SE445393B - Forfarande for immunoanalys med anvendning av f(ab')?712-fragment av immunoglobulin samt reagens - Google Patents
Forfarande for immunoanalys med anvendning av f(ab')?712-fragment av immunoglobulin samt reagensInfo
- Publication number
- SE445393B SE445393B SE7900661A SE7900661A SE445393B SE 445393 B SE445393 B SE 445393B SE 7900661 A SE7900661 A SE 7900661A SE 7900661 A SE7900661 A SE 7900661A SE 445393 B SE445393 B SE 445393B
- Authority
- SE
- Sweden
- Prior art keywords
- fragments
- immunoglobulin
- particles
- antigen
- latex
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title claims description 41
- 108060003951 Immunoglobulin Proteins 0.000 title claims description 26
- 102000018358 immunoglobulin Human genes 0.000 title claims description 26
- 238000000034 method Methods 0.000 title claims description 19
- 239000003153 chemical reaction reagent Substances 0.000 title claims description 7
- 238000004458 analytical method Methods 0.000 title description 4
- 239000004816 latex Substances 0.000 claims description 27
- 229920000126 latex Polymers 0.000 claims description 27
- 239000002245 particle Substances 0.000 claims description 27
- 239000000427 antigen Substances 0.000 claims description 20
- 102000036639 antigens Human genes 0.000 claims description 20
- 108091007433 antigens Proteins 0.000 claims description 20
- 239000000725 suspension Substances 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 230000004520 agglutination Effects 0.000 claims description 8
- 210000002966 serum Anatomy 0.000 claims description 6
- 239000011541 reaction mixture Substances 0.000 claims description 5
- 238000003018 immunoassay Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000011236 particulate material Substances 0.000 claims 3
- 101100298295 Drosophila melanogaster flfl gene Proteins 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 description 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 8
- 102000057297 Pepsin A Human genes 0.000 description 7
- 108090000284 Pepsin A Proteins 0.000 description 7
- 229940111202 pepsin Drugs 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000011534 incubation Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 229940078795 lactoferrin Drugs 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000004471 Glycine Substances 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 229960002449 glycine Drugs 0.000 description 4
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 4
- 238000012092 latex agglutination test Methods 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000008100 Human Serum Albumin Human genes 0.000 description 3
- 108091006905 Human Serum Albumin Proteins 0.000 description 3
- 108010063045 Lactoferrin Proteins 0.000 description 3
- 102100032241 Lactotransferrin Human genes 0.000 description 3
- 229920001213 Polysorbate 20 Polymers 0.000 description 3
- 239000008351 acetate buffer Substances 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 3
- 235000021242 lactoferrin Nutrition 0.000 description 3
- 239000013618 particulate matter Substances 0.000 description 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 102000008857 Ferritin Human genes 0.000 description 2
- 108050000784 Ferritin Proteins 0.000 description 2
