SE8001458L - Nya bensodiazepinforeningar - Google Patents

Nya bensodiazepinforeningar

Info

Publication number
SE8001458L
SE8001458L SE8001458A SE8001458A SE8001458L SE 8001458 L SE8001458 L SE 8001458L SE 8001458 A SE8001458 A SE 8001458A SE 8001458 A SE8001458 A SE 8001458A SE 8001458 L SE8001458 L SE 8001458L
Authority
SE
Sweden
Prior art keywords
compounds
benzodiazep
new
sulfino
compound
Prior art date
Application number
SE8001458A
Other languages
English (en)
Other versions
SE436882B (sv
Inventor
Y Ueda
Y Kagitani
E Sako
T Suyama
N Komatsu
D Satoh
Original Assignee
Green Cross Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp filed Critical Green Cross Corp
Publication of SE8001458L publication Critical patent/SE8001458L/sv
Publication of SE436882B publication Critical patent/SE436882B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SE8001458A 1979-07-17 1980-02-25 1h-pyrrolo /2,1-c//1,4/bensodiazepin-2-akrylamidforeningar, forfarande for deras framstellning och farmaceutisk komposition SE436882B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8988679A JPS5615289A (en) 1979-07-17 1979-07-17 Novel benzodiazepinnbased compound 3

Publications (2)

Publication Number Publication Date
SE8001458L true SE8001458L (sv) 1981-01-18
SE436882B SE436882B (sv) 1985-01-28

Family

ID=13983232

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8001458A SE436882B (sv) 1979-07-17 1980-02-25 1h-pyrrolo /2,1-c//1,4/bensodiazepin-2-akrylamidforeningar, forfarande for deras framstellning och farmaceutisk komposition

Country Status (11)

Country Link
US (1) US4309437A (sv)
JP (1) JPS5615289A (sv)
BE (1) BE882305A (sv)
CA (1) CA1152985A (sv)
CH (1) CH648848A5 (sv)
DE (1) DE3010544C2 (sv)
FR (1) FR2461711A1 (sv)
GB (1) GB2053894B (sv)
LU (1) LU82272A1 (sv)
NL (1) NL8001531A (sv)
SE (1) SE436882B (sv)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1214774A (en) * 1983-02-10 1986-12-02 Yusei Shiraga Benzodiazepine derivative
JPS59152329A (ja) * 1983-02-17 1984-08-31 Green Cross Corp:The 局所障害抑制剤
JPS60168512U (ja) * 1985-03-25 1985-11-08 株式会社栗田機械製作所 圧搾濾板の圧搾膜検査装置
PT1413582E (pt) * 1998-08-27 2006-07-31 Spirogen Ltd Pirrolobenzodiazepinas dimericas
GB9818732D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
GB9818731D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Compounds
GB9818730D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
GB0226593D0 (en) * 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) * 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
SI1720881T1 (sl) * 2004-03-01 2013-04-30 Spirogen Sarl 11-hidroksi-5H-pirolo(2,1-c)(1,4)benzodiazepin-5onski derivati kot ključni intermediati za pipravo C2 substituiranih pirolobenzodiazepinov
GB0404577D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
GB0404578D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
JP5166861B2 (ja) * 2004-03-09 2013-03-21 スピロゲン リミティッド ピロロベンゾジアゼピン
NZ563136A (en) 2005-04-21 2009-11-27 Spirogen Ltd Pyrrolobenzodiazepines
GB0813432D0 (en) * 2008-07-22 2008-08-27 Spirogen Ltd Pyrrolobenzodiazepines
GB0819095D0 (en) * 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
AU2011239522B2 (en) 2010-04-15 2014-10-23 Medimmune Limited Targeted pyrrolobenzodiazapine conjugates
AU2011239525B2 (en) 2010-04-15 2015-04-09 Medimmune Limited Pyrrolobenzodiazepines used to treat proliferative diseases
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
CA2849039C (en) 2011-09-20 2018-09-18 Spirogen Sarl Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
EA036202B1 (ru) 2011-10-14 2020-10-14 Сиэтл Дженетикс, Инк. Пирролбензодиазепины и конъюгаты направленного действия
EP3388435B1 (en) 2011-10-14 2023-05-03 Seagen Inc. Pyrrolobenzodiazepines and targeted conjugates
EA029046B1 (ru) 2011-10-14 2018-02-28 Медимьюн Лимитед Пирролобензодиазепины и промежуточные соединения для их получения, способы их синтеза
US9388187B2 (en) 2011-10-14 2016-07-12 Medimmune Limited Pyrrolobenzodiazepines
BR112014008888A2 (pt) 2011-10-14 2017-04-18 Seattle Genetics Inc pirrolobenzodiazepinas
BR112014027190B1 (pt) 2012-04-30 2020-03-03 Medimmune Limited Composto de pirrolobenzodiazepinas, sua composição farmacêutica e seu uso
WO2014057114A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-psma antibody conjugates
AU2013328673B2 (en) 2012-10-12 2017-07-13 Medimmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
NZ707534A (en) 2012-10-12 2018-08-31 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
EP2906297B1 (en) 2012-10-12 2017-12-06 ADC Therapeutics SA Pyrrolobenzodiazepine-antibody conjugates
NZ707486A (en) 2012-10-12 2018-09-28 Adc Therapeutics Sa Pyrrolobenzodiazepine - anti-psma antibody conjugates
CA3060520C (en) 2012-10-12 2022-05-17 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
MX364328B (es) 2012-10-12 2019-04-23 Medimmune Ltd Conjugados del anticuerpo pirrolobenzodiazepina.
DK2906251T3 (da) 2012-10-12 2017-11-20 Adc Therapeutics Sa Pyrrolobenzodiazepin-anti-CD22-antistofkonjugater
PL2766048T3 (pl) 2012-10-12 2015-05-29 Medimmune Ltd Pirolobenzodiazepiny i ich koniugaty
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
EP3054986B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
KR20170101895A (ko) 2014-11-25 2017-09-06 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항체 접합체
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
TW201808936A (zh) 2016-05-18 2018-03-16 美商梅爾莎納醫療公司 吡咯并苯并二氮呯類及其共軛物
US10526294B2 (en) 2016-06-24 2020-01-07 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
AU2018217926B2 (en) 2017-02-08 2019-10-03 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
EP3612537B1 (en) 2017-04-18 2022-07-13 Medimmune Limited Pyrrolobenzodiazepine conjugates
US20200129637A1 (en) 2017-04-20 2020-04-30 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
KR102442736B1 (ko) 2017-06-14 2022-09-16 에이디씨 테라퓨틱스 에스에이 항-cd19 adc의 투여를 위한 투약량 체제
JP7220203B2 (ja) 2017-08-18 2023-02-09 メドイミューン・リミテッド ピロロベンゾジアゼピン複合体
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
USD925487S1 (en) * 2019-10-22 2021-07-20 Lg Electronics Inc. Audio player

