14 Immunoassay and kit with two reagents that are cross-linked if they adhere to an analyte
PCT/SE1996/000779 WO1997000446A1 (en) 1995-06-16 1996-06-14 Immunoassay and kit with two reagents that are cross-linked if they adhere to an analyte
US08/981,310 US6878515B1 (en) 1995-06-16 1996-06-14 Ultrasensitive immunoassays
DE69614539T DE69614539T2 (de) 1995-06-16 1996-06-14 Immunoassay und kit mit zwei reagenzien, die vernetzt werden, wenn sie an einem analyten haften
US11/011,438 US20050233351A1 (en) 1995-06-16 2004-12-15 Ultrasensitive immunoassays

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9502196A SE504798C2 (sv) 1995-06-16 1995-06-16 Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten

Publications (3)

Publication Number Publication Date
SE9502196D0 true SE9502196D0 (sv) 1995-06-16
SE9502196L SE9502196L (sv) 1996-12-17
SE504798C2 SE504798C2 (sv) 1997-04-28

Family

ID=20398643

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9502196A SE504798C2 (sv) 1995-06-16 1995-06-16 Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten

Country Status (8)

Country Link
US (2) US6878515B1 (sv)
EP (1) EP0832431B1 (sv)
JP (1) JP4091113B2 (sv)
AU (1) AU702125B2 (sv)
CA (1) CA2224674C (sv)
DE (1) DE69614539T2 (sv)
SE (1) SE504798C2 (sv)
WO (1) WO1997000446A1 (sv)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE504798C2 (sv) * 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
EP1985714B1 (en) * 1998-03-25 2012-02-29 Olink AB Method and kit for detecting a target molecule employing at least two affinity probes and rolling circle replication of padlock probes
AT407160B (de) * 1998-06-04 2001-01-25 Immuno Ag Verfahren zur bestimmung von antigenen
US7306904B2 (en) 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
SE516272C2 (sv) * 2000-02-18 2001-12-10 Ulf Landegren Metoder och kit för analytdetektion mha proximitets-probning
GB2378245A (en) 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
CA2462625A1 (en) * 2001-10-03 2003-04-10 Iseao Technologies Limited Methods for detection of target molecules and molecular interactions
US20030109067A1 (en) 2001-12-06 2003-06-12 Immunetech, Inc. Homogeneous immunoassays for multiple allergens
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040018577A1 (en) * 2002-07-29 2004-01-29 Emerson Campbell John Lewis Multiple hybrid immunoassay
CA2522753C (en) 2003-04-18 2014-06-10 Becton, Dickinson And Company Immuno-amplification
WO2005074417A2 (en) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Multiple antigen detection assays and reagents
EP1681983A4 (en) 2003-10-14 2008-12-10 Monogram Biosciences Inc RECEPTOR TYROSINE KINASE SIGNAL PATH ANALYSIS FOR DIAGNOSIS AND THERAPY
JP4949038B2 (ja) 2003-12-01 2012-06-06 ダコ デンマーク アクティーゼルスカブ 免疫組織化学的検出のための方法および組成物
CN101208437B (zh) * 2003-12-12 2012-07-04 圣路易斯大学 检测大分子和其它分析物的生物传感器
EP1704256A4 (en) * 2004-01-13 2008-01-16 Us Genomics Inc DETECTION AND QUANTIFICATION OF ANALYTES IN SOLUTION USING POLYMERS
US7595160B2 (en) 2004-01-13 2009-09-29 U.S. Genomics, Inc. Analyte detection using barcoded polymers
EP1756307A1 (en) * 2004-05-20 2007-02-28 Trillion Genomics Limited Use of mass labelled probes to detect target nucleic acids using mass spectrometry
