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Ajinomoto Co Inc
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Ajinomoto Co Inc
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Application filed by Ajinomoto Co IncfiledCriticalAjinomoto Co Inc
Priority to JP13847679ApriorityCriticalpatent/JPS5661339A/en
Publication of JPS5661339ApublicationCriticalpatent/JPS5661339A/en
NEW MATERIAL:N-Benzoyl-( p-nitro )phenylalanyl-valyl- arginine-p- nitroanilide.
USE: A substrate for measuring the activity of enzymes such as α-thrombin or trypsin. It is used as a diagnostricum for diseases caused by these enzymes. The activity is measured with simple operations and high sensitivity.
PREPARATION: The objective compound is obtained through the conventional peptide synthesis process, for example, after each amino residual group of p-nitrophenylalanine and valine is appropriately protected, the condensation reaction of arginine-p-n-nitroanilide hydrochloride is effected.
METHOD OF ANALOGUE FOR THE PREPARATION OF PEPTIDS CONTAINING 2-7 AMINO ACID RESIDUES, DESAMINODIPEPTIDES OR AMIDES THEREOF WITH UBIQUITIN SIMILAR ACTIVITY OR PHARMACEUTICAL ACCEPTABLE ACID ADDITIONAL SALTS
Amino acid and peptide esters of leuco-indo anilines, process for their preparation and agents containing these compounds for the detection of proteolytic enzymes