FI56828B - Nya diagnostiskt verksamma substrat med hoeg specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser - Google Patents

Nya diagnostiskt verksamma substrat med hoeg specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser

Info

Publication number
FI56828B
FI56828B FI1299/73A FI129973A FI56828B FI 56828 B FI56828 B FI 56828B FI 1299/73 A FI1299/73 A FI 1299/73A FI 129973 A FI129973 A FI 129973A FI 56828 B FI56828 B FI 56828B
Authority
FI
Finland
Prior art keywords
hydrolaser
verksamma
enzymer
proteolytical
trombin
Prior art date
Application number
FI1299/73A
Other languages
English (en)
Other versions
FI56828C (fi
Inventor
Gustaf Erik Birger Blombaeck
Margareta Blombaeck
Karl Goeran Claeson
Lars-Gundro Svendsen
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Application granted granted Critical
Publication of FI56828B publication Critical patent/FI56828B/fi
Publication of FI56828C publication Critical patent/FI56828C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/976—Trypsin; Chymotrypsin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/802—Chromogenic or luminescent peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI1299/73A 1972-05-02 1973-04-24 Nya diagnostiskt verksamma substrat med hoeg specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser FI56828C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE7205757A SE380257B (sv) 1972-05-02 1972-05-02 Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
SE575772 1972-05-02

Publications (2)

Publication Number Publication Date
FI56828B true FI56828B (fi) 1979-12-31
FI56828C FI56828C (fi) 1980-04-10

Family

ID=20267168

Family Applications (1)

Application Number Title Priority Date Filing Date
FI1299/73A FI56828C (fi) 1972-05-02 1973-04-24 Nya diagnostiskt verksamma substrat med hoeg specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser

Country Status (23)

