SE454880B - 3-aminoalkyl-1h-indol-5-acetamider, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren - Google Patents

3-aminoalkyl-1h-indol-5-acetamider, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren

Info

Publication number
SE454880B
SE454880B SE8104781A SE8104781A SE454880B SE 454880 B SE454880 B SE 454880B SE 8104781 A SE8104781 A SE 8104781A SE 8104781 A SE8104781 A SE 8104781A SE 454880 B SE454880 B SE 454880B
Authority
SE
Sweden
Prior art keywords
compound
formula
group
solution
indole
Prior art date
Application number
SE8104781A
Other languages
English (en)
Swedish (sv)
Other versions
SE8104781L (sv
Inventor
D E Bays
C F Webb
M D Dowle
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SE8104781L publication Critical patent/SE8104781L/xx
Publication of SE454880B publication Critical patent/SE454880B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
SE8104781A 1980-08-12 1981-08-11 3-aminoalkyl-1h-indol-5-acetamider, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren SE454880B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8026286 1980-08-12

Publications (2)

Publication Number Publication Date
SE8104781L SE8104781L (sv) 1982-02-13
SE454880B true SE454880B (sv) 1988-06-06

Family

ID=10515410

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8104781A SE454880B (sv) 1980-08-12 1981-08-11 3-aminoalkyl-1h-indol-5-acetamider, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren

Country Status (16)

Country Link
US (1) US4650810A (cg-RX-API-DMAC7.html)
JP (1) JPS5764669A (cg-RX-API-DMAC7.html)
AU (1) AU548467B2 (cg-RX-API-DMAC7.html)
BE (1) BE889929A (cg-RX-API-DMAC7.html)
CA (1) CA1169428A (cg-RX-API-DMAC7.html)
CH (1) CH651551A5 (cg-RX-API-DMAC7.html)
DE (1) DE3131728A1 (cg-RX-API-DMAC7.html)
DK (1) DK157920C (cg-RX-API-DMAC7.html)
ES (5) ES504693A0 (cg-RX-API-DMAC7.html)
FR (1) FR2488607A1 (cg-RX-API-DMAC7.html)
IE (1) IE51491B1 (cg-RX-API-DMAC7.html)
IT (1) IT1171449B (cg-RX-API-DMAC7.html)
NL (1) NL8103769A (cg-RX-API-DMAC7.html)
NZ (1) NZ197996A (cg-RX-API-DMAC7.html)
SE (1) SE454880B (cg-RX-API-DMAC7.html)
ZA (1) ZA815540B (cg-RX-API-DMAC7.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79215B (cg-RX-API-DMAC7.html) * 1982-06-07 1984-10-22 Glaxo Group Ltd
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
EP0225726B1 (en) * 1985-11-08 1991-04-17 Glaxo Group Limited Indole derivatives
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
PT97888B (pt) * 1990-06-07 1998-12-31 Zeneca Ltd Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
US5254383A (en) * 1992-09-14 1993-10-19 Allied-Signal Inc. Composites having improved penetration resistance and articles fabricated from same
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
ES2084560B1 (es) * 1994-03-09 1997-01-16 Almirall Lab Procedimiento de preparacion de derivados el indol.
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US20030096379A1 (en) * 2001-03-28 2003-05-22 Kilgore James L. Method for producing tryptamine derivatives
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
EP2666772B1 (en) * 2002-12-20 2017-03-01 Basf Se Synthesis of amines and intermediates for the synthesis thereof
US8148377B2 (en) 2007-02-11 2012-04-03 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US8173813B2 (en) 2007-03-23 2012-05-08 Neuraxon, Inc. Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity
EP2141148B1 (en) 2007-03-29 2013-07-03 Daiichi Sankyo Company, Limited Indole derivative having cpla2 inhibitory activity, use of the same and method for producing the same
US20110171141A1 (en) * 2009-06-26 2011-07-14 Kellerman Donald J Administration of dihydroergotamine mesylate particles using a metered dose inhaler
EP3628325A1 (en) 2011-07-22 2020-04-01 The University of Chicago Treatments for migraine and related disorders
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
ES8301210A1 (es) 1982-12-01
ES520783A0 (es) 1985-05-01
IT8149084A1 (it) 1983-02-11
FR2488607A1 (fr) 1982-02-19
SE8104781L (sv) 1982-02-13
AU548467B2 (en) 1985-12-12
FR2488607B1 (cg-RX-API-DMAC7.html) 1984-11-16
DK357081A (da) 1982-02-13
ES520784A0 (es) 1984-11-01
ES8500902A1 (es) 1984-11-01
ES8500903A1 (es) 1984-11-01
AU7399481A (en) 1982-02-18
NL8103769A (nl) 1982-03-01
IE811830L (en) 1982-02-12
ES513933A0 (es) 1984-01-16
IT1171449B (it) 1987-06-10
ES8402268A1 (es) 1984-01-16
DE3131728C2 (cg-RX-API-DMAC7.html) 1992-04-30
ZA815540B (en) 1983-03-30
DK157920B (da) 1990-03-05
DK157920C (da) 1990-08-06
DE3131728A1 (de) 1982-03-11
NZ197996A (en) 1985-08-16
US4650810A (en) 1987-03-17
JPH0247462B2 (cg-RX-API-DMAC7.html) 1990-10-19
BE889929A (fr) 1982-02-11
IT8149084A0 (it) 1981-08-11
JPS5764669A (en) 1982-04-19
ES520785A0 (es) 1984-11-01
ES504693A0 (es) 1982-12-01
IE51491B1 (en) 1987-01-07
CH651551A5 (fr) 1985-09-30
CA1169428A (en) 1984-06-19
ES8504706A1 (es) 1985-05-01

