FR2365583A1 - Complexe activateur de plasminogene et son procede de preparation - Google Patents

Complexe activateur de plasminogene et son procede de preparation

Info

Publication number
FR2365583A1
FR2365583A1 FR7728611A FR7728611A FR2365583A1 FR 2365583 A1 FR2365583 A1 FR 2365583A1 FR 7728611 A FR7728611 A FR 7728611A FR 7728611 A FR7728611 A FR 7728611A FR 2365583 A1 FR2365583 A1 FR 2365583A1
Authority
FR
France
Prior art keywords
plasminogen activator
preparation process
plasmin
activator complex
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7728611A
Other languages
English (en)
Other versions
FR2365583B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
REESE RES FOUND
Original Assignee
REESE RES FOUND
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by REESE RES FOUND filed Critical REESE RES FOUND
Publication of FR2365583A1 publication Critical patent/FR2365583A1/fr
Application granted granted Critical
Publication of FR2365583B1 publication Critical patent/FR2365583B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Complexe activateur de plasminogène et son procédé de préparation. L'invention concerne plus particulièrement une fraction fonctionnellement active de plasmine qui est capable de former avec la streptokinase un complexe ayant une activité d'activateur de plasminogène. On conduit la réaction en réduisant les liaisons disulfure des molécules de plasmine tout en inhibant l'activité de sérine protéase de la plasmine et en séparant la fraction chaîne légère B du produit de réaction. Application à l'industrie pharmaceutique.
FR7728611A 1976-09-24 1977-09-22 Complexe activateur de plasminogene et son procede de preparation Granted FR2365583A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/726,142 US4082612A (en) 1976-09-24 1976-09-24 Plasminogen activator complex

Publications (2)

Publication Number Publication Date
FR2365583A1 true FR2365583A1 (fr) 1978-04-21
FR2365583B1 FR2365583B1 (fr) 1981-07-10

Family

ID=24917422

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7728611A Granted FR2365583A1 (fr) 1976-09-24 1977-09-22 Complexe activateur de plasminogene et son procede de preparation

Country Status (10)

Country Link
US (1) US4082612A (fr)
JP (1) JPS5352606A (fr)
CA (1) CA1094449A (fr)
CH (2) CH637991A5 (fr)
DE (1) DE2742529C2 (fr)
DK (1) DK421577A (fr)
FR (1) FR2365583A1 (fr)
GB (1) GB1533205A (fr)
NL (1) NL7710451A (fr)
SE (3) SE442304B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028489A1 (fr) * 1979-11-05 1981-05-13 Beecham Group Plc Dérivés d'enzymes et leur préparation
EP0151308A2 (fr) * 1983-12-23 1985-08-14 Otsuka Pharmaceutical Co., Ltd. Complexe d'urokinase adsorbable par la fibrine et procédé de préparation

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58189122A (ja) * 1982-04-30 1983-11-04 Kaken Pharmaceut Co Ltd 高脂血症予防治療剤
US4536391A (en) * 1982-11-17 1985-08-20 Otsuka Pharmaceutical Co. Process for preparing urokinase complex
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
US4880776A (en) * 1983-12-24 1989-11-14 Beecham Group P.L.C. Plasmin A-chain urokinase B-chain hybrid protein
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
US4774087A (en) * 1987-08-14 1988-09-27 Northwestern University Micro-size fibrinolytic plasmin
DE3833936C1 (fr) * 1988-10-05 1989-09-21 Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin, De
US6355243B1 (en) 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US7544500B2 (en) * 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
US6969515B2 (en) 1999-11-13 2005-11-29 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US6964764B2 (en) * 1999-11-13 2005-11-15 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
KR20110017903A (ko) * 2008-06-04 2011-02-22 테일크리스 바이오쎄러퓨틱스 아이엔씨. 플라스민의 제조를 위한 조성물, 방법 및 키트
WO2010101903A2 (fr) 2009-03-03 2010-09-10 Talecris Biotherapeutics, Inc. Compositions, procédés et kits pour préparer du plasminogène, et plasmine préparée à partir de celui-ci

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865692A (en) * 1974-01-11 1975-02-11 Abbott Lab Method for making highly potent plasminogen

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028489A1 (fr) * 1979-11-05 1981-05-13 Beecham Group Plc Dérivés d'enzymes et leur préparation
EP0151308A2 (fr) * 1983-12-23 1985-08-14 Otsuka Pharmaceutical Co., Ltd. Complexe d'urokinase adsorbable par la fibrine et procédé de préparation
EP0151308A3 (en) * 1983-12-23 1986-12-17 Otsuka Pharmaceutical Co., Ltd. Urokinase complex adsorbable by fibrin and process for preparing same

Also Published As

Publication number Publication date
SE442304B (sv) 1985-12-16
NL7710451A (nl) 1978-03-29
SE7710653L (sv) 1978-03-25
DE2742529A1 (de) 1978-03-30
SE8301795D0 (sv) 1983-03-30
SE8301794D0 (sv) 1983-03-30
GB1533205A (en) 1978-11-22
SE8301795L (sv) 1983-03-30
CH637991A5 (de) 1983-08-31
CA1094449A (fr) 1981-01-27
SE454047B (sv) 1988-03-28
SE454048B (sv) 1988-03-28
CH637992A5 (de) 1983-08-31
DK421577A (da) 1978-03-25
JPS5352606A (en) 1978-05-13
FR2365583B1 (fr) 1981-07-10
US4082612A (en) 1978-04-04
DE2742529C2 (de) 1984-01-05

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Legal Events

Date Code Title Description
ST Notification of lapse