Country Link
US (1) US3884896A (fi)
JP (1) JPS559199B2 (fi)
AT (1) AT324557B (fi)
AU (1) AU475377B2 (fi)
BE (1) BE798916A (fi)
CA (1) CA1010849A (fi)
CH (1) CH590476A5 (fi)
CS (1) CS187376B2 (fi)
DD (1) DD108281A5 (fi)
DE (1) DE2322116B2 (fi)
ES (1) ES414252A1 (fi)
FI (1) FI56828C (fi)
FR (1) FR2183188B1 (fi)
GB (1) GB1428039A (fi)
HU (1) HU170670B (fi)
IL (1) IL42123A (fi)
IT (1) IT1050662B (fi)
NL (1) NL7306085A (fi)
NO (1) NO135245C (fi)
PL (1) PL90746B1 (fi)
SE (1) SE380257B (fi)
SU (1) SU671721A3 (fi)
ZA (1) ZA732976B (fi)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50139215U (fi) * 1974-04-30 1975-11-17
DE2527932C2 (de) * 1974-07-02 1983-04-21 Pentapharm AG, 4052 Basel Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein
US4016259A (en) * 1974-07-26 1977-04-05 Research Corporation Contraceptive polypeptides
US4162941A (en) * 1974-12-05 1979-07-31 Ab Kabi Method for determining a proteolytic enzyme
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
CH622286A5 (fi) * 1975-06-23 1981-03-31 Pentapharm Ag
US4169015A (en) * 1975-07-11 1979-09-25 Ab Kabi Novel chromogenic thrombin substrates
SE407405B (sv) * 1975-07-11 1979-03-26 Kabi Ab Nya kromogena trombinsubstrat
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
SE407115B (sv) * 1975-10-06 1979-03-12 Kabi Ab Forfarande och metelektroder for studium av enzymatiska och andra biokemiska reaktioner
SE419871B (sv) * 1975-12-01 1981-08-31 Pharmacia Ab Sett att bestemma aktiviteten hos faktor xa-inhibitor i blod
CH634662A5 (de) * 1976-05-28 1983-02-15 Pentapharm Ag Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
FR2416883A2 (fr) * 1977-02-18 1979-09-07 Delalande Sa Nouveaux oligopeptides trifluoromethyles, leur procede de preparation et leur application en therapeutique
JPS5415797A (en) * 1977-06-14 1979-02-05 Seikagaku Kogyo Co Ltd Detection and measurement of toxin in cells
CA1087075A (en) * 1977-08-05 1980-10-07 Robert J. Gargiulo Composition and method for determining transferase and protease activity
DE2757992A1 (de) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh Verfahren zur prothrombin-bestimmung
SE7801373L (sv) * 1978-02-07 1979-08-08 Kabi Ab Lett spjelkbara substrat for kvantifiering av proteaser
DE2812943C3 (de) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma
US4302538A (en) * 1978-03-27 1981-11-24 Ortho Diagnostics Inc. Buffer system in an anti-thrombin III test
IL60888A (en) * 1978-06-16 1984-07-31 Yeda Res & Dev Substrates and process for the quantitative assay of enzymes
DE2964956D1 (en) * 1978-07-18 1983-04-07 Kabi Ab Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing them
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
US4336186A (en) * 1978-08-03 1982-06-22 Gargiulo Robert J Analytical fluorogenic substrates for proteolytic enzymes
US4166825A (en) * 1978-08-17 1979-09-04 Abbott Laboratories Chromogenic substrates
US4161488A (en) * 1978-08-17 1979-07-17 Abbott Laboratories Enzymatic substrates
JPS5559150A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
JPS5559149A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
JPS59499B2 (ja) * 1978-11-02 1984-01-07 味の素株式会社 ペプチド誘導体
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
US4217269A (en) * 1979-03-23 1980-08-12 Abbott Laboratories Dipeptide chromogenic substrates
US4219497A (en) 1979-04-06 1980-08-26 Abbott Laboratories Chromogenic substrates
US4409140A (en) * 1979-04-23 1983-10-11 Smith Robert E Substrates and method for determining enzymes
EP0018002B1 (de) * 1979-04-24 1983-02-09 Marcel Jozefonvicz Neues Bestimmungsverfahren für Proteasen und Antiproteasen
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
US4221706A (en) * 1979-06-14 1980-09-09 Abbott Laboratories Chromogenic substrates
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
US4308202A (en) * 1979-10-25 1981-12-29 Torii & Co., Ltd. Prolylphenylalanylarginine derivatives, process for producing same and method for measuring activity of enzymes using same
JPS5661339A (en) * 1979-10-26 1981-05-26 Ajinomoto Co Inc Arginine derivative
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
DK155051C (da) * 1980-05-06 1989-07-03 Pentapharm Ag Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf
WO1982000641A1 (en) * 1980-08-25 1982-03-04 Ab Kabivitrum Peptide substrates for determination of protease activity
US4568636A (en) * 1981-03-25 1986-02-04 Pentapharm Ag Tripeptide derivatives
US4388233A (en) * 1981-05-15 1983-06-14 The Regents Of The University Of California Synthetic substrates for enzyme analysis
US4434096A (en) 1981-06-30 1984-02-28 E. I. Du Pont De Nemours And Company Substrates for the quantitative determination of proteolytic enzymes
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
JPS5863399A (ja) * 1981-10-14 1983-04-15 Nitto Boseki Co Ltd 新規なプラスミン測定用基質
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
DE3268329D1 (en) * 1981-11-02 1986-02-13 Pentapharm Ag Process for the quantitative determination of the blood clotting factor xii in human plasma
SE8203887D0 (sv) * 1982-06-23 1982-06-23 Kabivitrum Ab Nya trombininhiberande foreningar
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
JPS6117956A (ja) * 1984-07-04 1986-01-25 Nitto Boseki Co Ltd 新規な尿中カリクレイン測定用基質
US4897444A (en) * 1985-05-31 1990-01-30 The Research Foundation Of The State University Of New York Immobilized fluorogenic substrates for enzymes; and processes for their preparation
JPH0413880Y2 (fi) * 1985-08-22 1992-03-30
US5187069A (en) * 1990-08-06 1993-02-16 Henry Ford Health System Active site labelling of plasminogen
EP0535485B1 (en) * 1991-10-03 1997-07-16 Bayer Corporation Device and method of separating and assaying whole blood
AU4287593A (en) * 1992-04-27 1993-11-29 Avocet Medical, Inc. Test article and method for performing blood coagulation assays
US5580744A (en) * 1992-04-27 1996-12-03 Avocet Medical, Inc. Test article and method for performing blood coagulation assays
US5399487A (en) * 1993-03-04 1995-03-21 Haematologic Technologies, Inc. 6-peptidylamino-1-naphthalenesulfonamides useful as fluorogenic proteolytic enzyme substrates
US6297024B1 (en) 1998-10-15 2001-10-02 Cell Activation, Inc. Methods for assessing complement activation
US6235494B1 (en) 1999-02-08 2001-05-22 The Scripps Research Institute Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates

Also Published As

Publication number Publication date
JPS4949695A (fi) 1974-05-14
NL7306085A (fi) 1973-11-06
AT324557B (de) 1975-09-10
ES414252A1 (es) 1976-05-01
AU475377B2 (en) 1976-08-19
CH590476A5 (fi) 1977-08-15
JPS559199B2 (fi) 1980-03-08
FR2183188B1 (fi) 1977-02-11
HU170670B (fi) 1977-08-28
FI56828C (fi) 1980-04-10
SU671721A3 (ru) 1979-06-30
AU5503873A (en) 1974-11-07
IL42123A (en) 1978-01-31
ZA732976B (en) 1974-11-27
BE798916A (fr) 1973-08-16
DE2322116B2 (de) 1980-01-10
PL90746B1 (fi) 1977-01-31
NO135245B (fi) 1976-11-29
GB1428039A (en) 1976-03-17
DD108281A5 (fi) 1974-09-12
IL42123A0 (en) 1973-06-29
CS187376B2 (en) 1979-01-31
US3884896A (en) 1975-05-20
NO135245C (fi) 1977-03-09
FR2183188A1 (fi) 1973-12-14
SE380257B (sv) 1975-11-03
IT1050662B (it) 1981-03-20
CA1010849A (en) 1977-05-24
DE2322116A1 (de) 1973-11-22

Similar Documents

Publication Publication Date Title
FI56828B (fi) Nya diagnostiskt verksamma substrat med hoeg specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
FI56829B (fi) Nya diagnostiskt verksamma substrat med hoeg specifitet foer trypsin och andra enzymer av typen peptidylpeptidhydrolaser
FI56478B (fi) Foerfaringssaett foer framstaellning av en fettemulsion med laogt kalorivaerde och hoeg proteinhalt
IT994884B (it) Umidificatore clinico
SE382059B (sv) Forfarande for framstellning av nya substituerade piperidinderivat
FI56676B (fi) Foerfarande foer framstaellning av nya amidderivat av nonapeptid som befraemjar loesgoerandet av aeggceller
SE402916B (sv) Sett att framstella nya alfa-sulfobensylpenicillindiaminsalter
SE386445B (sv) Forfaranden for framstellning av nya bensotiadiazoler
SE382060B (sv) Forfarande for framstellning av nya substituerade piperidinoalkanonoximderivat
SE431756B (sv) Fenoxi-2-oxopropylfosfonat till anvendning som mellanprodukt vid framstellning av nya w-pentanorprostaglandiner
SE420322B (sv) Anvendning av nya gamma-glutamyl-4-nitroanild-derivat for bestemning av gamma-glutsmyltranspeptidas
SE384853B (sv) Forfarande for framstellning av nya aminer
FI55029C (fi) Foerfarande foer framstaellning av nya terapeutiskt aktiva isoindolinderivat
SE389856B (sv) Forfarande for framstellning av alkaliperkarbonater
SE397976B (sv) Nya kinoxalin-di-n-oxider med tillvextbefordrande verkan
SE405851B (sv) Forfarande for framstellning av nya 2-aminometylenindanoner med analgetisk verkan
SE386902B (sv) Forfarande for framstellning av nya cefalosporiner
AR195823A1 (es) Esteres liquidos cristalinos
SE395885B (sv) Forfarande for framstellning av nya kortikotropinpeptider
SE385883B (sv) Forfarande for framstellning av nya pyridinkarbonsyraestrar
SE397088B (sv) Forfarande for framstellning av nya 2-propanolderivat
FI55198C (fi) Foerfarande foer framstaellning av nya terapeutiskt aktiva isoindolinderivat
SE384027B (sv) Forfarande for framstellning av nya alfa-alkylsulfobensylpenicilliner
FI54475B (fi) Foerfarande foer framstaellning av nya 3,5-disubstituerade 1-laogalkyl-1,2,4-triazoler med hoeg hypnotisk aktivitet
SE373585B (sv) Forfarande for framstellning av nya hypnotiskt aktiva oxo-dihydrobensotiazin-s-dioxider