US7914987B2 (en) 2004-06-14 2011-03-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for use in analyte detection using proximity probes
CN103146808A (zh) * 2004-11-03 2013-06-12 意力速分子诊断股份有限公司 均相分析物检测
ATE530666T1 (de) 2004-11-03 2011-11-15 Iris Molecular Diagnostics Inc Mikrobläschen zur affinitätstrennung
US20060204999A1 (en) * 2005-03-14 2006-09-14 Stephen Macevicz Detecting molecular complexes
US7795009B2 (en) * 2005-06-15 2010-09-14 Saint Louis University Three-component biosensors for detecting macromolecules and other analytes
US8956857B2 (en) * 2005-06-06 2015-02-17 Mediomics, Llc Three-component biosensors for detecting macromolecules and other analytes
WO2006135527A2 (en) 2005-06-10 2006-12-21 Saint Louis University Methods for the selection of aptamers
US7811809B2 (en) * 2005-06-15 2010-10-12 Saint Louis University Molecular biosensors for use in competition assays
US7883848B2 (en) * 2005-07-08 2011-02-08 Olink Ab Regulation analysis by cis reactivity, RACR
GB0605584D0 (en) * 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
US8778846B2 (en) * 2006-12-04 2014-07-15 General Electric Company Composition, device and associated method
US8133701B2 (en) * 2006-12-05 2012-03-13 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US7902345B2 (en) * 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
WO2009032781A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for universal size-specific polymerase chain reaction
EP2703816B1 (en) 2008-11-21 2016-10-05 Saint Louis University Biosensor for detecting multiple epitopes on a target
EP2408936A4 (en) * 2009-03-18 2013-01-30 Sequenom Inc USE OF HEAT-STAINED ENDONUCLEASES FOR THE PREPARATION OF REPORTER MOLECULES
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US9040287B2 (en) 2010-02-12 2015-05-26 Mediomics, Llc Molecular biosensors capable of signal amplification
GB201004292D0 (en) * 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
CA2794522C (en) 2010-04-05 2019-11-26 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
WO2012049316A1 (en) 2010-10-15 2012-04-19 Olink Ab Dynamic range methods
WO2012057689A1 (en) * 2010-10-29 2012-05-03 Ge Healthcare Bio-Sciences Ab Proximity ligation technology for western blot applications
JP5766296B2 (ja) 2010-12-23 2015-08-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
EP2694709B1 (en) 2011-04-08 2016-09-14 Prognosys Biosciences, Inc. Peptide constructs and assay systems
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US10597701B2 (en) 2011-05-11 2020-03-24 Navinci Diagnostics Ab Unfolding proximity probes and methods for the use thereof
GB201108678D0 (en) 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
CN103454427A (zh) * 2012-06-03 2013-12-18 河北省健海生物芯片技术有限责任公司 利用抗体-核酸联合扩增技术检测血中微量蛋白质的方法
ES2597228T3 (es) 2012-06-27 2017-01-17 F. Hoffmann-La Roche Ag Procedimiento para la selección y la producción de entidades de objetivación, como dianas, altamente selectivas y multiespecíficas, personalizadas, las cuales contienen por lo menos dos entidades de unión diferentes, y utilización de éstas
WO2014001325A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
