SE7907938L - Terapeutiskt aktiva polypeptider eller syraadditionssalter och forfaringssett for framstellning av sadana foreningar - Google Patents
Terapeutiskt aktiva polypeptider eller syraadditionssalter och forfaringssett for framstellning av sadana foreningarInfo
- Publication number
- SE7907938L SE7907938L SE7907938A SE7907938A SE7907938L SE 7907938 L SE7907938 L SE 7907938L SE 7907938 A SE7907938 A SE 7907938A SE 7907938 A SE7907938 A SE 7907938A SE 7907938 L SE7907938 L SE 7907938L
- Authority
- SE
- Sweden
- Prior art keywords
- amino acid
- group
- glucose
- addition salts
- acid addition
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 5
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 3
- 239000008103 glucose Substances 0.000 abstract 3
- -1 phthalimidomethyl Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 230000004060 metabolic process Effects 0.000 abstract 2
- 230000003389 potentiating effect Effects 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- 102400000321 Glucagon Human genes 0.000 abstract 1
- 108060003199 Glucagon Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical group [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 210000001789 adipocyte Anatomy 0.000 abstract 1
- 150000003862 amino acid derivatives Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
- 229960004666 glucagon Drugs 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/645—Secretins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/66—Thymopoietins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK430478 | 1978-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE7907938L true SE7907938L (sv) | 1980-03-29 |
Family
ID=8132257
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7907938A SE7907938L (sv) | 1978-09-28 | 1979-09-25 | Terapeutiskt aktiva polypeptider eller syraadditionssalter och forfaringssett for framstellning av sadana foreningar |
| SE7907939A SE7907939L (sv) | 1978-09-28 | 1979-09-25 | Terapeutiskt aktiva polypeptider eller syraadditionssalter derav och forfaringssett for framstellning av sadana foreningar |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7907939A SE7907939L (sv) | 1978-09-28 | 1979-09-25 | Terapeutiskt aktiva polypeptider eller syraadditionssalter derav och forfaringssett for framstellning av sadana foreningar |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4356119A (de) |
| JP (2) | JPS5576849A (de) |
| AT (1) | AT375338B (de) |
| AU (2) | AU526149B2 (de) |
| BE (2) | BE879087A (de) |
| CA (2) | CA1140116A (de) |
| CH (2) | CH648568A5 (de) |
| DE (2) | DE2939135A1 (de) |
| ES (2) | ES484926A1 (de) |
| FI (2) | FI68244C (de) |
| FR (2) | FR2437399A1 (de) |
| GB (2) | GB2031436B (de) |
| IT (2) | IT1125421B (de) |
| NL (2) | NL7907187A (de) |
| NO (2) | NO148923C (de) |
| SE (2) | SE7907938L (de) |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA616330A (en) * | 1961-03-14 | Schwyzer Robert | Polypeptide and derivatives thereof and process for their manfuacture | |
| CA685075A (en) * | 1964-04-21 | Schwyzer Robert | Polypeptides and process for their manufacture | |
| CA798855A (en) * | 1968-11-12 | Bernardi Luigi | Process for preparing a new undecapeptide | |
| GB1064417A (en) * | 1963-12-09 | 1967-04-05 | Kyowa Hakko Kogyo Kk | Process for the preparation of copolypeptides |
| US3400118A (en) * | 1966-05-27 | 1968-09-03 | Squibb & Sons Inc | Intermediates in the preparation of secretin |
| US3832337A (en) * | 1970-07-28 | 1974-08-27 | Squibb & Sons Inc | Peptide enzyme inhibitors |
| US3856770A (en) * | 1972-03-08 | 1974-12-24 | Akzona Inc | Psychopharmacologically active tetra-, penta-, hexa-, and heptapeptides |
| NL175174C (nl) * | 1972-03-31 | 1984-10-01 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat als actief bestanddeel bevat, alsmede een werkwijze ter bereiding van deze peptiden. |
