SE8200522L - PREPARATION OF 6,6'-OXIBIS (4-HALO-2H-PYRAN-3 (6H) -ON - Google Patents

PREPARATION OF 6,6'-OXIBIS (4-HALO-2H-PYRAN-3 (6H) -ON

Info

Publication number
SE8200522L
SE8200522L SE8200522A SE8200522A SE8200522L SE 8200522 L SE8200522 L SE 8200522L SE 8200522 A SE8200522 A SE 8200522A SE 8200522 A SE8200522 A SE 8200522A SE 8200522 L SE8200522 L SE 8200522L
Authority
SE
Sweden
Prior art keywords
pyrones
gamma
pyran
preparation
oxibis
Prior art date
Application number
SE8200522A
Other languages
Swedish (sv)
Other versions
SE444565B (en
Inventor
T M Brennan
D P Brannegan
P D Weeks
D E Kuhla
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/721,885 external-priority patent/US4082717A/en
Application filed by Pfizer filed Critical Pfizer
Publication of SE8200522L publication Critical patent/SE8200522L/en
Publication of SE444565B publication Critical patent/SE444565B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol

Abstract

The gamma-pyrones of formula I in which the symbols have the meaning given in Claim 1 are obtained by a simple and economic "one-pot" process by reaction of a furfuryl alcohol of formula III with at least 2 equivalents of a halogenated oxidising agent, in aqueous solution at a temperature of between -50 DEG and +50 DEG C, and then the reaction mixture is heated until hydrolysis of the intermediate formed is virtually complete. The gamma-pyrones obtained can be used as products which enhance flavour and fragrance in food and cosmetic preparations.

Claims (1)

PATENTXRAV:PATENTXRAV: 1. En 6,6'-0xibis74-ha-2E-pyran-3(61-i)-ony-ftirening fbr anvandning sasom ett interwediat vid framstallning av gammapyroner,kannetecknaddarav, att den har formeln (V) van i R är vate eller alkyl med 1-4 kolatomer och X ar klor eller brom.A 6,6'-oxybis74-ha-2E-pyran-3 (61-i) -onyphthyrene for use as an interwediat in the preparation of gamma-pyrones, characterized in that it has the formula (V) or alkyl of 1-4 carbon atoms and X is chlorine or bromine.
SE8200522A 1976-08-02 1982-01-29 6,6'-OXIBIS / 4-HALO-2H-PYRANE-3 (6H) -ON / COMPOUNDS FOR USE AS INTERMEDIATE IN THE PREPARATION OF GAMMA PYRONS AND PROCEDURE FOR PREPARING THEREOF SE444565B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71090176A 1976-08-02 1976-08-02
US05/721,885 US4082717A (en) 1976-08-02 1976-09-09 Preparation of gamma-pyrones

Publications (2)

Publication Number Publication Date
SE8200522L true SE8200522L (en) 1982-01-29
SE444565B SE444565B (en) 1986-04-21

Family

ID=27108548

Family Applications (6)

Application Number Title Priority Date Filing Date
SE7707035A SE433079B (en) 1976-08-02 1977-06-16 PROCEDURE FOR MANUFACTURING V-PYRONS
SE8200522A SE444565B (en) 1976-08-02 1982-01-29 6,6'-OXIBIS / 4-HALO-2H-PYRANE-3 (6H) -ON / COMPOUNDS FOR USE AS INTERMEDIATE IN THE PREPARATION OF GAMMA PYRONS AND PROCEDURE FOR PREPARING THEREOF
SE8200520A SE444564B (en) 1976-08-02 1982-01-29 4-HALOGENE DIHYDROPYRANE COMPOUNDS FOR USE AS INTERMEDIATE IN THE PREPARATION OF GAMMA PYRONS AND PROCEDURE FOR PREPARING THEREOF
SE8200519A SE445042B (en) 1976-08-02 1982-01-29 PROCEDURE FOR MANUFACTURING GAMMA PYRONS
SE8200518A SE445041B (en) 1976-08-02 1982-01-29 PROCEDURE FOR MANUFACTURING GAMMA PYRONS
SE8200521A SE452616B (en) 1976-08-02 1982-01-29 PROCEDURE FOR PREPARATION OF 4-HALO-2H-PYRANE-3 (6H) -ON COMPOUNDS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7707035A SE433079B (en) 1976-08-02 1977-06-16 PROCEDURE FOR MANUFACTURING V-PYRONS

Family Applications After (4)