CA2871386A1 (en) * 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for the selection and production of tailor-made, selective and multi-specific therapeutic molecules comprising at least two different targeting entities and uses thereof
BR112015003938A2 (pt) 2012-09-14 2018-09-04 Hoffmann La Roche métodos de produção de polipeptídeos, de produção de aglutinantes multiespecíficos, de seleção de aglutinantes multiespecíficos, de seleção de anticorpos biespecíficos e de determinação de combinação, anticorpo biespecífico, formulação farmcêutica e uso de anticorpo biespecífico
CN104955963A (zh) 2012-11-14 2015-09-30 欧凌科公司 Rca报告探针及其用于检测核酸分子的用途
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
KR20220038550A (ko) 2013-03-13 2022-03-28 메소 스케일 테크놀러지즈, 엘엘시 개선된 분석 방법
EP3578977B1 (en) 2013-03-14 2020-12-23 The Regents of The University of California Nanopipette device and method for subcellular analysis
EP2972366B1 (en) 2013-03-15 2020-06-17 Prognosys Biosciences, Inc. Methods for detecting peptide/mhc/tcr binding
BR112015023775B1 (pt) 2013-03-15 2022-08-16 Lubrizol Advanced Materials, Inc Composições de cpvc isentas de metal pesado
IE86624B1 (en) 2013-05-21 2016-02-10 Src Inc Methods and systems for quantitative fluorescence-based detection of molecules and proteins
US9879313B2 (en) 2013-06-25 2018-01-30 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
US20160146804A1 (en) * 2013-06-27 2016-05-26 The Board Of Trustees Of The Leland Stanford Junior University Dna-conjugated antibodies for improved antibody affinity and reduced antibody cross reactivity
WO2015070037A2 (en) 2013-11-08 2015-05-14 Prognosys Biosciences, Inc. Polynucleotide conjugates and methods for analyte detection
US9957554B1 (en) 2013-12-19 2018-05-01 National Technology & Engineering Solutions Of Sandia, Llc Microfluidic platform for multiplexed detection in single cells and methods thereof
GB201401885D0 (en) 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
AU2015259048B2 (en) 2014-05-15 2021-09-09 Meso Scale Technologies, Llc. Improved assay methods
EP3191843A1 (en) 2014-09-12 2017-07-19 Mediomics, LLC Molecular biosensors with a modular design
PL3227332T3 (pl) 2014-12-03 2020-06-15 F. Hoffmann-La Roche Ag Wielospecyficzne przeciwciała
EP4119677B1 (en) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
CN107614699A (zh) * 2015-04-17 2018-01-19 加利福尼亚大学董事会 用于检测凝集的方法以及用于实践该方法的组合物
EP3933047A1 (en) 2015-09-24 2022-01-05 AbVitro LLC Affinity-oligonucleotide conjugates and uses thereof
GB201614023D0 (en) 2016-08-16 2016-09-28 Olink Bioscience Ab Double-stranded circle probes
AU2017332495A1 (en) 2016-09-24 2019-04-11 Abvitro Llc Affinity-oligonucleotide conjugates and uses thereof
GB201700567D0 (en) 2017-01-12 2017-03-01 Genagon Therapeutics Ab Therapeutic agents
US20210255189A1 (en) 2018-06-15 2021-08-19 Olink Proteomics Ab Biomarker panel for ovarian cancer
EP3931201A1 (en) * 2019-03-01 2022-01-05 Meso Scale Technologies, LLC Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
AU2021283174A1 (en) 2020-06-02 2023-01-05 10X Genomics, Inc. Nucleic acid library methods
CN116249785A (zh) 2020-06-02 2023-06-09 10X基因组学有限公司 用于抗原-受体的空间转录组学
EP4162074B1 (en) 2020-06-08 2024-04-24 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
CN117377774A (zh) 2021-05-25 2024-01-09 卡维迪有限公司 用于敏感分析物检测测定的方法及其试剂盒

