SE440019B - COXAL PRODUCT CONTAINING SODIUM CHLORIDE AND PHYSIOLOGICALLY PREPARABLE POTASSIUM AND MAGNESIUM COMPOUNDS - Google Patents

COXAL PRODUCT CONTAINING SODIUM CHLORIDE AND PHYSIOLOGICALLY PREPARABLE POTASSIUM AND MAGNESIUM COMPOUNDS

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Publication number
SE440019B
SE440019B SE7901586A SE7901586A SE440019B SE 440019 B SE440019 B SE 440019B SE 7901586 A SE7901586 A SE 7901586A SE 7901586 A SE7901586 A SE 7901586A SE 440019 B SE440019 B SE 440019B
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Sweden
Prior art keywords
potassium
magnesium
sodium chloride
physiologically
ratios
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SE7901586A
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Swedish (sv)
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SE7901586L (en
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H Karppanen
E Bergqvist
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Cederroth Nordic Ab
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Application filed by Cederroth Nordic Ab filed Critical Cederroth Nordic Ab
Publication of SE7901586L publication Critical patent/SE7901586L/en
Publication of SE440019B publication Critical patent/SE440019B/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/40—Table salts; Dietetic salt substitutes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Confectionery (AREA)
  • Dairy Products (AREA)

Abstract

Compsn. for oral admin. which contain cations in desired physiological ratios, are prepd. by mixing the cpds, in known manner, in proportions such that the molar ratios of the obtd. products falls within the following limits:-. Potassium:Sodium = 1:10 to 100:1 (pref. 1:1) and/or Potassium: Magnesium = 1:10 to 100:1 (pref. 3-4:1) and/or Magnesium:Calcium = 1:10 to 100:1 (pref. 1:2-1). - Used for preparation of products with cations in the desired ratios so as to avoid health problems due to food, medicaments etc. contg. disproportionate ratios of electrolytes e.g. electrolyte unbalance may lead to hypertension, cardiac troubles as vascular degeneration.

Description

7901586-3 bl a tiazider, som används i hypertoniterapín. Karakteris- tiskt för de använda metoderna är likväl, att de är in- riktade på sjukdomstillstånd och endast på en kompensering av överskottet av natriumkatjoner utan att fästa någon uppmärksamhet på proportionerna av de övriga på situa- tionen dynamiskt inverkande katjonerna. Det nuvarande tänkesättet tar sålunda inte i beaktande betydelsen av en disproportionerlig tillgång på elektrolyter som orsak till svåra hälsovådliga störningar, och de nuvarande metoderna erbjuder ingen väsentlig möjlighet till eliminering av de rådande disproportionerna. 7901586-3 including thiazides, which are used in hypertension therapy. Characteristic of the methods used is, however, that they focus on disease states and only on compensating for the excess sodium cations without paying any attention to the proportions of the other cations dynamically influencing the situation. Thus, the current way of thinking does not take into account the importance of a disproportionate supply of electrolytes as a cause of severe health disturbances, and the current methods do not offer a significant possibility of eliminating the prevailing disproportions.

I den föreliggande uppfinningen har med stöd av omfattande vetenskapligt material en ny helhetslösning frambringats, medelst vilken belastningsföreteelserna till följd av felaktiga förbrukningsvanor och en icke-optimal samman- sättning av födan, läkemedel och övriga elektrolytkällor effektivt kan elimineras, exempelvis genom tillsats av koksaltprodukten enligt uppfinningen. I denna koksaltpro- dukt enligt uppfinningen föreligger kalium, magnesium och natrium i form av ett mängdmässigt avpassat för- hållande mellan fysiologiskt fördragbara föreningar, varvid det inbördes förhållandet mellan katjonerna svarar mot dynamiken hos det elektrolytiska systemet i organismen.In the present invention, with the aid of extensive scientific material, a new complete solution has been produced, by means of which the stress phenomena due to incorrect consumption habits and a non-optimal composition of food, drugs and other electrolyte sources can be effectively eliminated, for example by adding the saline product according to the invention . In this saline product according to the invention, potassium, magnesium and sodium are present in the form of a quantitatively matched ratio between physiologically tolerable compounds, the mutual ratio of the cations corresponding to the dynamics of the electrolytic system in the organism.

