ATE148T1 - Verfahren zur herstellung von 2,3-dihydro-2-aethylbenzofuran-5-ylessigsaeure. - Google Patents
Verfahren zur herstellung von 2,3-dihydro-2-aethylbenzofuran-5-ylessigsaeure.Info
- Publication number
- ATE148T1 ATE148T1 AT79103127T AT79103127T ATE148T1 AT E148 T1 ATE148 T1 AT E148T1 AT 79103127 T AT79103127 T AT 79103127T AT 79103127 T AT79103127 T AT 79103127T AT E148 T1 ATE148 T1 AT E148T1
- Authority
- AT
- Austria
- Prior art keywords
- dihydro
- ethylbenzofurane
- acid
- solvent
- reaction
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 3
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 2
- PCYKOMNKTKPEET-UHFFFAOYSA-N 2-ethyl-2,3-dihydro-1-benzofuran Chemical compound C1=CC=C2OC(CC)CC2=C1 PCYKOMNKTKPEET-UHFFFAOYSA-N 0.000 abstract 2
- 238000005727 Friedel-Crafts reaction Methods 0.000 abstract 2
- -1 aliphatic chlorinated hydrocarbons Chemical class 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- OWZFULPEVHKEKS-UHFFFAOYSA-N ethyl 2-chloro-2-oxoacetate Chemical compound CCOC(=O)C(Cl)=O OWZFULPEVHKEKS-UHFFFAOYSA-N 0.000 abstract 2
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 2
- MYQXHLQMZLTSDB-UHFFFAOYSA-N 2-(2-ethyl-2,3-dihydro-1-benzofuran-5-yl)acetic acid Chemical compound OC(=O)CC1=CC=C2OC(CC)CC2=C1 MYQXHLQMZLTSDB-UHFFFAOYSA-N 0.000 abstract 1
- 229910021627 Tin(IV) chloride Inorganic materials 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- XSTQBSRXKNGBRF-UHFFFAOYSA-N ethyl 2-(2-ethyl-2,3-dihydro-1-benzofuran-5-yl)-2-oxoacetate Chemical compound CCOC(=O)C(=O)C1=CC=C2OC(CC)CC2=C1 XSTQBSRXKNGBRF-UHFFFAOYSA-N 0.000 abstract 1
- 125000003827 glycol group Chemical group 0.000 abstract 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Substances NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 abstract 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT03520/78A IT1111639B (it) | 1978-09-05 | 1978-09-05 | Procedimento per la preparazione dell acido 2.3 diidro 2 etil benzofuran 5 il acetico |
| EP79103127A EP0008752B1 (de) | 1978-09-05 | 1979-08-24 | Verfahren zur Herstellung von 2,3-Dihydro-2-äthylbenzofuran-5-ylessigsäure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE148T1 true ATE148T1 (de) | 1981-09-15 |
Family
ID=11108924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT79103127T ATE148T1 (de) | 1978-09-05 | 1979-08-24 | Verfahren zur herstellung von 2,3-dihydro-2-aethylbenzofuran-5-ylessigsaeure. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0008752B1 (de) |
| AT (1) | ATE148T1 (de) |
| DE (1) | DE2960637D1 (de) |
| DK (1) | DK369479A (de) |
| ES (1) | ES483856A1 (de) |
| IT (1) | IT1111639B (de) |
| NO (1) | NO792850L (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0026593A1 (de) * | 1979-09-15 | 1981-04-08 | Pfizer Limited | Bicyclische Keto- und Aminosäuren, Ester und Amide und deren pharmazeutische Zusammensetzungen |
| US4816473A (en) * | 1983-07-14 | 1989-03-28 | Syntex (U.S.A.) Inc. | Aroyl benzofuran and benzothiophene acetic and propionic acids |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1483061A (en) * | 1974-06-12 | 1977-08-17 | Schiapparelli Stabilment | Benzopyranyl-,naphtho-(2,1-6)furanyl-,and naphtho(2,1-6)pyranyl-substituted acetic and propionic acid derivatives |
-
1978
- 1978-09-05 IT IT03520/78A patent/IT1111639B/it active
-
1979
- 1979-08-24 DE DE7979103127T patent/DE2960637D1/de not_active Expired
- 1979-08-24 EP EP79103127A patent/EP0008752B1/de not_active Expired
- 1979-08-24 AT AT79103127T patent/ATE148T1/de not_active IP Right Cessation
- 1979-09-04 DK DK369479A patent/DK369479A/da not_active Application Discontinuation
- 1979-09-04 ES ES483856A patent/ES483856A1/es not_active Expired
- 1979-09-04 NO NO792850A patent/NO792850L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2960637D1 (en) | 1981-11-12 |
| IT7803520A0 (it) | 1978-09-05 |
| EP0008752B1 (de) | 1981-08-12 |
| NO792850L (no) | 1980-03-06 |
| EP0008752A1 (de) | 1980-03-19 |
| ES483856A1 (es) | 1980-04-16 |
| IT1111639B (it) | 1986-01-13 |
| DK369479A (da) | 1980-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |