GB933809A - Acylthio halo octanoic acid derivatives - Google Patents

Acylthio halo octanoic acid derivatives

Info

Publication number
GB933809A
GB933809A GB403462A GB403462A GB933809A GB 933809 A GB933809 A GB 933809A GB 403462 A GB403462 A GB 403462A GB 403462 A GB403462 A GB 403462A GB 933809 A GB933809 A GB 933809A
Authority
GB
United Kingdom
Prior art keywords
acylthio
acid
halo
reacting
specified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB403462A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of GB933809A publication Critical patent/GB933809A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of the formula XCH2CH2CHR1(CH2)4COOH and esters thereof, where X is a halogen (e.g. Cl, Br or I) and R1 is an acylthio radical; and their production by reacting a compound as above in which R1 is an organic sulphonyloxy radical, with an monothiocarboxylic acid and an alkali, or with a metal salt of a monothiocarboxylic acid, in the presence or absence of a solvent. Specified thiocarboxylic acids are thioformic, thioacetic, thiopropionic, thiobenzoic and phenyl thioacetic acids; specified alkalies are alkali metal or alkaline earth metal hydroxides, alkyl or aryl amines, and pyridine. The starting materials may be prepared by reacting a 6-hydroxy-8-halooctanoic acid or its derivatives with an organic sulphonyl halide, e.g. a methane, ethane, benzene or toluene sulphonyl halide.
GB403462A 1961-02-02 1962-02-02 Acylthio halo octanoic acid derivatives Expired GB933809A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP367361 1961-02-02

Publications (1)

Publication Number Publication Date
GB933809A true GB933809A (en) 1963-08-14

Family

ID=11563927

Family Applications (1)

Application Number Title Priority Date Filing Date
GB403462A Expired GB933809A (en) 1961-02-02 1962-02-02 Acylthio halo octanoic acid derivatives

Country Status (2)

Country Link
CH (1) CH415604A (en)
GB (1) GB933809A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0763533A1 (en) * 1995-09-13 1997-03-19 Arzneimittelwerk Dresden Gmbh Preparation and use of the pure enantiomers of 8-chloro-6-sulfonyloxy-octanoic acid and its alkyl esters and of the pure enantiomers of 6,8-dichloro-octanoic acid and its alkyl esters
DE19601787C1 (en) * 1996-01-19 1997-07-24 Asta Medica Ag Production and use of salts of 6,8-bis (amidiniumthio) octanoic acid

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0763533A1 (en) * 1995-09-13 1997-03-19 Arzneimittelwerk Dresden Gmbh Preparation and use of the pure enantiomers of 8-chloro-6-sulfonyloxy-octanoic acid and its alkyl esters and of the pure enantiomers of 6,8-dichloro-octanoic acid and its alkyl esters
DE19601787C1 (en) * 1996-01-19 1997-07-24 Asta Medica Ag Production and use of salts of 6,8-bis (amidiniumthio) octanoic acid
US6013815A (en) * 1996-01-19 2000-01-11 Asta Medica Aktiengesellschaft Production and use of salts of 6,8-bis (amidiniumthio)-octanoic acid

Also Published As

Publication number Publication date
CH415604A (en) 1966-06-30

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