SE380257B - Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser - Google Patents

Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser

Info

Publication number
SE380257B
SE380257B SE7205757A SE575772A SE380257B SE 380257 B SE380257 B SE 380257B SE 7205757 A SE7205757 A SE 7205757A SE 575772 A SE575772 A SE 575772A SE 380257 B SE380257 B SE 380257B
Authority
SE
Sweden
Prior art keywords
peptidyl
thrombin
high specificity
proteolytic enzymes
new diagnostic
Prior art date
Application number
SE7205757A
Other languages
English (en)
Swedish (sv)
Inventor
G E B Blombeck
M Blombeck
K G Claesson
L G Svendsen
Original Assignee
Bofors Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bofors Ab filed Critical Bofors Ab
Priority to SE7205757A priority Critical patent/SE380257B/xx
Priority to US354036A priority patent/US3884896A/en
Priority to FI1299/73A priority patent/FI56828C/fi
Priority to IL42123A priority patent/IL42123A/xx
Priority to HUBO1430A priority patent/HU170670B/hu
Priority to SU731916396A priority patent/SU671721A3/ru
Priority to DD170548A priority patent/DD108281A5/xx
Priority to BE130583A priority patent/BE798916A/xx
Priority to NO1790/73A priority patent/NO135245C/no
Priority to ES414252A priority patent/ES414252A1/es
Priority to AT381173A priority patent/AT324557B/de
Priority to AU55038/73A priority patent/AU475377B2/en
Priority to JP4899373A priority patent/JPS559199B2/ja
Priority to CA170,179A priority patent/CA1010849A/en
Priority to GB2069373A priority patent/GB1428039A/en
Priority to PL1973162270A priority patent/PL90746B1/pl
Priority to NL7306085A priority patent/NL7306085A/xx
Priority to DE2322116A priority patent/DE2322116B2/de
Priority to ZA732976A priority patent/ZA732976B/xx
Priority to CS733128A priority patent/CS187376B2/cs
Priority to CH626773A priority patent/CH590476A5/xx
Priority to FR7315771A priority patent/FR2183188B1/fr
Priority to IT50204/73A priority patent/IT1050662B/it
Publication of SE380257B publication Critical patent/SE380257B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/976—Trypsin; Chymotrypsin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/802—Chromogenic or luminescent peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SE7205757A 1972-05-02 1972-05-02 Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser SE380257B (sv)

Priority Applications (23)

Application Number Priority Date Filing Date Title
SE7205757A SE380257B (sv) 1972-05-02 1972-05-02 Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
US354036A US3884896A (en) 1972-05-02 1973-04-24 New substrates for diagnostic use, with high susceptibility to thrombin and other proteolytic
FI1299/73A FI56828C (fi) 1972-05-02 1973-04-24 Nya diagnostiskt verksamma substrat med hoeg specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
IL42123A IL42123A (en) 1972-05-02 1973-04-27 Substrate for the determination of proteolytic enzymes
HUBO1430A HU170670B (xx) 1972-05-02 1973-04-28
SU731916396A SU671721A3 (ru) 1972-05-02 1973-04-28 Способ получени трипептидов или их солей
DD170548A DD108281A5 (xx) 1972-05-02 1973-04-28
BE130583A BE798916A (fr) 1972-05-02 1973-04-30 Nouveaux substrats pour diagnostic
NO1790/73A NO135245C (xx) 1972-05-02 1973-04-30
ES414252A ES414252A1 (es) 1972-05-02 1973-04-30 Procedimiento de obtencion de un nuevo sustrato para uso diagnostico altamente sensible a la trombina y otras enzimasproteoliticas del tipo peptido peptidohidrolasas.
AT381173A AT324557B (de) 1972-05-02 1973-04-30 Bestimmung von peptid-peptidohydrolasen oder deren proenzymen, aktivatoren, antienzymen und enzyminhibitoren
AU55038/73A AU475377B2 (en) 1972-05-02 1973-05-01 New substrates for diagnostic use, with high susceptibility to thrombin and other proteolytic enzymes of the type peptide peptidehydrolases
JP4899373A JPS559199B2 (xx) 1972-05-02 1973-05-01
CA170,179A CA1010849A (en) 1972-05-02 1973-05-01 Substrates for diagnostic use, with high susceptibility to thrombin and other proteolytic enzymes of the type peptide peptidohydrolases
GB2069373A GB1428039A (en) 1972-05-02 1973-05-01 Compounds for disgnostic use with high susceptibility to thrombin and ohter proteolytic enzymes of the type peptide peptidohydrolases
PL1973162270A PL90746B1 (xx) 1972-05-02 1973-05-02
NL7306085A NL7306085A (xx) 1972-05-02 1973-05-02
DE2322116A DE2322116B2 (de) 1972-05-02 1973-05-02 Tri- und Tetrapeptide und deren Verwendung zur Bestimmung von Peptid-Peptidohydrolasen
ZA732976A ZA732976B (en) 1972-05-02 1973-05-02 New substrates for diagnostic use,with high susceptibility to thrombin and other proteolytic enzymes of the type peptide peptidohydrolases
CS733128A CS187376B2 (en) 1972-05-02 1973-05-02 Method of producing novel substrates for serine proteas
CH626773A CH590476A5 (xx) 1972-05-02 1973-05-02
FR7315771A FR2183188B1 (xx) 1972-05-02 1973-05-02
IT50204/73A IT1050662B (it) 1972-05-02 1973-05-24 Composizione per la determinazione quantitativa di enzimi proteolitici in particolare del tipo delle peptidoidrolasi peptidiche

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7205757A SE380257B (sv) 1972-05-02 1972-05-02 Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser

Publications (1)

Publication Number Publication Date
SE380257B true SE380257B (sv) 1975-11-03

Family

ID=20267168

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7205757A SE380257B (sv) 1972-05-02 1972-05-02 Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser

Country Status (23)

Country Link
US (1) US3884896A (xx)
JP (1) JPS559199B2 (xx)
AT (1) AT324557B (xx)
AU (1) AU475377B2 (xx)
BE (1) BE798916A (xx)
CA (1) CA1010849A (xx)
CH (1) CH590476A5 (xx)
CS (1) CS187376B2 (xx)
DD (1) DD108281A5 (xx)
DE (1) DE2322116B2 (xx)
ES (1) ES414252A1 (xx)
FI (1) FI56828C (xx)
FR (1) FR2183188B1 (xx)
GB (1) GB1428039A (xx)
HU (1) HU170670B (xx)
IL (1) IL42123A (xx)
IT (1) IT1050662B (xx)
NL (1) NL7306085A (xx)
NO (1) NO135245C (xx)
PL (1) PL90746B1 (xx)
SE (1) SE380257B (xx)
SU (1) SU671721A3 (xx)
ZA (1) ZA732976B (xx)

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DE2527932C2 (de) * 1974-07-02 1983-04-21 Pentapharm AG, 4052 Basel Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein
US4016259A (en) * 1974-07-26 1977-04-05 Research Corporation Contraceptive polypeptides
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
US4162941A (en) * 1974-12-05 1979-07-31 Ab Kabi Method for determining a proteolytic enzyme
CH622286A5 (xx) * 1975-06-23 1981-03-31 Pentapharm Ag
US4169015A (en) * 1975-07-11 1979-09-25 Ab Kabi Novel chromogenic thrombin substrates
SE407405B (sv) * 1975-07-11 1979-03-26 Kabi Ab Nya kromogena trombinsubstrat
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
SE407115B (sv) * 1975-10-06 1979-03-12 Kabi Ab Forfarande och metelektroder for studium av enzymatiska och andra biokemiska reaktioner
SE419871B (sv) * 1975-12-01 1981-08-31 Pharmacia Ab Sett att bestemma aktiviteten hos faktor xa-inhibitor i blod
CH634662A5 (de) * 1976-05-28 1983-02-15 Pentapharm Ag Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
FR2416883A2 (fr) * 1977-02-18 1979-09-07 Delalande Sa Nouveaux oligopeptides trifluoromethyles, leur procede de preparation et leur application en therapeutique
JPS5415797A (en) * 1977-06-14 1979-02-05 Seikagaku Kogyo Co Ltd Detection and measurement of toxin in cells
CA1087075A (en) * 1977-08-05 1980-10-07 Robert J. Gargiulo Composition and method for determining transferase and protease activity
DE2757992A1 (de) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh Verfahren zur prothrombin-bestimmung
SE7801373L (sv) * 1978-02-07 1979-08-08 Kabi Ab Lett spjelkbara substrat for kvantifiering av proteaser
DE2812943C3 (de) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma
US4302538A (en) * 1978-03-27 1981-11-24 Ortho Diagnostics Inc. Buffer system in an anti-thrombin III test
IL60888A (en) * 1978-06-16 1984-07-31 Yeda Res & Dev Substrates and process for the quantitative assay of enzymes
US4336186A (en) * 1978-08-03 1982-06-22 Gargiulo Robert J Analytical fluorogenic substrates for proteolytic enzymes
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
US4161488A (en) * 1978-08-17 1979-07-17 Abbott Laboratories Enzymatic substrates
US4166825A (en) * 1978-08-17 1979-09-04 Abbott Laboratories Chromogenic substrates
JPS5559150A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
JPS5559149A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
JPS59499B2 (ja) * 1978-11-02 1984-01-07 味の素株式会社 ペプチド誘導体
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
US4217269A (en) * 1979-03-23 1980-08-12 Abbott Laboratories Dipeptide chromogenic substrates
US4219497A (en) 1979-04-06 1980-08-26 Abbott Laboratories Chromogenic substrates
US4409140A (en) * 1979-04-23 1983-10-11 Smith Robert E Substrates and method for determining enzymes
DE3061860D1 (en) * 1979-04-24 1983-03-17 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
US4221706A (en) * 1979-06-14 1980-09-09 Abbott Laboratories Chromogenic substrates
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
US4308202A (en) * 1979-10-25 1981-12-29 Torii & Co., Ltd. Prolylphenylalanylarginine derivatives, process for producing same and method for measuring activity of enzymes using same
JPS5661339A (en) * 1979-10-26 1981-05-26 Ajinomoto Co Inc Arginine derivative
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EP0046742B1 (en) * 1980-08-25 1984-06-27 KabiVitrum AB Peptide substrates for determination of protease activity
US4568636A (en) * 1981-03-25 1986-02-04 Pentapharm Ag Tripeptide derivatives
US4388233A (en) * 1981-05-15 1983-06-14 The Regents Of The University Of California Synthetic substrates for enzyme analysis
US4434096A (en) 1981-06-30 1984-02-28 E. I. Du Pont De Nemours And Company Substrates for the quantitative determination of proteolytic enzymes
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
JPS5863399A (ja) * 1981-10-14 1983-04-15 Nitto Boseki Co Ltd 新規なプラスミン測定用基質
DE3268329D1 (en) * 1981-11-02 1986-02-13 Pentapharm Ag Process for the quantitative determination of the blood clotting factor xii in human plasma
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
SE8203887D0 (sv) * 1982-06-23 1982-06-23 Kabivitrum Ab Nya trombininhiberande foreningar
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
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US4897444A (en) * 1985-05-31 1990-01-30 The Research Foundation Of The State University Of New York Immobilized fluorogenic substrates for enzymes; and processes for their preparation
JPH0413880Y2 (xx) * 1985-08-22 1992-03-30
US5187069A (en) * 1990-08-06 1993-02-16 Henry Ford Health System Active site labelling of plasminogen
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DE69329280T2 (de) * 1992-04-27 2001-03-15 Avocet Medical, Inc. Testvorrichtung und verfahren zur durchführung von blutgerinnungstests
US5580744A (en) * 1992-04-27 1996-12-03 Avocet Medical, Inc. Test article and method for performing blood coagulation assays
US5399487A (en) * 1993-03-04 1995-03-21 Haematologic Technologies, Inc. 6-peptidylamino-1-naphthalenesulfonamides useful as fluorogenic proteolytic enzyme substrates
US6297024B1 (en) 1998-10-15 2001-10-02 Cell Activation, Inc. Methods for assessing complement activation
US6235494B1 (en) 1999-02-08 2001-05-22 The Scripps Research Institute Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980000252A1 (en) * 1978-07-18 1980-02-21 Kabi Ab Bradykinin-inhibiting tripeptide derivatives

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US3884896A (en) 1975-05-20
NL7306085A (xx) 1973-11-06
FR2183188A1 (xx) 1973-12-14
IT1050662B (it) 1981-03-20
ES414252A1 (es) 1976-05-01
SU671721A3 (ru) 1979-06-30
BE798916A (fr) 1973-08-16
CS187376B2 (en) 1979-01-31
FI56828B (fi) 1979-12-31
HU170670B (xx) 1977-08-28
GB1428039A (en) 1976-03-17
AT324557B (de) 1975-09-10
AU5503873A (en) 1974-11-07
CA1010849A (en) 1977-05-24
PL90746B1 (xx) 1977-01-31
ZA732976B (en) 1974-11-27
JPS4949695A (xx) 1974-05-14
AU475377B2 (en) 1976-08-19
IL42123A0 (en) 1973-06-29
FI56828C (fi) 1980-04-10
DE2322116A1 (de) 1973-11-22
JPS559199B2 (xx) 1980-03-08
DE2322116B2 (de) 1980-01-10
CH590476A5 (xx) 1977-08-15
IL42123A (en) 1978-01-31
NO135245B (xx) 1976-11-29
DD108281A5 (xx) 1974-09-12
NO135245C (xx) 1977-03-09
FR2183188B1 (xx) 1977-02-11

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