Application Number Title Priority Date Filing Date
SE8200520A SE444564B (en) 1976-08-02 1982-01-29 4-HALOGENE DIHYDROPYRANE COMPOUNDS FOR USE AS INTERMEDIATE IN THE PREPARATION OF GAMMA PYRONS AND PROCEDURE FOR PREPARING THEREOF
SE8200519A SE445042B (en) 1976-08-02 1982-01-29 PROCEDURE FOR MANUFACTURING GAMMA PYRONS
SE8200518A SE445041B (en) 1976-08-02 1982-01-29 PROCEDURE FOR MANUFACTURING GAMMA PYRONS
SE8200521A SE452616B (en) 1976-08-02 1982-01-29 PROCEDURE FOR PREPARATION OF 4-HALO-2H-PYRANE-3 (6H) -ON COMPOUNDS

Country Status (36)

Country Link
JP (7) JPS5318578A (en)
AR (1) AR216080A1 (en)
AT (3) AT362790B (en)
BE (1) BE855965A (en)
BG (4) BG28849A3 (en)
BR (1) BR7703970A (en)
CA (3) CA1095921A (en)
CH (4) CH625798A5 (en)
CS (3) CS203921B2 (en)
DD (1) DD132494A5 (en)
DE (3) DE2760220C2 (en)
DK (4) DK153483C (en)
EG (1) EG13080A (en)
ES (5) ES459994A1 (en)
FI (6) FI72722C (en)
FR (1) FR2372821A1 (en)
GB (5) GB1538372A (en)
GR (1) GR68938B (en)
HK (5) HK30481A (en)
HU (4) HU186026B (en)
IE (5) IE45643B1 (en)
IT (1) IT1106258B (en)
LU (1) LU77600A1 (en)
MX (1) MX4597E (en)
MY (3) MY8100267A (en)
NL (5) NL170955C (en)
NO (7) NO150561C (en)
NZ (1) NZ184342A (en)
PH (5) PH13557A (en)
PL (4) PL215008A1 (en)
PT (1) PT66694B (en)
RO (4) RO78951A2 (en)
SE (6) SE433079B (en)
SU (2) SU955859A3 (en)
TR (1) TR19652A (en)
YU (4) YU40166B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1095921A (en) 1976-08-02 1981-02-17 Thomas M. Brennan Preparation of gamma-pyrones
JPS5444675A (en) * 1977-09-12 1979-04-09 Shin Etsu Chem Co Ltd Production of 3-hydroxy-4-pyrone analog
FR2402654A1 (en) * 1977-09-12 1979-04-06 Shinetsu Chemical Co Tetra:hydro-pyranone derivs. - useful as intermediates for cpds. used as food flavours
JPS5741226U (en) * 1980-08-20 1982-03-05
JPS59135008U (en) * 1983-02-28 1984-09-10 松下電工株式会社 Distribution board device
JPS6050245A (en) * 1983-08-29 1985-03-19 Nissan Motor Co Ltd Fuel injection device in internal-combustion engine
JPH0226945Y2 (en) * 1985-09-11 1990-07-20
JP2586607B2 (en) * 1987-10-30 1997-03-05 日産化学工業株式会社 Production method of optically active alcohol
WO2008116301A1 (en) 2007-03-28 2008-10-02 Apotex Technologies Inc. Fluorinated derivatives of deferiprone
UA102254C2 (en) 2008-04-25 2013-06-25 Апотекс Технолоджис Инк. Normal;heading 1;heading 2;heading 3;LIQUID FORMULATION FOR DEFERIPRONE WITH PALATABLE TASTE
MA33985B1 (en) 2009-07-03 2013-02-01 Apotex Technologies Inc FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES
WO2017168309A1 (en) * 2016-03-29 2017-10-05 Dr. Reddy’S Laboratories Limited Process for preparation of eribulin and intermediates thereof
CN108609456B (en) * 2016-12-13 2021-03-12 奥的斯电梯公司 Openable expansion panel and elevator suspended ceiling, elevator car and elevator system with same
CN111606879A (en) * 2020-05-25 2020-09-01 安徽金禾实业股份有限公司 Method for preparing 2-hydroxymethyl-3-alkoxy-4H-pyran-4-ketone by one-pot method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3491122A (en) * 1966-09-14 1970-01-20 Monsanto Co Synthesis of 4-pyrones
US3547912A (en) * 1968-07-29 1970-12-15 American Home Prod Derivatives of 2h-pyran-3(6h)-ones and preparation thereof
JPS5145565B1 (en) * 1968-10-12 1976-12-04
US3621063A (en) * 1968-12-24 1971-11-16 Monsanto Co Unsaturated acyclic ketones
US3832357A (en) * 1971-05-26 1974-08-27 Daicel Ltd Process for preparation of 3-hydroxy-2-alkyl-4-pyrone
JPS5212166A (en) * 1975-07-17 1977-01-29 Tatsuya Shono Process for preparation of 4-pyron derivatives
IE42789B1 (en) * 1975-08-28 1980-10-22 Pfizer Preparation of gamma-pyrones
CA1095921A (en) * 1976-08-02 1981-02-17 Thomas M. Brennan Preparation of gamma-pyrones

Also Published As

Publication number Publication date
RO78951A2 (en) 1982-04-12
MY8100262A (en) 1981-12-31
FR2372821B1 (en) 1980-10-17
NL182478B (en) 1987-10-16
ES470745A1 (en) 1979-01-16
HK30781A (en) 1981-07-10
AT362790B (en) 1981-06-10
JPS5436269A (en) 1979-03-16
GR68938B (en) 1982-03-29
FI73424C (en) 1987-10-09
FR2372821A1 (en) 1978-06-30
YU40166B (en) 1985-08-31
NO821849L (en) 1978-02-03
DK153484B (en) 1988-07-18
FI73424B (en) 1987-06-30
PL215007A1 (en) 1979-12-17
NL8105539A (en) 1982-04-01
NO150042C (en) 1984-08-15
IE790586L (en) 1978-02-02
SE7707035L (en) 1978-02-03
DE2760221C2 (en) 1989-10-05
JPS5436266A (en) 1979-03-16
MY8100287A (en) 1981-12-31
YU43190B (en) 1989-04-30
NL7706811A (en) 1978-02-06
DK326186A (en) 1986-07-09
PL115497B1 (en) 1981-04-30
NL182476C (en) 1988-03-16
HK30481A (en) 1981-07-10
NO821847L (en) 1978-02-03
DK325986D0 (en) 1986-07-09
FI831703A0 (en) 1983-05-16
PL199798A1 (en) 1979-08-27
DK276177A (en) 1978-02-03
DK326086D0 (en) 1986-07-09
YU42613B (en) 1988-10-31
IE790587L (en) 1978-02-02
IE45643B1 (en) 1982-10-20
IE45645B1 (en) 1982-10-20
IE45644B1 (en) 1982-10-20
SU955859A3 (en) 1982-08-30
CA1110254A (en) 1981-10-06
FI72721C (en) 1987-07-10
SE8200518L (en) 1982-01-29
GB1538375A (en) 1979-01-17
TR19652A (en) 1979-09-17
SE445042B (en) 1986-05-26
IT1106258B (en) 1985-11-11
PL215006A1 (en) 1979-12-17
NO821851L (en) 1978-02-03
PT66694B (en) 1978-11-17
FI831701A0 (en) 1983-05-16
SE452616B (en) 1987-12-07
NO150042B (en) 1984-04-30
JPS5729034B2 (en) 1982-06-19
HU185687B (en) 1985-03-28
ES459994A1 (en) 1978-11-16
NO834236L (en) 1978-02-03
AT363470B (en) 1981-08-10
BG29136A3 (en) 1980-09-15
NO772193L (en) 1978-02-03
DK153483B (en) 1988-07-18
EG13080A (en) 1981-03-31
FI72722C (en) 1987-07-10
NL170955C (en) 1983-01-17
CH625798A5 (en) 1981-10-15
AT364356B (en) 1981-10-12
NL8105540A (en) 1982-04-01
NL182476B (en) 1987-10-16
PH15185A (en) 1982-09-10
CS203921B2 (en) 1981-03-31
DK326186D0 (en) 1986-07-09
SE8200520L (en) 1982-01-29
YU274782A (en) 1983-12-31
NL182477B (en) 1987-10-16
FI831701L (en) 1983-05-16
NO150560C (en) 1984-11-07
NO151365B (en) 1984-12-17
BG28849A3 (en) 1980-07-15
GB1538373A (en) 1979-01-17
FI831704A0 (en) 1983-05-16
DK153401C (en) 1988-11-28
SE445041B (en) 1986-05-26
SU1015826A3 (en) 1983-04-30
ES470746A1 (en) 1979-01-16
GB1538374A (en) 1979-01-17
HU185686B (en) 1985-03-28
FI771934A (en) 1978-02-03
NL182805C (en) 1988-05-16
ATA124480A (en) 1981-01-15
DK153483C (en) 1988-11-28
YU166383A (en) 1986-02-28
CH626357A5 (en) 1981-11-13
NO821850L (en) 1978-02-03
NL8105537A (en) 1982-04-01
JPS5420500B2 (en) 1979-07-23
