SE437155B - Sett att framstella nya derivat av perhydro-aza-heterocykler - Google Patents

Sett att framstella nya derivat av perhydro-aza-heterocykler

Info

Publication number
SE437155B
SE437155B SE7709784A SE7709784A SE437155B SE 437155 B SE437155 B SE 437155B SE 7709784 A SE7709784 A SE 7709784A SE 7709784 A SE7709784 A SE 7709784A SE 437155 B SE437155 B SE 437155B
Authority
SE
Sweden
Prior art keywords
perhydro
make new
new derivatives
aza heterocycles
aza
Prior art date
Application number
SE7709784A
Other languages
English (en)
Swedish (sv)
Other versions
SE7709784L (sv
Inventor
R Paioni
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of SE7709784L publication Critical patent/SE7709784L/xx
Publication of SE437155B publication Critical patent/SE437155B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE7709784A 1976-09-01 1977-08-31 Sett att framstella nya derivat av perhydro-aza-heterocykler SE437155B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75701 1976-09-01

Publications (2)

Publication Number Publication Date
SE7709784L SE7709784L (sv) 1978-03-02
SE437155B true SE437155B (sv) 1985-02-11

Family

ID=19728341

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7709784A SE437155B (sv) 1976-09-01 1977-08-31 Sett att framstella nya derivat av perhydro-aza-heterocykler

Country Status (29)

Country Link
US (3) US4160837A (fi)
JP (1) JPS5331659A (fi)
AT (1) AT361464B (fi)
AU (1) AU514675B2 (fi)
BE (1) BE858283A (fi)
CA (1) CA1112242A (fi)
CH (5) CH633776A5 (fi)
CS (3) CS205087B2 (fi)
CY (1) CY1212A (fi)
DD (1) DD132584A5 (fi)
DE (1) DE2738477A1 (fi)
DK (1) DK156301C (fi)
ES (6) ES462040A1 (fi)
FI (1) FI68229C (fi)
FR (1) FR2363559A1 (fi)
GB (1) GB1585133A (fi)
GR (1) GR72965B (fi)
HK (1) HK8884A (fi)
HU (1) HU179440B (fi)
IE (1) IE45511B1 (fi)
IL (1) IL52858A0 (fi)
MY (1) MY8500100A (fi)
NL (1) NL7709604A (fi)
NO (1) NO150081C (fi)
NZ (1) NZ185062A (fi)
PT (1) PT66955B (fi)
SE (1) SE437155B (fi)
SG (1) SG63783G (fi)
ZA (1) ZA775267B (fi)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE45511B1 (en) * 1976-09-01 1982-09-08 Ciba Geigy Ag New derivatives of perhydro-aza-heterocycles and processesfor the production thereof
MX6634E (es) * 1979-01-09 1985-09-12 Robins Co Inc A H Procedimiento para preparar el isomero trans de 3-ariloxi-4-hidroxipirrolidinas
US4230718A (en) * 1979-01-09 1980-10-28 A. H. Robins Company, Inc. 1-Substituted-3,4-epoxypyrrolidines
US4251541A (en) * 1979-01-09 1981-02-17 A. H. Robins Company, Inc. 1-Substituted-3-arylthio-4-hydroxypyrrolidines
US4585785A (en) * 1979-01-09 1986-04-29 A. H. Robins Company, Inc. Cis and trans-3-aryloxy-4-hydroxypyrrolidines used as anti-arrhythmics
US4443462A (en) * 1979-08-06 1984-04-17 Merrell Dow Pharmaceuticals Inc. Antipsychotic 4-(naphthalenyloxy)piperidine derivatives
US4452809A (en) * 1980-03-10 1984-06-05 A. H. Robins Company, Inc. Trans-4-(2-chlorophenoxy)-1-ethyl-3-pyrrolidinol and anti-depressant use thereof
IL74140A (en) * 1984-04-10 1988-05-31 Robins Co Inc A H Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidine-carboxamides and pharmaceutical compositions containing them
US4639528A (en) * 1985-02-21 1987-01-27 Bristol-Myers Company Crystalline form of 7-(dimethylaminomethylene-amino-9a-methoxymitosane
US4797397A (en) * 1987-07-31 1989-01-10 Warner-Lambert Company 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells
ES2043943T3 (es) * 1988-05-20 1994-01-01 Zambon Spa Procedimiento para la preparacion de compuestos con actividad analgesica central.
FR2696445B1 (fr) * 1992-10-01 1994-12-16 Rennes Inst Nal Sciences Appli Composition pour l'obtention de produits à base de chaux pure, application de cette composition et procédé pour sa mise en Óoeuvre.
DK0863875T3 (da) * 1995-09-07 2003-12-01 Hoffmann La Roche Hidtil ukendte 4-(oxyalkoxyphenyl)-3-oxy-piperiner til behandling af hjerte- og nyrelidelser
JP3064425B2 (ja) * 1995-09-15 2000-07-12 ノイロサーチ アクティーゼルスカブ カルシウムチャンネル・ブロッカーとしてのピペリジン化合物
ES2426915T3 (es) 2003-09-10 2013-10-25 Brentwood Equities Ltd. Diastereoisómeros de 4-ariloxi-3-hidroxipiperidinas
US20070142389A1 (en) * 2005-12-20 2007-06-21 Pfizer Inc. Piperidine derivatives