- 238000008416 Ferritin Methods 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 239000012888 bovine serum Substances 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- IVLXQGJVBGMLRR-UHFFFAOYSA-N 2-aminoacetic acid;hydron;chloride Chemical compound Cl.NCC(O)=O IVLXQGJVBGMLRR-UHFFFAOYSA-N 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 101100515472 Mus musculus Mycl gene Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000001166 ammonium sulphate Substances 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 125000002668 chloroacetyl group Chemical group ClCC(=O)* 0.000 description 1
- ZCDOYSPFYFSLEW-UHFFFAOYSA-N chromate(2-) Chemical compound [O-][Cr]([O-])(=O)=O ZCDOYSPFYFSLEW-UHFFFAOYSA-N 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000005188 flotation Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229960001269 glycine hydrochloride Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB323778 | 1978-01-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7900661L SE7900661L (sv) | 1979-07-27 |
| SE445393B true SE445393B (sv) | 1986-06-16 |
Family
ID=9754542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7900661A SE445393B (sv) | 1978-01-26 | 1979-01-24 | Forfarande for immunoanalys med anvendning av f(ab')?712-fragment av immunoglobulin samt reagens |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4397960A (enExample) |
| JP (2) | JPS54119292A (enExample) |
| AU (1) | AU524656B2 (enExample) |
| BE (1) | BE873673A (enExample) |
| CA (1) | CA1118345A (enExample) |
| CH (1) | CH639208A5 (enExample) |
| DE (1) | DE2902676C2 (enExample) |
| FR (1) | FR2415809B1 (enExample) |
| GB (1) | GB2013211B (enExample) |
| IT (1) | IT1119257B (enExample) |
| NL (1) | NL7900586A (enExample) |
| SE (1) | SE445393B (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2013211B (en) * | 1978-01-26 | 1982-06-30 | Technicon Instr | Immunoassays using f(ab')2 fragments |
| JPS54139595A (en) * | 1978-04-20 | 1979-10-30 | Mitsubishi Chem Ind | Reagent for detecting antigen |
| US4342566A (en) * | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
| AU543007B2 (en) * | 1980-04-15 | 1985-03-28 | Technicon Instruments Corportion | Agglutination immunoassay |
| JPS56162055A (en) * | 1980-05-19 | 1981-12-12 | Eiken Kagaku Kk | Method for determining immunity using immunoglobulin fragment mixture sensitizing latex particles |
| DE3168691D1 (en) * | 1980-11-07 | 1985-03-14 | Technicon Instr | Immunoassay of proteins |
| JPS57182168A (en) * | 1981-05-02 | 1982-11-09 | Mitsubishi Chem Ind Ltd | Immunochemical reagent |
| EP0083869B1 (en) * | 1982-01-05 | 1985-10-16 | International Institute Of Cellular And Molecular Pathology (Icp) | Method of immunoassay |
| DE3225027A1 (de) * | 1982-07-05 | 1984-01-05 | Boehringer Mannheim Gmbh, 6800 Mannheim | Immunchemisches messverfahren |
| EP0101228B1 (en) * | 1982-08-06 | 1986-10-08 | International Institute Of Cellular And Molecular Pathology (Icp) | Particle agglutination assay of antigens |
| JPS59202064A (ja) * | 1983-04-30 | 1984-11-15 | Fujirebio Inc | 抗原決定基具有物質を測定する方法 |
| US4623620A (en) * | 1983-08-02 | 1986-11-18 | Stichting Vrienden Van De Stichting Dr. Karl Landsteiner | Enucleated granulocytes, their preparation and use |
| DE3331627A1 (de) * | 1983-09-01 | 1985-03-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verfahren zur immunologischen bestimmung fuer proteine in koerperfluessigkeiten, unter verwendung monovalenter antikoerperfragmente |
| US4551426A (en) * | 1983-10-03 | 1985-11-05 | E. I. Du Pont De Nemours And Company | Heterogeneous immunoassay for digoxin using ouabain as a separation means |
