SE448457B - Derivat av nor-tropan och granatan, deras framstelling och farmaceutiska komposition - Google Patents

Derivat av nor-tropan och granatan, deras framstelling och farmaceutiska komposition

Info

Publication number
SE448457B
SE448457B SE8106425A SE8106425A SE448457B SE 448457 B SE448457 B SE 448457B SE 8106425 A SE8106425 A SE 8106425A SE 8106425 A SE8106425 A SE 8106425A SE 448457 B SE448457 B SE 448457B
Authority
SE
Sweden
Prior art keywords
formula
group
compounds
benzyl
combination
Prior art date
Application number
SE8106425A
Other languages
English (en)
Swedish (sv)
Other versions
SE8106425L (sv
Inventor
P Dostert
T Imbert
B Bucher
Original Assignee
Delalande Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande Sa filed Critical Delalande Sa
Publication of SE8106425L publication Critical patent/SE8106425L/xx
Publication of SE448457B publication Critical patent/SE448457B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE8106425A 1980-11-07 1981-10-30 Derivat av nor-tropan och granatan, deras framstelling och farmaceutiska komposition SE448457B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8023785A FR2493848B2 (fr) 1980-11-07 1980-11-07 Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
SE8106425L SE8106425L (sv) 1982-05-08
SE448457B true SE448457B (sv) 1987-02-23

Family

ID=9247763

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8106425A SE448457B (sv) 1980-11-07 1981-10-30 Derivat av nor-tropan och granatan, deras framstelling och farmaceutiska komposition

Country Status (15)

Country Link
US (1) US4434170A (es)
JP (1) JPS57108090A (es)
BE (1) BE890962R (es)
CA (1) CA1209574A (es)
CH (1) CH651561A5 (es)
DE (1) DE3144183A1 (es)
ES (1) ES8301979A2 (es)
FR (1) FR2493848B2 (es)
GB (1) GB2088364B (es)
GR (1) GR75112B (es)
IT (1) IT1140040B (es)
LU (1) LU83737A7 (es)
NL (1) NL8105042A (es)
SE (1) SE448457B (es)
ZA (1) ZA817675B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440946A2 (fr) * 1978-01-20 1980-06-06 Ile De France Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement
EP0067615B1 (en) * 1981-06-17 1986-01-08 Beecham Group Plc Alkylthio derivatives of azabicyclobenzamides, their preparation and pharmaceutical compositions
DE3275296D1 (en) * 1981-10-01 1987-03-05 Beecham Group Plc Azabicyclo-(3,3,1)-nonylbenzamide derivatives, processes for their preparation, and pharmaceutical compositions containing them
EP0083737A1 (en) * 1981-12-15 1983-07-20 Beecham Group Plc N-azabicycloalkane benzamides, process for their preparation and pharmaceutical compositions containing them
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives
FR2546169B1 (fr) * 1983-05-20 1986-03-21 Delalande Sa N-oxydes de derives aminocycliques, leur procede de preparation et leur application en therapeutique
FR2548666A1 (fr) * 1983-07-08 1985-01-11 Delalande Sa Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique
DE3429830A1 (de) * 1983-08-26 1985-03-07 Sandoz-Patent-GmbH, 7850 Lörrach Automatische carbonsaeure- und sulfonsaeureester oder -amide
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
DE3587151T2 (de) * 1984-12-20 1993-07-15 Sandoz Ag Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
DE3689974T2 (de) * 1985-03-14 1994-11-03 Beecham Group Plc Arzneimittel zur Behandlung von Emesis.
GB8516371D0 (en) * 1985-06-28 1985-07-31 Beecham Group Plc Compounds
HU202108B (en) * 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
GB9027098D0 (en) * 1990-12-13 1991-02-06 Beecham Group Plc Pharmaceuticals
DE69319939T2 (de) * 1992-02-04 1999-02-18 Eisai Co., Ltd., Tokio/Tokyo Aminobenzoesäure Derivate
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
ES2322709T3 (es) * 2004-02-18 2009-06-25 Astrazeneca Ab Derivados de benzamida y su uso como agentes activadores de la glucocinasa.
CA2554686A1 (en) * 2004-02-18 2005-09-01 Astrazeneca Ab Compounds
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
BRPI0516595A (pt) 2004-10-16 2008-09-23 Astrazeneca Ab processo para fabricar um composto, e, composto
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
EP1891069A1 (en) * 2005-05-24 2008-02-27 AstraZeneca AB 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
BRPI0622262A2 (pt) * 2005-07-09 2011-08-09 Astrazeneca Ab composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto
US20110053910A1 (en) * 2005-07-09 2011-03-03 Mckerrecher Darren 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
EP2027113A1 (en) * 2005-07-09 2009-02-25 AstraZeneca AB Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
SA07280576B1 (ar) * 2006-10-26 2011-06-22 استرازينيكا ايه بي مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز
KR20090090390A (ko) * 2006-12-21 2009-08-25 아스트라제네카 아베 Ｇｌｋ 활성제로서 유용한 신규 결정 화합물
EA201100097A1 (ru) * 2008-08-04 2011-10-31 Астразенека Аб Производные пиразоло[3,4]пиримидин-4-ила и их применения для лечения диабета и ожирения
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
WO2010116177A1 (en) 2009-04-09 2010-10-14 Astrazeneca Ab A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity
AR076221A1 (es) * 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3134782A (en) 1964-05-26 Chjxch-
GB774858A (en) 1954-10-20 1957-05-15 Sandoz Ltd Tropane and -Î-tropane derivatives and process for preparation thereof
FR1162129A (fr) * 1954-10-20 1958-09-09 Sandoz Ag Dérivés amidés du tropane et leur préparation
CH374679A (de) 1958-11-26 1964-01-31 Sandoz Ag Verfahren zur Herstellung von neuen Tropan-Derivaten
US4179567A (en) 1978-04-10 1979-12-18 Sterling Drug Inc. 2-Aryltropane compounds
JPS5592384A (en) * 1978-12-30 1980-07-12 Beecham Group Ltd Compound having pharmacological activity
IL59004A0 (en) 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
FR2476088A2 (fr) * 1979-01-16 1981-08-21 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
FR2446823A1 (fr) * 1979-01-16 1980-08-14 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
DE3144183A1 (de) 1982-08-12
ZA817675B (en) 1982-10-27
NL8105042A (nl) 1982-06-01
US4434170A (en) 1984-02-28
JPS57108090A (en) 1982-07-05
GB2088364A (en) 1982-06-09
SE8106425L (sv) 1982-05-08
CA1209574A (en) 1986-08-12
ES507394A0 (es) 1983-02-01
BE890962R (fr) 1982-05-03
GR75112B (es) 1984-07-13
GB2088364B (en) 1984-10-31
ES8301979A2 (es) 1983-02-01
IT8124835A0 (it) 1981-11-03
FR2493848A2 (fr) 1982-05-14
JPS6344753B2 (es) 1988-09-06
IT1140040B (it) 1986-09-24
FR2493848B2 (fr) 1986-05-16
CH651561A5 (fr) 1985-09-30
DE3144183C2 (es) 1992-01-23
LU83737A7 (fr) 1983-09-01