NO150043B (en) 1984-04-30
NO821848L (en) 1978-02-03
NL170955B (en) 1982-08-16
PH14625A (en) 1981-10-12
PL115586B1 (en) 1981-04-30
FI72722B (en) 1987-03-31
FI72723B (en) 1987-03-31
CS203922B2 (en) 1981-03-31
IE790585L (en) 1978-02-02
ATA124380A (en) 1981-03-15
PL115496B1 (en) 1981-04-30
MX4597E (en) 1982-06-25
PH13874A (en) 1980-10-24
YU270382A (en) 1983-10-31
IE790584L (en) 1978-02-02
DK154079C (en) 1989-02-27
FI72721B (en) 1987-03-31
DE2728499A1 (en) 1978-02-09
SE8200519L (en) 1982-01-29
HK30681A (en) 1981-07-10
FI831704L (en) 1983-05-16
SE444565B (en) 1986-04-21
YU146977A (en) 1983-06-30
ES470744A1 (en) 1979-01-16
JPS5436267A (en) 1979-03-16
JPS5436270A (en) 1979-03-16
SE433079B (en) 1984-05-07
AR216080A1 (en) 1979-11-30
HU186026B (en) 1985-05-28
NL182477C (en) 1988-03-16
PT66694A (en) 1977-07-01
NO150559B (en) 1984-07-30
BG28989A4 (en) 1980-08-15
DK326086A (en) 1986-07-09
DE2760220C2 (en) 1987-08-20
NL182805B (en) 1987-12-16
FI72119C (en) 1987-04-13
CS203923B2 (en) 1981-03-31
DK153401B (en) 1988-07-11
AU2601777A (en) 1978-09-21
NO150560B (en) 1984-07-30
RO74367A (en) 1981-11-24
RO78953A (en) 1982-04-12
NO151365C (en) 1985-03-27
CH626358A5 (en) 1981-11-13
JPS5618596B2 (en) 1981-04-30
NO150559C (en) 1984-11-07
IE45642B1 (en) 1982-10-20
MY8100267A (en) 1981-12-31
IE45641L (en) 1978-02-02
JPS5318578A (en) 1978-02-20
CA1095921A (en) 1981-02-17
IE45641B1 (en) 1982-10-20
NO150043C (en) 1984-08-15
DK154079B (en) 1988-10-10
CH625235A5 (en) 1981-09-15
FI831702A0 (en) 1983-05-16
ATA440477A (en) 1980-11-15
HU180040B (en) 1983-01-28
FI831700A0 (en) 1983-05-16
HK30381A (en) 1981-07-10
NO150561C (en) 1984-11-07
RO78952A (en) 1982-04-12
DD132494A5 (en) 1978-10-04
BE855965A (en) 1977-12-21
FI831702L (en) 1983-05-16
JPS5618597B2 (en) 1981-04-30
SE8200521L (en) 1982-01-29
CA1117541A (en) 1982-02-02
FI72720C (en) 1987-07-10
ES470743A1 (en) 1979-01-16
DK153484C (en) 1988-11-28
BG28988A4 (en) 1980-08-15
GB1538372A (en) 1979-01-17
NL8105538A (en) 1982-04-01
NZ184342A (en) 1978-09-25
DK325986A (en) 1986-07-09
FI72119B (en) 1986-12-31
SE444564B (en) 1986-04-21
BR7703970A (en) 1978-07-04
JPS5814433B2 (en) 1983-03-18
FI831700L (en) 1983-05-16
GB1538371A (en) 1979-01-17
PH13557A (en) 1980-06-26
FI72720B (en) 1987-03-31
HK30581A (en) 1981-07-10
FI831703L (en) 1983-05-16
NO150561B (en) 1984-07-30
PH13926A (en) 1980-11-04
PL215008A1 (en) 1979-12-17
JPS5436268A (en) 1979-03-16
DE2728499C2 (en) 1986-04-03
LU77600A1 (en) 1978-02-01
NL182478C (en) 1988-03-16
FI72723C (en) 1987-07-10
JPS5436271A (en) 1979-03-16

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