Koksaltprodukten enligt uppfinningen kännetecknas av att den innehåller 50 - 65 vikt-% natriumklorid, 20 - 40 vikt-% av en fysiologiskt fördragbar kaliumförening och - 20 vikt-% av en fysiologiskt fördragbar magnesium- förening, räknat på totalblandningens vikt.The saline product according to the invention is characterized in that it contains 50 - 65% by weight of sodium chloride, 20 - 40% by weight of a physiologically tolerable potassium compound and - 20% by weight of a physiologically tolerable magnesium compound, based on the weight of the total mixture.

Som bekant kan biokemiska livsfenomina endast ske i vissa vattenhaltiga elektrolytlösningar. I organismen upprätthålls dessa lösningar inom exakta gränser av ett centralt styrt vätske- och elektrolytsystem. De tre strukturella huvud- delarna i systemet är blodplasman, den interstitiella vätskan och intracellulära vätskan. Till grund för upprätt- hållandet av den materiella balansen ligger ett kontinuer- 7901586-3 ligt kompletterande flöde av vatten och elektrolyter, som från tarmarna strömmar genom systemet och avgår huvudsakligen genom njurarna. Upprätthållandet av skarpt avvikande katjon- och anjonhalter i cellorganen, den intracellulära vätskan och extracellulärutrymmet förutsätter en aktiv regleringsverksamhet och en aktuell och genomsnittlig komplettering av de olika komponenterna inom måttliga gränser. Om tillgången på en eller flera katjoner under- eller överskrider de optimala gränserna, utsätts elektrolytsystemets regelsystem för en belast- ning, som direkt eller indirekt leder till förändringar och störningar inom systemet och övriga med dess funktion sammankopplade organiska system.As is well known, biochemical life phenomena can only occur in certain aqueous electrolyte solutions. In the organism, these solutions are maintained within precise limits by a centrally controlled fluid and electrolyte system. The three main structural components of the system are the blood plasma, the interstitial fluid and the intracellular fluid. The basis for maintaining the material balance is a continuous supplementary flow of water and electrolytes, which flows from the intestines through the system and leaves mainly through the kidneys. The maintenance of sharply deviating cation and anion levels in the cell organs, the intracellular fluid and the extracellular space presupposes an active regulatory activity and a current and average supplementation of the various components within moderate limits. If the availability of one or more cations exceeds or exceeds the optimal limits, the electrolyte system's control system is exposed to a load, which directly or indirectly leads to changes and disturbances within the system and other organic systems connected to its function.

En av de viktigaste disproportionerna i den nuvarande nutritionen är den alltför rikliga tillgången på nat- rium, som framgår vid jämförelse av följande för vuxna rekommenderade optimimängder natrium 10-60 mmol/dygn kalium 50-100 mmol/dygn magnesium 12-40 mmol/dygn kalcium 20-35 mmol/dygn med de mängder som invånarna i ett industrialiserat land har befunnits intaga i genomsnitt, d v s natrium 230 mmol/dygn, max 460 mmol/dygn kalium 60 mmol/dygn, min 10 mmol/dygn magnesium 15 mmol/dygn, min 2 mmol/dygn kalcium 60 mmol/dygn, max 210 mmol/dygn.One of the most important disproportions in the current nutrition is the excessive supply of sodium, which is evident when comparing the following recommended optimal amounts of sodium for adults 10-60 mmol / day potassium 50-100 mmol / day magnesium 12-40 mmol / day calcium 20-35 mmol / day with the amounts that the inhabitants of an industrialized country have been found to consume on average, ie sodium 230 mmol / day, max 460 mmol / day potassium 60 mmol / day, min 10 mmol / day magnesium 15 mmol / day , min 2 mmol / day calcium 60 mmol / day, max 210 mmol / day.

(Karppanen -78, Meanly -76).(Karppanen -78, Meanly -76).

En av de centrala mekanismerna i natriumöverskottet grundar sig på förmågan hos natrium att öka avsöndringen av kalium i njurkanalerna, vilket åter leder till en kaliumförlust i organismen. Då tillgången på kalium, såsom även framgår av tabellerna, ofta är otillräcklig, är resultatet ofta '7901586-3 l5 en ökad disproportion i detta fysiologiskt viktiga jonpar.One of the central mechanisms of excess sodium is based on the ability of sodium to increase the excretion of potassium in the renal ducts, which in turn leads to a loss of potassium in the organism. As the availability of potassium, as also shown in the tables, is often insufficient, the result is often an increased disproportion in this physiologically important ion pair.

