ATE148T1 - PROCESS FOR THE PREPARATION OF 2,3-DIHYDRO-2-AETHYLBENZOFURAN-5-YLEACETIC ACID. - Google Patents

PROCESS FOR THE PREPARATION OF 2,3-DIHYDRO-2-AETHYLBENZOFURAN-5-YLEACETIC ACID.

Info

Publication number
ATE148T1
ATE148T1 AT79103127T AT79103127T ATE148T1 AT E148 T1 ATE148 T1 AT E148T1 AT 79103127 T AT79103127 T AT 79103127T AT 79103127 T AT79103127 T AT 79103127T AT E148 T1 ATE148 T1 AT E148T1
Authority
AT
Austria
Prior art keywords
dihydro
ethylbenzofurane
acid
solvent
reaction
Prior art date
Application number
AT79103127T
Other languages
German (de)
Inventor
G Tamagnone
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Application granted granted Critical
Publication of ATE148T1 publication Critical patent/ATE148T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1. A process for preparing 2,3-dihydro-2-ethylbenzofurane-5-ylacetic acid by reacting essentially equimolar quantities of chloroglyoxylic acid ethylester and 2,3-dihydro-2-ethylbenzofurane in the presence of a Friedel-Crafts catalyst in a solvent at low temperature as well as in the further course making use of a reaction with hydrazine hydrate as reactant, characterized in that one uses for the reaction of the chloroglyoxylic acid ethylester with the 2,3-dihydro-2-ethylbenzofurane as Friedel-Crafts catalyst titanium tetrachloride and/or tin tetrachloride an as a solvent 1 or more lower aliphatic chlorinated hydrocarbons and one applies as temperature form -30 to +50 degrees C as well as one makes to react the obtained 2,3-dihydro-2-ethylbenzofurane-5-ylglyoxylic acid ethylester isolated from the reaction mixture immediately with 80 to 100 % hydrazine hydrate in the presence of 1 or more alcohols having from 1 to 6 carbon atoms and/or glycoles having from 2 to 4 carbon atoms as solvent(s) to yield 2,3-dihydro-2-ethylbenzofurane-5-ylgyoxylic acid hydrazine hydrazone and one heats the latter immediately in the presence of a solution of 1 or more strong inorganic bases to a temperature of 100 to 200 degrees C.
AT79103127T 1978-09-05 1979-08-24 PROCESS FOR THE PREPARATION OF 2,3-DIHYDRO-2-AETHYLBENZOFURAN-5-YLEACETIC ACID. ATE148T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT03520/78A IT1111639B (en) 1978-09-05 1978-09-05 ACID PREPARATION PROCEDURE 2.3 DIHYDRO 2 ETHYL BENZOFURAN 5 IL ACETICO
EP79103127A EP0008752B1 (en) 1978-09-05 1979-08-24 Process for the preparation of 2,3-dihydro-2-ethyl-benzofuran-5-acetic acid

Publications (1)

Publication Number Publication Date
ATE148T1 true ATE148T1 (en) 1981-09-15

Family

ID=11108924

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79103127T ATE148T1 (en) 1978-09-05 1979-08-24 PROCESS FOR THE PREPARATION OF 2,3-DIHYDRO-2-AETHYLBENZOFURAN-5-YLEACETIC ACID.

Country Status (7)

Country Link
EP (1) EP0008752B1 (en)
AT (1) ATE148T1 (en)
DE (1) DE2960637D1 (en)
DK (1) DK369479A (en)
ES (1) ES483856A1 (en)
IT (1) IT1111639B (en)
NO (1) NO792850L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026593A1 (en) * 1979-09-15 1981-04-08 Pfizer Limited Bicyclic keto- and amino- acids, esters and amides and pharmaceutical compositions thereof
US4816473A (en) * 1983-07-14 1989-03-28 Syntex (U.S.A.) Inc. Aroyl benzofuran and benzothiophene acetic and propionic acids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1483061A (en) * 1974-06-12 1977-08-17 Schiapparelli Stabilment Benzopyranyl-,naphtho-(2,1-6)furanyl-,and naphtho(2,1-6)pyranyl-substituted acetic and propionic acid derivatives

Also Published As

Publication number Publication date
ES483856A1 (en) 1980-04-16
DK369479A (en) 1980-03-06
NO792850L (en) 1980-03-06
IT7803520A0 (en) 1978-09-05
EP0008752A1 (en) 1980-03-19
IT1111639B (en) 1986-01-13
EP0008752B1 (en) 1981-08-12
DE2960637D1 (en) 1981-11-12

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