ATE105480T1 - Thrombin bindende substanz und verfahren zu ihrer herstellung. - Google Patents
Thrombin bindende substanz und verfahren zu ihrer herstellung.Info
- Publication number
- ATE105480T1 ATE105480T1 AT8989115272T AT89115272T ATE105480T1 AT E105480 T1 ATE105480 T1 AT E105480T1 AT 8989115272 T AT8989115272 T AT 8989115272T AT 89115272 T AT89115272 T AT 89115272T AT E105480 T1 ATE105480 T1 AT E105480T1
- Authority
- AT
- Austria
- Prior art keywords
- thrombin
- binding substance
- binding
- conditions
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/834—Urine; urinary system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21413988 | 1988-08-29 | ||
JP11647189 | 1989-05-10 | ||
JP1202027A JPH0720997B2 (ja) | 1988-08-29 | 1989-08-03 | 新規なトロンビン結合性物質及びその製法 |
EP89115272A EP0356836B1 (de) | 1988-08-29 | 1989-08-18 | Thrombin bindende Substanz und Verfahren zu ihrer Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE105480T1 true ATE105480T1 (de) | 1994-05-15 |
Family
ID=27313158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT8989115272T ATE105480T1 (de) | 1988-08-29 | 1989-08-18 | Thrombin bindende substanz und verfahren zu ihrer herstellung. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5043425A (de) |
EP (1) | EP0356836B1 (de) |
JP (1) | JPH0720997B2 (de) |
KR (2) | KR900003207A (de) |
AT (1) | ATE105480T1 (de) |
DE (1) | DE68915226T2 (de) |
ES (1) | ES2056164T3 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5202421A (en) * | 1988-12-27 | 1993-04-13 | Mochida Pharmaceutical Co., Ltd. | Anticoagulant substance obtained from urine and process for the preparation thereof |
US6063763A (en) * | 1989-04-28 | 2000-05-16 | Schering Aktiengesellschaft | Protease-resistant thrombomodulin analogs |
JPH03259084A (ja) * | 1990-03-06 | 1991-11-19 | Kowa Co | トロンビン結合性物質の製造法 |
JP3180824B2 (ja) * | 1991-08-30 | 2001-06-25 | シスメックス株式会社 | 血液凝固試薬 |
US5716795A (en) * | 1991-10-04 | 1998-02-10 | Matschiner; John T. | Thrombomodulin-based coagulometric assay of the protein C system |
US20050089543A1 (en) * | 2001-02-01 | 2005-04-28 | Weiser Mark J. | Animal scent based repellent and attractant compositions |
US20060083733A1 (en) * | 2002-01-18 | 2006-04-20 | Fumihide Nishio | High-concentration preparation of soluble thrombomodulin |
WO2008044631A1 (fr) * | 2006-10-06 | 2008-04-17 | Asahi Kasei Pharma Corporation | Agent thérapeutique et/ou améliorant pour la coagulation intravasculaire disséminée |
SG184699A1 (en) | 2007-03-23 | 2012-10-30 | Asahi Kasei Pharma Corp | Method for producing high-purity soluble thrombomodulin |
JP2011178687A (ja) * | 2010-02-26 | 2011-09-15 | Kochi Univ | 造血細胞移植に伴う疼痛の予防および/または治療剤 |
EP2565269B1 (de) | 2010-04-30 | 2016-11-16 | Asahi Kasei Pharma Corporation | Verfahren zur herstellung von hochreinem löslichen thrombomodulin |
CN103974710B (zh) | 2011-11-15 | 2016-07-06 | 旭化成制药株式会社 | 用于败血症的治疗和/或改善的药物 |
NZ702242A (en) | 2012-05-31 | 2016-03-31 | Asahi Kasei Pharma Corp | Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent |
US11497795B2 (en) | 2018-09-28 | 2022-11-15 | Asahi Kasei Pharma Corporation | Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent |
EP3871684B1 (de) | 2018-10-22 | 2024-06-26 | Asahi Kasei Pharma Corporation | Arzneimittel zur behandlung und/oder verbesserung der septikämie in zusammenhang mit einer gerinnungsstörung |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60199819A (ja) * | 1984-03-23 | 1985-10-09 | Kowa Co | トロンビン結合性物質およびその製法 |
WO1987000050A1 (en) * | 1985-06-28 | 1987-01-15 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel physiologically active substance having blood coagulation controlling activity |
JPH0689014B2 (ja) * | 1986-01-21 | 1994-11-09 | 興和株式会社 | トロンビン結合性物質およびその製法 |
DE3750664T2 (de) * | 1986-07-15 | 1995-06-22 | Kowa Co | Throminbindende Substanz und Verfahren zu ihrer Herstellung. |
JP2738428B2 (ja) * | 1987-01-08 | 1998-04-08 | 旭化成工業株式会社 | トロンビンによるプロテインcの活性化を促進する作用を有するペプチド |
US4912207A (en) * | 1987-05-06 | 1990-03-27 | Washington University | DNA clone of human thrombomodulin and portions thereof |
-
1989
- 1989-08-03 JP JP1202027A patent/JPH0720997B2/ja not_active Expired - Fee Related
- 1989-08-16 US US07/394,715 patent/US5043425A/en not_active Expired - Fee Related
- 1989-08-18 DE DE68915226T patent/DE68915226T2/de not_active Expired - Fee Related
- 1989-08-18 EP EP89115272A patent/EP0356836B1/de not_active Expired - Lifetime
- 1989-08-18 ES ES89115272T patent/ES2056164T3/es not_active Expired - Lifetime
- 1989-08-18 AT AT8989115272T patent/ATE105480T1/de not_active IP Right Cessation
- 1989-08-23 KR KR1019890012016A patent/KR900003207A/ko not_active Application Discontinuation
-
1994
- 1994-07-18 KR KR1019940017334A patent/KR940027658A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US5043425A (en) | 1991-08-27 |
DE68915226T2 (de) | 1995-01-05 |
JPH0720997B2 (ja) | 1995-03-08 |
DE68915226D1 (de) | 1994-06-16 |
EP0356836B1 (de) | 1994-05-11 |
EP0356836A2 (de) | 1990-03-07 |
KR940027658A (ko) | 1994-12-10 |
KR900003207A (ko) | 1990-03-26 |
EP0356836A3 (en) | 1990-03-28 |
JPH0386900A (ja) | 1991-04-11 |
ES2056164T3 (es) | 1994-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |