SE8302347L - Bensoazacykloalkyl-spiro-imidazolidiner, framstellning derav och farmaceutiska kompositioner innehallande dem - Google Patents

Bensoazacykloalkyl-spiro-imidazolidiner, framstellning derav och farmaceutiska kompositioner innehallande dem

Info

Publication number
SE8302347L
SE8302347L SE8302347A SE8302347A SE8302347L SE 8302347 L SE8302347 L SE 8302347L SE 8302347 A SE8302347 A SE 8302347A SE 8302347 A SE8302347 A SE 8302347A SE 8302347 L SE8302347 L SE 8302347L
Authority
SE
Sweden
Prior art keywords
bensoazacycloylkyl
imidazolidines
spiro
preparing
pharmaceutical compositions
Prior art date
Application number
SE8302347A
Other languages
English (en)
Swedish (sv)
Other versions
SE8302347D0 (sv
Inventor
C Malen
J-L Peglion
J Duhault
M Boulanger
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of SE8302347D0 publication Critical patent/SE8302347D0/xx
Publication of SE8302347L publication Critical patent/SE8302347L/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SE8302347A 1982-04-27 1983-04-26 Bensoazacykloalkyl-spiro-imidazolidiner, framstellning derav och farmaceutiska kompositioner innehallande dem SE8302347L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8207203A FR2525603A1 (fr) 1982-04-27 1982-04-27 Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
SE8302347D0 SE8302347D0 (sv) 1983-04-26
SE8302347L true SE8302347L (sv) 1983-10-28

Family

ID=9273425

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8302347A SE8302347L (sv) 1982-04-27 1983-04-26 Bensoazacykloalkyl-spiro-imidazolidiner, framstellning derav och farmaceutiska kompositioner innehallande dem

Country Status (22)

Country Link
JP (1) JPS5910584A (es)
KR (1) KR840004428A (es)
AT (1) ATA125383A (es)
AU (1) AU1395383A (es)
BE (1) BE896572A (es)
DD (1) DD209833A5 (es)
DE (1) DE3315106A1 (es)
DK (1) DK183583A (es)
ES (1) ES8405796A1 (es)
FR (1) FR2525603A1 (es)
GB (1) GB2133401B (es)
GR (1) GR78481B (es)
IL (1) IL68497A0 (es)
IT (1) IT1167123B (es)
LU (1) LU84770A1 (es)
MA (1) MA19783A1 (es)
NL (1) NL8301476A (es)
NO (1) NO831473L (es)
OA (1) OA07412A (es)
PT (1) PT76595B (es)
SE (1) SE8302347L (es)
ZA (1) ZA832927B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
EP1636191A2 (en) 2003-06-17 2006-03-22 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases
CN1805938B (zh) 2003-06-17 2010-06-16 艾尼纳制药公司 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
NZ555981A (en) 2004-12-21 2011-01-28 Arena Pharm Inc Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
EP1833473B1 (en) 2004-12-23 2009-09-09 Arena Pharmaceuticals, Inc. 5ht2c receptor modulator compositions and methods of use
CA2646044A1 (en) 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
CA2670285A1 (en) 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
WO2009111004A1 (en) 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
MX2013002418A (es) 2010-09-01 2013-08-01 Arena Pharm Inc Administracion de lorcaserina a individuos con daño renal.
SG188361A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
CN103189053A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 用于体重控制的5-ht2c激动剂的调节释放剂型
JP2013539470A (ja) 2010-09-01 2013-10-24 アリーナ ファーマシューティカルズ， インコーポレイテッド ロルカセリンと光学活性な酸との塩
BR112015007779A2 (pt) 2012-10-09 2017-07-04 Arena Pharm Inc célula de fluxo de permeabilidade e sistema de condutância hidráulica

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209630A (en) * 1976-10-18 1980-06-24 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives

Also Published As

Publication number Publication date
FR2525603B1 (es) 1984-09-14
JPS5910584A (ja) 1984-01-20
PT76595B (fr) 1986-01-21
BE896572A (fr) 1983-10-26
MA19783A1 (fr) 1983-12-31
FR2525603A1 (fr) 1983-10-28
KR840004428A (ko) 1984-10-15
PT76595A (fr) 1983-05-01
SE8302347D0 (sv) 1983-04-26
IT8348155A0 (it) 1983-04-26
OA07412A (fr) 1984-11-30
IL68497A0 (en) 1983-07-31
GB8311508D0 (en) 1983-06-02
DK183583A (da) 1983-10-28
NO831473L (no) 1983-10-28
AU1395383A (en) 1983-11-03
NL8301476A (nl) 1983-11-16
DD209833A5 (de) 1984-05-23
IT1167123B (it) 1987-05-13
ATA125383A (de) 1986-05-15
GR78481B (es) 1984-09-27
GB2133401B (en) 1985-10-23
LU84770A1 (fr) 1984-11-28
DE3315106A1 (de) 1983-11-03
GB2133401A (en) 1984-07-25
ES521895A0 (es) 1984-06-16
ES8405796A1 (es) 1984-06-16
ZA832927B (en) 1984-06-27
DK183583D0 (da) 1983-04-26

Similar Documents

Publication Publication Date Title
SE8302347L (sv) Bensoazacykloalkyl-spiro-imidazolidiner, framstellning derav och farmaceutiska kompositioner innehallande dem
HK57197A (en) Naphthalene derivatives procedure for their preparation and pharmaceutical compositions containing them
IL101819A0 (en) Amidinophenylalanine derivatives,a process for the preparation thereof,use thereof and agents containing these as anticoagulants
DK161382C (da) Fremgangsmaade til fremstilling af 1,2,4-triazol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
ZA805499B (en) Substituted oxiranecarboxylic acids, processes for their preparation, their use and medicaments containing them
DE3850603D1 (de) Arylaralkylether, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung.
ATE41772T1 (de) Polymethoxybenzyl-piperazin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende pharmazeutische zusammensetzungen.
ES8308552A1 (es) Un procedimiento para la preparacion de derivados de benzotiazolina.
IL79910A0 (en) Tricyclic compounds,process for the preparation thereof and pharmaceutical compositions containing the same
ATE37533T1 (de) Derivate der 4-phenyl-4-oxo-buten-2-saeure, verfahren zu ihrer herstellung, medikamente und mischungen mit diesen derivaten.
JPS57126441A (en) Novel cinnamoylcinnamic acid derivative, manufacture and therapeutical composition containing same
SE8304410D0 (sv) Cyklohexylkarboxylsyraderivat och sett for deras framstellning
FI821288L (fi) Fenetanolaminderivat, deras framstaellning och deras terapeutiska anvaendning
ZA875727B (en) 1,4-dihydropyridine derivatives,the process for preparing them and the pharmaceutical compositions which contain them
ZA84261B (en) Bicyclo(4.2.0)1,3,5-octatriene derivatives,a process for their preparation and pharmaceutical compositions containing them
ES2067710T3 (es) Compuestos no ionicos yodados, su procedimiento de preparacion y productos de contraste que contienen los mismos.
IL76652A0 (en) Thiadiazole derivatives,their preparation and pharmaceutical compositions containing them
DE3062417D1 (en) Process for regulating plant growth
DE3363575D1 (en) Furyloxazolylacetic acid derivatives, process for preparing same and pharmaceutical compositions containing same
IL71430A0 (en) Iminosulfonamides and process for their production,pharmaceutical compositions containing such compounds and the use thereof
SE7907656L (sv) 3,4-dihydroxikanelaldehydderivat
ES484086A1 (es) Procedimiento para la preparacion de compuestos de isopropi-lamina
GB2018770A (en) Hexahydro-1-mercaptoacyl-1H- azepine-2-carboxylic acids and esters
ES2013316A6 (es) Un proceso para preparar un derivado de guanidinotiazol
SE7806445L (sv) Alkanolaminderivat och sett for deras framstellning

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 8302347-3

Format of ref document f/p: F