SE439166B - Forfarande for framstellning av imidazobensodiazepinderivat - Google Patents

Forfarande for framstellning av imidazobensodiazepinderivat

Info

Publication number
SE439166B
SE439166B SE8005317A SE8005317A SE439166B SE 439166 B SE439166 B SE 439166B SE 8005317 A SE8005317 A SE 8005317A SE 8005317 A SE8005317 A SE 8005317A SE 439166 B SE439166 B SE 439166B
Authority
SE
Sweden
Prior art keywords
formula
compound
acid
chloro
benzodiazepine
Prior art date
Application number
SE8005317A
Other languages
English (en)
Swedish (sv)
Other versions
SE8005317L (sv
Inventor
A Walser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SE8005317L publication Critical patent/SE8005317L/xx
Publication of SE439166B publication Critical patent/SE439166B/sv

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SE8005317A 1979-07-25 1980-07-22 Forfarande for framstellning av imidazobensodiazepinderivat SE439166B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/060,258 US4226771A (en) 1979-07-25 1979-07-25 1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives

Publications (2)

Publication Number Publication Date
SE8005317L SE8005317L (sv) 1981-01-26
SE439166B true SE439166B (sv) 1985-06-03

Family

ID=22028366

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8005317A SE439166B (sv) 1979-07-25 1980-07-22 Forfarande for framstellning av imidazobensodiazepinderivat

Country Status (17)

Country Link
US (1) US4226771A (da)
JP (1) JPS5620590A (da)
KR (1) KR840002269B1 (da)
AT (1) AT375942B (da)
CA (1) CA1126270A (da)
CH (1) CH645897A5 (da)
DK (1) DK155049C (da)
ES (1) ES493657A0 (da)
FI (1) FI68834C (da)
GR (1) GR69339B (da)
HU (1) HU182156B (da)
LU (1) LU82651A1 (da)
NL (2) NL193145C (da)
NO (1) NO154168C (da)
PT (1) PT71606B (da)
SE (1) SE439166B (da)
YU (1) YU43221B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN184976B (da) * 1996-06-13 2000-10-14 Ranbaxy Lab Ltd
CA2206219A1 (en) * 1996-06-13 1997-12-13 Ranbaxy Laboratories Limited A novel process for the manufacture of 8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo [1,5a] [1,4] benzodiazepine (midazolam)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852461A (en) * 1971-08-04 1974-12-03 Upjohn Co Benzodiapines used as minor tranquilizers
ZA755418B (en) * 1974-09-11 1977-06-29 Hoffmann La Roche Diazepine derivatives
US4125726A (en) * 1977-03-11 1978-11-14 Hoffmann-La Roche Inc. Imidazo[1,5-a][1,4]benzodiazepines
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates

Also Published As

Publication number Publication date
US4226771A (en) 1980-10-07
NL980040I1 (nl) 1999-02-01
GR69339B (da) 1982-05-17
JPS5620590A (en) 1981-02-26
YU188880A (en) 1983-09-30
NL8004271A (nl) 1981-01-27
KR840002269B1 (ko) 1984-12-14
KR830003487A (ko) 1983-06-20
NO154168C (no) 1986-07-30
JPH0250907B2 (da) 1990-11-05
DK155049B (da) 1989-01-30
DK155049C (da) 1989-06-26
PT71606B (en) 1981-12-17
NO802243L (no) 1981-01-26
AT375942B (de) 1984-09-25
CA1126270A (en) 1982-06-22
YU43221B (en) 1989-06-30
FI68834B (fi) 1985-07-31
NO154168B (no) 1986-04-21
PT71606A (en) 1980-08-01
FI68834C (fi) 1985-11-11
DK316080A (da) 1981-01-26
CH645897A5 (de) 1984-10-31
LU82651A1 (de) 1982-02-17
NL193145C (nl) 1998-12-04
ATA383480A (de) 1984-02-15
FI802349A (fi) 1981-01-26
ES8106307A1 (es) 1981-06-16
SE8005317L (sv) 1981-01-26
ES493657A0 (es) 1981-06-16
HU182156B (en) 1983-12-28

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