KR870010186A - 가수분해효소 활성 축진제 - Google Patents

가수분해효소 활성 축진제 Download PDF

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Publication number
KR870010186A
KR870010186A KR870003408A KR870003408A KR870010186A KR 870010186 A KR870010186 A KR 870010186A KR 870003408 A KR870003408 A KR 870003408A KR 870003408 A KR870003408 A KR 870003408A KR 870010186 A KR870010186 A KR 870010186A
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South Korea
Prior art keywords
hydrolase
promoter
coagulation
promoter according
proteases
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KR870003408A
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English (en)
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KR950006614B1 (ko
Inventor
히데오 안라꾸
Original Assignee
히로다 가오루
세끼스이 가가꾸 고교 가부시기 가이샤
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Priority claimed from JP61084455A external-priority patent/JPH084499B2/ja
Priority claimed from JP61084457A external-priority patent/JPH0725672B2/ja
Priority claimed from JP61084456A external-priority patent/JPH0643342B2/ja
Priority claimed from JP23047886A external-priority patent/JPH065230B2/ja
Application filed by 히로다 가오루, 세끼스이 가가꾸 고교 가부시기 가이샤 filed Critical 히로다 가오루
Publication of KR870010186A publication Critical patent/KR870010186A/ko
Application granted granted Critical
Publication of KR950006614B1 publication Critical patent/KR950006614B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/04—Nickel compounds
    • C07F15/045—Nickel compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/06—Cobalt compounds
    • C07F15/065—Cobalt compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/06—Aluminium compounds
    • C07F5/069—Aluminium compounds without C-aluminium linkages
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96458—Factor XII (3.4.21.38)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

가수분해효소 활성 축진제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 다음 일반식 (Ⅰ)에서 표시한 구조와 같이 실질적으로 상호 동일 평면상인 상호 인접한 카르보닐기를 가지는 유기 고리화합물을 리간드로서 함유하는 배위 화합물 또는 금속착화합물로 구성되는 가수분해 효소 활성 촉진제.
    여기서 A는 고리화합물 부분이다.
  2. 제 1항에 있어서, 가수분해효소가 세린 프로티아제인 가수분해효소 활성촉진제.
  3. 제 2항에 있어서, 가수분해효소가 혈액응고 제XII인자인 가수분해효소 활성 촉진제.
  4. 청구범위 제1,2또는 3항의 가수분해효소 활성촉진제를 함유한 혈액응고 촉진제.
  5. 제 4항에 있어서, 혈액 응고 촉진제가 공촉진제로서 가수분해효소를 추가로 함유하며, 본 가수분해효소가 알기닌과 어느 아미노산 잔기 사이의 결합 그리고/또는 라이신과 펩티드쇄상의 어느 아미노산 잔기 사이의 결합을 가수분해할 수 있는 효소인 혈액 응고 촉진제.
  6. 제 5항에 있어서, 가수분해효소가 세린 프로티아제, 티올 프로티아제, 그리고 금속 프로티아제로부터 선택된 적어도 하나인 혈액 응고 촉진제.
  7. 제 4항 또는 제 5항에 있어서, 아미노염 그리고/또는 사가 질소를 가진 유기화합물을 추가로 함유하는 혈액 응고 촉진제.
  8. 제 4항, 제 5항 또는 제 7항에 있어서, 항 피브리놀리시스제 그리고/또는 항플라스민제를 추가로 함유하는 혈액응고 촉진제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870003408A 1986-04-11 1987-04-10 혈액응고 촉진방법 KR950006614B1 (ko)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
JP84457 1983-05-13
JP84455 1986-04-11
JP61084455A JPH084499B2 (ja) 1986-04-11 1986-04-11 加水分解酵素活性促進剤
JP61084457A JPH0725672B2 (ja) 1986-04-11 1986-04-11 血液凝固促進剤
JP84456 1986-04-11
JP86-84457 1986-04-11
JP86-84456 1986-04-11
JP61084456A JPH0643342B2 (ja) 1986-04-11 1986-04-11 血液凝固促進剤
JP86-84455 1986-04-11
JP23047886A JPH065230B2 (ja) 1986-09-29 1986-09-29 血液凝固促進剤
JP230478 1986-09-29
JP86-230478 1986-09-29