Similar Documents

Publication Publication Date Title
SE454880B (sv) 3-aminoalkyl-1h-indol-5-acetamider, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren
SE454881B (sv) N-(3-(aminoalkyl)-1h-indol-5-yl-metyl) sulfonamider, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren
FI92397C (fi) Menetelmä valmistaa farmaseuttisesti käyttökelpoisia indolijohdoksia
DE3444572C2 (de) Indolderivate, Verfahren zu ihrer Herstellung, sie enthaltende pharmazeutische Zubereitungen und ihre Verwendung
DE69433984T2 (de) Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
SE452459B (sv) Indol-5-metansulfonamid, en farmaceutisk komposition och ett forfarande for framstellning av foreningen
SE448628B (sv) 5-indolamider, farmaceutisk komposition innehallande dessa och forfarande for framstellning av foreningarna
SE454777B (sv) 5-substituerade 3-aminoalkyl-1h-indoler, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren
CZ404191A3 (en) Indole derivative, process of its preparation and pharmaceutical preparations containing thereof
JPH0148896B2 (cg-RX-API-DMAC7.html)
FR2735127A1 (fr) Nouvelles piperazines heteroaromatiques utiles comme medicaments.
AU701560B2 (en) 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists
JP3447291B2 (ja) 医薬として有用であるインドールピペラジンから誘導される５−ｈｔ１ｄ−５−ｈｔ１ｂ受容体の選択的リガンド
JPH09510706A (ja) ドパミン作動性活性を有するベンゾイミダゾール誘導体
EP1007524B1 (fr) Derives d'indole comme agonistes de 5-ht1b et 5-ht1d
FR2595352A1 (fr) Derives de l'indole utiles comme medicaments et procede et intermediaires pour leur preparation
US4898863A (en) Heterocyclic carboxamides
JP2001525398A (ja) 選択的β３アドレナリン作動性アゴニスト
US3328407A (en) 1-(indolyl lower-alkyl)-4-phenyl-piperazines
KR20080070822A (ko) 유도가능 산화질소 신타제 이량체화 억제제의 염
JPS63301881A (ja) インドリルピペリジン誘導体
FR2521993A1 (fr) Composes heterocycliques azotes, leur preparation et leur utilisation therapeutique en tant qu'antagonistes de l'histamine
DK165976B (da) 5-aminosulfonyl-methyl-indolderivater og farmaceutiske praeparater med indhold deraf
FR2731224A1 (fr) Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8104781-3

Effective date: 19910315

Format of ref document f/p: F