SE8301795L - Plasminogenaktivatorkomplex - Google Patents
PlasminogenaktivatorkomplexInfo
- Publication number
- SE8301795L SE8301795L SE8301795A SE8301795A SE8301795L SE 8301795 L SE8301795 L SE 8301795L SE 8301795 A SE8301795 A SE 8301795A SE 8301795 A SE8301795 A SE 8301795A SE 8301795 L SE8301795 L SE 8301795L
- Authority
- SE
- Sweden
- Prior art keywords
- complex
- plasmin
- streptokinase
- chain
- plasminogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (1)
1. FOrfarande for framstallning av ett komplex av strepto- kinas Och en latt plasminkedja med ett serinproteasaktivt ccntrum, vilket innefattar en reaktion av en substans, bestaende av manniskoplasminogen, som bar varmebehandlats vidlagst 60°C under minst 10 timmar, eller plasmin framstallt ur manniskoplasminogen, som her varmebehandlats vid lagst 60°C under minst 10 timmar, med en ungefar ekvimolar mangd streptokinas for att framstalla ett streptokinaskomplex, reduktion av reaktionsprodukten vid plasminmolekylernas disulfidbindningar mellan kedjorna for att bilda en tong kedja och ett komplex av latt kedja och streptokinaskomplex och darpa separering av komplexet frAn den tunga kedjan.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/726,142 US4082612A (en) | 1976-09-24 | 1976-09-24 | Plasminogen activator complex |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8301795D0 SE8301795D0 (sv) | 1983-03-30 |
SE8301795L true SE8301795L (sv) | 1983-03-30 |
SE454048B SE454048B (sv) | 1988-03-28 |
Family
ID=24917422
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7710653A SE442304B (sv) | 1976-09-24 | 1977-09-22 | Forfarande for framstellning av en lett plasminkedja med ett serinproteasaktivt centrum |
SE8301794A SE454047B (sv) | 1976-09-24 | 1983-03-30 | Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum |
SE8301795A SE454048B (sv) | 1976-09-24 | 1983-03-30 | Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7710653A SE442304B (sv) | 1976-09-24 | 1977-09-22 | Forfarande for framstellning av en lett plasminkedja med ett serinproteasaktivt centrum |
SE8301794A SE454047B (sv) | 1976-09-24 | 1983-03-30 | Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum |
Country Status (10)
Country | Link |
---|---|
US (1) | US4082612A (sv) |
JP (1) | JPS5352606A (sv) |
CA (1) | CA1094449A (sv) |
CH (2) | CH637991A5 (sv) |
DE (1) | DE2742529C2 (sv) |
DK (1) | DK421577A (sv) |
FR (1) | FR2365583A1 (sv) |
GB (1) | GB1533205A (sv) |
NL (1) | NL7710451A (sv) |
SE (3) | SE442304B (sv) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0028489B1 (en) * | 1979-11-05 | 1983-10-05 | Beecham Group Plc | Enzyme derivatives, and their preparation |
JPS58189122A (ja) * | 1982-04-30 | 1983-11-04 | Kaken Pharmaceut Co Ltd | 高脂血症予防治療剤 |
EP0109653A3 (en) * | 1982-11-17 | 1986-01-29 | Otsuka Pharmaceutical Co., Ltd. | Process for preparing urokinase complex |
JPS60136520A (ja) * | 1983-12-23 | 1985-07-20 | Otsuka Pharmaceut Co Ltd | フイブリン吸着性ウロキナ−ゼ複合体 |
US4880776A (en) * | 1983-12-24 | 1989-11-14 | Beecham Group P.L.C. | Plasmin A-chain urokinase B-chain hybrid protein |
GB8334498D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Compounds |
GB8334499D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Derivatives |
GB8400653D0 (en) * | 1984-01-11 | 1984-02-15 | Beecham Group Plc | Conjugates |
DE3584902D1 (de) * | 1984-02-29 | 1992-01-30 | Asahi Chemical Ind | Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren. |
US4774087A (en) * | 1987-08-14 | 1988-09-27 | Northwestern University | Micro-size fibrinolytic plasmin |
DE3833936C1 (sv) * | 1988-10-05 | 1989-09-21 | Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin, De | |
US6969515B2 (en) | 1999-11-13 | 2005-11-29 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
US6964764B2 (en) * | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
US7544500B2 (en) * | 1999-11-13 | 2009-06-09 | Talecris Biotherapeutics, Inc. | Process for the production of a reversibly inactive acidified plasmin composition |
US6355243B1 (en) | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
MX2010013282A (es) * | 2008-06-04 | 2010-12-21 | Talecris Biotherapeutics Inc | Composicion, metodo y kit para la preparacion de plasmina. |
PL2403865T3 (pl) | 2009-03-03 | 2016-01-29 | Grifols Therapeutics Inc | Sposoby wytwarzania plazminogenu |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3865692A (en) * | 1974-01-11 | 1975-02-11 | Abbott Lab | Method for making highly potent plasminogen |
-
1976
- 1976-09-24 US US05/726,142 patent/US4082612A/en not_active Expired - Lifetime
-
1977
- 1977-08-16 CA CA284,760A patent/CA1094449A/en not_active Expired
- 1977-09-19 GB GB38933/77A patent/GB1533205A/en not_active Expired
- 1977-09-21 JP JP11276977A patent/JPS5352606A/ja active Pending
- 1977-09-21 DE DE2742529A patent/DE2742529C2/de not_active Expired
- 1977-09-22 FR FR7728611A patent/FR2365583A1/fr active Granted
- 1977-09-22 SE SE7710653A patent/SE442304B/sv not_active IP Right Cessation
- 1977-09-23 CH CH1165677A patent/CH637991A5/de not_active IP Right Cessation
- 1977-09-23 NL NL7710451A patent/NL7710451A/xx not_active Application Discontinuation
- 1977-09-23 DK DK421577A patent/DK421577A/da not_active Application Discontinuation
-
1982
- 1982-08-27 CH CH511282A patent/CH637992A5/de not_active IP Right Cessation
-
1983
- 1983-03-30 SE SE8301794A patent/SE454047B/sv not_active IP Right Cessation
- 1983-03-30 SE SE8301795A patent/SE454048B/sv not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SE454048B (sv) | 1988-03-28 |
SE8301795D0 (sv) | 1983-03-30 |
CH637991A5 (de) | 1983-08-31 |
DK421577A (da) | 1978-03-25 |
NL7710451A (nl) | 1978-03-29 |
SE442304B (sv) | 1985-12-16 |
JPS5352606A (en) | 1978-05-13 |
DE2742529A1 (de) | 1978-03-30 |
US4082612A (en) | 1978-04-04 |
GB1533205A (en) | 1978-11-22 |
SE454047B (sv) | 1988-03-28 |
SE8301794D0 (sv) | 1983-03-30 |
CA1094449A (en) | 1981-01-27 |
SE7710653L (sv) | 1978-03-25 |
CH637992A5 (de) | 1983-08-31 |
DE2742529C2 (de) | 1984-01-05 |
FR2365583B1 (sv) | 1981-07-10 |
FR2365583A1 (fr) | 1978-04-21 |
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Legal Events
Date | Code | Title | Description |
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NUG | Patent has lapsed |
Ref document number: 8301795-4 Effective date: 19900703 Format of ref document f/p: F |