SE8301795L - Plasminogenaktivatorkomplex - Google Patents

Plasminogenaktivatorkomplex

Info

Publication number
SE8301795L
SE8301795L SE8301795A SE8301795A SE8301795L SE 8301795 L SE8301795 L SE 8301795L SE 8301795 A SE8301795 A SE 8301795A SE 8301795 A SE8301795 A SE 8301795A SE 8301795 L SE8301795 L SE 8301795L
Authority
SE
Sweden
Prior art keywords
complex
plasmin
streptokinase
chain
plasminogen
Prior art date
Application number
SE8301795A
Other languages
English (en)
Other versions
SE8301795D0 (sv
SE454048B (sv
Inventor
K C Robbins
L Summaria
Original Assignee
Reese Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reese Res Found filed Critical Reese Res Found
Publication of SE8301795D0 publication Critical patent/SE8301795D0/sv
Publication of SE8301795L publication Critical patent/SE8301795L/sv
Publication of SE454048B publication Critical patent/SE454048B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (1)

PATENTERAV
1. FOrfarande for framstallning av ett komplex av strepto- kinas Och en latt plasminkedja med ett serinproteasaktivt ccntrum, vilket innefattar en reaktion av en substans, bestaende av manniskoplasminogen, som bar varmebehandlats vidlagst 60°C under minst 10 timmar, eller plasmin framstallt ur manniskoplasminogen, som her varmebehandlats vid lagst 60°C under minst 10 timmar, med en ungefar ekvimolar mangd streptokinas for att framstalla ett streptokinaskomplex, reduktion av reaktionsprodukten vid plasminmolekylernas disulfidbindningar mellan kedjorna for att bilda en tong kedja och ett komplex av latt kedja och streptokinaskomplex och darpa separering av komplexet frAn den tunga kedjan.
SE8301795A 1976-09-24 1983-03-30 Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum SE454048B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/726,142 US4082612A (en) 1976-09-24 1976-09-24 Plasminogen activator complex

Publications (3)

Publication Number Publication Date
SE8301795D0 SE8301795D0 (sv) 1983-03-30
SE8301795L true SE8301795L (sv) 1983-03-30
SE454048B SE454048B (sv) 1988-03-28

Family

ID=24917422

Family Applications (3)

Application Number Title Priority Date Filing Date
SE7710653A SE442304B (sv) 1976-09-24 1977-09-22 Forfarande for framstellning av en lett plasminkedja med ett serinproteasaktivt centrum
SE8301795A SE454048B (sv) 1976-09-24 1983-03-30 Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum
SE8301794A SE454047B (sv) 1976-09-24 1983-03-30 Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7710653A SE442304B (sv) 1976-09-24 1977-09-22 Forfarande for framstellning av en lett plasminkedja med ett serinproteasaktivt centrum

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8301794A SE454047B (sv) 1976-09-24 1983-03-30 Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum

Country Status (10)

Country Link
US (1) US4082612A (sv)
JP (1) JPS5352606A (sv)
CA (1) CA1094449A (sv)
CH (2) CH637991A5 (sv)
DE (1) DE2742529C2 (sv)
DK (1) DK421577A (sv)
FR (1) FR2365583A1 (sv)
GB (1) GB1533205A (sv)
NL (1) NL7710451A (sv)
SE (3) SE442304B (sv)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028489B1 (en) * 1979-11-05 1983-10-05 Beecham Group Plc Enzyme derivatives, and their preparation
JPS58189122A (ja) * 1982-04-30 1983-11-04 Kaken Pharmaceut Co Ltd 高脂血症予防治療剤
US4536391A (en) * 1982-11-17 1985-08-20 Otsuka Pharmaceutical Co. Process for preparing urokinase complex
JPS60136520A (ja) * 1983-12-23 1985-07-20 Otsuka Pharmaceut Co Ltd フイブリン吸着性ウロキナ−ゼ複合体
US4880776A (en) * 1983-12-24 1989-11-14 Beecham Group P.L.C. Plasmin A-chain urokinase B-chain hybrid protein
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
US4774087A (en) * 1987-08-14 1988-09-27 Northwestern University Micro-size fibrinolytic plasmin
DE3833936C1 (sv) * 1988-10-05 1989-09-21 Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin, De
US6964764B2 (en) * 1999-11-13 2005-11-15 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US6355243B1 (en) * 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US7544500B2 (en) * 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
US6969515B2 (en) 1999-11-13 2005-11-29 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
WO2009149199A2 (en) * 2008-06-04 2009-12-10 Talecris Biotherapeutics, Inc. Composition, method and kit for preparing plasmin
PT2403865E (pt) 2009-03-03 2015-11-18 Grifols Therapeutics Inc Métodos de preparação de plasminogénio

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865692A (en) * 1974-01-11 1975-02-11 Abbott Lab Method for making highly potent plasminogen

Also Published As

Publication number Publication date
DK421577A (da) 1978-03-25
SE8301795D0 (sv) 1983-03-30
DE2742529C2 (de) 1984-01-05
SE442304B (sv) 1985-12-16
CH637992A5 (de) 1983-08-31
JPS5352606A (en) 1978-05-13
NL7710451A (nl) 1978-03-29
US4082612A (en) 1978-04-04
SE8301794D0 (sv) 1983-03-30
FR2365583B1 (sv) 1981-07-10
SE7710653L (sv) 1978-03-25
CA1094449A (en) 1981-01-27
DE2742529A1 (de) 1978-03-30
GB1533205A (en) 1978-11-22
SE454048B (sv) 1988-03-28
FR2365583A1 (fr) 1978-04-21
CH637991A5 (de) 1983-08-31
SE454047B (sv) 1988-03-28

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