| DE3400027A1 (de) * | 1984-01-02 | 1985-07-18 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur bestimmung eines polyvalenten antigens und reagenz hierfuer |
| BE899664A (fr) * | 1984-05-15 | 1984-08-31 | Inst Internat De Pathologie Ce | Procede de dosage immunologique d'une substance dans un echantillon liquide. |
| CA1261743A (en) * | 1984-07-23 | 1989-09-26 | Shai Inbar | Biological diagnostic assay product, and process utilizing labeled fab fragments |
| GB8422452D0 (en) * | 1984-09-05 | 1984-10-10 | Serono Diagnostics Ltd | Assay |
| JPS6175262A (ja) * | 1984-09-21 | 1986-04-17 | Teijin Ltd | 免疫複合体測定用試薬及びそれを用いた免疫複合体の測定法 |
| US4560504A (en) * | 1984-12-06 | 1985-12-24 | Uop Inc. | Carboxyl anchored immobilized antibodies |
| GB2171999A (en) * | 1985-03-04 | 1986-09-10 | Iq | Antibodies |
| DE3638767A1 (de) * | 1986-11-13 | 1988-05-26 | Behringwerke Ag | Laktoferrin enthaltendes inkubationsmedium fuer festphasenimmunometrisches verfahren und seine verwendung |
| US4921787A (en) * | 1987-05-01 | 1990-05-01 | Cambridge Bioscience Corporation | Detection of antibodies to human immunodeficiency virus by agglutination of antigen coated latex |
| US4791067A (en) * | 1987-06-25 | 1988-12-13 | Fisher Scientific Co. | Agglutination immunoassay for hapten involving monoclonal antibody of IgA class reagent |
| US4829011A (en) * | 1987-08-27 | 1989-05-09 | Biotrack, Inc. | Agglutination assay |
| GB8800293D0 (en) * | 1988-01-07 | 1988-02-10 | Int Inst Cellular Molecul Path | Antibodies attached to solid surface |
| US4914041A (en) * | 1988-02-12 | 1990-04-03 | Beckman Instruments, Inc. | Reagent and method for detecting rheumatoid factor |
| US5389523A (en) * | 1988-05-31 | 1995-02-14 | The United States Of Americas, As Represented By The Secretary Of Commerce | Liposome immunoanalysis by flow injection assay |
| DE3829245A1 (de) * | 1988-08-29 | 1990-03-01 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung einer spezifisch bindefaehigen substanz |
| FR2654836B1 (fr) * | 1989-11-17 | 1994-01-28 | Biotrol Sa Laboratoires | Appareil d'execution automatique d'un immunodosage en plusieurs etapes successives d'au moins une substance biologique dans une pluralite d'echantillons biologiques, procede et reactif mettant en óoeuvre ledit appareil. |
| CA2038260A1 (en) * | 1990-05-11 | 1991-11-12 | John C. Mauck | Use of enzyme-labeled antibody fragment in determination of chlamydial or gonococcal antigens |
| US5231004A (en) * | 1990-05-11 | 1993-07-27 | Eastman Kodak Company | Use of heme-containing proteins as stabilizers for enzyme-labeled immunoreactants |
| US5585278A (en) * | 1994-10-27 | 1996-12-17 | Bayer Corporation | Method for coupling antibody to novel latex substrate and its use in immunoassay |
| DK0849595T3 (da) * | 1996-12-18 | 2001-05-28 | Diagnostische Forsch Stiftung | Syntetiske partikler som agglutinationsreagenser |
| GB9705376D0 (en) * | 1997-03-14 | 1997-04-30 | Harris William J | Antibody fragment formulations and assay formats for detecting the presence an d concentration of analytes |
| WO1999001477A1 (en) * | 1997-06-17 | 1999-01-14 | Palingen, Inc. | Method for diagnosing systemic lupus erythematosus |
| US6977142B2 (en) * | 2003-09-23 | 2005-12-20 | Agy Therapeutics, Inc. | High-throughput turbidometric assay for screening inhibitors of protein disulfide isomerase activity |