Publications (2)

Publication Number Publication Date
KR870010186A true KR870010186A (ko) 1987-11-30
KR950006614B1 KR950006614B1 (ko) 1995-06-19

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Application Number Title Priority Date Filing Date
KR1019870003408A KR950006614B1 (ko) 1986-04-11 1987-04-10 혈액응고 촉진방법

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US (2) US5041558A (ko)
EP (1) EP0241314B1 (ko)
KR (1) KR950006614B1 (ko)
CA (1) CA1313997C (ko)
DE (1) DE3750344T2 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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WO1991016453A1 (en) * 1990-04-17 1991-10-31 Analytical Control Systems, Inc. Coagulation assays and reagents
AU674265B2 (en) * 1993-11-04 1996-12-12 Dade Behring Inc. Tetrahydroxyquinone as an activator component for activated partial thromboplastine time test of blood coagulation and as a detector of blood coagulation disorders
US6245573B1 (en) * 1998-02-12 2001-06-12 University Of Medicine And Dentistry Of New Jersey Rapid assessment of the coagulant activity of blood
WO2001097826A2 (en) * 2000-06-16 2001-12-27 University Of Medicine And Dentistry Of New Jersey Hemostatic compositions, devices and methods
US6632678B2 (en) * 2001-01-03 2003-10-14 Sienco, Inc. Method for performing activated clotting time test with reduced sensitivity to the presence of aprotinin and for assessing aprotinin sensitivity
FR2822462B1 (fr) 2001-03-23 2005-07-15 Stago Diagnostica Composes activateurs de la coagulation endogene utilisation pour l'exploration de la coagulation endogene
EP1580551B1 (en) * 2002-11-19 2013-02-20 Sekisui Medical Co., Ltd. Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane
CN106883273B (zh) * 2017-02-22 2019-06-18 南京林业大学 双黄酮-钴配合物及其制备方法和应用
EP4079388A4 (en) * 2019-12-18 2023-10-04 Sekisui Medical Co., Ltd. BLOOD COLLECTION CONTAINER
CN114921447B (zh) * 2022-07-01 2023-12-12 可孚医疗科技股份有限公司 酶试剂的制备方法及含该酶试剂的凝血酶原时间检测卡

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US3093659A (en) * 1956-06-20 1963-06-11 Pfizer & Co C Antifungal and insecticidal halokojic acid metal complexes
US3177237A (en) * 1963-07-01 1965-04-06 Du Pont Silicon and germanium chelates of tropolones
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US4329498A (en) * 1979-09-11 1982-05-11 Allied Corporation Preparation of 6-aminocaproic acid via muconic acid mononitrile
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JPS6011519A (ja) * 1983-06-30 1985-01-21 Nisshinbo Ind Inc 導電性多孔質構造体
JPS6027858A (ja) * 1983-07-25 1985-02-12 Sekisui Chem Co Ltd 血清と血餅との分離方法
GB8410290D0 (en) * 1984-04-19 1984-05-31 Callingham B A Pharmaceutical compositions
JPS60174952A (ja) * 1984-02-21 1985-09-09 Sekisui Chem Co Ltd 血液凝固促進剤
JPS60186760A (ja) * 1984-03-05 1985-09-24 Sekisui Chem Co Ltd 血液凝固促進剤
JPH0627858A (ja) * 1990-12-04 1994-02-04 Ricoh Co Ltd 画像形成装置
JP3203567B2 (ja) * 1992-06-26 2001-08-27 株式会社トキメック 加速度計

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EP0241314A3 (en) 1990-02-07
AU7142487A (en) 1987-10-15
US5041558A (en) 1991-08-20
EP0241314A2 (en) 1987-10-14
EP0241314B1 (en) 1994-08-10
DE3750344D1 (de) 1994-09-15
KR950006614B1 (ko) 1995-06-19
DE3750344T2 (de) 1994-12-08
CA1313997C (en) 1993-03-02
AU619442B2 (en) 1992-01-30
US5413786A (en) 1995-05-09

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