GB992166A - New 5-nitro-furfurylidene derivatives - Google Patents

New 5-nitro-furfurylidene derivatives

Info

Publication number
GB992166A
GB992166A GB45619/63A GB4561963A GB992166A GB 992166 A GB992166 A GB 992166A GB 45619/63 A GB45619/63 A GB 45619/63A GB 4561963 A GB4561963 A GB 4561963A GB 992166 A GB992166 A GB 992166A
Authority
GB
United Kingdom
Prior art keywords
reacting
dioxide
methyl
nitro
oxathiane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB45619/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB992166A publication Critical patent/GB992166A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/70—Nitro radicals
    • C07D307/71—Nitro radicals attached in position 5
    • C07D307/72—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2
    • C07D307/74—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2 by hydrazino or hydrazono or such substituted radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0992166/C2/1> wherein R represents a hydrogen atom or from 1 to 4 alkyl radicals, each containing up to 4 carbon atoms; and a process for their preparation comprising reacting a 4-amino-tetrahydro-1,4-thiazine-1,1-dioxide with 5-nitro-furfural, the reaction preferably being carried out in an organic solvent medium in which both starting components are soluble and in which the desired end product is insoluble. 4 - Amino - 3 - methyl - tetrahydro - 1,4 - thiazine-1,1-dioxide is prepared by reacting 2-mercapto-ethanol with propylene oxide in the presence of KOH, distilling the resulting 2 - hydroxyethyl - 2 - hydroxypropyl sulphide over p-toluene sulphonic acid or KHSO4 at atmospheric pressure to produce 2-methyl-1,4-oxathiane, oxidizing this compound with H2O2 in acetic acid, and reacting the thus obtained 2 - methyl - 1,4 - oxathiane - 4,4 - dioxide with excess hydrazine. The corresponding 2-ethyl compound is prepared in an analogous manner. Specification 889,068 is referred to.
GB45619/63A 1962-11-23 1963-11-19 New 5-nitro-furfurylidene derivatives Expired GB992166A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF38378A DE1170957B (en) 1962-11-23 1962-11-23 Process for the preparation of 5-nitro-furfurylidene- (2) -imino derivatives

Publications (1)

Publication Number Publication Date
GB992166A true GB992166A (en) 1965-05-19

Family

ID=7097312

Family Applications (1)

Application Number Title Priority Date Filing Date
GB45619/63A Expired GB992166A (en) 1962-11-23 1963-11-19 New 5-nitro-furfurylidene derivatives

Country Status (7)

Country Link
US (1) US3262930A (en)
AT (1) AT241450B (en)
BR (1) BR6354789D0 (en)
CH (1) CH426830A (en)
DE (1) DE1170957B (en)
FR (1) FR3257M (en)
GB (1) GB992166A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670657C3 (en) * 1966-01-05 1975-01-23 Bayer Ag, 5090 Leverkusen 4-square bracket to 5-NHrofurfuryliden- (2 ') - lmino square bracket to -tetrahydro-M-thlazln-i.i-dioxld-Derhrate and process for their production
DE1670840A1 (en) * 1967-03-31 1971-03-11 Bayer Ag Process for the preparation of tetra-hydro-1,4-thiazine-1,1-dioxides
DE2020298A1 (en) * 1970-04-25 1971-11-11 Bayer Ag 4- (5'-Nitrofurfurylidene-amino) -octahydro-4H-1,4-benz-thiazine-1,1-dioxide, a process for its preparation and its use as a medicine
US8406309B2 (en) 2005-10-21 2013-03-26 Qualcomm Incorporated Video rate adaptation to reverse link conditions
DE102008031284A1 (en) * 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft New control possibility of Giardiose
DE102008031283A1 (en) * 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft New possibility of combating diseases caused by trichomonadida
EP3750527A1 (en) 2019-06-13 2020-12-16 Bayer AG Stable tablet formulation of nifurtimox and process for producing the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3001992A (en) * 1961-09-26 S-niteo-z-fubftjewdene

Also Published As

Publication number Publication date
CH426830A (en) 1966-12-31
US3262930A (en) 1966-07-26
BR6354789D0 (en) 1973-07-12
AT241450B (en) 1965-07-26
DE1170957B (en) 1964-05-27
FR3257M (en) 1965-04-20

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