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3523941A (en) * 1967-03-06 1970-08-11 Hoffmann La Roche Benzodiazepine compounds and process for their preparation
US3524849A (en) * 1967-10-27 1970-08-18 Hoffmann La Roche Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein

Also Published As

Publication number Publication date
FR2461711A1 (fr) 1981-02-06
DE3010544C2 (de) 1982-07-01
US4309437A (en) 1982-01-05
FR2461711B1 (sv) 1983-05-13
GB2053894B (en) 1983-04-20
NL8001531A (nl) 1981-01-20
CH648848A5 (de) 1985-04-15
JPS6237631B2 (sv) 1987-08-13
SE436882B (sv) 1985-01-28
BE882305A (fr) 1980-07-16
JPS5615289A (en) 1981-02-14
CA1152985A (en) 1983-08-30
DE3010544A1 (de) 1981-01-29
LU82272A1 (fr) 1980-07-01
GB2053894A (en) 1981-02-11

Similar Documents

Publication Publication Date Title
SE8001458L (sv) Nya bensodiazepinforeningar
NO160781C (no) 1,2,5-tiadiazolderivater.
AU522217B2 (en) Fungicidal 1, 2-dichlorocyanovinyl compounds
BE867353A (fr) Ethers d'azolyl-acetophenone-oxime utiles comme fongicides
ZA80240B (en) Pesticidal compounds and their production,compositions and uses
NL7804386A (nl) Mechanische afdichting,.
DK148515C (da) Sammenfoejning af paeleafsnit i forlaengelse af hinanden.
OA05774A (fr) Composés de sulfure de N.bis carbamoyl substitué.
NL7701080A (nl) Landbouwmachine, zoals een maaimachine of een combine-maaimachine met een zwenkbare kast.
CY1224A (en) Neue tetralinderivate,ihre herstellung und verwendung
BE842874A (fr) 2-halogeno-5-trichloromethyl-1,3,4-thiadiazoles utiles comme fongicides
TR20170A (tr) Mikrobisitler olarak 1,1 difenileten tuerevleri
AU497414B2 (en) 1, 3 dithiolane compounds
CH625933B (de) Momentan umschaltendes kalenderwerk.
AR220110A1 (es) Compuestos de 2,1,3-benzotiadiazin-2,2 dioxido-4-ona o 4-tiona
SE8005303L (sv) 6-alkyl-7-fenyl-1,6-naftyridin-5(6h)-onderivat
AR215308A1 (es) Procedimiento para producir el compuesto antibiotico 64,192
TR20428A (tr) 3,4-metano pirrolidin tuerevle,terkipleri ve bitki bueyuemesini ayar layici maddeler olarak kullanilmasi
ES449308A1 (es) Un procedimiento de preparacion de derivados de alamina n,n-disustituidos.
SE7807988L (sv) Herbicidalt verksamma 1,2,4-triazin-5-on-derivat
ES260318Y (es) Disposicion de piezas conjuntamente montables a modo de cajade construcciones.
NL7808137A (nl) 1-vertakte alkyl-carbonyl-3-(3,5-dihalogeenfenyl)imida- zolidine-2,4-dionen.
SU825814A1 (ru) Замок
IT1209408B (it) Composti disolfuro polifunzionali.
BE843235A (fr) 2,6-dinitroanilines 3-substituees utiles comme fongicides

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8001458-2

Effective date: 19880125

Format of ref document f/p: F