I omfattande undersökningar, som täckt flera länder, har hypertonifrekvensen visat sig korrelera kraftigt med det disproportionerliga bruket av natríum och kalium.In extensive studies, which covered several countries, the frequency of hypertension has been shown to correlate strongly with the disproportionate use of sodium and potassium.

Normalt borde födan innehålla natrium och kalium i ett optimalt molförhållande av Na : K = 1 : 1.Normally the food should contain sodium and potassium in an optimal molar ratio of Na: K = 1: 1.

Haltproportionerna av kalcium och magnesium är av en central betydelse för ett flertal av hjärtats och nerv- systemets elektrofysiologiska och enzymatiska reaktioner.The content proportions of calcium and magnesium are of central importance for a number of the electrophysiological and enzymatic reactions of the heart and nervous system.

Som optimalt förhållande för deras molhalter i födan har beräknats: Ca : Mg = 1 : l - 2 : 1. Magnesium har vidare visat sig ha en avgörande, till utnyttjandet av kalium bidragande verkan. Även om den dagliga födan skulle innehålla kalium t 0 m i rikliga mängder, är organismen inte i stånd att utnyttja det, utan kaliumet avsöndras snabbt under rådande brist på magnesium. Den intra- cellulära elektrolytjämvikten förutsätter ett visst mol- förhållande i födan mellan magnesium och kalium, som optimalt är Mg : K = 1 i 4. Det har visat sig, att frek- vensen av vissa hjärtsjukdomar kraftigt korrelerar med en brist på kalium, speciellt då även tillgången på magnesium är otillräcklig (Karppanen 1978). Ifall födan innehåller kalcium i riklig mängd och magnesium i ringa mängd, minskar den rikliga kalciummängden väsentligt absorptionen av magnesium. Detta innebär, att vid en minskande tillgång på magnesium försvåras även det bio- logiska utnyttjandet av kalium. Optimalt borde födan innehålla kalcium och magnesium i ett molförhållande av Ca : Mg = l : 1 - 2 : 1.The optimal ratio for their molar contents in the diet has been calculated: Ca: Mg = 1: 1 - 2: 1. Magnesium has also been shown to have a decisive effect on the utilization of potassium. Even if the daily diet would contain potassium up to 0 m in copious amounts, the organism is not able to utilize it, but the potassium is excreted rapidly during the prevailing lack of magnesium. The intracellular electrolyte balance assumes a certain molar ratio in the diet between magnesium and potassium, which is optimally Mg: K = 1 in 4. It has been shown that the frequency of certain heart diseases strongly correlates with a lack of potassium, especially as the supply of magnesium is also insufficient (Karppanen 1978). If the food contains calcium in abundant amounts and magnesium in small amounts, the abundant amount of calcium significantly reduces the absorption of magnesium. This means that with a declining supply of magnesium, the biological utilization of potassium is also made more difficult. Optimally, the diet should contain calcium and magnesium in a molar ratio of Ca: Mg = 1: 1 - 2: 1.

Trots detta har tillsvidare inga allmänna åtgärder för optimering av tillgången på elektrolyter vidtagits inom den normala nutritionen. Från terapin av hjärtsjukdomar emanerar några begränsade försök att eliminera en alltför stor natriumbelastning genom att ersätta en del av salt- 7901586-3 behovet i dieten vanligast med kalium- eller ammonium- haltiga substituter.Despite this, so far no general measures have been taken to optimize the supply of electrolytes in normal nutrition. From the therapy of heart disease emanates some limited attempts to eliminate an excessive sodium load by replacing part of the salt requirement in the diet most commonly with potassium- or ammonium-containing substitutes.

Likaledes har kaliumtabletter använts för ersättning av kaliumförlusten, som förorsakas av vissa vid behandling av hypertoni använda läkemedel (tiazider).Potassium tablets have also been used to compensate for the loss of potassium caused by certain medicines used in the treatment of hypertension (thiazides).

