SE454698B - 6-karboxamidoderivat av 5-oxo-5h-1,3,4-tiadiazolo/3,2-a/pyrimidiner, forfarande for deras framstellning samt farmaceutiska kompositioner innehallande desamma - Google Patents

6-karboxamidoderivat av 5-oxo-5h-1,3,4-tiadiazolo/3,2-a/pyrimidiner, forfarande for deras framstellning samt farmaceutiska kompositioner innehallande desamma

Info

Publication number
SE454698B
SE454698B SE8307133A SE8307133A SE454698B SE 454698 B SE454698 B SE 454698B SE 8307133 A SE8307133 A SE 8307133A SE 8307133 A SE8307133 A SE 8307133A SE 454698 B SE454698 B SE 454698B
Authority
SE
Sweden
Prior art keywords
pyridyl
thiadiazolo
oxo
pyrimidine
carboxamide
Prior art date
Application number
SE8307133A
Other languages
English (en)
Swedish (sv)
Other versions
SE8307133D0 (sv
SE8307133L (sv
Inventor
G Doria
C Passarotti
A Buttinoni
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838329746A external-priority patent/GB8329746D0/en
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of SE8307133D0 publication Critical patent/SE8307133D0/xx
Publication of SE8307133L publication Critical patent/SE8307133L/xx
Publication of SE454698B publication Critical patent/SE454698B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE8307133A 1982-12-23 1983-12-22 6-karboxamidoderivat av 5-oxo-5h-1,3,4-tiadiazolo/3,2-a/pyrimidiner, forfarande for deras framstellning samt farmaceutiska kompositioner innehallande desamma SE454698B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8236642 1982-12-23
GB838329746A GB8329746D0 (en) 1983-11-08 1983-11-08 Carboxamido-derivatives

Publications (3)

Publication Number Publication Date
SE8307133D0 SE8307133D0 (sv) 1983-12-22
SE8307133L SE8307133L (sv) 1984-06-24
SE454698B true SE454698B (sv) 1988-05-24

Family

ID=26284768

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8307133A SE454698B (sv) 1982-12-23 1983-12-22 6-karboxamidoderivat av 5-oxo-5h-1,3,4-tiadiazolo/3,2-a/pyrimidiner, forfarande for deras framstellning samt farmaceutiska kompositioner innehallande desamma

Country Status (15)

Country Link
US (1) US4522944A (pm)
AT (1) AT385036B (pm)
AU (1) AU558600B2 (pm)
CA (1) CA1211440A (pm)
CH (1) CH657136A5 (pm)
DE (1) DE3346223A1 (pm)
DK (1) DK593983A (pm)
FI (1) FI834698A7 (pm)
FR (1) FR2538392B1 (pm)
GR (1) GR79479B (pm)
IL (1) IL70522A (pm)
IT (1) IT1194521B (pm)
NL (1) NL8304340A (pm)
SE (1) SE454698B (pm)
SU (1) SU1297731A3 (pm)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3702758A1 (de) * 1987-01-30 1988-09-29 Hoechst Ag Substituierte 3-phenyl-7h-thiazolo (3,2-b) (1,2,4) triazin-7-one, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung, sowie einige bei der herstellung der genannten verbindungen gebildete zwischenprodukte
KR102065319B1 (ko) 2007-03-12 2020-01-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 치환된 헤테로환 융합 감마-카르볼린 합성
WO2013155504A1 (en) 2012-04-14 2013-10-17 Intra-Cellular Therapies, Inc. Novel methods
WO2014145192A1 (en) 2013-03-15 2014-09-18 Intra-Cellular Therapies, Inc. Organic compounds
CN105939712A (zh) 2013-12-03 2016-09-14 细胞内治疗公司 新方法
KR20170012210A (ko) 2014-04-04 2017-02-02 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
US9745300B2 (en) 2014-04-04 2017-08-29 Intra-Cellular Therapies, Inc. Organic compounds
KR20240170975A (ko) 2016-01-26 2024-12-05 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
US11014925B2 (en) 2016-03-28 2021-05-25 Intra-Cellular Therapies, Inc. Co-crystals of 1-(4-fluoro-phenyl)-4-((6bR,1OaS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3′,4′:4,51_pyrrolo [1,2,3-delqcuinoxalin-8-yl)-butan-1-one with nicotinamide or isonicotinamide
EP3436083A4 (en) 2016-03-28 2019-11-27 Intra-Cellular Therapies, Inc. NOVEL COMPOSITIONS AND METHOD
EP3436455A4 (en) 2016-03-28 2019-09-04 Intra-Cellular Therapies, Inc. NOVEL SALTS AND CRYSTALS
EP3525763B1 (en) 2016-10-12 2025-03-05 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
US10906906B2 (en) 2016-12-29 2021-02-02 Intra-Cellular Therapies, Inc. Organic compounds
IL268970B2 (en) 2017-03-24 2023-12-01 Intra Cellular Therapies Inc Oral preparations of heterocyclic gamma carboline derivatives fused for absorption through mucous membranes
CN111093664B (zh) 2017-07-26 2023-06-02 细胞内治疗公司 有机化合物
CA3071119A1 (en) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines for treatment or prophylaxis of central nervous system disorders
WO2019183341A1 (en) 2018-03-23 2019-09-26 Intra-Cellular Therapies, Inc. Organic compounds
CN112384218B (zh) 2018-06-06 2024-04-26 细胞内治疗公司 盐和晶体
EP3801527B1 (en) 2018-06-08 2025-02-19 Intra-Cellular Therapies, Inc. Fused gamma-carbolines for acute treatment of anxiety or depression
WO2019241278A1 (en) 2018-06-11 2019-12-19 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
US12144808B2 (en) 2018-08-29 2024-11-19 Intra-Cellular Therapies, Inc. Compositions and methods
KR20210052472A (ko) 2018-08-31 2021-05-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
CA3108553A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
CN114072150A (zh) 2019-07-07 2022-02-18 细胞内治疗公司 新方法
US11753419B2 (en) 2019-12-11 2023-09-12 Intra-Cellular Therapies, Inc. 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)phenyl)butan-1-one for treating conditions of the central nervous system and cardiac disorders
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5129981B2 (pm) * 1973-07-17 1976-08-28
GB1568962A (en) * 1975-10-31 1980-06-11 Beecham Group Ltd Reparation and compositions containing them (heterocyclic-carbonylamino)pencillins methods for their p
JPS55115889A (en) * 1979-02-28 1980-09-06 Teijin Ltd 6-carbamoylthiazolo 3,2-a pyrimidine derivative and its preparation
JPS57142989A (en) * 1981-02-27 1982-09-03 Dai Ichi Seiyaku Co Ltd Thiazolopyrimidine derivative