Similar Documents

Publication Publication Date Title
SE448457B (sv) Derivat av nor-tropan och granatan, deras framstelling och farmaceutiska komposition
FI63744B (fi) Foerfarande foer framstaellning av nya spasmolytiska tyrosinderivat
US4194045A (en) 1-(3,3-Diaryl-3-oxadiazolalkyl)-4-phenyl-4-piperidinomethanols and related compounds
CH642619A5 (it) Esteri di acil carnitine, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
CZ289787A3 (cs) Substituovaný benzamidový derivát, způsob jeho výroby a farmaceutický prostředek na jeho bázi
EP0492485A1 (en) N-Acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same
FI63572C (fi) Foerfarande foer framstaellning av en terapeutiskt anvaendbar 5-(1,1-difenyl-3-(2-azabicyklo(2,2,2)okt-2-yl)propyl)-2-metyl-1,3,4-oxadiazol
DD251973A5 (de) Verfahren zur herstellung von 3(2h)-pyridazinon-derivaten
CS221806B2 (en) Method of making the trans-2-substituted-5-aryl-2,3,4,4a5, 98-hexahydro-1h-pyrido/1,3-b/indole
PL129063B1 (en) Process for preparing novel substituted oxiranocarboxylic acids
PL84191B1 (en) 3-aroyl-alkenyleneimines[us3835149a]
US4301159A (en) N-(Diethylaminoethyl)-2-alkoxy-benzamide derivatives
DE4015137C2 (de) Thieno-triazolo-diazepinderivate, Verfahren ihrer Herstellung und diese enthaltende therapeutische Zusammensetzungen
SE442403B (sv) 3-fluor-10-piperazino-8-substituerade 10,11-dihydrodibenso(b,f)tiepiner och additionssalter derav
Baggaley et al. Inhibitors of blood platelet aggregation. Effects of some 1, 2-benzisothiazol-3-ones on platelet responsiveness to adenosine diphosphate and collagen
US4115569A (en) Cyclic diamine derivatives
CA1058208A (en) Pharmaceutical n,n&#39;(phenylphenylene) dioxamic acid derivatives
IE43009B1 (en) Sulfonamide derivatives
SE452462B (sv) Nya 2-guanidinotiazolderivat
FI73413B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara substituerade pyrrolidinylsulfamoylbensoesyraderivat.
US4069332A (en) Compounds, compositions and methods of use
DK142200B (da) Analogifremgangsmåde til fremstilling af 14-substituerede vincanderivater eller syreadditionssalte eller kvaternære salte deraf.
US3692913A (en) Cyclohexenyl amines in the treatment of pain
FI65426C (fi) Analogifoerfarande foer framstaellning av nya farmakologiskt verkande n-(2-morfolinoetyl)bensamider
DD215545A5 (de) Verfahren zur herstellung eines (1,2,4)triazolo (4,3-a)chin-oxalin-4-amin-derivats

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8106425-5

Effective date: 19940510

Format of ref document f/p: F