| US20080108147A1 (en) * | 2006-11-03 | 2008-05-08 | Tie Wei | Reduction of non-specific binding in immunoassays |
| WO2018074467A1 (ja) | 2016-10-19 | 2018-04-26 | 栄研化学株式会社 | 免疫学的測定方法および測定試薬 |
| JP7136355B2 (ja) | 2019-07-03 | 2022-09-13 | 富士電機株式会社 | 半導体モジュールの回路構造 |
| WO2021193870A1 (ja) | 2020-03-26 | 2021-09-30 | デンカ株式会社 | Ｆｃ領域の一部を欠損した抗体を含む試薬 |
| US20260043800A1 (en) | 2022-08-15 | 2026-02-12 | Solventum Intellectual Properties Company | Functionalized porous substrates and their use for detecting analytes |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE29474E (en) | 1966-06-02 | 1977-11-15 | Pharmacia Ab | Method for the determination of proteins and polypeptides |
| CA943459A (en) * | 1968-12-16 | 1974-03-12 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
| US3646346A (en) * | 1968-12-26 | 1972-02-29 | Pharmacia Ab | Antibody-coated tube system for radioimmunoassay |
| US4070246A (en) * | 1976-04-09 | 1978-01-24 | Abbott Laboratories | Reactive matrices |
| US4115534A (en) * | 1976-08-19 | 1978-09-19 | Minnesota Mining And Manufacturing Company | In vitro diagnostic test |
| DE2643207C2 (de) * | 1976-09-25 | 1986-09-11 | Behringwerke Ag, 3550 Marburg | Verfahren zum Nachweis und zur Bestimmung eines Partners einer immunologischen Reaktion |
| JPS5344622A (en) * | 1976-09-30 | 1978-04-21 | Mochida Pharm Co Ltd | Immunologically measuring method |
| DE2644249A1 (de) * | 1976-09-30 | 1978-04-06 | Abbott Lab | Reaktive matrices |
| GB2013688B (en) * | 1978-01-26 | 1982-06-30 | Technicon Instr | Insolubilised proteins and immunoassays utilising them |
| GB2013211B (en) * | 1978-01-26 | 1982-06-30 | Technicon Instr | Immunoassays using f(ab')2 fragments |
-
1979
- 1979-01-15 GB GB7901424A patent/GB2013211B/en not_active Expired
- 1979-01-22 FR FR7901537A patent/FR2415809B1/fr not_active Expired
- 1979-01-23 AU AU43565/79A patent/AU524656B2/en not_active Ceased
- 1979-01-24 SE SE7900661A patent/SE445393B/sv not_active IP Right Cessation
- 1979-01-24 BE BE0/193049A patent/BE873673A/xx not_active IP Right Cessation
- 1979-01-24 DE DE2902676A patent/DE2902676C2/de not_active Expired - Lifetime
- 1979-01-25 CA CA000320278A patent/CA1118345A/en not_active Expired
- 1979-01-25 NL NL7900586A patent/NL7900586A/xx active Search and Examination
- 1979-01-25 IT IT67165/79A patent/IT1119257B/it active
- 1979-01-26 JP JP730379A patent/JPS54119292A/ja active Granted
- 1979-01-26 CH CH82179A patent/CH639208A5/de not_active IP Right Cessation
-
1982
- 1982-03-26 US US06/362,334 patent/US4397960A/en not_active Expired - Lifetime
-
1989
- 1989-10-30 JP JP1280006A patent/JPH02276968A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| NL7900586A (nl) | 1979-07-30 |
| FR2415809B1 (fr) | 1985-04-12 |
| JPH0521186B2 (enExample) | 1993-03-23 |
| GB2013211A (en) | 1979-08-08 |
| DE2902676A1 (de) | 1979-08-02 |
| CH639208A5 (de) | 1983-10-31 |
| FR2415809A1 (fr) | 1979-08-24 |
| AU524656B2 (en) | 1982-09-30 |
| GB2013211B (en) | 1982-06-30 |
| US4397960A (en) | 1983-08-09 |
| JPS54119292A (en) | 1979-09-17 |
| AU4356579A (en) | 1979-08-02 |
| JPH02276968A (ja) | 1990-11-13 |
| IT1119257B (it) | 1986-03-10 |
| JPS6338668B2 (enExample) | 1988-08-01 |
| IT7967165A0 (it) | 1979-01-25 |
| BE873673A (fr) | 1979-07-24 |
| DE2902676C2 (de) | 1996-10-17 |
| SE7900661L (sv) | 1979-07-27 |
| CA1118345A (en) | 1982-02-16 |
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