Also Published As

Publication number Publication date
AT385036B (de) 1988-02-10
SE8307133D0 (sv) 1983-12-22
SU1297731A3 (ru) 1987-03-15
DE3346223A1 (de) 1984-06-28
SE8307133L (sv) 1984-06-24
CA1211440A (en) 1986-09-16
AU2252583A (en) 1984-06-28
IL70522A (en) 1986-02-28
AU558600B2 (en) 1987-02-05
FR2538392B1 (fr) 1987-01-16
CH657136A5 (de) 1986-08-15
ATA438383A (de) 1987-07-15
NL8304340A (nl) 1984-07-16
DK593983D0 (da) 1983-12-22
FR2538392A1 (fr) 1984-06-29
DK593983A (da) 1984-06-24
FI834698A7 (fi) 1984-06-24
IL70522A0 (en) 1984-03-30
IT1194521B (it) 1988-09-22
US4522944A (en) 1985-06-11
IT8324207A0 (it) 1983-12-16
GR79479B (pm) 1984-10-30
FI834698A0 (fi) 1983-12-20

Similar Documents

Publication Publication Date Title
SE454698B (sv) 6-karboxamidoderivat av 5-oxo-5h-1,3,4-tiadiazolo/3,2-a/pyrimidiner, forfarande for deras framstellning samt farmaceutiska kompositioner innehallande desamma
EP0465254B1 (en) Fused thiophene compounds and uses thereof
RU2700004C1 (ru) Конденсированные трициклические производные имидазола в качестве модуляторов активности tnf
FI96857C (fi) Menetelmä valmistaa farmakologisesti käyttökelpoista tiatsoliyhdistettä
US5366972A (en) 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
AU651353B2 (en) Pyrazolopyridine compound and processes for preparation thereof
FI74469C (fi) Foerfarande foer framstaellning av substituerade 1h-pyrazolo/1,5-a/pyrimidiner.
AU763758B2 (en) Novel compounds
AU705039B2 (en) Pyrido{2, 3-D} pyrimidine derivatives and pharmaceutical compositions thereof
KR20100105847A (ko) 항균성 농축 티아졸
EP1986645A1 (en) Glucokinase activators
AU2003291670A1 (en) Anti-infective agents
US8957211B2 (en) (Heterocycle/condensed piperidine)-(piperazinyl)-1-alkanone or (heterocycle/condensed pyrrolidine)-(piperazinyl)-1-alkanone derivatives and use thereof as p75 inhibitors
CA1309407C (en) Cinnoline-carboxamides and process for their preparation
CS236753B2 (en) Processing of thieno (1,5) benzodiazepine derivatives
CA1218656A (en) Pyridothienotriazines
SE437158B (sv) Substituerade pyrido/1,2-a/pyrimidiner, forfarande for framstellning derav och farmaceutisk komposition
US3636041A (en) 4 5-dihydro-7h-thieno(2 3-c)thiopyrans
US20210261539A1 (en) Compound having bet inhibitory activity and preparation method and use therefor
GB2132200A (en) Carboxamido-derivatives of 5H-1,3,4-thiadiazolo[3,2-a]-pyrimidines and process for their preparation
NZ206816A (en) Substituted carboxy-thiazolo(3,2-a)pyrimidine derivatives and pharmaceutical compositions
AU705938B2 (en) Pyridazino quinoline compounds
GB2116971A (en) 1H-pyrazolo [1,5-a] pyrimidines
IE46185B1 (en) 2,5-dihydro-1,2-thiazino (5,6-b)indol-3-carboxamide-1,1-dioxid derivatives
HU176066B (en) Process for producing 2,6-bis-bracket-amino-acylamino-bracket closed-benzo-square bracket-1,2-d.,5,4-d-comma above-square bracket closed-bis-thiasoles and 2-amino-6-bracket-amino-acylamino-bracket closed-benzo-square bracket-1,2-d., 5,4-d-comma above-square bracket closed-bis-thiasoles

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8307133-2

Effective date: 19901106

Format of ref document f/p: F