Karakteristiskt för de använda metoderna är likväl att de ägnar sin uppmärksamhet åt kompenseringen av en enda viss katjon. I den moderna industrialiserade världen är likväl natrium-, kalium-, magnesium- och kalciumhalterna i en frisk persons föda disproportionerliga i förhållande till varandra. Kvantitativt överskrider natrium och kalcium avsevärt rekommendationerna i den dagliga dieten medan kalium- och magnesiummängderna förblir mindre än rekommenderat. Av denna anledning finns det skäl att rikta speciell uppmärksamhet på elektrolytbalansen och mineralmängderna i den dagliga födan.Characteristic of the methods used, however, is that they pay attention to the compensation of a single particular cation. In the modern industrialized world, however, the sodium, potassium, magnesium and calcium levels in a healthy person's diet are disproportionate to each other. Quantitatively, sodium and calcium significantly exceed the recommendations in the daily diet, while the amounts of potassium and magnesium remain less than recommended. For this reason, there is reason to pay special attention to the electrolyte balance and the mineral amounts in the daily diet.

Koksaltprodukten enligt uppfinningen kan framställas genom tillsats av kalium och magnesium i form av fysio- logiskt fördragbara föreningar till natriumklorid i sådana mängder att ett lämpligt förhållande mellan katjonerna uppnås.The saline product according to the invention can be prepared by adding potassium and magnesium in the form of physiologically tolerable compounds to sodium chloride in such amounts that a suitable ratio of the cations is achieved.

Fysiologiskt lämpliga föreningar är klorider, bromider, jodider, sulfater och aspargater. Föreningarna är företrädesvis klorider och sulfater. Genom tillsats av en saltprodukt enligt uppfinningen till födoämnen eller råmaterial därför, och till individuella måltider samt till kryddor såsom sojaolja, kan en mer optimal balans uppnås i födan med hänsyn till elektrolyter.Physiologically suitable compounds are chlorides, bromides, iodides, sulphates and asparagates. The compounds are preferably chlorides and sulphates. By adding a salt product according to the invention to foods or raw materials therefor, and to individual meals as well as to spices such as soybean oil, a more optimal balance can be achieved in the diet with regard to electrolytes.

Säkerheten vid användning av saltprodukten enligt upp- finningen skall bedömas mot bakgrund av det faktum att det när helst det konsumeras ersätter användningen av vanligt bordssalt (natriumklorid). 7901586-3 Saltets sammansättning är avpassat att säkerställa 1) en betydande sänkning av NaCl-innehållet 2) tillräckliga men säkra mängder av kalium och mag- nesium, och 3) i allt väsentligt ingen smakändring jämfört med ren natriumklorid.The safety of using the salt product according to the invention must be assessed in the light of the fact that whenever it is consumed it replaces the use of ordinary table salt (sodium chloride). 7901586-3 The composition of the salt is adapted to ensure 1) a significant reduction of the NaCl content 2) sufficient but safe amounts of potassium and magnesium, and 3) substantially no taste change compared to pure sodium chloride.

Uppfinningen belyses närmare nedan i anslutning till några utföringsexempel.The invention is further elucidated below in connection with some embodiments.

Exemgel l En koksaltprodukt framställdes genom blandning av följande beståndsdelar: NaCl 65 vikt-% KCl 25 vikt-% Mgso4. 7H2o 10 vikt-az Exemgel 2 En koksaltprodukt framställdes genom blandning av följande beståndsdelar: NaCl 65 vikt-% KCl 25 vikt-% MgCl2.6H2O 10 vikt-% Exemgel 3 En koksaltprodukt framställdes genom blandning av följande beståndsdelar: NaCl 50 vikt-% KCl 40 vikt-1 MgCl2.6H2O 10 vikt-% 7901586-3 Exemgel 4 En koksaltprodukt framställdes genom blandning av följande beståndsdelar: NaCl 65 vikt-% KCl 30 vikt-% MgCl2.6H2O 5 vikt-%Example 1 A saline product was prepared by mixing the following ingredients: NaCl 65% by weight KCl 25% by weight MgSO 4. 7H 2 O 10 wt-az Example 2 A saline product was prepared by mixing the following ingredients: NaCl 65 wt% KCl 25 wt% MgCl 2 .6H 2 O 10 wt% Exemgel 3 40 wt-1 MgCl2.6H2O 10 wt% 7901586-3 Example gel 4 A saline product was prepared by mixing the following ingredients: NaCl 65 wt% KCl 30 wt% MgCl2.6H2O 5 wt%

Claims (2)