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU34026A1 (fi) * 1954-12-23
US3117975A (en) * 1960-04-22 1964-01-14 Rohm & Haas Substituted pyrrolidinones and piperidinones
US3260723A (en) * 1963-08-27 1966-07-12 Parke Davis & Co 4-phenoxy piperidines; alpha4-phenoxy piperideines
US3360526A (en) * 1964-01-15 1967-12-26 Bristol Myers Co Heterocyclicamino methylene ethers of benzylphenols
US3446897A (en) * 1966-09-30 1969-05-27 Robins Co Inc A H Compositions and methods for the control of cardiac arrhythmia with o-substituted pyrrolidinols and s-substituted thiopyrrolidinols
CH500226A (de) 1968-08-02 1970-12-15 Ciba Geigy Ag Verfahren zur Herstellung neuer Pyrimidinderivate
DE1937459A1 (de) * 1968-08-02 1970-02-05 Ciba Geigy Neue Pyrimidinderivate und Verfahren zu ihrer Herstellung
US3823151A (en) * 1968-08-02 1974-07-09 Ciba Geigy Corp 4,5,6,7-tetrahydrothieno(2,3-d)pyridines
US3577432A (en) * 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-phenoxypyrrolidines
GB1280699A (en) * 1968-12-23 1972-07-05 Robins Co Inc A H 0-substituted-4-phenoxypiperidines
US3542794A (en) * 1969-11-07 1970-11-24 Grover Cleveland Helsley 1-carbamoyl-4-phenoxypiperidines
US3686169A (en) * 1970-07-20 1972-08-22 Monsanto Co Thiocycloamides
US3743645A (en) * 1970-10-19 1973-07-03 Robins Co Inc A H 1-substituted-4-phenoxypiperidines
JPS5119987B2 (fi) * 1973-02-05 1976-06-22
US4065290A (en) * 1975-07-03 1977-12-27 Eli Lilly And Company Herbicidal β-phenyl-4-piperidinones
IE45511B1 (en) * 1976-09-01 1982-09-08 Ciba Geigy Ag New derivatives of perhydro-aza-heterocycles and processesfor the production thereof
US4230718A (en) 1979-01-09 1980-10-28 A. H. Robins Company, Inc. 1-Substituted-3,4-epoxypyrrolidines
MX6634E (es) 1979-01-09 1985-09-12 Robins Co Inc A H Procedimiento para preparar el isomero trans de 3-ariloxi-4-hidroxipirrolidinas
US4251541A (en) 1979-01-09 1981-02-17 A. H. Robins Company, Inc. 1-Substituted-3-arylthio-4-hydroxypyrrolidines

Also Published As

Publication number Publication date
ES471739A1 (es) 1979-10-16
CH637932A5 (de) 1983-08-31
ZA775267B (en) 1978-07-26
DE2738477A1 (de) 1978-03-02
CH637934A5 (de) 1983-08-31
ES479190A1 (es) 1979-07-01
DE2738477C2 (fi) 1989-11-09
CY1212A (en) 1984-04-06
DK156301B (da) 1989-07-31
DK156301C (da) 1989-12-11
ES462040A1 (es) 1978-12-01
FI68229B (fi) 1985-04-30
PT66955B (en) 1979-02-07
US4246269A (en) 1981-01-20
NO150081C (no) 1984-08-15
FR2363559B1 (fi) 1982-03-26
HK8884A (en) 1984-02-10
PT66955A (en) 1977-09-01
NZ185062A (en) 1980-10-08
CH633776A5 (de) 1982-12-31
NL7709604A (nl) 1978-03-03
GR72965B (fi) 1984-01-19
ATA627977A (de) 1980-08-15
ES479112A1 (es) 1979-07-01
NO773009L (no) 1978-03-02
CH637933A5 (de) 1983-08-31
ES471740A1 (es) 1979-10-16
CS205085B2 (en) 1981-04-30
IE45511L (en) 1978-03-01
US4320137A (en) 1982-03-16
GB1585133A (en) 1981-02-25
CS205087B2 (en) 1981-04-30
IL52858A0 (en) 1977-10-31
JPS6340785B2 (fi) 1988-08-12
ES471738A1 (es) 1979-10-16
US4160837A (en) 1979-07-10
NO150081B (no) 1984-05-07
SG63783G (en) 1984-07-27
IE45511B1 (en) 1982-09-08
DK387177A (da) 1978-03-02
AU514675B2 (en) 1981-02-19
CA1112242A (en) 1981-11-10
CS205084B2 (en) 1981-04-30
BE858283A (fr) 1978-02-28
FR2363559A1 (fr) 1978-03-31
AT361464B (de) 1981-03-10
CH637935A5 (de) 1983-08-31
SE7709784L (sv) 1978-03-02
FI68229C (fi) 1985-08-12
HU179440B (en) 1982-10-28
DD132584A5 (de) 1978-10-11
AU2838577A (en) 1979-03-08
MY8500100A (en) 1985-12-31
FI772566A (fi) 1978-03-02
JPS5331659A (en) 1978-03-25

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