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2079172A (en) * 1934-02-28 1937-05-04 Chandler & Price Co Platen printing press
US4748111A (en) * 1984-03-12 1988-05-31 Molecular Diagnostics, Inc. Nucleic acid-protein conjugate used in immunoassay
US4690890A (en) * 1984-04-04 1987-09-01 Cetus Corporation Process for simultaneously detecting multiple antigens using dual sandwich immunometric assay
US5011771A (en) * 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4563417A (en) * 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US5242794A (en) * 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4824775A (en) * 1985-01-03 1989-04-25 Molecular Diagnostics, Inc. Cells labeled with multiple Fluorophores bound to a nucleic acid carrier
US5026653A (en) * 1985-04-02 1991-06-25 Leeco Diagnostic, Inc. Scavenger antibody mixture and its use for immunometric assay
US5656731A (en) * 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US4988617A (en) * 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5079172A (en) * 1988-11-04 1992-01-07 Board Of Trustees Operating Michigan State University Method for detecting the presence of antibodies using gold-labeled antibodies and test kit
US5948634A (en) * 1988-12-21 1999-09-07 The General Hospital Coporation Neural thread protein gene expression and detection of alzheimer's disease
US6143508A (en) * 1989-06-29 2000-11-07 Rhone-Poulenc Rorer Pharmaceuticals Inc. Device and process for cell capture and recovery
HU218095B (hu) * 1990-05-01 2000-05-28 Amgen Inc. Eljárás átvitt szennyeződések csökkentésére, amplifikációs eljárásokban
PT97580B (pt) 1990-05-04 1998-08-31 Chiron Corp Sondas de preparacao de sondas de proteina-acido nucleico e imunoensaios que utilizam as mesmas
JPH07505293A (ja) * 1992-03-31 1995-06-15 アボツト・ラボラトリーズ 多重リガーゼ連鎖反応方法
JPH08505531A (ja) * 1993-01-15 1996-06-18 ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク Ｒｎａバイナリ・プローブとリボザイムリガーゼを用いたｒｎａ検定法
EP0688366B1 (en) 1993-01-15 2002-05-22 The Public Health Research Institute Of The City Of New York, Inc. Sensitive nucleic acid sandwich hybridization assays and kits
US5985548A (en) * 1993-02-04 1999-11-16 E. I. Du Pont De Nemours And Company Amplification of assay reporters by nucleic acid replication
US5384255A (en) * 1993-06-21 1995-01-24 Rappaport Family Institute For Research In The Medical Sciences Ubiquitin carrier enzyme E2-F1, purification, production, and use
US5635602A (en) * 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates
US5415839A (en) * 1993-10-21 1995-05-16 Abbott Laboratories Apparatus and method for amplifying and detecting target nucleic acids
SE9400522D0 (sv) * 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US5596081A (en) * 1994-03-11 1997-01-21 University Of Kentucky Research Foundation Nucleotide or nucleoside photoaffinity compound modified antibodies, methods for their manufacture and use thereof as diagnostics and therapeutics
US5667974A (en) * 1995-06-07 1997-09-16 Abbott Laboratories Method for detecting nucleic acid sequences using competitive amplification
EP0832280A2 (en) * 1995-06-07 1998-04-01 Abbott Laboratories Probe masking method of reducing background in an amplification reaction
SE504798C2 (sv) * 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
US5780231A (en) * 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US5804384A (en) * 1996-12-06 1998-09-08 Vysis, Inc. Devices and methods for detecting multiple analytes in samples
US5812272A (en) * 1997-01-30 1998-09-22 Hewlett-Packard Company Apparatus and method with tiled light source array for integrated assay sensing
US5919626A (en) * 1997-06-06 1999-07-06 Orchid Bio Computer, Inc. Attachment of unmodified nucleic acids to silanized solid phase surfaces
EP1985714B1 (en) * 1998-03-25 2012-02-29 Olink AB Method and kit for detecting a target molecule employing at least two affinity probes and rolling circle replication of padlock probes
US7306904B2 (en) * 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US6511809B2 (en) 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
GB0016953D0 (en) * 2000-07-11 2000-08-30 Wilson Stuart M A method for distinguishing aggregated or polymerised forms of a given molecule from the unaggregated or unpolymerised form
US20030148335A1 (en) * 2001-10-10 2003-08-07 Li Shen Detecting targets by unique identifier nucleotide tags
CA2481093A1 (en) * 2002-04-04 2003-10-16 Mount Sinai Hospital Methods for detecting ovarian cancer
CA2522753C (en) * 2003-04-18 2014-06-10 Becton, Dickinson And Company Immuno-amplification
US7572409B2 (en) * 2003-05-23 2009-08-11 Applied Biosystems, Llc Ionic liquid apparatus and method for biological samples

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US6878515B1 (en) 2005-04-12
JP4091113B2 (ja) 2008-05-28
JPH11508040A (ja) 1999-07-13
CA2224674C (en) 2009-02-24
AU6143996A (en) 1997-01-15
AU702125B2 (en) 1999-02-11
SE504798C2 (sv) 1997-04-28
CA2224674A1 (en) 1997-01-03
EP0832431B1 (en) 2001-08-16
EP0832431A1 (en) 1998-04-01
US20050233351A1 (en) 2005-10-20
DE69614539T2 (de) 2002-05-23
SE9502196L (sv) 1996-12-17
WO1997000446A1 (en) 1997-01-03
DE69614539D1 (de) 2001-09-20

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