7901586-3 P a t e n t k r a V7901586-3 P a t e n t k r a V 1. Koksaltprodukt innehållande natriumklorid, k ä n - n e t e c k n a d av att den innehåller 50 - 65 vikt-% natriumklorid, 20 - 40 vikt-% av en fysiologiskt fördrag- bar kaliumförening och 5 - 20 vikt-% av en fysiologiskt 5 fördragbar magnesiumförening, räknat på totalblandningens vikt.Saline product containing sodium chloride, characterized in that it contains 50 to 65% by weight of sodium chloride, 20 to 40% by weight of a physiologically tolerable potassium compound and 5 to 20% by weight of a physiologically tolerable magnesium compound, calculated on the weight of the total mixture. 2. Koksaltprodukt enligt krav l, k ä n n e t e c k - n a d av att kalium- och magnesiumföreningarna utgöres av klorider eller sulfater.Saline product according to claim 1, characterized in that the potassium and magnesium compounds consist of chlorides or sulphates.
SE7901586A 1978-02-24 1979-02-22 COXAL PRODUCT CONTAINING SODIUM CHLORIDE AND PHYSIOLOGICALLY PREPARABLE POTASSIUM AND MAGNESIUM COMPOUNDS SE440019B (en)

Applications Claiming Priority (1)

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FI780627A FI60107C (en) 1978-02-24 1978-02-24 SOM KRYDDA ELLER SOM KONSERVERINGSMEDEL FOER LIVSMEDEL ANVAENDBAR BORDSSALTPRODUKT

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SE7901586L SE7901586L (en) 1979-08-25
SE440019B true SE440019B (en) 1985-07-15

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SE7901586A SE440019B (en) 1978-02-24 1979-02-22 COXAL PRODUCT CONTAINING SODIUM CHLORIDE AND PHYSIOLOGICALLY PREPARABLE POTASSIUM AND MAGNESIUM COMPOUNDS
SE8403228A SE448145B (en) 1978-02-24 1984-06-14 MINERAL WATER WITH PHYSIOLOGICALLY OPTIMIZED CATION COMPOSITION

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SE8403228A SE448145B (en) 1978-02-24 1984-06-14 MINERAL WATER WITH PHYSIOLOGICALLY OPTIMIZED CATION COMPOSITION

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JP (1) JPS54126778A (en)
AT (1) AT379294B (en)
AU (1) AU529716B2 (en)
BE (1) BE874413A (en)
BR (1) BR7901216A (en)
CA (1) CA1112173A (en)
CH (1) CH642827A5 (en)
DE (1) DE2906697A1 (en)
DK (1) DK150697C (en)
FI (1) FI60107C (en)
FR (1) FR2450568B1 (en)
GB (1) GB2015863B (en)
IN (1) IN149964B (en)
IT (1) IT1119908B (en)
NL (1) NL7901469A (en)
NO (1) NO150704C (en)
SE (2) SE440019B (en)
SU (1) SU1079166A3 (en)
ZA (1) ZA79796B (en)

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DK73779A (en) 1979-08-25
GB2015863A (en) 1979-09-19
CA1112173A (en) 1981-11-10
ZA79796B (en) 1980-02-27
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BR7901216A (en) 1979-10-02
SE8403228L (en) 1984-06-14
IT1119908B (en) 1986-03-19
FR2450568A1 (en) 1980-10-03
ATA144179A (en) 1985-05-15
NO150704C (en) 1984-12-05
FI60107B (en) 1981-08-31
SE448145B (en) 1987-01-26
FI780627A (en) 1979-08-25
SE8403228D0 (en) 1984-06-15
DE2906697A1 (en) 1979-09-06
SU1079166A3 (en) 1984-03-07
IT7967413A0 (en) 1979-02-23
JPS5756858B2 (en) 1982-12-01
CH642827A5 (en) 1984-05-15
NL7901469A (en) 1979-08-28
AT379294B (en) 1985-12-10
JPS54126778A (en) 1979-10-02
BE874413A (en) 1979-06-18
AU529716B2 (en) 1983-06-16
IN149964B (en) 1982-06-19
NO150704B (en) 1984-08-27
SE7901586L (en) 1979-08-25
DK150697B (en) 1987-06-01
AU4440279A (en) 1979-08-30
FI60107C (en) 1982-12-13
NO790635L (en) 1979-08-27
DK150697C (en) 1991-11-25
FR2450568B1 (en) 1987-05-22

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