| NL175988C (nl) * | 1972-05-24 | 1985-02-01 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat dat afgeleid is van een de aminozuren 4-10 omvattend, fragment van adrenocorticotroop hormoon als actief bestanddeel bevat, alsmede een werkwijze ter bereiding van deze peptiden. |
| NL175618C (nl) * | 1972-07-15 | 1984-12-03 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat bevat, alsmede een werkwijze ter bereiding van dergelijke peptiden. |
| DE2315271C3 (de) * | 1973-03-27 | 1975-09-11 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | L- Norleucin-13-Motilin, Verfahren zu dessen Herstellung und dasselbe enthaltendes Mittel |
| GB1532211A (en) * | 1974-10-25 | 1978-11-15 | Wellcome Found | Lh-rh peptide analogues |
| US3975365A (en) * | 1975-01-27 | 1976-08-17 | G. D. Searle & Co. | Inhibitory octapeptides angiotensin II |
| DE2602443A1 (de) * | 1975-04-04 | 1976-10-21 | Univ California | Biologisch aktive polypeptide |
| US4171299A (en) * | 1975-04-04 | 1979-10-16 | The Regents Of The University Of California | Polypeptide agents for blocking the human allergic response |
| US4058512A (en) * | 1975-04-28 | 1977-11-15 | Ab Kabi | Synthetic peptides having growth promoting activity |
| US4024121A (en) * | 1976-01-27 | 1977-05-17 | Schally Andrew Victor | (Pyro)-Glu-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHR and intermediates |
| SE436645C (sv) * | 1976-04-29 | 1996-07-22 | Bonnierfoeretagen Ab | Antigeniskt aktiv polypeptid, som kan användas vid cancerdiagnosticering och vid framställning av antikroppar |
| US4110321A (en) * | 1976-07-12 | 1978-08-29 | Folkers Karl | Synthetic tridecapeptide [Gln4 ]-neurotensin having hormonal activity |
| US4086220A (en) * | 1976-08-09 | 1978-04-25 | G. D. Searle & Co. | Fragments of secretin |
-
1979
- 1979-09-24 US US06/078,424 patent/US4356119A/en not_active Expired - Lifetime
- 1979-09-25 SE SE7907938A patent/SE7907938L/ not_active Application Discontinuation
- 1979-09-25 SE SE7907939A patent/SE7907939L/ not_active Application Discontinuation
- 1979-09-26 AU AU51245/79A patent/AU526149B2/en not_active Ceased
- 1979-09-26 AU AU51246/79A patent/AU533684B2/en not_active Ceased
- 1979-09-26 FI FI793001A patent/FI68244C/fi not_active IP Right Cessation
- 1979-09-26 FI FI793002A patent/FI68245C/fi not_active IP Right Cessation
- 1979-09-27 CA CA000336681A patent/CA1140116A/en not_active Expired
- 1979-09-27 FR FR7924077A patent/FR2437399A1/fr active Granted
- 1979-09-27 DE DE19792939135 patent/DE2939135A1/de not_active Withdrawn
- 1979-09-27 DE DE19792939109 patent/DE2939109A1/de not_active Withdrawn
- 1979-09-27 NO NO793112A patent/NO148923C/no unknown
- 1979-09-27 NL NL7907187A patent/NL7907187A/nl not_active Application Discontinuation
- 1979-09-27 CA CA000336694A patent/CA1158640A/en not_active Expired
- 1979-09-27 CH CH8715/79A patent/CH648568A5/de not_active IP Right Cessation
- 1979-09-27 AT AT0634679A patent/AT375338B/de not_active IP Right Cessation
- 1979-09-27 CH CH8714/79A patent/CH648567A5/de not_active IP Right Cessation
- 1979-09-27 GB GB7933541A patent/GB2031436B/en not_active Expired
- 1979-09-27 FR FR7924078A patent/FR2437400A1/fr active Granted
- 1979-09-27 NL NL7907188A patent/NL7907188A/nl not_active Application Discontinuation
- 1979-09-27 GB GB7933540A patent/GB2031435B/en not_active Expired
- 1979-09-27 NO NO793111A patent/NO148922C/no unknown
- 1979-09-28 IT IT26111/79A patent/IT1125421B/it active
- 1979-09-28 BE BE0/197392A patent/BE879087A/fr not_active IP Right Cessation
- 1979-09-28 ES ES484926A patent/ES484926A1/es not_active Expired
- 1979-09-28 BE BE0/197391A patent/BE879086A/fr not_active IP Right Cessation
- 1979-09-28 ES ES484928A patent/ES484928A1/es not_active Expired
- 1979-09-28 IT IT26112/79A patent/IT1125422B/it active
- 1979-09-28 JP JP12522179A patent/JPS5576849A/ja active Pending
- 1979-09-28 JP JP12522079A patent/JPS5569550A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 7907938-0 |